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Mapping soil organic matter in cultivated land based on multi-year composite images on monthly time scales
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作者 Jie Song Dongsheng Yu +4 位作者 Siwei Wang Yanhe Zhao Xin Wang Lixia Ma Jiangang Li 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第4期1393-1408,共16页
Rapid and accurate acquisition of soil organic matter(SOM)information in cultivated land is important for sustainable agricultural development and carbon balance management.This study proposed a novel approach to pred... Rapid and accurate acquisition of soil organic matter(SOM)information in cultivated land is important for sustainable agricultural development and carbon balance management.This study proposed a novel approach to predict SOM with high accuracy using multiyear synthetic remote sensing variables on a monthly scale.We obtained 12 monthly synthetic Sentinel-2 images covering the study area from 2016 to 2021 through the Google Earth Engine(GEE)platform,and reflectance bands and vegetation indices were extracted from these composite images.Then the random forest(RF),support vector machine(SVM)and gradient boosting regression tree(GBRT)models were tested to investigate the difference in SOM prediction accuracy under different combinations of monthly synthetic variables.Results showed that firstly,all monthly synthetic spectral bands of Sentinel-2 showed a significant correlation with SOM(P<0.05)for the months of January,March,April,October,and November.Secondly,in terms of single-monthly composite variables,the prediction accuracy was relatively poor,with the highest R^(2)value of 0.36 being observed in January.When monthly synthetic environmental variables were grouped in accordance with the four quarters of the year,the first quarter and the fourth quarter showed good performance,and any combination of three quarters was similar in estimation accuracy.The overall best performance was observed when all monthly synthetic variables were incorporated into the models.Thirdly,among the three models compared,the RF model was consistently more accurate than the SVM and GBRT models,achieving an R^(2)value of 0.56.Except for band 12 in December,the importance of the remaining bands did not exhibit significant differences.This research offers a new attempt to map SOM with high accuracy and fine spatial resolution based on monthly synthetic Sentinel-2 images. 展开更多
关键词 soil organic matter Sentinel-2 monthly synthetic images machine learning model spatial prediction
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T2-weighted imaging-based radiomic-clinical machine learning model for predicting the differentiation of colorectal adenocarcinoma
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作者 Hui-Da Zheng Qiao-Yi Huang +4 位作者 Qi-Ming Huang Xiao-Ting Ke Kai Ye Shu Lin Jian-Hua Xu 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第3期819-832,共14页
BACKGROUND The study on predicting the differentiation grade of colorectal cancer(CRC)based on magnetic resonance imaging(MRI)has not been reported yet.Developing a non-invasive model to predict the differentiation gr... BACKGROUND The study on predicting the differentiation grade of colorectal cancer(CRC)based on magnetic resonance imaging(MRI)has not been reported yet.Developing a non-invasive model to predict the differentiation grade of CRC is of great value.AIM To develop and validate machine learning-based models for predicting the differ-entiation grade of CRC based on T2-weighted images(T2WI).METHODS We retrospectively collected the preoperative imaging and clinical data of 315 patients with CRC who underwent surgery from March 2018 to July 2023.Patients were randomly assigned to a training cohort(n=220)or