Burden of gastrointestinal cancers among working-age population over past thirty years in China

BACKGROUND Although gastrointestinal(GI)cancers have been becoming a great public health concern in China,there is currently a lack of comprehensive literature on the overall burden and changing trends of GI cancers in the working-age population.AIM To assess the burden of GI cancers and to examine the overall,age-and genderspecific trends among the working-age population in China from 1990 to 2019.METHODS Data were extracted from the Global Burden of Disease Study 2019.The burden of GI cancers was indicated by incidence,mortality,disability-adjusted life-years(DALYs),age-standardized incidence rate(ASIR),age-standardized mortality rate,and age-standardized DALYs rate.Trends in the burden of GI cancers from 1990 to 2019 were examined using annual percent change and average annual percent change with Joinpoint regression models.RESULTS For overall GI cancers,a declining trend was observed in the ASIR,age-standardized mortality rate,and agestandardized DALYs rate,with reductions of 0.74%,2.23%,and 2.22%,respectively,from 1999 to 2019 in the Chinese working-age population.However,an increasing trend was observed in the ASIR for overall GI cancers from 2016-2019.The number of either incident cases,mortality cases,and DALYs was higher for colon/rectum cancer and liver cancer in younger participants but lower for esophageal,gallbladder,biliary tract,pancreatic,and stomach cancer among older subjects.Moreover,sex disparity in the GI cancers burden was also examined over 30 years.CONCLUSION The total burden of GI cancers remained heavy among the working-age population in China,although declining trends were observed from 1999 to 2019.Disparities in the GI cancers burden existed between sexes,age groups,and cancer types.Population-based precision prevention strategies are needed to tackle GI cancers among working-age individuals,considering the age,sex,and cancer type disparities in China.

Epidemiological, Clinical Aspects and Factors Associated with Typical Gastroesophageal Reflux Disease in the General Population of Parakou, Republic of Benin

Introduction: Gastroesophageal reflux disease (GERD) is a benign and chronic disease that can impair the quality of life. Objective: To study the epidemiological, clinical aspects and factors associated with typical GERD in the general population of Parakou in the Republic of Benin. Methods: This was a descriptive and analytical cross-sectional study with prospective data collection which took place from May 1, 2019 to June 30, 2019. The study population consisted of any subject aged at least 15 years and living in Parakou. Subjects aged at least 15 years, present on the day of the survey and having given their free and informed verbal consent were included. The Short form of QRS®(Reflux-Qual Short form) questionnaire and the “Hospital Anxiety and Depression” score were used to assess the quality of life and anxiety/depression, respectively. The sampling was probabilistic through a 2-stage cluster sampling. The variable of interest was the presence of GERD. Results: Out of 390 subjects surveyed, 28 had symptoms of typical GERD, representing a prevalence of 7.18%. The average age of these subjects was 27.11 ± 7.88 years. Fifteen subjects (53.57%) were male, giving a sex ratio of 1.15. Fourteen (50%) had a secondary level of education, 12 (42.86%) were pupils/students, 18 (64.29%) were single. The monthly income of 22 subjects (78.57%) was lower than the guaranteed interprofessional minimum wage (40,000 FCFA). The average duration of progression of symptoms was 15.89 ± 4.97 months. Symptoms occurred less than twice a week in 22 subjects (78.57%). The clinical manifestations were both diurnal and nocturnal in 12 subjects (42.86%). None of the 28 subjects with GERD had clinical warning signs. Asthma, diabetes, consumption of high fat or spice foods, carbonated drinks, non-steroidal anti-inflammatory drugs, alcoholic beverages and tobacco were statistically associated with the occurrence of GERD. Each of the 28 subjects had at least one associated factor. A significant impair in quality of life was observed in 27 patients (96.43%). Conclusion: Typical GERD is relatively common in the general population of Parakou in the Republic of Benin. It often affects young males. Among the risk factors identified, the most common are carbonated drinks, spicy meals and diabetes. GERD significantly impairs quality of life. Raising awareness about the disease and its associated factors is necessary among the general population.

