Winning a Nobel Prize

A man is driving down a country road,when he spots a farmer standing in the middle of a huge field of grass.He pulls the car over to the side of the road and notices that the farmer is just standing there, doing nothing,looking at nothing.

基于WinForm窗体的光谱扫描系统设计

目前,国内市场上广泛使用的紫外–可见分光光度计、紫外–荧光分光光度计大部分不具备自动波长扫描功能,只能人工操作和读数,因此使用受到了极大的限制。本文设计了一款基于Visual C#WinForm窗体的光谱仪软件,通过串口接收紫外–可见分光光度计、紫外–荧光分光光度计等光谱仪器的检测数据,并在电脑端对数据进行处理后,可以自动计算出吸光度、透光率、荧光强度等光谱参数,直观地显示波长扫描光谱图。

Molar Mass Distribution and Chain Conformation of Polysaccharides from Fortunella margarita(Lour.) Swingle

In order to study the effects of different extraction methods on the molar mass distribution and chain conformation of Fortunella margarita （Lour.） Swingle polysaccharides （FP）, we used extraction by hot water （WFP）, ultrasonic-assisted treatment （UFP）, microwave-assisted treatment （MFP） and ultrasonic/microwave-assisted treatment （UMFP）, and then Fourier transform infrared （FT-IR） spectroscopy as well as 1H and 13C nuclear magnetic resonance （NMR） spectroscopy to characterize the structural properties of FP extracted. The molar weight （Mw）, polydispersity index （Mw/Mn）, root-mean-square （RMS） turning radius （Rg）, molar mass distribution and chain conformation of FP were studied systematically using size-exclusion chromatography （SEC）, multi-angle laser light-scattering （MALLS） and refractive index （RI）. WFP, UFP, MFP and UMFP are all typical carbohydrates according to 1H NMR, laC NMR and FT-IR measurements. The type of glycosidic linkage is mainly a fl-glycosidic bond with a small amount of a-glycosidic bond. The results obtained by the SEC-MALLS-RI system showed the molar masses of WFP and UMFP were distributed mainly in the range of 5.0x10^6-1.0x10^7 g-mo1-1 and they accounted for 57.80% and 56.84% of total FP, respectively. The molar masses of UFP and MFP were distributed mainly in the 1.0x10^6-5.0x10^6 g.mol-1 range, which accounted for 38.24% and 52.39% of FP, respectively. WFP and UMFP in water were uniform spherical polymers; UFP and MFP were typical highly branched polymers and the degree of branching for MFP was higher compared to UFP. These results indicated the ultrasonic- and microwave-assisted extraction methods caused a significant decrease of the molar mass of FP but the ultrasonic/microwave synergistic extraction method had no effect.

Mechanism of combination membrane and electro-winning process on treatment and remediation of Cu^(2+) polluted water body

Mechanism of treatment and remediation of synthetic Cu^2＋ polluted water body by membrane and electro-winning combination process was investigated.The influences of electrolysis voltage,pH,and electrolysis time on the metal recovery effciencies were studied.Relationship between trans-membrane pressure drop（△P）,additions ratio,initial Cu^2＋ concentration on operating effciency,stability of membrane and the possibility of water reuse were also investigated.The morphology of membrane and electrodes were observed using scanning electron microscopy（SEM）,the composition of surface deposits was ascertained using combined energy dispersive X-ray spectroscopy（EDX） and atomic absorption spectrophotometer.The results showed that using low pressure reverse osmosis（LPRO）,Cu^2＋ concentration could increase from 20 to 100 mg/L or even higher in concentrated solutions and permeate water conductivity could be less than 20 μS/cm.The addition of sodium dodecy/sulfate sodium dodecyl sulfate improved Cu^2＋ removal effciency,while EDTA had little side influence.In electro-reduction process,using plante electrode cell,Cu^2＋ concentration could be further reduced to 5 mg/L,and the average current effciency ranged from 9% to 40%.Using 3D electrolysis treatment,Cu^2＋ concentration could be reduced to 0.5 mg/L with a current effciency range 60%-70%.