a validation cohort(n=95)at a 7:3 ratio.Lesions were delineated layer by layer on high-resolution T2WI.Least absolute shrinkage and selection operator regression was applied to screen for radiomic features.Radiomics and clinical models were constructed using the multilayer perceptron(MLP)algorithm.These radiomic features and clinically relevant variables(selected based on a significance level of P<0.05 in the training set)were used to construct radiomics-clinical models.The performance of the three models(clinical,radiomic,and radiomic-clinical model)were evaluated using the area under the curve(AUC),calibration curve and decision curve analysis(DCA).RESULTS After feature selection,eight radiomic features were retained from the initial 1781 features to construct the radiomic model.Eight different classifiers,including logistic regression,support vector machine,k-nearest neighbours,random forest,extreme trees,extreme gradient boosting,light gradient boosting machine,and MLP,were used to construct the model,with MLP demonstrating the best diagnostic performance.The AUC of the radiomic-clinical model was 0.862(95%CI:0.796-0.927)in the training cohort and 0.761(95%CI:0.635-0.887)in the validation cohort.The AUC for the radiomic model was 0.796(95%CI:0.723-0.869)in the training cohort and 0.735(95%CI:0.604-0.866)in the validation cohort.The clinical model achieved an AUC of 0.751(95%CI:0.661-0.842)in the training cohort and 0.676(95%CI:0.525-0.827)in the validation cohort.All three models demonstrated good accuracy.In the training cohort,the AUC of the radiomic-clinical model was significantly greater than that of the clinical model(P=0.005)and the radiomic model(P=0.016).DCA confirmed the clinical practicality of incorporating radiomic features into the diagnostic process.CONCLUSION In this study,we successfully developed and validated a T2WI-based machine learning model as an auxiliary tool for the preoperative differentiation between well/moderately and poorly differentiated CRC.This novel approach may assist clinicians in personalizing treatment strategies for patients and improving treatment efficacy. 展开更多
关键词 Radiomics Colorectal cancer Differentiation grade Machine learning T2-weighted imaging
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Retrieving chlorophyll content and equivalent water thickness of Moso bamboo(Phyllostachys pubescens) forests under Pantana phyllostachysae Chao-induced stress from Sentinel-2A/B images in a multiple LUTs-based PROSAIL framework 被引量:1
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作者 Zhanghua Xu Anqi He +10 位作者 Yiwei Zhang Zhenbang Hao Yifan Li Songyang Xiang Bin Li Lingyan Chen Hui Yu Wanling Shen Xuying Huang Xiaoyu Guo Zenglu Li 《Forest Ecosystems》 SCIE CSCD 2023年第2期252-267,共16页
Biochemical components of Moso bamboo(Phyllostachys pubescens)are critical to physiological and ecological processes and play an important role in the material and energy cycles of the ecosystem.The coupled PROSPECT w... Biochemical components of Moso bamboo(Phyllostachys pubescens)are critical to physiological and ecological processes and play an important role in the material and energy cycles of the ecosystem.The coupled PROSPECT with SAIL(PROSAIL)radiative transfer model is widely used for vegetation biochemical component content inversion.However,the presence of leaf-eating pests,such as Pantana phyllostachysae Chao(PPC),weakens the performance of the model for estimating biochemical components of Moso bamboo and thus must be considered.Therefore,this study considered pest-induced stress signals associated with Sentinel-2A/B images and field data and established multiple sets of biochemical canopy reflectance look-up tables(LUTs)based on the PROSAIL framework by setting different