OBJECTIVE Obstructive sleep apnea(OSA)is a potential cardiovascular risk.We aimed to investigate the association of OSA with heart rhythm disorders and prognosis in elderly patients with new-onset acute myocardial inf...OBJECTIVE Obstructive sleep apnea(OSA)is a potential cardiovascular risk.We aimed to investigate the association of OSA with heart rhythm disorders and prognosis in elderly patients with new-onset acute myocardial infarction(AMI).METHODS We prospectively enrolled 252 AMI elderly patients(mean age,68.5±6.9 years)who were undergoing revascularization and completed a sleep study during their hospitalization.All subjects were categorized into non-OSA(apnea–hypopnea index(AHI)<15,n=130)and OSA(AHI≥15,n=122)groups based on the AHI.The changes in the autonomic nervous system,incidence of arrhythmia during nocturnal sleep,and major adverse cardiovascular and cerebrovascular events(MACCEs)were compared between the groups.RESULTS The mean AHI value in all AMI patients was 22.8±10.9.OSA patients showed higher levels of body mass index and peak high-sensitivity C-reactive protein and lower levels of minimum nocturnal oxygen saturation(Min Sa O2),as well as greater proportion of multivessel coronary artery disease(all P<0.05).The OSA group also showed significant increases in heart rate variability and heart rate turbulence onset(both P<0.05)and higher incidence of arrhythmia(including sinus,atrial,and ventricular in origin).At a median follow-up of 6 months(mean 0.8–1.6 years),OSA(AHI≥15)combined with hypoxia(Min Sa O2≤80%)was independently associated with the incidence of MACCEs(hazard ratio[HR]:4.536;95%confidence interval[CI]:1.461-14.084,P=0.009)after adjusting for traditional risk factors.CONCLUSIONS OSA and OSA-induced hypoxia may correlate with the severity of myocardial infarction,increase the occurrence of heart rhythm disorders in elderly subacute MI patients,and worsen their short-term poor outcomes.展开更多
A Chinese political advisor on Saturday warned a continued over- expectation for the appreciation of the Chinese currency Yuan would bring in more inflows of hot money and worsen the already excessive liquidity.
ALASHAN AND ORDOS,Inner Mongolia-Dust,five centimeters thick, and rat holes cover the landscape of the Shilekai village,about 300 kilometers from the city of Ordos, Inner Mongolia.
Investigations into a mine explosion in north China have revealed that attempts to cover up the accident led to more deaths Acoalmine explosion in Hongdong County,north China’s Shanxi Province,has killed 105 people, ...Investigations into a mine explosion in north China have revealed that attempts to cover up the accident led to more deaths Acoalmine explosion in Hongdong County,north China’s Shanxi Province,has killed 105 people, and injured another 18,four seri- ously.The explosion occurred on December 5 at Xinyao Coal Mine.At the moment of the explosion,128 miners were working in the shaft,more than double of the maximum 60 miners permitted in one shaft under the rules of the provincial work safety authorities. An investigation team was formed on December 9 with Minister of the State Administration of Work Safety Li Yizhong as its head.At the same time,the Central Government issued a five-point instruction to enforce safety regulations,and ordered all illegally operated coalmines to close.展开更多
目的初步编制精神分裂症复发（恶化）征兆问卷（early signs inventory of relapse／worsen in schizophrenia，ESIS）。方法通过访谈和文献复习方法，归纳总结精神分裂症复发（恶化）征兆的内容和维度，编制问卷初稿。分别对200例和10...目的初步编制精神分裂症复发（恶化）征兆问卷（early signs inventory of relapse／worsen in schizophrenia，ESIS）。方法通过访谈和文献复习方法，归纳总结精神分裂症复发（恶化）征兆的内容和维度，编制问卷初稿。分别对200例和100例精神分裂症患者家属进行探索性因素分析和信度分析。结果探索性因素分析抽取6个因素并对其命名，形成28题的初始问卷。各条目得分与总问卷得分间的相关系数为0．150～0．603，各条目得分与其所属因子得分间的相关系数为0．483～0．811。各因子得分间的相关系数为0．024—0．469。各因子得分与总问卷得分问相关系数为0．164～0．820。比较精神分裂症患者缓解期和复发时问卷结果，除躯体不适感因子得分两者之问差异无统计学意义外（P〉0．05），两者间问卷总分、各因子得分差异均具统计学意义（P〈0．01）。总问卷的标准Cronbach α系数为0．845，各因子的Cronbach α系数为0．590～0．779。总问卷的Spearman—Brown分半信度为0．719，各因子的Spearman—Brown分半信度为0．500～0．772。总问卷的重测相关系数为0．721，各因子的重测相关系数为0．484～0．900，相关系数有统计学意义（P〈0．01）。结论精神分裂症复发（恶化）征兆问卷信效度特性基本符合心理测量学要求，可初步用于临床指导家属评估患者复发（恶化）征兆。展开更多
