To reveal the mechanism of shear failure of en-echelon joints under cyclic loading,such as during earthquakes,we conducted a series of cyclic shear tests of en-echelon joints under constant normal stiffness(CNS)condit...To reveal the mechanism of shear failure of en-echelon joints under cyclic loading,such as during earthquakes,we conducted a series of cyclic shear tests of en-echelon joints under constant normal stiffness(CNS)conditions.We analyzed the evolution of shear stress,normal stress,stress path,dilatancy characteristics,and friction coefficient and revealed the failure mechanisms of en-echelon joints at different angles.The results show that the cyclic shear behavior of the en-echelon joints is closely related to the joint angle,with the shear strength at a positive angle exceeding that at a negative angle during shear cycles.As the number of cycles increases,the shear strength decreases rapidly,and the difference between the varying angles gradually decreases.Dilation occurs in the early shear cycles(1 and 2),while contraction is the main feature in later cycles(310).The friction coefficient decreases with the number of cycles and exhibits a more significant sensitivity to joint angles than shear cycles.The joint angle determines the asperities on the rupture surfaces and the block size,and thus determines the subsequent shear failure mode(block crushing and asperity degradation).At positive angles,block size is more greater and asperities on the rupture surface are smaller than at nonpositive angles.Therefore,the cyclic shear behavior is controlled by block crushing at positive angles and asperity degradation at negative angles.展开更多
In this paper,we study normal families of meromorphic functions.By using the idea in[11],we obtain some normality criteria for families of meromorphic functions that concern the number of zeros of the differential pol...In this paper,we study normal families of meromorphic functions.By using the idea in[11],we obtain some normality criteria for families of meromorphic functions that concern the number of zeros of the differential polynomial,which extends the related result of Li,and Chen et al..An example is given to show that the hypothesis on the zeros of a(z)is necessary.展开更多
This socialized environment among educated and developed people causes themto focusmore on their appearance and health,which turns them towards medical-related treatments,leading us to discuss anti-aging treatment met...This socialized environment among educated and developed people causes themto focusmore on their appearance and health,which turns them towards medical-related treatments,leading us to discuss anti-aging treatment methods for each age group,particularly for urban people who are interested in this.Some anti-aging therapies are used to address the alterations brought on by aging in human life without the need for surgery or negative effects.Five anti-aging therapies such as microdermabrasion or dermabrasion,laser resurfacing anti-aging skin treatments,chemical peels,dermal fillers for aged skin,and botox injections are considered in this study.Based on the criteria of safety risk,investment cost,customer happiness,and side effects,the optimal alternative is picked.As a result,a NormalWiggly Hesitant Pythagorean Fuzzy Set(NWHPFS)is constructed and used in Multi-Criteria Decision-Making(MCDM)using traditional wavy mathematical approaches.The entropy approach is utilized to determine weight values,and the Normal Wiggly Hesitant Pythagorean-VlseKriterijumska Optimizacija I Kompromisno Resenje(NWHPF-VIKOR)method is utilized to rank alternatives using MCDM methodologies.Sensitivity analysis and comparative analysis were performed to ensure the robustness and reliability of the proposed method.The smart final choice will undoubtedly assist Decision Makers(DM)in making the right judgments,and the MCDM approach will undoubtedly assist individuals in understanding the medicine.展开更多
The normal direction to the normal direction to a line in Minkowski geometries generally does not give the original line. We show that in lp geometries with p>1?repeatedly finding the normal line through the origin...The normal direction to the normal direction to a line in Minkowski geometries generally does not give the original line. We show that in lp geometries with p>1?repeatedly finding the normal line through the origin gives sequences of lines that monotonically approach specific lines of symmetry of the unit circle. Which lines of symmetry that are approached depends upon the value of p and the slope of the initial line.展开更多
This article presents a ground theory to explain why some individuals choose to be unhappy rather than happy,supported by empirical data collected from a sample of 750 professionals in Greece’s public and private sec...This article presents a ground theory to explain why some individuals choose to be unhappy rather than happy,supported by empirical data collected from a sample of 750 professionals in Greece’s public and private sectors.We begin by reviewing the existing literature on happiness and well-being,highlighting the debate between hedonic and eudaimonic perspectives.We then introduce our research questions and rationale,and describe our methods,sample,and psychometric tools used to measure happiness and other variables of interest.Our results indicate that various factors,including cultural influences,past experiences,and personal values,contribute to individuals’pursuit of unhappiness.We conclude with a thorough discussion of our results and their implications for future research and interventions aimed at promoting well-being.展开更多
The problem of best approximating, a given square complex matrix in the Frobenius norm by normal matrices under a given spectral restriction is considered. The ne cessary and sufficient condition for the solvability ...The problem of best approximating, a given square complex matrix in the Frobenius norm by normal matrices under a given spectral restriction is considered. The ne cessary and sufficient condition for the solvability of the problem is given. A numerical algorithm for solving the problem is provided and a numerical example is presented.展开更多
