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泛素蛋白酶体系统在Wnt通路中的研究进展
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作者 朱剑军 朱晓华 +2 位作者 黄平 蒋辉 邓世山 《川北医学院学报》 CAS 2015年第2期255-259,共5页
Wnt信号传导通路是一个由多种分子参与、相互影响、相互制约和协同作用的复杂体系,与细胞信号转导、细胞周期、细胞增殖、细胞凋亡、细胞黏附和迁移以及干细胞的分化潜能等有关。泛素蛋白酶体系统通过调控蛋白活性、亚细胞定位以及蛋白... Wnt信号传导通路是一个由多种分子参与、相互影响、相互制约和协同作用的复杂体系,与细胞信号转导、细胞周期、细胞增殖、细胞凋亡、细胞黏附和迁移以及干细胞的分化潜能等有关。泛素蛋白酶体系统通过调控蛋白活性、亚细胞定位以及蛋白间相互作用等方式在细胞活动中发挥重要的作用。Wnt信号传导通路中β-catenin等关键分子受泛素蛋白酶体途径精密调控。本文就泛素蛋白酶体系统和Wnt通路信号传导相互之间的关系作一综述。 展开更多
关键词 泛素蛋白酶 WRIT E3连接酶 Β-CATENIN
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看图写作(六)
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作者 贺云 《英语自学》 2005年第6期39-44,共6页
关键词 MOTHER FATHER SOMETHING putting DOING leaning WRIT
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Experiment of Adopting the Learner Blog in CALL-based Practical English Writing Course
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作者 王飞 《海外英语》 2012年第19期8-10,共3页
The learner blog is adopted in the instruction of CALL-based Practical English Writing course for A-level non-Eng lish major sophomores in our school in the spring this year.After examining how the program is implemen... The learner blog is adopted in the instruction of CALL-based Practical English Writing course for A-level non-Eng lish major sophomores in our school in the spring this year.After examining how the program is implemented in detail,sugges tions are provided for future instructors in this related program.To ensure the program a good start,it is advisable for instructors to set aside a certain time to help each student to create a blog account in the beginning.Besides,it is requisite to provide stu dents with blogs titles with elaborate design and with the evaluation and further comment of the blog in the course of face-toface communication.Using of blogs in CALL-based Practical English Course is helpful in improving students'writing quality,in gearing up self-introspection for participants,in creating cooperative learning community,in fostering autonomous learning and cooperative learning,in building up communicative channels between students and instructors and among students themselves. 展开更多
关键词 the LEARNER BLOG CALL-based Practical English WRIT
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Blind reconstruction of convolutional code based on segmented Walsh-Hadamard transform 被引量:10
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作者 Fenghua Wang Hui Xie Zhitao Huang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2014年第5期748-754,共7页
Walsh-Hadamard transform (WriT) can solve linear error equations on Field F2, and the method can be used to recover the parameters of convolutional code. However, solving the equations with many unknowns needs enorm... Walsh-Hadamard transform (WriT) can solve linear error equations on Field F2, and the method can be used to recover the parameters of convolutional code. However, solving the equations with many unknowns needs enormous computer memory which limits the application of WriT. In order to solve this problem, a method based on segmented WriT is proposed in this paper. The coefficient vector of high dimension is reshaped and two vectors of lower dimension are obtained. Then the WriT is operated and the requirement for computer memory is much reduced. The code rate and the constraint length of convolutional code are detected from the Walsh spectrum. And the check vector is recovered from the peak position. The validity of the method is verified by the simulation result, and the performance is proved to be optimal. 展开更多
关键词 convolutional code blind reconstruction Walsh-Hadamard transform (WriT) tinear error equation.
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样信展台
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《当代体育(扣篮)》 2004年第21期51-51,共1页
www.xcyz.net提供的一封电子邮件样信!