Studies on rice seed quality through analysis of a large- scale T-DNA insertion population

A rice （Oryza sativa） T-DNA insertion population, which included more than 63 000 independent transgenic lines and 8 840 identified flanking sequence tags （FSTs） that were mapped onto the rice genome, was developed to systemi- cally study the rice seed quality control. Genome-wide analysis of the FST distribution showed that T-DNA insertions were positively correlated with expressed genes, but negatively with transposable elements and small RNAs. In addition, the recovered T-DNAs were preferentially located at the untranslated region of the expressed genes. More than 11 000 putative homozygous lines were obtained through multi-generations of planting and resistance screening, and measurement of seed quality of around half of them, including the contents of starch, amylose, protein and fat, with a nondestructive near-infrared spectroscopy method, identified 551 mutants with unique or multiple altered param- eters of seed quality. Analysis of the corresponding FSTs showed that genes participating in diverse functions, including metabolic processes and transcriptional regulation, were involved, indicating that seed quality is regulated by a complex network.

Study on Quality Improvement Effect and Separate Character of Soybean Male Sterile (MS1) Recurrent Selection Population

To solve the problem that soybean has narrow genetic base, we constructed a series of male sterile recurrent selection populations, and studied the effects of quality improvement and practical value. An LD-base population, which fits to our ecology type was constructed by 6 years＇ gene enrichment through the introduction of new genes from 23 local varieties and recurrent selection. The LD-base populations were then improved by making crosses with high protein and high oil genotypes. As a result we obtained a high protein sub-population （db） and a high oil sub-population （gy）, For the db sub-population, the protein content is 1.18% higher than the base population, 22.38% of the individuals contain 45% or more of protein, which is 10.99% higher than the base population. For the gy sub-population, oil content is 0.24% higher than the base population. Individuals with oil content of 20% or more are 11.05% higher than the base population. The quantitative characters such as flowering date, mature date, pod habit, and hilum color, etc., all showed wide range of separation, and the segregation ratio approached balance. The c.v. of branch number of ms1 recurrent population （72.8%） is higher than general cross-population （57.3%）, and the c.v. of 100 seed weight of ms1 （18.1%） is higher than general cross population （16.5%）, the coefficient of variation of plant height, pods per plant, and seeds per pod were not significantly different. It was demonstrated in this paper that the quality character of ms 1 male sterile recurrent selection population was improved by adding new genes. And the segregation of other characters widened, making the populations suitable for the objective of soybean breeding. In this paper, we also discussed the breeding method, key technology, and selection effect of soybean ms 1 population.

A strategy for population pharmaceutical quality assessment based on quality by design

From a regulatory perspective,drug quality consistency evaluation must concern different processes used for the same drug.In this study,an assessment strategy based on quality by design(QbD)was developed for population pharmaceutical quality evaluation.A descriptive analysis method based on QbD concept was first established to characterize the process by critical evaluation attributes(CEAs).Then quantitative analysis method based on an improved statistical process control(SPC)method was established to investigate the process indicators(PIs)in the process population,such as mean distribution,batch-to-batch difference and abnormal quality probability.After that rules for risk assessment were established based on the SPC limitations and parameters.Both the SPC parameters of the CEAs and the risk of PIs were visualized according to the interaction test results to obtain a better understanding of the population pharmaceutical quality.Finally,an assessment strategy was built and applied to generic drug consistency assessment,process risk assessment and quality trend tracking.The strategy demonstrated in this study could help reveal quality consistency from the perspective of process control and process risk,and further show the recent development status of domestic pharmaceutical production processes.In addition,a process risk assessment and population quality trend tracking provide databased information for approval.Not only can this information serve as a further basis for decisionmaking by the regulatory authority regarding early warnings,but it can also reduce some avoidable adverse reactions.With continuous addition of data,dynamic population pharmaceutical quality is meaningful for emergencies and decision-making regarding drug regulation.