The Qinghai-Xizang Plateau, or Tibetan Plateau, is a sensitive region for climate change, where the manifestation of global warming is particularly noticeable. The wide climate variability in this region significantly...The Qinghai-Xizang Plateau, or Tibetan Plateau, is a sensitive region for climate change, where the manifestation of global warming is particularly noticeable. The wide climate variability in this region significantly affects the local land ecosystem and could consequently lead to notable vegetation changes. In this paper, the interannual variations of the plateau vegetation are investigated using a 21-year normalized difference vegetation index (NDVI) dataset to quantify the consequences of climate warming for the regional ecosystem and its interactions. The results show that vegetation coverage is best in the eastern and southern plateau regions and deteriorates toward the west and north. On the whole, vegetation activity demonstrates a gradual enhancement in an oscillatory manner during 1982-2002. The temporal variation also exhibits striking regional differences: an increasing trend is most apparent in the west, south, north and southeast, whereas a decreasing trend is present along the southern plateau boundary and in the central-east region. Covariance analysis between the NDVI and surface temperature/precipitation suggests that vegetation change is closely related to climate change. However, the controlling physical processes vary geographically. In the west and east, vegetation variability is found to be driven predominantly by temperature, with the impact of precipitation being of secondary importance. In the central plateau, however, temperature and precipitation factors are equally important in modulating the interannual vegetation variability.展开更多
In this editorial,we focus specifically on the mechanisms by which pancreatic inflammation affects pancreatic cancer.Cancer of the pancreas remains one of the deadliest cancer types.The highest incidence and mortality...In this editorial,we focus specifically on the mechanisms by which pancreatic inflammation affects pancreatic cancer.Cancer of the pancreas remains one of the deadliest cancer types.The highest incidence and mortality rates of pancreatic cancer are found in developed countries.Trends of pancreatic cancer incidence and mortality vary considerably worldwide.A better understanding of the etiology and identification of the risk factors is essential for the primary prevention of this disease.Pancreatic tumors are characterized by a complex microenvironment that orchestrates metabolic alterations and supports a milieu of interactions among various cell types within this niche.In this editorial,we highlight the foundational studies that have driven our understanding of these processes.In our experimental center,we have carefully studied the mechanisms of that link pancreatic inflammation and pancreatic cancer.We focused on the role of mast cells(MCs).MCs contain pro-angiogenic factors,including tryptase,that are associated with increased angiogenesis in various tumors.In this editorial,we address the role of MCs in angiogenesis in both pancreatic ductal adenocarcinoma tissue and adjacent normal tissue.The assessment includes the density of c-Kit receptor-positive MCs,the density of tryptase-positive MCs,the area of tryptasepositive MCs,and angiogenesis in terms of microvascularization density.展开更多
A number of investigations into application of polymers for macro-morphological modification of tool surface have been carried out. These researches, with extensive stress on convex or domed protuberations as one of t...A number of investigations into application of polymers for macro-morphological modification of tool surface have been carried out. These researches, with extensive stress on convex or domed protuberations as one of the widely used construction units, have tried to harness benefits from using polymers in agriculture. Ultra high molecular weight polyethylene (UHMW-PE) has proved an emerging polymer in its application to reduce soil adhesion. This research was conducted to study the effect of shape (flat, semi-spherical, semi-oblate, semi short-prolate and semi long-prolate) and dimensions (base diameter and dome height) on sliding resistance and normal adhesion of biomimetic plates. To incorporate both shape and size, a dimensionless ratio of height to diameter (HDR) was introduced to characterize the effect of construction unit's physique. Experiments were conducted in Bangkok clay soil with dry ( 19.8% d.b.), sticky (36.9% d.b.) and flooded (60.1% d.b.) soil conditions respectively. Soil at sticky limit exhibited the highest sliding resistance (77.8 N) and normal adhesion (3 kPa to 7 kPa), whereas these values were 61.7 N and 〈0.2 kPa in dry, and 53.7 N and 0.5 kPa to 1.5 kPa in flooded soil conditions. Protuberances with HDR ≤ 0.5 lowered sliding resistance by 10% - 30% and the same reduced normal adhesion by 10% - 60%. The amount of reduction in both sliding resistance and normal adhesion was higher in flooded soil. Lighter normal loads obviously produced lesser resistance and adhesion.展开更多
AIM: To determine the association of diabetes mellitus (DM) and international normalized ratio (INR) level in hepatocellular carcinoma (HCC) patients. METHODS: Our present study included 375 HCC patients who were trea...AIM: To determine the association of diabetes mellitus (DM) and international normalized ratio (INR) level in hepatocellular carcinoma (HCC) patients. METHODS: Our present study included 375 HCC patients who were treated at the China-Japan Friendship Hospital, Ministry of Health (Beijing, China), in the period from January 2003 to April 2012, and with a hospital discharge diagnosis of HCC. The demographic, clinical, laboratory, metabolic and instrumental features were analyzed. χ2 test, Student's t test and Mann-Whitney U test were used to compare the differences between HCC patients with and without DM. Unconditional multivariable logistic regression analysis was used to determine the association of DM and INR level in HCC patients. A sub-group analysis was performed to assess the effect of liver cirrhosis or hepatitis B virus (HBV) infection on the results. The Pearson correlation test was used to determine the relationship between INR level and fasting