A comparison of MLT wind between meteor radar chain data and SDWACCM results

A meteor radar chain located along the 120°E meridian in the Northern Hemisphere from low to middle latitudes provides longterm horizontal wind observations of the mesosphere and lower thermosphere(MLT)region.In this study,we report a seasonal variation and its latitudinal feature in the horizontal mean wind in the MLT region observed by six meteor radar instruments located at Mohe(53.5°N,122.3°E),Beijing(40.3°N,116.2°E),Mengcheng(33.4°N,116.5°E),Wuhan(30.6°N,114.4°E),Kunming(25.6°N,108.3°E),and Fuke(19.5°N,109.1°E)stations.In addition,we compare the wind in the MLT region measured by the meteor radar stations with those simulated by the Whole Atmosphere Community Climate Model(WACCM).In general,the WACCM appears to capture well the seasonal and latitudinal variations in the zonal wind component.In particular,the temporal evolution of the eastward zonal wind maximum shifts from July to May as the latitude decreases.However,the simulated WACCM meridional wind exhibits differences from the meteor radar observations.

WIN55212-2通过调控mTOR/HIF-1α/PFKFB3信号通路抑制糖酵解并减轻脓毒症小鼠急性肺损伤

目的:探究大麻素受体激动剂WIN55212-2(WIN)对脓毒症小鼠急性肺损伤(ALI)的影响,并探讨其通过糖酵解发挥作用的可能机制。方法:采用腹腔注射脂多糖(LPS)创建小鼠脓毒症ALI模型。将雄性C57BL/6J小鼠随机分为4组:对照(control)组、LPS组(腹腔注射10 mg/kg LPS)、LPS+WIN组(注射LPS前30 min腹腔注射1 mg/kg WIN)和LPS+WIN+MHY1485[哺乳动物雷帕霉素靶蛋白(mTOR)活化剂]组(LPS造模前1 d腹腔注射10 mg/kg MHY1485,并在造模前30 min腹腔注射1 mg/kg WIN和10 mg/kg MHY1485),每组6只。造模24 h后取材,计算肺指数;HE染色观察肺组织病理变化;ELISA检测肺组织炎症因子白细胞介素1β(IL-1β)和IL-10表达水平,以及血清乳酸和乳酸脱氢酶A(LDHA)水平;Western blot检测mTOR/缺氧诱导因子1α(HIF-1α)/6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶3(PFKFB3)信号通路相关蛋白水平。结果:相比于control组,LPS组小鼠肺指数增加,HE染色显示肺组织受损,肺组织中IL-10水平降低(P<0.05),IL-1β水平升高(P<0.05),血清乳酸和LDHA水平升高(P<0.05),磷酸化mTOR(p-mTOR)、HIF-1α和PFKFB3蛋白水平升高(P<0.05)。相较于LPS组,LPS+WIN组肺指数降低(P<0.05),HE染色显示肺组织受损减轻,肺组织IL-1β水平降低(P<0.05),IL-10水平升高(P<0.05),血清乳酸和LDHA水平降低(P<0.05),p-mTOR、HIF-1α和PFKFB3蛋白水平降低(P<0.05)。相较于LPS+WIN组,LPS+WIN+MHY1485组肺指数增加,HE染色显示肺组织受损,肺组织IL-1β水平升高(P<0.05),IL-10水平降低(P<0.05),血清乳酸和LDHA水平升高(P<0.05),p-mTOR、HIF-1α和PFKFB3蛋白水平升高(P<0.05)。结论:WIN55212-2可以减轻脓毒症小鼠ALI,其机制可能是通过调控mTOR/HIF-1α/PFKFB3信号通路,抑制糖酵解,减轻炎症反应。

Automated Dimensioning Method of Engineering Drawings for Mechanical Products Based on Curve Chain

An automated method based on the curve chain was proposed for dimensioning of engineering drawings for the mechanical products.According to the internal relation between the features of 3D model feature and elements of 2D drawing,the curve chain was established to reflect the geometric topological structure between the elements.It divides the dimensions into the absolute dimensions within the cure chain and the relative dimensions between the curve chains.The parallel and lengthy relationship between the drawing elements of the constructed X and Y parallel matrix was solved to remove redundant elements in the curve chain and labeled the absolute dimensions of the remaining valid elements.The average minimum weight coefficient was introduced to judge the dependence on the relative dimensions between curve chains.Through the analysis of the overlap between the circular rectangular areas,including all the absolute dimensions of the curve chains,overlapping curve chains were merged,and their dimensions were rearranged to avoid the cross interference between them.The method was seamlessly integrated into the drafting module of product design software NX,and it developed an automated dimensioning system.The examples show that the system has excellent interactivity and robustness in the dimensioning of product engineering drawings.The dimension information is complete,accurate and reliable.