parameter ranges according to infestation levels.Quantitative inversions of leaf area index(LAI),leaf chlorophyll content(LCC),and leaf equivalent water thickness(LEWT)were derived.The scale conversions from LCC to canopy chlorophyll content(CCC)and LEWT to canopy equivalent water thickness(CEWT)were calculated.The results showed that LAI,CCC,and CEWT were inversely related with PPC-induced stress.When applying multiple LUTs,the p-values were<0.01;the R2 values for LAI,CCC,and CEWT were 0.71,0.68,and 0.65 with root mean square error(RMSE)(normalized RMSE,NRMSE)values of 0.38(0.16),17.56μg cm-2(0.20),and 0.02 cm(0.51),respectively.Compared to the values obtained for the traditional PROSAIL model,for October,R2 values increased by 0.05 and 0.10 and NRMSE decreased by 0.09 and 0.02 for CCC and CEWT,respectively and RMSE decreased by 0.35μg cm-2 for CCC.The feasibility of the inverse strategy for integrating pest-induced stress factors into the PROSAIL model,while establishing multiple LUTs under different pest-induced damage levels,was successfully demonstrated and can potentially enhance future vegetation parameter inversion and monitoring of bamboo forest health and ecosystems. 展开更多
关键词 Moso bamboo Chlorophyll content Equivalent water thickness PROSAIL model Multiple LUTs Pantana phyllostachysae Chao Sentinel-2A/B images
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MRI T_2 star mapping、T_1 images与3D DESS融合图在隐匿性膝关节软骨损伤中的应用 被引量:4
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作者 范伟雄 杨志企 +3 位作者 程凤燕 黄健 于昭 侯文忠 《临床医学工程》 2017年第4期437-439,共3页
目的探讨T_2 star mapping、T_1 images与3D DESS融合伪彩图在关节软骨损伤中的诊断价值。方法对26例关节软骨损伤患者行T_2 star mapping、T_1 images和3D DESS扫描,并将T_1 images、T_2 star mapping与3D DESS图像融合,评价患者股骨... 目的探讨T_2 star mapping、T_1 images与3D DESS融合伪彩图在关节软骨损伤中的诊断价值。方法对26例关节软骨损伤患者行T_2 star mapping、T_1 images和3D DESS扫描,并将T_1 images、T_2 star mapping与3D DESS图像融合,评价患者股骨、胫骨、髌骨关节软骨损伤程度并与关节镜结果对比,计算融合伪彩图诊断软骨损伤的特异性、敏感性及与关节镜诊断结果一致性。结果 T_1 images-3D DESS融合伪彩图诊断关节软骨损伤的敏感度、特异度及Kappa值分别为92.8%、93.0%、0.769,T_2 star mapping-3D DESS融合伪彩图诊断关节软骨损伤的敏感度、特异度及Kappa值分别为91.4%、94.2%、0.787。结论 T_2 star mapping、T_1 images与3D DESS融合伪彩图在关节软骨早期损伤评价上优于关节镜。 展开更多
关键词 膝关节 关节软骨 磁共振成像 T2 star mapping T1 images 3D DESS
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2型糖尿病患者骨骼肌厚度和弹性变化及其影响因素
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作者 冯晓蕾 黄丽丽 +1 位作者 周琦 李苗 《中国医学影像技术》 CSCD 北大核心 2024年第2期270-274,共5页
目的观察2型糖尿病患者骨骼肌厚度和弹性变化及其影响因素。方法前瞻性招募62例2型糖尿病患者(T2DM组)及60名健康成年人(HC组),以剪切波弹性成像(SWE)技术检测其放松及收缩状态下腹直肌和腓肠肌最大杨氏模量(E_(max)),比较组间2种状态... 目的观察2型糖尿病患者骨骼肌厚度和弹性变化及其影响因素。方法前瞻性招募62例2型糖尿病患者(T2DM组)及60名健康成年人(HC组),以剪切波弹性成像(SWE)技术检测其放松及收缩状态下腹直肌和腓肠肌最大杨氏模量(E_(max)),比较组间2种状态下骨骼肌厚度及弹性模量,并采用多重线性回归分析影响腹直肌和腓肠肌弹性模量的因素。结果组间放松及收缩状态下腹直肌和腓肠肌厚度差异均无统计学意义(P均>0.05);T2DM组放松及收缩状态下腹直肌及腓肠肌Emax均低于HC组(P均<0.05)。多重线性回归分析显示,T2DM组放松及收缩状态下腹直肌及腓肠肌弹性模量均随病程、空腹血糖(FBG)及糖化血红蛋白(HbA1c)而呈线性降低(P均<0.05)。结论2型糖尿病患者骨骼肌弹性模量降低,且随病程、FBG及HbA1c而呈线性下降。 展开更多
关键词 糖尿病 2 骨骼 弹性成像技术 前瞻性研究
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糖尿病前期及2型糖尿病皮层萎缩与认知功能的相关性研究
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作者 李欣 张雯 +6 位作者 刘佳妮 傅琳清 缪应雯 张鑫 陈玖 毕艳 张冰 《磁共振成像》 CAS CSCD 北大核心 2024年第4期9-14,19,共7页
目的探讨糖尿病前期(pre-diabetes mellitus,PDM)和2型糖尿病(type 2 diabetes mellitus,T2DM)大脑皮层的改变模式及其与认知功能的关系,以期探寻血糖代谢异常被试早期脑损害的影像标志物。材料与方法本研究纳入96例T2DM患者、30例PDM... 目的探讨糖尿病前期(pre-diabetes mellitus,PDM)和2型糖尿病(type 2 diabetes mellitus,T2DM)大脑皮层的改变模式及其与认知功能的关系,以期探寻血糖代谢异常被试早期脑损害的影像标志物。材料与方法本研究纳入96例T2DM患者、30例PDM被试以及48名正常对照(normal control,NC),对被试进行了认知功能测试、临床生化检查及高分辨率3D-T1WI磁共振扫描。使用CAT12软件进行基于体素的形态学分析和基于表面的形态学分析得到全脑灰质体积和皮层厚度、局部回指数等皮层结构参数,并比较3组间的差异,结果均使用P<0.05的阈值和FWE校正进行多重比较校正。进一步提取组间具有差异的参数,与生化指标及认知量表得分进行相关分析。结果与NC相比,PDM被试右侧额下回眶部及左侧中央后回灰质萎缩(P<0.05,FWE校正),T2DM患者出现更多灰质萎缩,特别是右侧颞上回、右侧额下回眶部、右侧颞中回及左侧中央后回,右侧前额叶皮层厚度减小(P<0.05,FWE校正)。在血糖代谢异常被试中全脑灰质体积与胰岛素抵抗指数(r=−0.227,P=0.012,未校正)及连线测试A得分(r=−0.250,P=0.001,FDR校正)呈负相关,与数字广度-倒背得分呈正相关(r=0.267,P=0.003,FDR校正);皮层厚度与糖化血红蛋白(r=−0.181,P=0.040,未校正)及餐后2 h血糖(r=−0.272,P=0.020,未校正)呈负相关,与餐后2 h胰岛素(r=0.236,P=0.010,未校正)及胰岛β细胞功能指数(r=0.207,P=0.022,未校正)呈正相关。结论本研究发现PDM人群已存在脑区灰质萎缩,T2DM患者出现更多的灰质萎缩,且与注意和工作记忆功能相关,因此皮层萎缩有可能是糖尿病相关脑损伤早期的影像标志物。 展开更多