关键词 THINK RESTING HOUGH FOOTBALL definitely YOUNG WRIT
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Customer-oriented Strategies in Business Writing
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作者 刘晓丹 《海外英语》 2012年第8X期118-119,共2页
Customer-oriented strategy is a popular and effective writing principle in business writing.To different customers,the letter writer should adopt to different strategies according to the background of different custom... Customer-oriented strategy is a popular and effective writing principle in business writing.To different customers,the letter writer should adopt to different strategies according to the background of different customers,therefore,the writer can remain good relationship with various customers. 展开更多
关键词 customer-oriented WRITING STRATEGIES BUSINESS WRIT
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经典Wnt通路与肿瘤放射抗性关系的研究进展 被引量:4
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作者 杨玉 周欢娣 +2 位作者 薛晓英 张歌 韩雪涛 《中华放射医学与防护杂志》 CAS CSCD 北大核心 2017年第4期316-320,共5页
放疗是治疗恶性肿瘤的重要手段,放射抗性是影响放疗疗效的重要因素,也是放疗失败的主要原因之一.近年来经典Wnt信号通路与肿瘤放射抗性的关系,逐渐受到学者的关注.本文检索了近10年来有关经典Wnt信号通路与肿瘤放射抗性的相关研究,并进... 放疗是治疗恶性肿瘤的重要手段,放射抗性是影响放疗疗效的重要因素,也是放疗失败的主要原因之一.近年来经典Wnt信号通路与肿瘤放射抗性的关系,逐渐受到学者的关注.本文检索了近10年来有关经典Wnt信号通路与肿瘤放射抗性的相关研究,并进行综述,对经典Wnt信号通路参与放射抗性形成的分子机制及功能进行系统分析和梳理,力求寻找某些规律和不同作用途径的内在联系,为进一步深入研究寻找有价值的线索. 展开更多
关键词 经典Writ通路 肿瘤 放射抗性
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Wnt3a诱导小鼠胚胎干细胞向心肌细胞分化的研究 被引量:1
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作者 高胜利 高淑红 刘丽霞 《现代生物医学进展》 CAS 2009年第20期3852-3854,F0003,共4页
目的:研究Wnt3a在诱导小鼠胚胎干细胞心肌细胞分化中的作用和原理。方法:设计不同浓度,不同成分的Wnt3a条件培养基对小鼠胚胎干细胞诱导分化,对分化细胞进行形态学鉴定,通过免疫细胞化学检测心肌肌钙蛋白-T(cTnT)的表达,通过RT-PCR检测... 目的:研究Wnt3a在诱导小鼠胚胎干细胞心肌细胞分化中的作用和原理。方法:设计不同浓度,不同成分的Wnt3a条件培养基对小鼠胚胎干细胞诱导分化,对分化细胞进行形态学鉴定,通过免疫细胞化学检测心肌肌钙蛋白-T(cTnT)的表达,通过RT-PCR检测肌球蛋白重链(α-MHC)和肌球蛋白轻链(MLC-2v)的表达。结果:Wnt3a诱导小鼠胚胎干细胞分化为心肌样细胞,分化细胞具有自动收缩性,免疫细胞化学检测心肌肌钙蛋白-T(cTnT)表达阳性,RT-PCR检测肌球蛋白重链(α-MHC)和肌球蛋白轻链(MLC-2v)表达阳性。经典Wnt信号途径的抑制剂Frizzled-8/Fc,能够抑制Wnt3a的诱导分化作用。结论:Wnt3a通过经典Wnt信号途径诱导小鼠胚胎干细胞向心肌细胞分化。 展开更多
关键词 胚胎干细胞 心肌分化 WNT3A 经典Writ信号途径
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Wnt、Notch信号参与造血微环境调控造血机制的研究
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作者 周琨 胡采红 +2 位作者 黄丽芳 刘文励 孙汉英 《中华血液学杂志》 CAS CSCD 北大核心 2009年第12期799-803,共5页
目的探讨造血发育过程中Wnt和Notch信号通路参与造血微环境调控造血的机制。方法磁珠分选法分离小鼠骨髓c—kit^+造血干/祖细胞(HSPC)。贴壁培养法分离小鼠孕10.5d主动脉-中肾-肾上腺(AGM)区,孕12.5d、14.5d、16.5d胎肝以及... 目的探讨造血发育过程中Wnt和Notch信号通路参与造血微环境调控造血的机制。方法磁珠分选法分离小鼠骨髓c—kit^+造血干/祖细胞(HSPC)。贴壁培养法分离小鼠孕10.5d主动脉-中肾-肾上腺(AGM)区,孕12.5d、14.5d、16.5d胎肝以及骨髓来源的基质细胞。通过Transwell共培养以及流式细胞术计数.比较不同来源基质细胞支持HSPC增殖的能力。通过实时定量PCR和免疫荧光动态检测各发育阶段基质细胞中Wnt、Notch mRNA和蛋白的表达。结果体外培养7d,AGM区和胎肝基质细胞培养体系中c-kit^+细胞数由0.4×10^5/孔分别扩增为(19.2±3.2)×10^5/孔和(26.8±5.4)×10^5/孔.明显高于骨髓基质细胞培养体系的(9.6±2.9)×10^5/孔(P〈0.05);其中,AGM区和骨髓基质细胞培养体系中c—kit^+细胞比例分别为(75.2±7.1)%和(74.1±6.2)%,明显高于胎肝基质细胞培养体系的(63.4±5.3)%(P〈0.05)=Wnt、Notch在各阶段基质细胞均有表达,Wnt在ACM区和胎肝基质细胞表达水平较高,Notch在AGM区及骨髓基质细胞表达水平较高(P〈0.05)、结论造血发育过程中,造血微环境通过Wnt与Notch信号通路协作、交替、整合,精密调控HSPC的发育. 展开更多
关键词 基因 Writ 基因 Notch 造血微环境 造血干细胞 造血调控
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An Investigation of the Legality of the Writ of Diem Clausit Extremum
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作者 Zhang Naihe 《World History Studies》 2022年第2期78-86,共9页