Analysis of Noise at Coal Face by Fully-Mechanized Coal Winning Technology

The noise level of coal face by full-mechanized coal winning technology was measured in a coal mine. And then it was analyzed and evaluated using environment science, ergonomics and fussy mathematics analysis. Basis of the statistics and analysis of the measured noise level some measures, such as applying the new materials and improving the construction of the equipment, were carried out. The resuts show that they can reduce the noise level, improve the working environment and enhance the work efficiency.

Study on the Winning Probability for a Bid in Procurement Combinational Auction with Tree Structure

In this paper, the processes to determine winning probability for the corresponding bidder's deterministic bid are presented. The analysis of the winning probability is crucial for studying the bidding equilibria and designing the mechanism of procurement combinational auctions (CAs), and it also provides the decision making support for bidders who are in commercial synergies surrounding. Finally, an example is used to illustrate the feasibility and detailed processes of calculating winning probability.

Manufacturing Supply Chain Optimization Problem with Time Windows Based on Improved Orthogonal Genetic Algorithm

Aim to the manufacturing supply chain optimization problem with time windows,presents an improved orthogonal genetic algorithm to solve it. At first,we decompose this problem into two sub-problems (distribution and routing) plus an interface mechanism to allow the two algorithms to collaborate in a master-slave fashion,with the distribution algorithm driving the routing algorithm. At second,we describe the proposed improved orthogonal genetic algorithm for solving giving problem detailedly. Finally,the examples suggest that this proposed approach is feasible,correct and valid.

Schwinger-boson approach to anisotropy ferrimagnetic chain with bond alternation

We use the Schwinger-boson approach to study the anisotropy ferrimagnetic spin-（1/2,1） chain with bond alternation.Based on the effect of bond alternation δ,we obtain energy gap,free energy,and specific heat,respectively.The specific heat with larger bond alternation（δ 〉 0.7） displays a peak at low temperature.Based on the effect of XXZ anisotropy parameter Δ,we present excited spectrums,free energy,and specific heat,respectively.

Winning Strategies and Complexity of Nim-Type Computer Game on Plane

A Nim-type computer game of strategy on plane is described in this paper. It is demonstrated that winning strategies of this two-person game are determined by a system of equations with two unknown integer sequences. Properties of winning points/states are discussed and an O(loglogn) algorithm for the winning states is provided. Two varieties of the Game are also introduced and their winning strategies are analyzed.

Using Sports Wagering Markets to Evaluate and Compare Team Winning Streaks in Sports

Point spreads and money lines from sports wagering markets are used to evaluate the impressiveness of team streaks. Sports wagering data have previously been useful in assessing competitive balance in sports. Our approach was motivated by the amount of media scrutiny that accompanied the winning streak of the NBA’s Miami Heat and the point streak of the NHL’s Chicago Blackhawks which occurred simultaneously for the most part in 2013. The topic came to the forefront again with the 2014-2015 winning streak of the Atlanta Hawks. Three streaks are highlighted in our paper. The length of the streaks, the quality of the competition, injuries, and a variety of other factors were mentioned in the media but the discussion was limited to subjective opinions as no way of properly weighing relative influence of the factors was identified. Wagering markets provide an excellent source of information for making these judgments. Several complementary measures are described and the most impressive team streaks within and across professional baseball, basketball, football, and ice hockey are identified.

CLASSICAL HEISENBERG MAGNETIC CHAINS SHOWING CATIONIC SITE OCCUPATIONS CORRELATIONS

We propose a model for calculating the magnetic susceptibility of classical Heisenberg chains,showing nearest neighbor correlated cationic distributions.The result formally looks like expressions obtained for random chains where the neighboring cationic species are not correlated.In the present result the intervening scalar parameters are replaced,by vector and matricial expressions.

