Wang You’s thoughts on the compilation of Wu Zi Jin Si Lu reflect the thoughts of the scholars who took Zhu Xi as their mentor in the late Ming and early Qing Dynasties.Wang You combined four scholars in the Northern...Wang You’s thoughts on the compilation of Wu Zi Jin Si Lu reflect the thoughts of the scholars who took Zhu Xi as their mentor in the late Ming and early Qing Dynasties.Wang You combined four scholars in the Northern Song Dynasty(Zhou Dunyi,Zhang Zai,Cheng Yi,and Cheng Hao)and Zhu Xi into a whole,so that readers could grasp their thoughts as a whole.This also enabled the scholars of the time to access to the sages.His books were widely circulated in East Asia and were well received by Ly Dynasty,North Korea,with many copies printed.Inspired by Wang You’s compiling ideas,Ly Dynasty scholars in North Korea have compiled new documents reflecting the local Xing-li of learning,such as Li Duzhong’s Li Zi Jin Si Lu and Song Bingxuan’s Jin Si Xu Lu.The Huizhou scholars,represented by Wang You,spared no effort to construct the Jin Si Lu documents to adapt to the development of the times and to explain the essence of Jin Si Lu.It played a certain role in the dissemination of Neo-Confucianism in East Asia.展开更多
目的探讨苗药金乌健骨方总提物对类风湿关节炎滑膜组织成纤维样滑膜细胞(RA-FLS)白细胞介素6(IL-6)、转化生长因子-β(TGF-β)、白细胞介素17(IL^(-1)7)分泌及IL^(-1)7受体(IL^(-1)7R)蛋白的影响。方法采用组织块法体外培养原代RA-FLS;...目的探讨苗药金乌健骨方总提物对类风湿关节炎滑膜组织成纤维样滑膜细胞(RA-FLS)白细胞介素6(IL-6)、转化生长因子-β(TGF-β)、白细胞介素17(IL^(-1)7)分泌及IL^(-1)7受体(IL^(-1)7R)蛋白的影响。方法采用组织块法体外培养原代RA-FLS;分为金乌健骨方低、中、高剂量组(0.06,0.6,6.0 mg·m L^(-1)),雷公藤多苷组(0.03 mg·m L^(-1))及空白对照组,共5组。采用ELISA法检测IL-6、TGF-β、IL^(-1)7含量;PCR法检测IL^(-1)7R m RNA表达;Western Blot法检测IL^(-1)7R蛋白表达。结果与空白对照组比较,各给药组细胞培养上清液中IL-6、TGF-β、IL^(-1)7的浓度均有不同程度的降低(P<0.01),IL^(-1)7R m RNA及蛋白表达水平均明显下降(P<0.01)。与雷公藤多苷组比较,金乌健骨方高剂量组IL-6、TGF-β、IL^(-1)7水平及IL^(-1)7R蛋白表达量明显降低(P<0.05),金乌健骨方中、高剂量组IL^(-1)7R m RNA表达水平明显降低(P<0.05)。结论苗药金乌健骨方总提物能够下调RA-FLS中IL-6、TGF-β、IL^(-1)7的分泌,降低IL^(-1)7R m RNA及蛋白表达量。展开更多
文摘Wang You’s thoughts on the compilation of Wu Zi Jin Si Lu reflect the thoughts of the scholars who took Zhu Xi as their mentor in the late Ming and early Qing Dynasties.Wang You combined four scholars in the Northern Song Dynasty(Zhou Dunyi,Zhang Zai,Cheng Yi,and Cheng Hao)and Zhu Xi into a whole,so that readers could grasp their thoughts as a whole.This also enabled the scholars of the time to access to the sages.His books were widely circulated in East Asia and were well received by Ly Dynasty,North Korea,with many copies printed.Inspired by Wang You’s compiling ideas,Ly Dynasty scholars in North Korea have compiled new documents reflecting the local Xing-li of learning,such as Li Duzhong’s Li Zi Jin Si Lu and Song Bingxuan’s Jin Si Xu Lu.The Huizhou scholars,represented by Wang You,spared no effort to construct the Jin Si Lu documents to adapt to the development of the times and to explain the essence of Jin Si Lu.It played a certain role in the dissemination of Neo-Confucianism in East Asia.
文摘目的探讨苗药金乌健骨方总提物对类风湿关节炎滑膜组织成纤维样滑膜细胞(RA-FLS)白细胞介素6(IL-6)、转化生长因子-β(TGF-β)、白细胞介素17(IL^(-1)7)分泌及IL^(-1)7受体(IL^(-1)7R)蛋白的影响。方法采用组织块法体外培养原代RA-FLS;分为金乌健骨方低、中、高剂量组(0.06,0.6,6.0 mg·m L^(-1)),雷公藤多苷组(0.03 mg·m L^(-1))及空白对照组,共5组。采用ELISA法检测IL-6、TGF-β、IL^(-1)7含量;PCR法检测IL^(-1)7R m RNA表达;Western Blot法检测IL^(-1)7R蛋白表达。结果与空白对照组比较,各给药组细胞培养上清液中IL-6、TGF-β、IL^(-1)7的浓度均有不同程度的降低(P<0.01),IL^(-1)7R m RNA及蛋白表达水平均明显下降(P<0.01)。与雷公藤多苷组比较,金乌健骨方高剂量组IL-6、TGF-β、IL^(-1)7水平及IL^(-1)7R蛋白表达量明显降低(P<0.05),金乌健骨方中、高剂量组IL^(-1)7R m RNA表达水平明显降低(P<0.05)。结论苗药金乌健骨方总提物能够下调RA-FLS中IL-6、TGF-β、IL^(-1)7的分泌,降低IL^(-1)7R m RNA及蛋白表达量。
