＂Women＇s rights and interests are human rights＂ is now a concept accepted by all. The power of the law now safeguards the rights and interests of women. Recalling efforts in recent years to safeguard women＇s right...＂Women＇s rights and interests are human rights＂ is now a concept accepted by all. The power of the law now safeguards the rights and interests of women. Recalling efforts in recent years to safeguard women＇s rights and interests, we cannot but feel gratified to know that we have made great progress.展开更多
Previous studies have shown that baicalin prevented iron accumulation after substantia nigra injury, reduced divalent metal transporter 1 expression, and increased ferroportin 1 expression in the substantia nigra of r...Previous studies have shown that baicalin prevented iron accumulation after substantia nigra injury, reduced divalent metal transporter 1 expression, and increased ferroportin 1 expression in the substantia nigra of rotenone-induced Parkinson＇s disease rats. In the current study, we investigated the relationship between iron accumulation and transferrin expression in C6 cells, to explore the mechanisms of the inhibitory effect of baicalin on iron accumulation observed in Parkinson＇s disease rats. Iron content was detected using inductively coupled plasma-atomic emission spectroscopy. Results showed that iron content decreased 41% after blocking divalent metal transporter 1 and ferroportin 1 proteins. After treatment with ferric ammonium citrate of differing concentrations （10, 50, 100, 400 ktg/mL） in C6 glioma cells, cell survival rate and ferroportin 1 expression were negatively correlated with ferric ammonium citrate concentration, but divalent metal transporter 1 expression positively correlated with ferric ammonium citrate concentration. Baicalin or deferoxamine reduced divalent metal transporter 1 expression, but increased ferroportin 1 expression in the 100 μg/mL ferric ammonium citrate-loaded C6 cells. These results indicate that baicalin down-regulated iron concentration, which positively regulat- ed divalent metal transporter 1 expression and negatively regulated ferroportin 1 expression, and decreased iron accumulation in the substantia nigra.展开更多
Background:There is limited literature written on the course and outcomes for pregnant mothers with Shone complex.Methods:We describe a case series of five pregnancies in four women with Shone complex within a multidi...Background:There is limited literature written on the course and outcomes for pregnant mothers with Shone complex.Methods:We describe a case series of five pregnancies in four women with Shone complex within a multidisciplinary cardio-obstetrics clinic from 2016–2018.Results:Maternal age ranged from 21–39 years.Three patients had preserved left ventricular function while one had moderately decreased function.Gestational age at presentation ranged from 6–15 weeks.There were three successful pregnancies(mean gestational age=37 weeks,range 35–39 weeks)with one patient accounting for two unsuccessful pregnancies.All infants were delivered via Cesarean section.One infant required a NICU stay,but all other infants delivered were healthy.Conclusion:Patients with Shone complex can have successful pregnancies although complications can occur for both the mother and the baby.Comprehensive prenatal care,coordinated and consistent management during pregnancy,and tertiary care support can promote positive maternal and fetal outcomes.展开更多
Aim: This study investigated the lifestyle convenience of Insulin therapy for adult women patients with type 1 diabetes. Methods: Participants were type 1 diabetes adult women patients who switched from multiple daily...Aim: This study investigated the lifestyle convenience of Insulin therapy for adult women patients with type 1 diabetes. Methods: Participants were type 1 diabetes adult women patients who switched from multiple daily injection (MDI) therapy to Continuous Subcutaneous Insulin Infusion (CSII) therapy. We conducted semi-structured interviews with participants. To analyze, we referenced the classification table of Hamada’s study comparing the usefulness of both the NovoPen? and CSII. Semi-structured interviews were conducted with the research subjects. The questions focused mainly on diabetes management, instrument operation, everyday life, and social, psychological and lifestyle convenience aspects during MDI and CSII. Results: Research subjects were 4 women patients with type 1 diabetes. The average age was 35.3 ± 6.24 (SE) years old. Participants were undergoing MDI therapy;however, in the middle, they switched to CSII therapy. CSII therapy is convenient in terms of diabetes management, social and psychological. MDI therapy is convenient in terms of instrument operation and daily life. Compared to MDI therapy, CSII therapy is less convenient in terms of instrument operation and everyday life. However, since CSII therapy has more stable HbA1c and blood glucose levels compared to MDI therapy, it is more convenient in terms of social and psychological aspects and reduces those burdens. About economy CSII therapy, patients paid about 5000 yen more per month compared to MDI therapy. Conclusion: It is believed that patients prioritize therapeutic effects, and choose CSII, which is stable in psychological and social aspects, even though it is inconvenient with life.展开更多
IN the last year, 41 year-old Huang has suffered more frequently from chest pains and breathlessness, especially when she is tired or angry. These symptoms usually last three to five minutes but can linger for up to a...IN the last year, 41 year-old Huang has suffered more frequently from chest pains and breathlessness, especially when she is tired or angry. These symptoms usually last three to five minutes but can linger for up to an hour or two. Nitroglycerin sometimes helps alleviate the symptoms but not always. No tell-tale abnormal signs show up in Holter, heart supersonic or electrocardiogram checks when the problem is coming on.展开更多
文摘＂Women＇s rights and interests are human rights＂ is now a concept accepted by all. The power of the law now safeguards the rights and interests of women. Recalling efforts in recent years to safeguard women＇s rights and interests, we cannot but feel gratified to know that we have made great progress.