Analysis of Sleep Window of IEEE802.16m Network Based on State Transition Chain

Energy efficiency plays vital roles in wireless communication system due to the “energy limited battery service” of a mobile station (MS). To ensure longer battery life in WiMAX, a new protocol has been introduced in its IEEE802.16m version. This new sleep mode has extended listening window and adjustable sleep cycle length. In this paper, we analyze the probability of attaining at three states: serving state, state of timer inactivity and silent state in a simplified statistical model using traffic parameters of arrival rate, pdf (probability density function) of interarrival time and its threshold value. Finally we developed a new state transition chain of the above three states of a MS of IEEE802.16m and solved the chain in closed form.

Identification and epitope mapping of anti-p72 single-chain antibody against African swine fever virus based on phage display antibody library

African swine fever virus(ASFV)is a lethal pathogen that causes severe threats to the global swine industry and it has already had catastrophic socio-economic effects.To date,no licensed prophylactic vaccine exists.Limited knowledge exists about the major immunogens of ASFV and the epitope mapping of the key antigens.As such,there is a considerable requirement to understand the functional monoclonal antibodies(mAbs)and the epitope mapping may be of utmost importance in our understanding of immune responses and designing improved vaccines,therapeutics,and diagnostics.In this study,we generated an ASFV antibody phage-display library from ASFV convalescent swine PBMCs,further screened a specific ASFV major capsid protein(p72)single-chain antibody and fused with an IgG Fc fragment(scFv-83-Fc),which is a specific recognition antibody against ASFV Pig/HLJ/2018 strain.Using the scFv-83-Fc mAb,we selected a conserved epitope peptide(221MTGYKH226)of p72 retrieved from a phage-displayed random peptide library.Moreover,flow cytometry and cell uptake experiments demonstrated that the epitope peptide can significantly promote BMDCs maturation in vitro and could be effectively uptaken by DCs,which indicated its potential application in vaccine and diagnostic reagent development.Overall,this study provided a valuable platform for identifying targets for ASFV vaccine development,as well as to facilitate the optimization design of subunit vaccine and diagnostic reagents.

The Wine Chain in Puglia： A Cluster Analysis

The food industry is evolving more towards new forms of organization much more complex and characterized by a greater degree of coordination, whether in the form of vertical integration of explicit or implicit contracts between players of different levels of the industry. Therefore, the aim of this work is the search for mechanisms that can provide value to the production phase to better increase competitiveness of the sector. For the first time, in fact, discussion about food chains have as reference a recognized legal entity, which is the integrated projects of food chain as a result of actions of agricultural policy at community, national and regional levels. The methodology is related to two steps： the administration of questionnaires to the three companies participating in food chain partnerships that have proposed a draft of integrated design of food chain in response to the notice of the Apulia region for the submission of the integrated projects of the food chain; and a cluster analysis in the wine sector of the Italian regions. The results showed, thanks to Network Analysis, the importance for the chain development of relationships formed by market relations and cooperation relations （formal and informal） and the need for more actions for the enhancement of products by research and development activities.

Model-driven full system dynamics estimation of PMSM-driven chain shell magazine

Based on the system dynamic model, a full system dynamics estimation method is proposed for a chain shell magazine driven by a permanent magnet synchronous motor(PMSM). An adaptive extended state observer(AESO) is proposed to estimate the unmeasured states and disturbance, in which the model parameters are adjusted in real time. Theoretical analysis shows that the estimation errors of the disturbances and unmeasured states converge exponentially to zero, and the parameter estimation error can be obtained from the extended state. Then, based on the extended state of the AESO, a novel parameter estimation law is designed. Due to the convergence of AESO, the novel parameter estimation law is insensitive to controllers and excitation signal. Under persistent excitation(PE) condition, the estimated parameters will converge to a compact set around the actual parameter value. Without PE signal, the estimated parameters will converge to zero for the extended state. Simulation and experimental results show that the proposed method can accurately estimate the unmeasured states and disturbance of the chain shell magazine, and the estimated parameters will converge to the actual value without strictly continuous PE signals.

TELUS and ZTE Launch Award Winning Wireless Phone Featuring Fastap Keypad

August 9,2007,Vancouver,B.C.— TELUS,a leading national telecommunications company in Canada

Reviewing the Service Profit Chain： From Consumers＇ Perspective

This paper aims to show the change in mindset, showing the shift from selling in 1950s to the marketing concept and societal marketing concept today. The value of the Service Profit Chain （SPC） is also considered and looks not only at the importance to the customers but also the employees to the success of a business in ultimately winning over the consumer.