关键词 2型糖尿病 糖尿病前期 磁共振成像 皮层萎缩 认知功能
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基于Sentinel-2影像的巴尔托洛冰川冰面湖研究
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作者 刘晓 孙永玲 +1 位作者 孙世金 李敏 《测绘通报》 CSCD 北大核心 2024年第3期49-53,80,共6页
冰面湖是冰川的重要组成部分,是冰川消融的指示器,不仅对全球气候变化响应迅速,而且对了解和掌握区域水资源信息意义重大。本文基于Sentinel-2遥感数据,利用随机森林算法,对巴尔托洛冰川冰面湖进行识别提取,并基于提取结果分析研究区冰... 冰面湖是冰川的重要组成部分,是冰川消融的指示器,不仅对全球气候变化响应迅速,而且对了解和掌握区域水资源信息意义重大。本文基于Sentinel-2遥感数据,利用随机森林算法,对巴尔托洛冰川冰面湖进行识别提取,并基于提取结果分析研究区冰面湖的空间分布特征,以及冰面湖面积、数量与冰川高程的关系。本文冰面湖提取的准确率达96.07%,完整率达92.18%,错误率为11.59%;识别出巴尔托洛冰川冰面湖567个,面积为249.46~37134 m^(2);冰面湖多分布在距冰川末端3~26 km处,其中海拔3800~4300 m之间冰面湖数量最多,面积普遍较大,平均面积为1922 m^(2);随着高程的升高,冰面湖的数量和面积逐渐减少,在高程5300 m以上冰面湖数量仅为15个,平均面积为356 m^(2);高程升高导致冰面温度降低,是冰面湖数量和面积骤减的主要原因。 展开更多
关键词 巴尔托洛冰川 冰面湖 Sentinel-2影像 随机森林算法
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基于恒定梯度编码一维选层T_(2)谱的胶结砂岩层析成像方法
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作者 吴土荣 陈金定 +3 位作者 张群 赵希春 郭敏灵 程芳桂 《测井技术》 CAS 2024年第2期190-197,共8页
核磁共振成像是探究岩心尺度非均质性的先进技术,受岩石复杂性和编码技术影响,现有方法效果不佳。基于梯度场的二维/三维核磁共振技术成像容易但信噪比低,无梯度场的传统选层T_(2)谱(频率编码/相位编码)方法效率低。该研究提出恒定梯度... 核磁共振成像是探究岩心尺度非均质性的先进技术,受岩石复杂性和编码技术影响,现有方法效果不佳。基于梯度场的二维/三维核磁共振技术成像容易但信噪比低,无梯度场的传统选层T_(2)谱(频率编码/相位编码)方法效率低。该研究提出恒定梯度编码一维选层T_(2)谱层析成像方法,做到了成像数据体量小、信噪比高且信号更完整。层析T_(2)谱图像及其热度分布,能够有效表征毛细管压力和成岩作用对流体非均匀分布的影响。饱和油状态时,T_(2)谱层间差异性反映成岩作用影响。高饱和油阶段,轴向热度图反映了低毛细管压力游离油的脱出规律。完全驱替后毛细管压力进入稳定状态,轴向热度图反映了微孔中吸附油赋存状态的差异。该技术在胶结砂岩气驱油实验中取得了良好效果,并对解析强非均质岩石渗流规律有重要作用。 展开更多
关键词 岩心核磁共振 T_(2)谱成像 梯度编码 毛细管压力 非均质性
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基于规则的面向对象分类与监督分类对比研究——以WorldView-2影像为例
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作者 薛永福 刘炜 +1 位作者 樊瑶 赵尔平 《四川轻化工大学学报(自然科学版)》 CAS 2023年第4期43-51,共9页
针对传统监督分类方法在处理高分辨率影像时会产生“同物异谱,同谱异物”的现象,本文以杭州市WorldView-2遥感影像数据作为基础数据源,设计了一种基于规则的面向对象分类方法(ROOC)以提取研究区域地物,提高地物分类精度。首先,针对不同... 针对传统监督分类方法在处理高分辨率影像时会产生“同物异谱,同谱异物”的现象,本文以杭州市WorldView-2遥感影像数据作为基础数据源,设计了一种基于规则的面向对象分类方法(ROOC)以提取研究区域地物,提高地物分类精度。首先,针对不同地物的光谱特征差异构建分类规则函数;其次,依据地物图斑在不同分割层下的大小及形状不一致的特征,引入特征波段并参与多尺度分割;最后,将光谱特征分类规则函数与多尺度分割结果相结合构建ROOC方法,通过目视评价和定量分析的方法与MLC、SVM和NNC 3种监督分类结果进行对比。结果表明,ROOC方法的总体分类精度为81.5%,较MLC、SVM、NNC分别提高了10.0%、10.5%、8.0%;总体Kappa系数为0.7685,较MLC、SVM、NNC分别提高了0.1278、0.1295、0.1057。因此,ROOC方法通过将地物光谱特征差异与多尺度分割相结合,能够更准确地识别WorldView-2影像中光谱特征相近的地物,能有效减少地物混分现象,提高分类精度。 展开更多
关键词 worldview-2影像 分类规则函数 多尺度分割 特征增强
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2型糖尿病Gd-EOB-DTPA增强MRI肝肾影像改变
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作者 孙昊洋 张文玉 张文龙 《放射学实践》 CSCD 北大核心 2024年第2期213-217,共5页
目的:探讨2型糖尿病(T2D)患者钆塞酸二钠(Gd-EOB-DTPA)增强MRI肝胆期的肝肾影像改变。方法:搜集82例接受Gd-EOB-DTPA增强MRI腹部检查的患者(肝肾功能正常),其中T2D患者34例(观察组),非T2D患者48例(对照组)。两位医师分别计算肝胆期肝脏... 目的:探讨2型糖尿病(T2D)患者钆塞酸二钠(Gd-EOB-DTPA)增强MRI肝胆期的肝肾影像改变。方法:搜集82例接受Gd-EOB-DTPA增强MRI腹部检查的患者(肝肾功能正常),其中T2D患者34例(观察组),非T2D患者48例(对照组)。两位医师分别计算肝胆期肝脏相对信号强度(RL)、肾皮质和髓质相对信号强度(Rrc、Rrm)、肾皮髓质信号强度的相对差异(Rc-m)。采用独立样本t检验或Mann-Whitney U检验比较观察组与对照组的相关参数差异。选择组间差异有统计学意义的变量,使用受试者工作特征(ROC)曲线分析其鉴别T2D的效能;采用组内相关系数(ICC)评估其可重复性。结果:观察组的RL、Rc-m均较对照组降低,差异有统计学意义(P<0.05),两组的Rrc、Rrm差异均无统计学意义(P>0.05)。RL和Rc-m鉴别T2D的ROC曲线下面积分别为0.78和0.72,诊断敏感度分别为77.10%和64.60%,特异度分别为70.60%和79.40%。RL和Rc-m的观察者间一致性均较好,RL和Rc-m的ICC分别为0.91和0.89。结论:T2D患者Gd-EOB-DTPA增强MRI肝胆期肝肾RL和Rc-m降低。RL和Rc-m在一定条件下可能有助于鉴别T2D,其测量可重复性较好。 展开更多
关键词 2型糖尿病 GD-EOB-DTPA 磁共振成像 肝脏 肾脏
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3D-STI参数评价抗HER-2药物对乳腺癌患者心室功能变化的价值
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作者 勉丽 张茜 王霞 《中国医疗设备》 2024年第3期129-133,145,共6页