glucose. In addition, association between diabetes duration, and diabetes treatment and INR level was determined considering the potentially different effects. RESULTS: Of the total, 63 (16.8%) patients were diabetic (diabetic group) and 312 (83.2%) patients were diagnosed without diabetes (non-diabetic group). Their mean age was 56.4 ± 11.0 years and 312 (83.2%) patients were male. Compared with patients without DM, the HCC patients with diabetes were older (59.5 ± 10.3 vs 55.8 ± 11.1, P=0.015), had a lower incidence of HBV infection (79.4% vs 89.1%, P=0.033), had increased levels of systolic blood pressure (SBP) (133 ± 17 vs 129 ± 16 mmHg, P=0.048) and INR (1.31 ± 0.44 vs 1.18 ± 0.21, P=0.001), had lower values of hemoglobin (124.4 ± 23.9 vs 134.2 ± 23.4, P=0.003) and had a platelet count (median/interquartile-range: 113/64-157 vs 139/89-192, P=0.020). There was no statistically significant difference in the percentages of males, overweight or obesity, drinking, smoking, cirrhosis and Child classification. After controlling for the confounding effects of age, systolic blood pressure, hemoglobin, platelet count and HBV infection by logistic analyses, INR was shown as an independent variable [odds ratio (OR)=3.650; 95%CI: 1.372-9.714, P=0.010]. Considering the effect of liver cirrhosis on results, a sub-group analysis was performed and the study population was restricted to those patients with cirrhosis. Univariate analysis showed that diabetic patients had a higher INR than non-diabetic patients (1.43 ± 0.51 vs 1.25 ± 0.23, P=0.041). After controlling for confounding effect of age, SBP, hemoglobin, platelet count and HBV infection by logistic analyses, INR level remained as the sole independent variable (OR=5.161; 95%CI: 1.618-16.455, P=0.006). No significant difference in the relationship between INR level and fasting glucose was shown by Pearson test (r=0.070, P=0.184). Among the 63 diabetic patients, 35 (55.6%) patients had been diagnosed with DM for more than 5 years, 23 (36.5%) received oral anti-diabetic regimens, 11 (17.5%) received insulin, and 30 (47.6%) reported relying on diet alone to control serum glucose levels. No significant differences were found for the association between DM duration/treatment and INR level, except for the age at diabetes diagnosis. CONCLUSION: The INR level was increased in HCC patients with DM and these patients should be monitored for the coagulation function in clinical practice.展开更多
Based on high-resolution remote sensing image interpretation, digital elevation model 3-D analysis, field geologic field investigation, trenching engineering, and ground-penetrating radar, synthetic research on the ev...Based on high-resolution remote sensing image interpretation, digital elevation model 3-D analysis, field geologic field investigation, trenching engineering, and ground-penetrating radar, synthetic research on the evolution of the Yuguang Basin South Margin Fault (YBSMF) in northwest Beijing was carried out. We found that the propagation and growth of faults most often occurred often at two locations: the fault overlapping zone and the uneven or rough fault segment. Through detailed observation and analysis of all cropouts of faults along the YBSMF from zone a to zone i, we identified three major factors that dominate or affect fault propagation and growth. First, the irregularity of fault geometry determine the propagation and growth of the fault, and therefore, the faults always propagate and grow at such irregular fault segments. The fault finally cuts off and eliminates its irregularity, making the fault geometry and fault plane smoother than before, which contributes to the slipping movement of the half-graben block in the basin. Second, the scale of the irregularity of the fault geometry affects the result of fault propagation and growth, that is, the degree of the cutting off of fault irregularity. The degree of cutting off decreases as irregularity scale increases. Third, the maximum possible slip displacement of the fault segment influences the duration of fault propagation and growth. The duration at the central segments with a large slip displacement is longer than that at the end segments with a smaller slippage value.展开更多
In this context,we experimentally studied the anisotropic mechanical behaviors of rough-walled plaster joints using a servo-controlled direct shear apparatus under both constant normal load(CNL)and constant normal sti...In this context,we experimentally studied the anisotropic mechanical behaviors of rough-walled plaster joints using a servo-controlled direct shear apparatus under both constant normal load(CNL)and constant normal stiffness(CNS)conditions.The shear-induced variations in the normal displacement,shear stress,normal stress and sheared-off asperity mass are analyzed and correlated with the inclination angle of the critical waviness of joint surfaces.The results show that CNS condition gives rise to a smaller normal displacement due to the larger normal stress during shearing,compared with CNL condition.Under CNL conditions,there is one peak shear stress during shearing,whereas there are no peak shear stress for some cases and two peaks for other cases under CNS conditions depending on the geometry of joint surfaces.The inclination angle of the critical waviness has been verified to be capable of describing the joint surface roughness and anisotropy.The joint surface is more significantly damaged under CNS conditions than that under CNL conditions.With increment of the inclination angle of the critical waviness,both the normal displaceme nt and shea red-off asperity mass increase,following power law functions;yet the coefficient of deternination under CNL conditions is larger than that under CNS conditions.This is because the CNS condition significantly decreases the inclination angle of the critical waviness during shearing due to the larger degree of asperity degradation.展开更多