QTL and genetic analysis controlling fiber quality traits using paternal backcross population in upland cotton

Background:Genetic improvement in fiber quality is one of the main challenges for cotton breeders.Quantitative trait loci(QTL)mapping provides a powerful approach to dissect the molecular mechanism in fiber quality traits.In present study,F14 recombinant inbred line(RIL)population was backcrossed to paternal parent for a paternal backcross(BC/P)population,deriving from one upland cotton hybrid.Three repetitive BC/P field trials and one maternal backcross(BC/M)field trial were performed including both two BC populations and the original RIL population.Results:In total,24 novel QTLs are detected for fiber quality traits and among which 13 QTLs validated previous results.Thirty-five QTLs in BC/P populations explain 5.01%–22.09%of phenotype variation(PV).Among the 35 QTLs,23 QTLs are detected in BC/P population alone.Present study provides novel alleles of male parent for fiber quality traits with positive genetic effects.Particularly,qFS-Chr3–1 explains 22.09%of PV in BC/P population,which increaseds 0.48 cN·tex−1 for fiber strength.A total of 7,2,8,2 and 6 QTLs explain over 10.00%of PV for fiber length,fiber uniformity,fiber strength,fiber elongation and fiber micronaire,respectively.In RIL population,six common QTLs are detected in more than one environment:qFL-Chr1–2,qFS-Chr5–1,qFS-Chr9–1,qFS-Chr21–1,qFM-Chr9–1 and qFM-Chr9–2.Two common QTLs of qFE-Chr2–2(TMB2386-SWU12343)and qFM-Chr9–1(NAU2873-CGR6771)explain 22.42%and 21.91%of PV.The region between NAU4034 and TMB1296 harbor 30 genes(379 kb)in A05 and 42 genes(49 kb)in D05 for fiber length along the QTL qFL-Chr5–1 in BC/P population,respectively.In addition,a total of 142 and 46 epistatic QTLs and QTL×environments(E-QTLs and QQEs)are identified in recombinant inbred lines in paternal backcross(RIL-P)and paternal backcross(BC/P)populations,respectively.Conclusions:The present studies provide informative basis for improving cotton fiber quality in different populations.

Effects of "Three Controls" Nutrient Management on Population Quality and Yield Components of Rice

[Objectives]This study was conducted to explore the control mechanism of agricultural non-point source pollution,and investigate the feasibility of promoting rice"three controls"nutrient management in Enping City.[Methods]With high-quality conventional rice as a material,such three treatments as three controls fertilization A(ZHY)and B(ZHY)and farmers conventional fertilization method FFP(ZXL)were set up,and the whole process of the late-season plot experiment was recorded.The agronomic characteristics of rice population quality and yield components during rice growth and development under the"three controls"fertilization technology were analyzed.[Results]Compared with the conventional fertilization method,the three controls A(ZHY)fertilization method improved rice yield by 27.13%,seed setting rate by 2.11%and 1 000-grain weight by 3.30%when reducing N,P and K by 27.13%,10.89%and 27.31%,respectively.In the case of three controls B(ZHY)omitting the last fertilization in the three controls fertilization method(4∶2∶3∶1),which saved the formula fertilizer by 11.25%,no difference was caused in yield,but the seed setting rate and 1 000-grain weight were still improved by 3.47%and 2.79%,respectively.Compared with the conventional fertilization method,the top first,second and third basal nodes of the three controls A(ZHY)fertilization method were shortened by 18.82%,17.06%and 20.52%,respectively,which plays an important role in combating typhoon and resisting lodging.[Conclusions]Compared with the conventional fertilization method,rice"three controls"nutrient management can improve yield and lodging resistance of rice,reduce fertilizer loss and agricultural non-point source pollution,and protect ecological environment.