目的 探讨三维斑点追踪成像(Three Dimensional Speckle Tracking Imaging,3D-STI)参数评价抗人表皮生长因子受体-2(Human Epidermal Growth Factor Receptor-2,HER-2)药物对乳腺癌患者心室功能变化的价值。方法 选取我院2021年6月至202... 目的 探讨三维斑点追踪成像(Three Dimensional Speckle Tracking Imaging,3D-STI)参数评价抗人表皮生长因子受体-2(Human Epidermal Growth Factor Receptor-2,HER-2)药物对乳腺癌患者心室功能变化的价值。方法 选取我院2021年6月至2022年6月收治的50例需行辅助化疗乳腺癌患者作为观察组,选择同期30名健康志愿者作为对照组。比较对照组与观察组化疗前,化疗第2、4、6周期常规超声心动图指标与3D-STI参数,以临床病理诊断为“金标准”,并绘制3D-STI参数受试者工作特征(Receiver Operating Characteristic,ROC)曲线。结果 观察组化疗第6周期E/A值低于对照组和化疗前(P<0.05),观察组化疗第2、4、6周期左心室扭转、心肌综合指数值低于对照组和化疗前(P<0.05),观察组化疗第4、6周期整体纵向应变(GlobalLongitudinalStrain,GLS)低于对照组和化疗前(P<0.05);ROC曲线显示GLS敏感度最高,为96.00%,整体圆周应变特异性最高,为96.67%。结论 3D-STI参数可评估乳腺癌患者抗HER-2药物化疗后心室功能变化,为临床早期干预提供诊断依据。 展开更多
关键词 乳腺癌 人表皮生长因子受体-2 三维斑点追踪成像 心室功能
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Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids 被引量:3
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作者 Limei Li Qingce Zang +5 位作者 Xinzhu Li Ying Zhu Shanjing Wen Jiuming He Ruiping Zhang Zeper Abliz 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2023年第5期483-493,共11页
Three-dimensional(3D)cell spheroid models combined with mass spectrometry imaging(MSI)enables innovative investigation of in vivo-like biological processes under different physiological and pathological conditions.Her... Three-dimensional(3D)cell spheroid models combined with mass spectrometry imaging(MSI)enables innovative investigation of in vivo-like biological processes under different physiological and pathological conditions.Herein,airflow-assisted desorption electrospray ionization-MSI(AFADESI-MSI)was coupled with 3D HepG2 spheroids to assess the metabolism and hepatotoxicity of amiodarone(AMI).High-coverage imaging of>1100 endogenous metabolites in hepatocyte spheroids was achieved using AFADESI-MSI.Following AMI treatment at different times,15 metabolites of AMI involved in Ndesethylation,hydroxylation,deiodination,and desaturation metabolic reactions were identified,and according to their spatiotemporal dynamics features,the metabolic pathways of AMI were proposed.Subsequently,the temporal and spatial changes in metabolic disturbance within spheroids caused by drug exposure were obtained via metabolomic analysis.The main dysregulated metabolic pathways included arachidonic acid and glycerophospholipid metabolism,providing considerable evidence for the mechanism of AMI hepatotoxicity.In addition,a biomarker group of eight fatty acids was selected that provided improved indication of cell viability and could characterize the hepatotoxicity of AMI.The combination of AFADESI-MSI and HepG2 spheroids can simultaneously obtain spatiotemporal information for drugs,drug metabolites,and endogenous metabolites after AMI treatment,providing an effective tool for in vitro drug hepatotoxicity evaluation. 展开更多
关键词 Mass spectrometry imaging HepG2 spheroids HEPATOTOXICITY Drug metabolism AMIODARONE
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乳腺癌患者HER2、CA153表达与声触诊组织成像定量技术参数的相关性分析
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作者 丁颖 李家菊 王国亮 《中国医学装备》 2024年第3期78-81,107,共5页
目的:分析乳腺癌患者人表皮生长因子受体2(HER2)、糖类抗原153(CA153)表达与声触诊组织成像定量(VTIQ)技术参数的相关性。方法:选取2018年5月至2020年5月合肥市第三人民医院收治的80例女性乳腺癌患者,其中世界卫生组织(WHO)分期Ⅰ期14... 目的:分析乳腺癌患者人表皮生长因子受体2(HER2)、糖类抗原153(CA153)表达与声触诊组织成像定量(VTIQ)技术参数的相关性。方法:选取2018年5月至2020年5月合肥市第三人民医院收治的80例女性乳腺癌患者,其中世界卫生组织(WHO)分期Ⅰ期14例、Ⅱ期22例、Ⅲ期31例、Ⅳ期13例;另选取同时间段收治的53例女性乳腺良性疾病患者为对照。所有患者先行常规超声检查,随后进入超声VTIQ成像模式获得剪切波速度(SWV)均值参数;采用免疫组织化学法检测乳腺组织中HER2表达,采用罗氏E411电化学发光免疫分析仪检测血清CA153水平;采用Pearson法分析乳腺癌患者血清CA153水平与SWV均值的相关性。结果:与良性患者比较,乳腺癌患者VTIQ技术参数SWV均值、血清CA153水平及HRR2阳性表达率均显著升高,差异有统计学意义(F=39.107,78.353,P<0.05);与乳腺癌Ⅰ+Ⅱ期患者比较,乳腺癌Ⅲ、Ⅳ期患者VTIQ技术参数SWV均值、血清CA153水平、HRR2阳性表达率均显著升高,差异有统计学意义(t=2.685、3.556、8.326、10.455,P<0.05);与乳腺癌Ⅲ期比较,乳腺癌Ⅳ期患者VTIQ技术参数SWV均值、血清CA153水平、HRR2阳性表达率均显著升高,差异有统计学意义(t=4.632、8.659,P<0.05)。与HER2阴性表达乳腺癌患者SWV均值比较,HER2阳性表达乳腺癌患者SWV均值升高,差异有统计学意义(χ^(2)=59.751,P<0.05)。乳腺癌患者血清CA153水平与SWV均值呈正相关(r=0.501,P<0.05)。结论:乳腺癌患者VTIQ参数SWV均值与乳腺癌患者生物标志物HER2、CA153表达水平密切相关。 展开更多