基金supported by the Scientific Research Common Program of Beijing Municipal Commission of Education,No.KM20110025010
文摘Previous studies have shown that baicalin prevented iron accumulation after substantia nigra injury, reduced divalent metal transporter 1 expression, and increased ferroportin 1 expression in the substantia nigra of rotenone-induced Parkinson＇s disease rats. In the current study, we investigated the relationship between iron accumulation and transferrin expression in C6 cells, to explore the mechanisms of the inhibitory effect of baicalin on iron accumulation observed in Parkinson＇s disease rats. Iron content was detected using inductively coupled plasma-atomic emission spectroscopy. Results showed that iron content decreased 41% after blocking divalent metal transporter 1 and ferroportin 1 proteins. After treatment with ferric ammonium citrate of differing concentrations （10, 50, 100, 400 ktg/mL） in C6 glioma cells, cell survival rate and ferroportin 1 expression were negatively correlated with ferric ammonium citrate concentration, but divalent metal transporter 1 expression positively correlated with ferric ammonium citrate concentration. Baicalin or deferoxamine reduced divalent metal transporter 1 expression, but increased ferroportin 1 expression in the 100 μg/mL ferric ammonium citrate-loaded C6 cells. These results indicate that baicalin down-regulated iron concentration, which positively regulat- ed divalent metal transporter 1 expression and negatively regulated ferroportin 1 expression, and decreased iron accumulation in the substantia nigra.
文摘Background:There is limited literature written on the course and outcomes for pregnant mothers with Shone complex.Methods:We describe a case series of five pregnancies in four women with Shone complex within a multidisciplinary cardio-obstetrics clinic from 2016–2018.Results:Maternal age ranged from 21–39 years.Three patients had preserved left ventricular function while one had moderately decreased function.Gestational age at presentation ranged from 6–15 weeks.There were three successful pregnancies(mean gestational age=37 weeks,range 35–39 weeks)with one patient accounting for two unsuccessful pregnancies.All infants were delivered via Cesarean section.One infant required a NICU stay,but all other infants delivered were healthy.Conclusion:Patients with Shone complex can have successful pregnancies although complications can occur for both the mother and the baby.Comprehensive prenatal care,coordinated and consistent management during pregnancy,and tertiary care support can promote positive maternal and fetal outcomes.
文摘Aim: This study investigated the lifestyle convenience of Insulin therapy for adult women patients with type 1 diabetes. Methods: Participants were type 1 diabetes adult women patients who switched from multiple daily injection (MDI) therapy to Continuous Subcutaneous Insulin Infusion (CSII) therapy. We conducted semi-structured interviews with participants. To analyze, we referenced the classification table of Hamada’s study comparing the usefulness of both the NovoPen? and CSII. Semi-structured interviews were conducted with the research subjects. The questions focused mainly on diabetes management, instrument operation, everyday life, and social, psychological and lifestyle convenience aspects during MDI and CSII. Results: Research subjects were 4 women patients with type 1 diabetes. The average age was 35.3 ± 6.24 (SE) years old. Participants were undergoing MDI therapy;however, in the middle, they switched to CSII therapy. CSII therapy is convenient in terms of diabetes management, social and psychological. MDI therapy is convenient in terms of instrument operation and daily life. Compared to MDI therapy, CSII therapy is less convenient in terms of instrument operation and everyday life. However, since CSII therapy has more stable HbA1c and blood glucose levels compared to MDI therapy, it is more convenient in terms of social and psychological aspects and reduces those burdens. About economy CSII therapy, patients paid about 5000 yen more per month compared to MDI therapy. Conclusion: It is believed that patients prioritize therapeutic effects, and choose CSII, which is stable in psychological and social aspects, even though it is inconvenient with life.
文摘IN the last year, 41 year-old Huang has suffered more frequently from chest pains and breathlessness, especially when she is tired or angry. These symptoms usually last three to five minutes but can linger for up to an hour or two. Nitroglycerin sometimes helps alleviate the symptoms but not always. No tell-tale abnormal signs show up in Holter, heart supersonic or electrocardiogram checks when the problem is coming on.