Ernest Hemingway's world-wide influence and distinctive writing style-the Iceberg Style-caused a stylistic revolution in the field of literature all over the world.Hemingway always tries his best to avoid depictin...Ernest Hemingway's world-wide influence and distinctive writing style-the Iceberg Style-caused a stylistic revolution in the field of literature all over the world.Hemingway always tries his best to avoid depicting things by piling gorgeously big words;on the contrary,he adopts direct description and short sentences which are precise,laconic,bright and vivid.For instance,the novel titled The Short and Happy Life of Francis Macomber is universally acknowledged as his masterpiece,in which "Iceberg Theory"is skillfully presented.With a full analysis of the story,the uniqueness of "Iceberg Theory"will be emphasized in this paper.展开更多
This paper analyzes various earthquake fault types, mechanism solutions, stress field as well as other geophysical data to study the crust movement in the Tibetan plateau and its tectonic implications. The results sho...This paper analyzes various earthquake fault types, mechanism solutions, stress field as well as other geophysical data to study the crust movement in the Tibetan plateau and its tectonic implications. The results show that a lot of normal faulting type earthquakes concentrate in the central Tibetan plateau. Many of them are nearly perfect normal fault events. The strikes of the fault planes of the normal faulting earthquakes are almost in the N-S direction based on the analyses of the equal area projection diagrams of fault plane solutions. It implies that the dislocation slip vectors of the normal faulting type events have quite great components in the E-W direction. The extension is probably an eastward extensional motion, mainly a tectonic active regime in the altitudes of the plateau. The tensional stress in the E-W or WNW-ESE direction predominates the earthquake occurrence in the normal event region of the central plateau. A number of thrust fault and strike-slip fault type earthquakes with strong compressive stress nearly in the NNE-SSW direction occurred on the edges of the plateau. The eastward extensional motion in the Tibetan plateau is attributable to the eastward movement of materials in the upper mantle based on_seismo-tomographic results. The eastward extensional motion in the Tibetan plateau may be related to the eastward extrusion of hotter mantle materials beneath the east boundary of the plateau. The northward motion of the Tibetan plateau shortened in the N-S direction probably encounters strong obstructions at the western and northern margins. Extensional motions from the relaxation of the topography and/or gravitational collapse in the altitudes of the plateau occur hardly in the N-S direction. The obstruction for the plateau to move eastward is rather weak.展开更多
To investigate the influence of magnitude and distribution of the transverse normal pressure on deformation behavior of sheet metal,viscous pressure bulge test (VPB) of overlapping sheet metals is proposed,where the o...To investigate the influence of magnitude and distribution of the transverse normal pressure on deformation behavior of sheet metal,viscous pressure bulge test (VPB) of overlapping sheet metals is proposed,where the overlapped sheet metal is deformed under the dual-sided normal pressure provided by viscous medium and the overlapping sheet.The transverse normal pressure loading features provided by overlapping sheet metals are first simulated by DEFORM-2D.It shows that the magnitude and space distribution of transverse normal pressure are dependent on strain hardening exponent n-,strength coefficient K-and thickness t-values of the overlapping sheet metal.Based on the stress,deviator stress and strain distribution resulted from the finite element simulation,it indicated that the uniform transverse normal pressure has no effect on deviator stress,the figure and strain distribution of bulge specimens have no change.The non-uniform transverse normal pressure can remarkably change the figure and metal flow of specimens,and the formability of sheet metal can be improved by controlling the transverse normal pressure distribution.展开更多
The tribological behavior of aged Al-Sn-Cu alloy rubbed in the presence of lubricant over a range of sliding velocities and normal loads was investigated. The results showed that peak-aged (PA) alloy had a better tr...The tribological behavior of aged Al-Sn-Cu alloy rubbed in the presence of lubricant over a range of sliding velocities and normal loads was investigated. The results showed that peak-aged (PA) alloy had a better tribological behavior than under-aged (UA) and over-aged (OA) alloys, which could be attributed to the optimized strength-ductility matching and a better hardness under PA condition. Wear rate and friction coefficient showed great sensitivity to applied sliding velocity and normal load. The wear rate and friction coefficient of the alloy exhibited a reduction trend with the increase in sliding velocity. The low wear rate and friction coefficient of alloy at high velocities were due to the effectively protected film and homogeneous Sn on surface. However, an increase in normal load led to an obvious increment in wear rate. The friction coefficient exhibited a fluctuant trend with the increase of normal loads. The seriously destroyed film and abraded Sn resulted in poor tribological behavior at high normal loads. The Sn particles and lubricant film which includes low shear interfacial lubricating layer and oxide tribolayer are the key to the tribological behavior of Al-Sn-Cu alloy.展开更多
In this paper, the normal Luenberger function observer design for second-order descriptor linear systems is considered. It is shown that the main procedure of the design is to solve a so-called second-order generalize...In this paper, the normal Luenberger function observer design for second-order descriptor linear systems is considered. It is shown that the main procedure of the design is to solve a so-called second-order generalized Sylvester-observer matrix equation. Based on an explicit parametric solution to this equation, a parametric solution to the normal Luenberger function observer design problem is given. The design degrees of freedom presented by explicit parameters can be further utilized to achieve some additional design requirements.展开更多
基金financially supported by the National Natural Science Foundation of China(Grant No.42172292)Taishan Scholars Project Special Funding,and Shandong Energy Group(Grant No.SNKJ 2022A01-R26).