关键词 乳腺癌 声触诊组织成像定量技术 人表皮生长因子受体2(HER2) 糖类抗原153(CA153)
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Centimeter-sized Cs_(3)Cu_(2)I_(5)single crystals grown by oleic acid assisted inverse temperature crystallization strategy and their films for high-quality X-ray imaging 被引量:1
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作者 Tao Chen Xin Li +9 位作者 Yong Wang Feng Lin Ruliang Liu Wenhua Zhang Jie Yang Rongfei Wang Xiaoming Wen Bin Meng Xuhui Xu Chong Wang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第4期382-389,共8页
Low-dimensional halide perovskites have become the most promising candidates for X-ray imaging,yet the issues of the poor chemical stability of hybrid halide perovskite,the high poisonousness of lead halides and the r... Low-dimensional halide perovskites have become the most promising candidates for X-ray imaging,yet the issues of the poor chemical stability of hybrid halide perovskite,the high poisonousness of lead halides and the relatively low detectivity of the lead-free halide perovskites which seriously restrain its commercialization.Here,we developed a solution inverse temperature crystal growth(ITCG)method to bring-up high quality Cs_(3)Cu_(2)I_(5)crystals with large size of centimeter order,in which the oleic acid(OA)is introduced as an antioxidative ligand to inhibit the oxidation of cuprous ions effieiently,as well as to decelerate the crystallization rate remarkalby.Based on these fine crystals,the vapor deposition technique is empolyed to prepare high quality Cs_(3)Cu_(2)I_(5)films for efficient X-ray imaging.Smooth surface morphology,high light yields and short decay time endow the Cs_(3)Cu_(2)I_(5)films with strong radioluminescence,high resolution(12 lp/mm),low detection limits(53 nGyair/s)and desirable stability.Subsequently,the Cs_(3)Cu_(2)I_(5)films have been applied to the practical radiography which exhibit superior X-ray imaging performance.Our work provides a paradigm to fabricate nonpoisonous and chemically stable inorganic halide perovskite for X-ray imaging. 展开更多
关键词 Inverse temperature crystal growth Cs_(3)Cu_(2)I_(5)single crystal Vapor deposition Cs_(3)Cu_(2)I_(5)films X-ray imaging
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Combining WV-2 images and tree physiological factors to detect damage stages of Populus gansuensis by Asian longhorned beetle (Anoplophora glabripennis) at the tree level 被引量:3
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作者 Quan Zhou Xudong Zhang +2 位作者 Linfeng Yu Lili Ren Youqing Luo 《Forest Ecosystems》 SCIE CSCD 2021年第3期479-490,共12页
Background:Anoplophora glabripennis(Motschulsky),commonly known as Asian longhorned beetle(ALB),is a wood-boring insect that can cause lethal infestation to multiple borer leaf trees.In Gansu Province,northwest China,... Background:Anoplophora glabripennis(Motschulsky),commonly known as Asian longhorned beetle(ALB),is a wood-boring insect that can cause lethal infestation to multiple borer leaf trees.In Gansu Province,northwest China,ALB has caused a large number of deaths of a local tree species Populus gansuensis.The damaged area belongs to Gobi desert where every single tree is artificially planted and is extremely difficult to cultivate.Therefore,the monitoring of the ALB infestation at the individual tree level in the landscape is necessary.Moreover,the determination of an abnormal phenotype that can be obtained directly from remote-sensing images to predict the damage degree can greatly reduce the cost of field investigation and management.Methods:Multispectral WorldView-2(WV-2)images and 5 tree physiological factors were collected as