It has been argued that the legality of the writ of diem clausit extremum can be attributed to Magna Carta.In fact,the legal relationship between the writ and Magna Carta is still problematic in the English official d... It has been argued that the legality of the writ of diem clausit extremum can be attributed to Magna Carta.In fact,the legal relationship between the writ and Magna Carta is still problematic in the English official documents.Few scholars,domestically and internationally,focus on the topic which has constitutional significance in English legal history.My research on the topic is divided into four parts.In the first part,I will introduce and review the research background of the topic.It indicates that almost nobody recently shows any interest in the special topic except for Margaret McGlynn,who touched upon the topic in her book on royal prerogatives.In the second part,I would like to locate the topic in the English official documents and to search out the uncertain and discrepant parts that need resolving.In the third part,I will try to define and classify the writ of diem clausit extremum,and individually to trace back to its different legal foundations and legality.Finally,a brief conclusion will be given.It is concluded that the writ of diem clausit extremum is one of the royal prerogative writs,and has two different types,i.e.the Chancery writ and the Exchequer writ.The Chancery writ is not closely related with Magna Carta,while the Exchequer writ is undoubtedly founded on Magna Carta.Actually these different legality of the writ of diem clausit extremum can be attributed to the changing relationship between the common law and the statute law. 展开更多
关键词 LEGALITY the Writ of Diem Clausit Extremum Original and Judicial Writs Magna Carta
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United States Rules on Electronic Evidence Collected from Smartphones and their Influence on China
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作者 Yiyang Cao 《Journal of Forensic Science and Medicine》 2019年第2期104-111,共8页
The popularity and wide use of smartphones have led to an increase in the debate on the procedure relating to their investigation and search.We should not neglect the protection of citizens’privacy concerning the con... The popularity and wide use of smartphones have led to an increase in the debate on the procedure relating to their investigation and search.We should not neglect the protection of citizens’privacy concerning the content of their smartphones since they contain so much personal information.In 2014,the United States(US)Supreme Court addressed two cases,Riley v.California and US v.Wurie,which dealt with smartphone searches and the search incident to arrest exception to the warrant requirement.Police must obtain a warrant when they want to search for evidence in the smartphone of a potential suspect.However,there are exceptions to this requirement:emergencies and exigent circumstances;the consent to search exception;and the“plain view”exception.The procedural law of China contains no legal regulations on smartphone searches.Therefore,we should establish the principles of smartphone searches to strike a balance between the protection of citizens’privacy and the punishment of crime.It is helpful for us to learn from the experience of the US and other countries and limit warrantless searches,improve the writ principles and clarify the scope and procedure of smartphone searches.It is also important to establish corresponding procedural sanctioning and supervisory mechanisms. 展开更多
关键词 PRIVACY smartphone search warrantless search writ principle
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