文摘To reveal the mechanism of shear failure of en-echelon joints under cyclic loading,such as during earthquakes,we conducted a series of cyclic shear tests of en-echelon joints under constant normal stiffness(CNS)conditions.We analyzed the evolution of shear stress,normal stress,stress path,dilatancy characteristics,and friction coefficient and revealed the failure mechanisms of en-echelon joints at different angles.The results show that the cyclic shear behavior of the en-echelon joints is closely related to the joint angle,with the shear strength at a positive angle exceeding that at a negative angle during shear cycles.As the number of cycles increases,the shear strength decreases rapidly,and the difference between the varying angles gradually decreases.Dilation occurs in the early shear cycles(1 and 2),while contraction is the main feature in later cycles(310).The friction coefficient decreases with the number of cycles and exhibits a more significant sensitivity to joint angles than shear cycles.The joint angle determines the asperities on the rupture surfaces and the block size,and thus determines the subsequent shear failure mode(block crushing and asperity degradation).At positive angles,block size is more greater and asperities on the rupture surface are smaller than at nonpositive angles.Therefore,the cyclic shear behavior is controlled by block crushing at positive angles and asperity degradation at negative angles.
文摘In this paper,we study normal families of meromorphic functions.By using the idea in[11],we obtain some normality criteria for families of meromorphic functions that concern the number of zeros of the differential polynomial,which extends the related result of Li,and Chen et al..An example is given to show that the hypothesis on the zeros of a(z)is necessary.
基金funded by the Korean Government(MSIT)Grant NRF-2022R1C1C1006671.
文摘This socialized environment among educated and developed people causes themto focusmore on their appearance and health,which turns them towards medical-related treatments,leading us to discuss anti-aging treatment methods for each age group,particularly for urban people who are interested in this.Some anti-aging therapies are used to address the alterations brought on by aging in human life without the need for surgery or negative effects.Five anti-aging therapies such as microdermabrasion or dermabrasion,laser resurfacing anti-aging skin treatments,chemical peels,dermal fillers for aged skin,and botox injections are considered in this study.Based on the criteria of safety risk,investment cost,customer happiness,and side effects,the optimal alternative is picked.As a result,a NormalWiggly Hesitant Pythagorean Fuzzy Set(NWHPFS)is constructed and used in Multi-Criteria Decision-Making(MCDM)using traditional wavy mathematical approaches.The entropy approach is utilized to determine weight values,and the Normal Wiggly Hesitant Pythagorean-VlseKriterijumska Optimizacija I Kompromisno Resenje(NWHPF-VIKOR)method is utilized to rank alternatives using MCDM methodologies.Sensitivity analysis and comparative analysis were performed to ensure the robustness and reliability of the proposed method.The smart final choice will undoubtedly assist Decision Makers(DM)in making the right judgments,and the MCDM approach will undoubtedly assist individuals in understanding the medicine.
文摘The normal direction to the normal direction to a line in Minkowski geometries generally does not give the original line. We show that in lp geometries with p>1?repeatedly finding the normal line through the origin gives sequences of lines that monotonically approach specific lines of symmetry of the unit circle. Which lines of symmetry that are approached depends upon the value of p and the slope of the initial line.
文摘This article presents a ground theory to explain why some individuals choose to be unhappy rather than happy,supported by empirical data collected from a sample of 750 professionals in Greece’s public and private sectors.We begin by reviewing the existing literature on happiness and well-being,highlighting the debate between hedonic and eudaimonic perspectives.We then introduce our research questions and rationale,and describe our methods,sample,and psychometric tools used to measure happiness and other variables of interest.Our results indicate that various factors,including cultural influences,past experiences,and personal values,contribute to individuals’pursuit of unhappiness.We conclude with a thorough discussion of our results and their implications for future research and interventions aimed at promoting well-being.
文摘The problem of best approximating, a given square complex matrix in the Frobenius norm by normal matrices under a given spectral restriction is considered. The ne cessary and sufficient condition for the solvability of the problem is given. A numerical algorithm for solving the problem is provided and a numerical example is presented.