experimental materials.One-way ANOVA of the tree’s physiological factors helped in determining the phenotype to predict damage degrees.The original bands of WV-2 and derived vegetation indices were used as reference data to construct the dataset of a prediction model.Variance inflation factor and stepwise regression analyses were used to eliminate collinearity and redundancy.Finally,three machine learning algorithms,i.e.,Random Forest(RF),Support Vector Machine(SVM),Classification And Regression Tree(CART),were applied and compared to find the best classifier for predicting the damage stage of individual P.gansuensis.Results:The confusion matrix of RF achieved the highest overall classification accuracy(86.2%)and the highest Kappa index value(0.804),indicating the potential of using WV-2 imaging to accurately detect damage stages of individual trees.In addition,the canopy color was found to be positively correlated with P.gansuensis’damage stages.Conclusions:A novel method was developed by combining WV-2 and tree physiological index for semi-automatic classification of three damage stages of P.gansuensis infested with ALB.The canopy color was determined as an abnormal phenotype that could be directly assessed using remote-sensing images at the tree level to predict the damage degree.These tools are highly applicable for driving quick and effective measures to reduce damage to pure poplar forests in Gansu Province,China. 展开更多
关键词 worldview-2 Anoplophora glabripennis Populus gansuensis INFESTATION Degree of damage Canopy color Classification
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CO_(2)-水作用对层状页岩拉伸破坏影响的微观损伤研究
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作者 杜布戈 张广清 +3 位作者 周大伟 屈乐 邱仁怡 范宗洋 《岩土力学》 EI CAS CSCD 北大核心 2024年第1期59-67,共9页
CO_(2)压裂页岩储层时CO_(2)−水作用损伤页岩微观结构,改变拉伸破坏特征与裂缝扩展模式。为研究CO_(2)−水影响层状页岩拉伸破坏的微观损伤原因,设计了矿物含量测定、扫描电镜观察与巴西劈裂试验,对CO_(2)−水作用前后龙马溪与长7段页岩... CO_(2)压裂页岩储层时CO_(2)−水作用损伤页岩微观结构,改变拉伸破坏特征与裂缝扩展模式。为研究CO_(2)−水影响层状页岩拉伸破坏的微观损伤原因,设计了矿物含量测定、扫描电镜观察与巴西劈裂试验,对CO_(2)−水作用前后龙马溪与长7段页岩试件的微观损伤、破坏特征与裂缝扩展进行研究。结果表明:CO_(2)−水对层理的微观损伤作用较基质显著,层理黏土矿物脱水而体积减小,有机质被萃取收缩,纹层内产生沿层理分布的大尺寸(长度为10~30μm,开度为1~5μm)微裂缝,基质碳酸盐、长石等矿物被溶蚀,产生随机分布的小尺寸(长度小于1μm,开度小于0.5μm)微裂纹;CO_(2)−水作用后页岩抗拉强度降低且各向异性增强,破坏模式变为拉剪混合破坏,垂直层理加载试件的剪切作用更强;CO_(2)−水作用后层理对裂缝扩展的影响更大,垂直层理加载裂缝延伸被层理限制,裂缝沿层理方向水平扩展,平行加载裂缝扩展轨迹受层理约束,裂缝仅在层理扩展。 展开更多
关键词 CO_(2)-水作用 页岩 拉伸破坏 层理 数字图像相关
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一种具有识别Hg^(2+)和ClO^(-)荧光探针的设计和应用
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作者 廖元淏 王帅 +3 位作者 陈婉慧 冯华杰 陈光英 何文英 《发光学报》 EI CAS CSCD 北大核心 2024年第2期351-363,共13页
设计合成了一种含双酯基的1,2,3-三氮唑化合物,与罗丹明B酰肼结合生成了具有“开-关”性质的荧光探针(简称L_(2)),应用光谱学表征了L_(2)的物理化学参数。L_(2)分别在DMF/Tris-HCl(1:1,v/v,pH=6.0,20μmol/L)和MeOH(20μmol/L)溶液中对H... 设计合成了一种含双酯基的1,2,3-三氮唑化合物,与罗丹明B酰肼结合生成了具有“开-关”性质的荧光探针(简称L_(2)),应用光谱学表征了L_(2)的物理化学参数。L_(2)分别在DMF/Tris-HCl(1:1,v/v,pH=6.0,20μmol/L)和MeOH(20μmol/L)溶液中对Hg^(2+)和ClO^(-)显示出高选择性和灵敏性;利用荧光和紫外光谱分别测定了L_(2)对19种金属离子和14种阴离子的光学性能。实验表明,Hg^(2+)和ClO^(-)的存在使得L_(2)在585 nm和576 nm均有一个新的发射峰出现;同时伴随着荧光强度明显的增强,溶液体系发生了裸眼能识别的显色变化,表明Hg^(2+)可以将罗丹明分子的酰肼闭环结构转换为开环结构,并以1:2的比例方式生成了一种新配合物,这也被质谱、工作曲线、核磁滴定和TD-DFT计算的结果所证实;L_(2)对Hg^(2+)和ClO^(-)的检测限分别为7.45 nmol/L和0.67μmol/L。此外,生物活性测定显示L_(2)对HeLa细胞有非常低的毒性,并且可用于HeLa细胞中Hg^(2+)和ClO^(-)的细胞成像,表明L_(2)在体内可进行微测定Hg^(2+)和ClO^(-)的巨大潜力。 展开更多
关键词 1 2 3-三氮唑 罗丹明B Hg^(2+) ClO^(-) 细胞成像
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多参数MRI影像组学评估浸润性乳腺癌HER⁃2表达状态的临床应用价值
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作者 刘婷婷 林佳璐 +3 位作者 娄鉴娟 邹启桂 王思奇 蒋燕妮 《南京医科大学学报(自然科学版)》 CAS 北大核心 2024年第2期218-227,共10页