Population Growth,Available Resources,and Quality of Life:China’s Post-Reform Economic Development

Two opposing intellectual traditions and their contem-porary developments regarding the relations among population, available resources, and quality of life as reflected in economic growth are reviewed. What is at issue is whether population growth is detrimental to or beneficial for economic development. Neither of the extreme views gives a complete picture of the interplay among population, resources, and quality of life. Following previous literature on the topic, this paper establishes a more balanced approach that considers the function linking population and quality of life not constant but variable and regards the limitedness of resources as not absolute but relative to regions and societies. The proposed approach is more flexible in better explaining the relation between population and economic growth. China is examined as a case in point to shed light on the interaction of population growth, economic development, and available resources, and its recent post-economic reform experiences showcase the appropriateness of the synthetic approach.

Physical Quality of Tibet an Population

Physical development of teenagers is an important indicator of overall popu lation health quality.Surveys show the physical quality of children with primary and middle schooling in 1982 improved considerably,com-pared to 1965,with the height of school boys and gi rls increasingby7.81%and6.47%,weightby16.56%and11.02%,chest measurements by 3.87%and 1.67%。and sitting height by 7.14%and 6.32%re-spectively.

Population Quality-based Demographic Dividend,Industrial Transformation and Sustainable Development of the Chinese Economy and Society

China is faced with a decreasing labor supply and therefore is losing its cost advantage.However,benefiting from continuous improvement of population quality,China's population quality-based demographic dividend begins to replace the quantity-based dividend to play a dominant role in economic development.Thus,in supply-side structure,rather than essential factors,it paves the way for the sustainable development of the Chinese economy.With the addition of the successful industrial transformation and upgrading,China still has the advantage to overcome the middle income trap and maintain the momentum of economic growth.

The Impacts of Lower Population Growth on the Quality of Life and Economic Development：China＇s Experience

China is the most populous country in the world.The total Population on the mainland of China has in-creased from 540 million in 1949 to 1.18 billion by the end of 1993.China adopted a population policy by namc of"controlling population growth and im-proving the quality of the human resources',which has been deeply rooted in the hearts of the Chinese pcoplc.The overw helming majority of the Chinese people have recognized the necessity for implementing the family planning programme not only for the sustained devel-opment of the country,but also for the benefits of their own familie cs.

Population,Environment Dynamics,Poverty and Quality of Life in China

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Quality of life and influencing factors between local and itinerant populations during the COVID-19 pandemic

Objective:To determine the difference in quality of life and its influencing factors between local and itinerant populations in Nanjing during COVID-19.Methods:The quality of life questionnaire,which was based on the Brief Scale of WHO Quality of Life and redesigned by the research group,was used to randomly investigate 1150 people in 5 districts of Nanjing.Results:A total of 1112 valid questionnaires were collected(local population,n=558;itinerant population,n=554).The quality of life of the itinerant population was significantly lower than the local population.The itinerant population scores in physiology,psychology,social relationships,and environment were lower than the local population(all P values<0.05).COVID-19 had a greater impact on the itinerant population than on the local population,especially in medical assistance,enjoyment of life,and interpersonal relationships(all P values<0.05).Conclusion:The itinerant population had a lower quality of life than that of the local population during the prevention and control pandemic of COVID-19,thus more social support and help is warranted.

Mapping quantitative trait loci associated with starch paste viscosity attributes by using double haploid populations of rice (Oryza sativa L.)