基金supported by the foundation from:the program of the National Natural Science Foundation of China(40675037)the key program of the Sichuan Province Youth Science and Technology Fund(05ZQ026-023)the opening project of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics,Institute of Atmospheric Physics,Chinese Academy of Sciences.
文摘The Qinghai-Xizang Plateau, or Tibetan Plateau, is a sensitive region for climate change, where the manifestation of global warming is particularly noticeable. The wide climate variability in this region significantly affects the local land ecosystem and could consequently lead to notable vegetation changes. In this paper, the interannual variations of the plateau vegetation are investigated using a 21-year normalized difference vegetation index (NDVI) dataset to quantify the consequences of climate warming for the regional ecosystem and its interactions. The results show that vegetation coverage is best in the eastern and southern plateau regions and deteriorates toward the west and north. On the whole, vegetation activity demonstrates a gradual enhancement in an oscillatory manner during 1982-2002. The temporal variation also exhibits striking regional differences: an increasing trend is most apparent in the west, south, north and southeast, whereas a decreasing trend is present along the southern plateau boundary and in the central-east region. Covariance analysis between the NDVI and surface temperature/precipitation suggests that vegetation change is closely related to climate change. However, the controlling physical processes vary geographically. In the west and east, vegetation variability is found to be driven predominantly by temperature, with the impact of precipitation being of secondary importance. In the central plateau, however, temperature and precipitation factors are equally important in modulating the interannual vegetation variability.
文摘In this editorial,we focus specifically on the mechanisms by which pancreatic inflammation affects pancreatic cancer.Cancer of the pancreas remains one of the deadliest cancer types.The highest incidence and mortality rates of pancreatic cancer are found in developed countries.Trends of pancreatic cancer incidence and mortality vary considerably worldwide.A better understanding of the etiology and identification of the risk factors is essential for the primary prevention of this disease.Pancreatic tumors are characterized by a complex microenvironment that orchestrates metabolic alterations and supports a milieu of interactions among various cell types within this niche.In this editorial,we highlight the foundational studies that have driven our understanding of these processes.In our experimental center,we have carefully studied the mechanisms of that link pancreatic inflammation and pancreatic cancer.We focused on the role of mast cells(MCs).MCs contain pro-angiogenic factors,including tryptase,that are associated with increased angiogenesis in various tumors.In this editorial,we address the role of MCs in angiogenesis in both pancreatic ductal adenocarcinoma tissue and adjacent normal tissue.The assessment includes the density of c-Kit receptor-positive MCs,the density of tryptase-positive MCs,the area of tryptasepositive MCs,and angiogenesis in terms of microvascularization density.
文摘A number of investigations into application of polymers for macro-morphological modification of tool surface have been carried out. These researches, with extensive stress on convex or domed protuberations as one of the widely used construction units, have tried to harness benefits from using polymers in agriculture. Ultra high molecular weight polyethylene (UHMW-PE) has proved an emerging polymer in its application to reduce soil adhesion. This research was conducted to study the effect of shape (flat, semi-spherical, semi-oblate, semi short-prolate and semi long-prolate) and dimensions (base diameter and dome height) on sliding resistance and normal adhesion of biomimetic plates. To incorporate both shape and size, a dimensionless ratio of height to diameter (HDR) was introduced to characterize the effect of construction unit's physique. Experiments were conducted in Bangkok clay soil with dry ( 19.8% d.b.), sticky (36.9% d.b.) and flooded (60.1% d.b.) soil conditions respectively. Soil at sticky limit exhibited the highest sliding resistance (77.8 N) and normal adhesion (3 kPa to 7 kPa), whereas these values were 61.7 N and 〈0.2 kPa in dry, and 53.7 N and 0.5 kPa to 1.5 kPa in flooded soil conditions. Protuberances with HDR ≤ 0.5 lowered sliding resistance by 10% - 30% and the same reduced normal adhesion by 10% - 60%. The amount of reduction in both sliding resistance and normal adhesion was higher in flooded soil. Lighter normal loads obviously produced lesser resistance and adhesion.