目的:探讨基于多参数磁共振成像(magnetic resonance imaging,MRI)影像组学特征的模型预测浸润性乳腺癌人类表皮生长因子受体⁃2(human epidermal growth factor receptor⁃2,HER⁃2)表达状态的价值。方法:回顾性分析南京医科大学第一附属... 目的:探讨基于多参数磁共振成像(magnetic resonance imaging,MRI)影像组学特征的模型预测浸润性乳腺癌人类表皮生长因子受体⁃2(human epidermal growth factor receptor⁃2,HER⁃2)表达状态的价值。方法:回顾性分析南京医科大学第一附属医院2018年1月—2019年12月401例乳腺癌患者的基线期MRI图像及临床资料。使用ITK⁃SNAP软件在快速反转恢复序列(turbo inversion recovery magnitude,TIRM)、动态对比增强磁共振成像第2期(dynamic⁃contrast enhanced magnetic resonance imaging phase 2,DCE2)、动态对比增强磁共振成像第4期(dynamic⁃contrast enhanced magnetic resonance imaging phase 4,DCE4)、弥散加权成像(diffusion⁃weighted imaging,DWI)和表观弥散系数(apparent diffusion coefficient,ADC)的最大肿瘤层面手动勾画二维感兴趣区域(region of interest,ROI),并对所勾画的ROI区域进行特征提取及降维筛选。应用逻辑回归(logistic re⁃gression,LR)算法建立预测HER⁃2表达状态的单参数模型、组合模型和多参数模型。结果:最终筛选出26个最优特征,其中按权重排序位居首位的特征为DCE2_original_shape_SurfaceVolumeRatio。单参数模型中预测效能最好的是DCE2模型,训练集及测试集的曲线下面积(area under curve,AUC)分别为0.907、0.879;组合模型中联合增强特征的模型比其他未联合增强特征的模型预测效能更好(P均≤0.001);多参数模型预测效能最佳(训练集及测试集的AUC值分别为0.932、0.906)。结论:基于多参数影像特征构建的影像组学模型评估浸润性乳腺癌HER⁃2表达状态有一定的临床价值,其中增强早期特征的预测价值较高。 展开更多
关键词 乳腺癌 影像组学 HER⁃2 磁共振成像 异质性
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A Novel 2D Hyperchaotic with a Complex Dynamic Behavior for Color Image Encryption
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作者 Yongsheng Hu Liyong Nan 《Computers, Materials & Continua》 SCIE EI 2023年第3期6555-6571,共17页
The generation method of the key stream and the structure of the algorithm determine the security of the cryptosystem.The classical chaotic map has simple dynamic behavior and few control parameters,so it is not suita... The generation method of the key stream and the structure of the algorithm determine the security of the cryptosystem.The classical chaotic map has simple dynamic behavior and few control parameters,so it is not suitable for modern cryptography.In this paper,we design a new 2D hyperchaotic system called 2D simple structure and complex dynamic behavior map(2D-SSCDB).The 2D-SSCDB has a simple structure but has complex dynamic behavior.The Lyapunov exponent verifies that the 2D-SSCDB has hyperchaotic behavior,and the parameter space in the hyperchaotic state is extensive and continuous.Trajectory analysis and some randomness tests verify that the 2D-SSCDB can generate random sequences with good performance.Next,to verify the excellent performance of the 2D-SSCDB,we use the 2D-SSCDB to generate a keystream for color image encryption.In the encryption algorithm,the encryption algorithm scrambles and diffuses simultaneously,increasing the cryptographic system’s security.The horizontal correlation,vertical correlation,and diagonal correlation of ciphertext are−0.0004,−0.0004 and 0.0007,respectively.The average information entropy of the ciphertext is 7.9993.In addition,the designed encryption algorithm reduces the correlation between the three channels of the color image.Security analysis shows that the color image encryption algorithm designed using 2DSSCDB has good security,can resist standard attack methods,and has high efficiency. 展开更多
关键词 Chaos theory 2D-SSCDB CRYPTOGRAPHY image encryption
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基于U^(2)-Net+的透水混凝土CT影像孔隙分割
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作者 侯斌 孙水发 +2 位作者 张蕊 崔文超 李玉博 《水电能源科学》 北大核心 2024年第2期62-66,共5页
针对现阶段主流的透水混凝土CT影像孔隙分割方法存在的问题,提出了一种堆叠高效RSU模块的U^(2)-Net+的图像分割方法。该方法通过堆叠高效的RSU模块,在网络中引入了更多的上采样节点和跳跃连接,还原了更多下采样阶段丢失的特征图细节;在... 针对现阶段主流的透水混凝土CT影像孔隙分割方法存在的问题,提出了一种堆叠高效RSU模块的U^(2)-Net+的图像分割方法。该方法通过堆叠高效的RSU模块,在网络中引入了更多的上采样节点和跳跃连接,还原了更多下采样阶段丢失的特征图细节;在编码阶段增加了一个可学习的下采样操作,进一步提升了网络对细节的捕获能力;简化了原网络的深度监督,避免了底层特征图对融合输出特征图的负面影响;将单一的标准二分类交叉熵损失函数改为Focal loss和IoU loss组成的混合损失函数,提升了网络对高噪声孔隙的关注度;最后由于数据集的特点加网络改进的提升,原网络中各模块的中间通道数得以进一步缩减,减小了网络体积。试验结果表明,U^(2)-Net+相比U^(2)-Net†在保证轻量化和快速性的同时,平均交并比、精确度、F1得分由94.12%、88.89%、93.28%分别提升至94.24%、91.15%、94.29%;U^(2)-Net+综合指标优于U-Net、U-Net++、U-Net3+、U^(2)-Net、U^(2)-Net†,各指标相较于主流的阈值分割算法至少提高23.29%,实现了透水混凝土CT影像孔隙的精准、快速分割。 展开更多
关键词 透水混凝土CT影像 图像分割 深度学习 U^(2)-Net
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