The paste viscosity attributes of starch,measured by rapid visco analyzer(RVA),are important factors for the evaluation of the cooking and eating qualities of rice in breeding programs.To determine the genetic roots of the paste viscosity attributes of rice grains,quantitative trait loci(QTLs)associated with the paste viscosity attributes were mapped,using a double haploid(DH)population derived from Zhongjiazao 17(YK17),a super rice variety,crossed with D50,a tropic japonica variety.Fifty-four QTLs,for seven parameters of the RVA profiles,were identified in three planting seasons.The 54 QTLs were located on all of the 12 chromosomes,with a single QTL explaining 5.99 to 47.11%of phenotypic variation.From the QTLs identified,four were repeatedly detected under three environmental conditions and the other four QTLs were repeated under two environments.Most of the QTLs detected for peak viscosity(PKV),trough viscosity(TV),cool paste viscosity(CPV),breakdown viscosity(BDV),setback viscosity(SBV),and peak time(PeT)were located in the interval of RM 6775-RM 3805 under all three environmental conditions,with the exception of pasting temperature(PaT).For digenic interactions,eight QTLs with six traits were identified for additivexenvironment interactions in all three planting environments.The epistatic interactions were estimated only for PKV,SBV and PaT.The present study will facilitate further understanding of the genetic architecture of eating and cooking quality(ECQ)in the rice quality improvement program.

The Effect of Brown Coal Mining on the Environment and Health of the Population in Northern Bohemia (Czech Republic)

Coal mining has proven negative impacts on the landscape and health of inhabitants. Solid dust particles and SO2, which are the main polluting substances in coal mining and burning, are the main causes of diseases in areas with intensive coal mining. This contribution deals with areas in the Czech Republic which have the greatest problems in this regard, being North Bohemia (Chomutov, Most, Teplice and ústí nad Labem districts). It is an area with considerable anthropogenic activity, mainly due to the intensive mining of brown coal, which has a direct effect on the health of the inhabitants of the entire ústí nad Labem region. Along with the growing number of inhabitants, energy consumption demands are constantly increasing. Nevertheless, it’s important to focus primarily on renewable energy sources, which will ensure the sustainable development of the environment and society. At the same time, the question arises, which energy sources can potentially be utilized here after mining ends (2052). In terms of geography, wind energy has the greatest potential in this area. This and associated issues are dealt with by the project “Sustainable Forms of Management in an Anthropogenically Burdened Region” at the Faculty of Environment at the University of Jan E. Purkyně in ústí nad Labem.

A Study of the Universal Two-child Policy’s Impact on China’s Future Population

The most essential step in adjusting and improving the childbearing policy, the universal two-child policy will produce far-reaching impacts on the future development of China’s population. With its implementation, the country’s total population will peak later, the underage population and its proportion will increase substantially, the working-age population will experience a slower decline, and the aging of China’s population will be eased. However, the drop in the proportion of working-age people over the last 15 years has expedited the reduction of the demographic dividend, the elderly population will remain unaffected over the next 60 years, the aging of the population will continue to deepen, and at the same time, the increased child dependency burden will expand the overall dependency ratio.

Safety and Efficacy of a Proprietary Undenatured Beta-Glucan on Different Human Populations

After proving safety in animal and human models, a series of clinical trials were conducted to examine the administration of 1 mg/mL bid of an undenatured beta-glucan on the immune system;and on self-perceived effects on subjects’ quality of life (QoL) using a Visual Analogue Scale (VAS). In one study, a subject population that was self-perceived to be fatigued was administered an undetaured beta-glucan, to determine if this supplementation affected their quality-of-life as a result of an increased immune system response. 44 subjects were administered 1 mg/mL bid of the undenatured beta-glucan (Lentinex®) for four weeks. Prior to the beginning of the administration, and following the four-week administration period, the subjects were asked to fill out a quality-of-life VAS questionnaire. The changes in the two questionnaires revealed differences that occurred as a result of the beta-glucan administration. More than 75% of the subjects scored “better” (more than 1 cm on the VAS) with regard to feeling in a good mood, and feeling rested. More than 60% increased their energy and reduced their tiredness and exhaustion, and 70% felt less stressed. In a second study, subjects aged 40 years and older, believed to be in good general health, seeking therapy for tiredness/exhaustion/fatigue or similar conditions (neurasthenia) which were administered 1 mg/mL bid Lentinex®. The overall results indicated that the subjects felt significantly better (mean VAS = 5.91) after the last week of the study compared to how they felt initially (VAS = 4.73) (p < 0.0001). A statistically significant (p < 0.0001) change in distribution favoring a better situation after 4 weeks intake of supplement, with a remarkable fall in number of subjects scoring below normal (from 61.4% to 18.2%) accompanied by a significant shift in subjects feeling above normal, from 9.2% to 50.0%. These clinical studies, and others, showed that Lentinex® administration improved the perceived quality-of-life of subjects whose immune system was probably not functioning at optimal levels.