基金Supported by National Natural Science Foundation of China,No. 81273975the Research Fund of the China-Japan Friendship Hospital, Ministry of Health, No. 2010-QN-01
文摘AIM: To determine the association of diabetes mellitus (DM) and international normalized ratio (INR) level in hepatocellular carcinoma (HCC) patients. METHODS: Our present study included 375 HCC patients who were treated at the China-Japan Friendship Hospital, Ministry of Health (Beijing, China), in the period from January 2003 to April 2012, and with a hospital discharge diagnosis of HCC. The demographic, clinical, laboratory, metabolic and instrumental features were analyzed. χ2 test, Student's t test and Mann-Whitney U test were used to compare the differences between HCC patients with and without DM. Unconditional multivariable logistic regression analysis was used to determine the association of DM and INR level in HCC patients. A sub-group analysis was performed to assess the effect of liver cirrhosis or hepatitis B virus (HBV) infection on the results. The Pearson correlation test was used to determine the relationship between INR level and fasting glucose. In addition, association between diabetes duration, and diabetes treatment and INR level was determined considering the potentially different effects. RESULTS: Of the total, 63 (16.8%) patients were diabetic (diabetic group) and 312 (83.2%) patients were diagnosed without diabetes (non-diabetic group). Their mean age was 56.4 ± 11.0 years and 312 (83.2%) patients were male. Compared with patients without DM, the HCC patients with diabetes were older (59.5 ± 10.3 vs 55.8 ± 11.1, P=0.015), had a lower incidence of HBV infection (79.4% vs 89.1%, P=0.033), had increased levels of systolic blood pressure (SBP) (133 ± 17 vs 129 ± 16 mmHg, P=0.048) and INR (1.31 ± 0.44 vs 1.18 ± 0.21, P=0.001), had lower values of hemoglobin (124.4 ± 23.9 vs 134.2 ± 23.4, P=0.003) and had a platelet count (median/interquartile-range: 113/64-157 vs 139/89-192, P=0.020). There was no statistically significant difference in the percentages of males, overweight or obesity, drinking, smoking, cirrhosis and Child classification. After controlling for the confounding effects of age, systolic blood pressure, hemoglobin, platelet count and HBV infection by logistic analyses, INR was shown as an independent variable [odds ratio (OR)=3.650; 95%CI: 1.372-9.714, P=0.010]. Considering the effect of liver cirrhosis on results, a sub-group analysis was performed and the study population was restricted to those patients with cirrhosis. Univariate analysis showed that diabetic patients had a higher INR than non-diabetic patients (1.43 ± 0.51 vs 1.25 ± 0.23, P=0.041). After controlling for confounding effect of age, SBP, hemoglobin, platelet count and HBV infection by logistic analyses, INR level remained as the sole independent variable (OR=5.161; 95%CI: 1.618-16.455, P=0.006). No significant difference in the relationship between INR level and fasting glucose was shown by Pearson test (r=0.070, P=0.184). Among the 63 diabetic patients, 35 (55.6%) patients had been diagnosed with DM for more than 5 years, 23 (36.5%) received oral anti-diabetic regimens, 11 (17.5%) received insulin, and 30 (47.6%) reported relying on diet alone to control serum glucose levels. No significant differences were found for the association between DM duration/treatment and INR level, except for the age at diabetes diagnosis. CONCLUSION: The INR level was increased in HCC patients with DM and these patients should be monitored for the coagulation function in clinical practice.
基金financially supported by the Yuguang Basin 1:50000 Geological Mapping Project (no. 201210916),a subsubject of Active Fault Seismic Hazard Assessment Project of China's Key Area for Surveillance and Protection
文摘Based on high-resolution remote sensing image interpretation, digital elevation model 3-D analysis, field geologic field investigation, trenching engineering, and ground-penetrating radar, synthetic research on the evolution of the Yuguang Basin South Margin Fault (YBSMF) in northwest Beijing was carried out. We found that the propagation and growth of faults most often occurred often at two locations: the fault overlapping zone and the uneven or rough fault segment. Through detailed observation and analysis of all cropouts of faults along the YBSMF from zone a to zone i, we identified three major factors that dominate or affect fault propagation and growth. First, the irregularity of fault geometry determine the propagation and growth of the fault, and therefore, the faults always propagate and grow at such irregular fault segments. The fault finally cuts off and eliminates its irregularity, making the fault geometry and fault plane smoother than before, which contributes to the slipping movement of the half-graben block in the basin. Second, the scale of the irregularity of the fault geometry affects the result of fault propagation and growth, that is, the degree of the cutting off of fault irregularity. The degree of cutting off decreases as irregularity scale increases. Third, the maximum possible slip displacement of the fault segment influences the duration of fault propagation and growth. The duration at the central segments with a large slip displacement is longer than that at the end segments with a smaller slippage value.
基金partially funded by National Natural Science Foundation of China(Grant Nos.51979272 and 51709260)State Key Laboratory for Geomechanics and Deep Underground Engineering,China University of Mining and Technology,China(Grant No.SKLGDUEK1906)。
文摘In this context,we experimentally studied the anisotropic mechanical behaviors of rough-walled plaster joints using a servo-controlled direct shear apparatus under both constant normal load(CNL)and constant normal stiffness(CNS)conditions.The shear-induced variations in the normal displacement,shear stress,normal stress and sheared-off asperity mass are analyzed and correlated with the inclination angle of the critical waviness of joint surfaces.The results show that CNS condition gives rise to a smaller normal displacement due to the larger normal stress during shearing,compared with CNL condition.Under CNL conditions,there is one peak shear stress during shearing,whereas there are no peak shear stress for some cases and two peaks for other cases under CNS conditions depending on the geometry of joint surfaces.The inclination angle of the critical waviness has been verified to be capable of describing the joint surface roughness and anisotropy.The joint surface is more significantly damaged under CNS conditions than that under CNL conditions.With increment of the inclination angle of the critical waviness,both the normal displaceme nt and shea red-off asperity mass increase,following power law functions;yet the coefficient of deternination under CNL conditions is larger than that under CNS conditions.This is because the CNS condition significantly decreases the inclination angle of the critical waviness during shearing due to the larger degree of asperity degradation.