基金supported by National Natural Science Youth Fund of China(81100098)Shanghai Municipal Commission of Health and Family Planning for Key Discipline Establishment(2015ZB0503&201840083)Production,Teaching and Research Program for University Teachers in Shanghai(RC20190079)。
文摘OBJECTIVE Obstructive sleep apnea(OSA)is a potential cardiovascular risk.We aimed to investigate the association of OSA with heart rhythm disorders and prognosis in elderly patients with new-onset acute myocardial infarction(AMI).METHODS We prospectively enrolled 252 AMI elderly patients(mean age,68.5±6.9 years)who were undergoing revascularization and completed a sleep study during their hospitalization.All subjects were categorized into non-OSA(apnea–hypopnea index(AHI)<15,n=130)and OSA(AHI≥15,n=122)groups based on the AHI.The changes in the autonomic nervous system,incidence of arrhythmia during nocturnal sleep,and major adverse cardiovascular and cerebrovascular events(MACCEs)were compared between the groups.RESULTS The mean AHI value in all AMI patients was 22.8±10.9.OSA patients showed higher levels of body mass index and peak high-sensitivity C-reactive protein and lower levels of minimum nocturnal oxygen saturation(Min Sa O2),as well as greater proportion of multivessel coronary artery disease(all P<0.05).The OSA group also showed significant increases in heart rate variability and heart rate turbulence onset(both P<0.05)and higher incidence of arrhythmia(including sinus,atrial,and ventricular in origin).At a median follow-up of 6 months(mean 0.8–1.6 years),OSA(AHI≥15)combined with hypoxia(Min Sa O2≤80%)was independently associated with the incidence of MACCEs(hazard ratio[HR]:4.536;95%confidence interval[CI]:1.461-14.084,P=0.009)after adjusting for traditional risk factors.CONCLUSIONS OSA and OSA-induced hypoxia may correlate with the severity of myocardial infarction,increase the occurrence of heart rhythm disorders in elderly subacute MI patients,and worsen their short-term poor outcomes.
文摘A Chinese political advisor on Saturday warned a continued over- expectation for the appreciation of the Chinese currency Yuan would bring in more inflows of hot money and worsen the already excessive liquidity.
文摘ALASHAN AND ORDOS,Inner Mongolia-Dust,five centimeters thick, and rat holes cover the landscape of the Shilekai village,about 300 kilometers from the city of Ordos, Inner Mongolia.
文摘Investigations into a mine explosion in north China have revealed that attempts to cover up the accident led to more deaths Acoalmine explosion in Hongdong County,north China’s Shanxi Province,has killed 105 people, and injured another 18,four seri- ously.The explosion occurred on December 5 at Xinyao Coal Mine.At the moment of the explosion,128 miners were working in the shaft,more than double of the maximum 60 miners permitted in one shaft under the rules of the provincial work safety authorities. An investigation team was formed on December 9 with Minister of the State Administration of Work Safety Li Yizhong as its head.At the same time,the Central Government issued a five-point instruction to enforce safety regulations,and ordered all illegally operated coalmines to close.
文摘目的初步编制精神分裂症复发（恶化）征兆问卷（early signs inventory of relapse／worsen in schizophrenia，ESIS）。方法通过访谈和文献复习方法，归纳总结精神分裂症复发（恶化）征兆的内容和维度，编制问卷初稿。分别对200例和100例精神分裂症患者家属进行探索性因素分析和信度分析。结果探索性因素分析抽取6个因素并对其命名，形成28题的初始问卷。各条目得分与总问卷得分间的相关系数为0．150～0．603，各条目得分与其所属因子得分间的相关系数为0．483～0．811。各因子得分间的相关系数为0．024—0．469。各因子得分与总问卷得分问相关系数为0．164～0．820。比较精神分裂症患者缓解期和复发时问卷结果，除躯体不适感因子得分两者之问差异无统计学意义外（P〉0．05），两者间问卷总分、各因子得分差异均具统计学意义（P〈0．01）。总问卷的标准Cronbach α系数为0．845，各因子的Cronbach α系数为0．590～0．779。总问卷的Spearman—Brown分半信度为0．719，各因子的Spearman—Brown分半信度为0．500～0．772。总问卷的重测相关系数为0．721，各因子的重测相关系数为0．484～0．900，相关系数有统计学意义（P〈0．01）。结论精神分裂症复发（恶化）征兆问卷信效度特性基本符合心理测量学要求，可初步用于临床指导家属评估患者复发（恶化）征兆。
