“A Craftsman Must Sharpen His Tools to Do His Job,”said Confucius.Nuclear detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the...“A Craftsman Must Sharpen His Tools to Do His Job,”said Confucius.Nuclear detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the universe.Also,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,etc.The article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout Techniques.By explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community.展开更多
目的分析基于宽体探测器CT灌注成像评估的侧支循环与急性脑梗死体积及预后的关系。资料与方法回顾性选取2019年1月—2021年6月联勤保障部队第九〇九医院(厦门大学附属东南医院)145例急性脑梗死患者,均行取栓手术,且行CT灌注成像检查。...目的分析基于宽体探测器CT灌注成像评估的侧支循环与急性脑梗死体积及预后的关系。资料与方法回顾性选取2019年1月—2021年6月联勤保障部队第九〇九医院(厦门大学附属东南医院)145例急性脑梗死患者,均行取栓手术,且行CT灌注成像检查。根据临床及影像资料将患者分为侧支良好组71例与侧支不良组74例,分析两组患者临床资料的差异;并以随访3个月后的改良Rankin量表评估预后,分为预后良好组79例和预后不良组66例。采用单因素及多因素Logistic回归分析影响患者预后的相关独立危险因素。另选取2021年7月—2022年6月于本院行手术治疗的72例急性脑梗死患者作为外部验证,采用受试者工作特征曲线评估相关指标的预测效能,采用Hosmer-Lemeshow检验判断模型的拟合优度。结果侧支良好组患者年龄、基线美国国立卫生研究院卒中量表(NIHSS)、术后24 h NIHSS、核心梗死区、90 d后改良Rankin量表评分均低于侧支不良组(t/χ^(2)/Z=3.181、4.357、5.468、7.649、6.316,P<0.05);且侧支良好组患者心房颤动、心功能不全情况均优于侧支不良组(t=5.202、10.450,P<0.05)。预后良好组与预后不良组患者年龄、心房颤动、心功能不全、住院时间、基线NIHSS、术后24 h NIHSS、术后7 d NIHSS、出血转化、侧支循环情况、进展梗死体积、核心梗死区差异有统计学意义(t/χ^(2)/Z=4.392、9.965、12.755、3.385、6.775、9.327、8.264、19.362、29.630、7.535、9.224,P<0.05)。多因素分析显示,年龄、术后24 h NIHSS、出血转化、侧支循环情况、进展梗死体积均是影响患者预后的独立危险因素(OR=1.047、1.986、1.641、1.799、1.083,P<0.05)。上述多因素分析独立危险因素联合预测患者预后的受试者工作特征曲线下面积为0.861(95%CI 0.801~0.921),敏感度为82.3%,特异度为78.6%;Hosmer-Lemeshow拟合检验显示模型拟合效度好,预测价值高(χ^(2)=12.354,P=0.136)。模型外部验证敏感度为84.4%,特异度为70.0%,总准确率为76.4%。结论基于宽体探测器CT灌注成像评估的侧支循环与急性脑梗死患者的梗死体积及其预后具有相关性,年龄、术后24 h NIHSS、出血转化、侧支循环情况、进展梗死体积均是影响患者预后的独立危险因素。展开更多
基金supported by the National Natural Science Foundation of China(No.12222512,U2032209,12075045,12335011,1875097,11975257,62074146,11975115,12205374,12305210,11975292,12005276,12005278,12375193,12227805,12235012,12375191,12005279)the National Key Research and Development Program of China(2021YFA1601300)+13 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(XDB34000000)the CAS Pioneer Hundred Talent Programthe CAS“Light of West China”Programthe Natural Science Foundation of Liaoning Province(No.101300261)the Dalian Science and Technology Innovation Fund(2023JJ12GX013)the Special Projects of the Central Government in Guidance of Local Science and Technology Development(Research and development of three-dimensional prospecting technology based on Cosmic-ray muons)(YDZX20216200001297)the Science and Technology Planning Project of Gansu(20JR10RA645)the Lanzhou University Talent Cooperation Research Funds sponsored by both Lanzhou City(561121203)the Gansu provincial science and technology plan projects for talents(054000029)the Beijing Natural Science Foundation(No.1232033)the Beijing Hope Run Special Fund of Cancer Foundation of China(No.LC2021B23)the Guangdong Major Project of Basic and Applied Basic Research(No.2020B0301030008)the Scientific Instrument Developing Project of the Chinese Academy of Sciences(No.GJJSTD20210009)the Youth Innovation Promotion Association CAS(2021450)。
文摘“A Craftsman Must Sharpen His Tools to Do His Job,”said Confucius.Nuclear detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the universe.Also,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,etc.The article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout Techniques.By explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community.
文摘目的分析基于宽体探测器CT灌注成像评估的侧支循环与急性脑梗死体积及预后的关系。资料与方法回顾性选取2019年1月—2021年6月联勤保障部队第九〇九医院(厦门大学附属东南医院)145例急性脑梗死患者,均行取栓手术,且行CT灌注成像检查。根据临床及影像资料将患者分为侧支良好组71例与侧支不良组74例,分析两组患者临床资料的差异;并以随访3个月后的改良Rankin量表评估预后,分为预后良好组79例和预后不良组66例。采用单因素及多因素Logistic回归分析影响患者预后的相关独立危险因素。另选取2021年7月—2022年6月于本院行手术治疗的72例急性脑梗死患者作为外部验证,采用受试者工作特征曲线评估相关指标的预测效能,采用Hosmer-Lemeshow检验判断模型的拟合优度。结果侧支良好组患者年龄、基线美国国立卫生研究院卒中量表(NIHSS)、术后24 h NIHSS、核心梗死区、90 d后改良Rankin量表评分均低于侧支不良组(t/χ^(2)/Z=3.181、4.357、5.468、7.649、6.316,P<0.05);且侧支良好组患者心房颤动、心功能不全情况均优于侧支不良组(t=5.202、10.450,P<0.05)。预后良好组与预后不良组患者年龄、心房颤动、心功能不全、住院时间、基线NIHSS、术后24 h NIHSS、术后7 d NIHSS、出血转化、侧支循环情况、进展梗死体积、核心梗死区差异有统计学意义(t/χ^(2)/Z=4.392、9.965、12.755、3.385、6.775、9.327、8.264、19.362、29.630、7.535、9.224,P<0.05)。多因素分析显示,年龄、术后24 h NIHSS、出血转化、侧支循环情况、进展梗死体积均是影响患者预后的独立危险因素(OR=1.047、1.986、1.641、1.799、1.083,P<0.05)。上述多因素分析独立危险因素联合预测患者预后的受试者工作特征曲线下面积为0.861(95%CI 0.801~0.921),敏感度为82.3%,特异度为78.6%;Hosmer-Lemeshow拟合检验显示模型拟合效度好,预测价值高(χ^(2)=12.354,P=0.136)。模型外部验证敏感度为84.4%,特异度为70.0%,总准确率为76.4%。结论基于宽体探测器CT灌注成像评估的侧支循环与急性脑梗死患者的梗死体积及其预后具有相关性,年龄、术后24 h NIHSS、出血转化、侧支循环情况、进展梗死体积均是影响患者预后的独立危险因素。