文摘Ernest Hemingway's world-wide influence and distinctive writing style-the Iceberg Style-caused a stylistic revolution in the field of literature all over the world.Hemingway always tries his best to avoid depicting things by piling gorgeously big words;on the contrary,he adopts direct description and short sentences which are precise,laconic,bright and vivid.For instance,the novel titled The Short and Happy Life of Francis Macomber is universally acknowledged as his masterpiece,in which "Iceberg Theory"is skillfully presented.With a full analysis of the story,the uniqueness of "Iceberg Theory"will be emphasized in this paper.
基金supported by the Natural Science Foundation of China (No. 40674026)Commonweal Special Science Foundation of China (Grant No. 200811037)
文摘This paper analyzes various earthquake fault types, mechanism solutions, stress field as well as other geophysical data to study the crust movement in the Tibetan plateau and its tectonic implications. The results show that a lot of normal faulting type earthquakes concentrate in the central Tibetan plateau. Many of them are nearly perfect normal fault events. The strikes of the fault planes of the normal faulting earthquakes are almost in the N-S direction based on the analyses of the equal area projection diagrams of fault plane solutions. It implies that the dislocation slip vectors of the normal faulting type events have quite great components in the E-W direction. The extension is probably an eastward extensional motion, mainly a tectonic active regime in the altitudes of the plateau. The tensional stress in the E-W or WNW-ESE direction predominates the earthquake occurrence in the normal event region of the central plateau. A number of thrust fault and strike-slip fault type earthquakes with strong compressive stress nearly in the NNE-SSW direction occurred on the edges of the plateau. The eastward extensional motion in the Tibetan plateau is attributable to the eastward movement of materials in the upper mantle based on_seismo-tomographic results. The eastward extensional motion in the Tibetan plateau may be related to the eastward extrusion of hotter mantle materials beneath the east boundary of the plateau. The northward motion of the Tibetan plateau shortened in the N-S direction probably encounters strong obstructions at the western and northern margins. Extensional motions from the relaxation of the topography and/or gravitational collapse in the altitudes of the plateau occur hardly in the N-S direction. The obstruction for the plateau to move eastward is rather weak.
文摘To investigate the influence of magnitude and distribution of the transverse normal pressure on deformation behavior of sheet metal,viscous pressure bulge test (VPB) of overlapping sheet metals is proposed,where the overlapped sheet metal is deformed under the dual-sided normal pressure provided by viscous medium and the overlapping sheet.The transverse normal pressure loading features provided by overlapping sheet metals are first simulated by DEFORM-2D.It shows that the magnitude and space distribution of transverse normal pressure are dependent on strain hardening exponent n-,strength coefficient K-and thickness t-values of the overlapping sheet metal.Based on the stress,deviator stress and strain distribution resulted from the finite element simulation,it indicated that the uniform transverse normal pressure has no effect on deviator stress,the figure and strain distribution of bulge specimens have no change.The non-uniform transverse normal pressure can remarkably change the figure and metal flow of specimens,and the formability of sheet metal can be improved by controlling the transverse normal pressure distribution.
基金Project(2013AH100055)supported by the Special Foundation for Science and Technology Innovation of Foshan,China
文摘The tribological behavior of aged Al-Sn-Cu alloy rubbed in the presence of lubricant over a range of sliding velocities and normal loads was investigated. The results showed that peak-aged (PA) alloy had a better tribological behavior than under-aged (UA) and over-aged (OA) alloys, which could be attributed to the optimized strength-ductility matching and a better hardness under PA condition. Wear rate and friction coefficient showed great sensitivity to applied sliding velocity and normal load. The wear rate and friction coefficient of the alloy exhibited a reduction trend with the increase in sliding velocity. The low wear rate and friction coefficient of alloy at high velocities were due to the effectively protected film and homogeneous Sn on surface. However, an increase in normal load led to an obvious increment in wear rate. The friction coefficient exhibited a fluctuant trend with the increase of normal loads. The seriously destroyed film and abraded Sn resulted in poor tribological behavior at high normal loads. The Sn particles and lubricant film which includes low shear interfacial lubricating layer and oxide tribolayer are the key to the tribological behavior of Al-Sn-Cu alloy.
基金This work was supported by National Natural Science Foundation of China(No.60710002)Program for Changjiang Scholars and Innovative Research Team in University(PCSIRT).
文摘In this paper, the normal Luenberger function observer design for second-order descriptor linear systems is considered. It is shown that the main procedure of the design is to solve a so-called second-order generalized Sylvester-observer matrix equation. Based on an explicit parametric solution to this equation, a parametric solution to the normal Luenberger function observer design problem is given. The design degrees of freedom presented by explicit parameters can be further utilized to achieve some additional design requirements.