Combining the integrated technology of ecological quantity analytical method with GIS technology, based on the Landsat TM images and SPOT images in 1995 and 2009, this paper made a quantitative analysis of the changin...Combining the integrated technology of ecological quantity analytical method with GIS technology, based on the Landsat TM images and SPOT images in 1995 and 2009, this paper made a quantitative analysis of the changing process of land use/cover. The results showed that land use/cover in study area had undergone obviously changes from 1995 to 2009. The artificial landscapes which were mainly tropical crops plantation increased dramatically, natural forest and rubber forest was substantially reduced. The major patterns of land use change in the study area were the conversions of the natural forest and rubber forest to tropical crops plantation and cultivated land, cultivated land converted to tropical crops plantation and residential area. The analysis of landscape index showed that the role of landscape structure more diverse and uniform with the diversity of landscape fragmentation increases, the dominance of natural forest and rubber forest on the overall control of landscape reduced under the influence of human activities in the study area. The driving force analysis showed that economic development, agriculture industrial structure, policy and technology factors were the dominant factors of land use/change in the study area in the short term.展开更多
Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exert...Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway.展开更多
基金Supported by National Natural Science Foundation (40963001,40661013,40061003)~~
文摘Combining the integrated technology of ecological quantity analytical method with GIS technology, based on the Landsat TM images and SPOT images in 1995 and 2009, this paper made a quantitative analysis of the changing process of land use/cover. The results showed that land use/cover in study area had undergone obviously changes from 1995 to 2009. The artificial landscapes which were mainly tropical crops plantation increased dramatically, natural forest and rubber forest was substantially reduced. The major patterns of land use change in the study area were the conversions of the natural forest and rubber forest to tropical crops plantation and cultivated land, cultivated land converted to tropical crops plantation and residential area. The analysis of landscape index showed that the role of landscape structure more diverse and uniform with the diversity of landscape fragmentation increases, the dominance of natural forest and rubber forest on the overall control of landscape reduced under the influence of human activities in the study area. The driving force analysis showed that economic development, agriculture industrial structure, policy and technology factors were the dominant factors of land use/change in the study area in the short term.
基金supported by the National Natural Science Foundation of China (Grant Nos. 81373470, 81573489, 81522047 and 81402998)the Natural Science Foundation of Guangdong Province (No. 2015A030313124)
文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway.