人口“数量-质量”转换、经济增长与养老金可持续性研究

党的二十大报告中强调要发展多层次、多支柱、可持续的养老保险体系,但随着人口老龄化问题加剧,劳动占比下降、老年抚养比上升等问题开始影响养老制度可持续性。本文从人口数量-质量转换视角,先建立数理模型研究人口结构变动对经济增长和养老金可持续性的影响,再通过数值模拟分析不同老龄化程度下人口结构变化的宏观经济结果,最后以2001—2022年全国30个省、直辖市、自治区的省级面板数据为样本(剔除西藏)进行实证检验。结果显示:(1)人口数量结构转变对经济增长存在显著的负向影响,人口质量结构转变对经济增长存在显著的正向影响;人口质量提高会缓解人口数量下降给经济增长带来的冲击,即人口数量-质量转换可以促进经济增长。(2)人口质量提高通过促进经济增长增强养老金可持续性。(3)人口数量-质量转换可以增强养老金可持续性。无论以教育投资为代表的人力资本水平提高是父代主动的、有意识的行为,还是行政性政策的结果,人口质量的提高都有利于促进经济增长和维持养老金收支平衡。

以数字技术推动人口高质量发展——基于健康人力资本的跨国实证研究

数字技术在促进经济增长和改善社会福祉方面发挥了积极作用,成为实现经济和社会高质量发展的重要引擎。数字技术是促进健康人力资本积累的重要途径和实现人口高质量发展的关键支撑。本文从理论层面系统阐述了数字技术促进健康人力资本积累的逻辑机制,并采用全球118个国家1990—2020年跨国面板数据,结合不同国家经济发展水平差异,从人口“生命长度和生命质量”两个维度,实证检验数字技术对健康人力资本积累的具体影响。研究发现,数字技术在大健康领域的广泛应用,有助于降低人口死亡率、提高人口健康预期寿命,进而促进健康人力资本积累;其作用途径主要通过提高政府卫生支出效率、提升数字健康素养、增加闲暇时间和促进环境改善四个路径来实现;数字技术在改善健康人力资本方面的差异与国家经济发展水平差距密切相关。基于以上分析,研究认为应加大医疗技术创新,发挥新型举国体制的优势,集中力量技术攻关,实现现代数字技术、医疗健康大数据、医疗全流程、医疗健康行业相关方多要素融合,创新中国式精准医疗发展模式。

高质量发展视域下的中国人口均衡发展

在人口形势发生重要转折性变化之际,高质量发展要求更加重视人口素质,以“提质”替代“增量”,以“人才”替代“人力”,充分发挥凝结在人口自身的素质要素的作用,使更多民众更好地享受高质量发展的成果,享受高品质生活。长期均衡发展是人口发展的主要目标,也是人口高质量发展的内在要求。人口均衡发展不仅体现在人口系统内部要素间的依存制约以及人口系统与社会经济系统之间的协调适应,还体现在代际间的传承永续。年龄结构失衡是当前人口非均衡发展的突出表现,应聚焦结构失衡,弥补制约人口均衡发展的短板;同时充分发挥作为人口结构中坚力量的劳动年龄人口的作用,通过与经济高质量发展相协调以及推动人口均衡分布,促进人口均衡发展,助力实现人口高质量发展。