With the advancement in X-ray astronomical detection technology,various celestial polarization detection projects have been initiated.To meet the calibration requirements of polarimeters on the ground,a polarized X-ra...With the advancement in X-ray astronomical detection technology,various celestial polarization detection projects have been initiated.To meet the calibration requirements of polarimeters on the ground,a polarized X-ray radiation facility was designed for this study.The design was based on the principle that X-rays incident at 45°on a crystal produce polarized X-rays,and a second crystal was used to measure the polarization of the X-rays produced by the facility after rotation.The effects of different diaphragm sizes on the degree of polarization were compared,and the facility produced X-rays with polarization degrees of up to 99.55±0.96%using LiF200 and LiF220 crystals.This result revealed that the polarization of incident X-rays is one of the factors affecting the diffraction efficiency of crystals.The replacement of different crystals can satisfy the calibration requirements of polarized X-ray detectors with more energy points in the energy range(4-10)keV.In the future,the facility should be placed in a vacuum environment to meet the calibration requirements at lower energies.展开更多
An X-ray radiation source with approximately constant radiation temperature is realized by irradiating golden hohlraum with a shaped laser pulse. A simple theoretical model based on power balance is used to design the...An X-ray radiation source with approximately constant radiation temperature is realized by irradiating golden hohlraum with a shaped laser pulse. A simple theoretical model based on power balance is used to design the shape of the drive laser pulse. Experiments are carried out on the Shenguang III prototype laser facility, and the experimentM results are presented for radiation sources with the flat-top lasting about 2.5 ns at two different peak temperatures of about 150 eV and 170 eV, respectively, including the the drive laser pulses and the time integrated possible improvements are discussed. time histories of the temperatures, the shapes of radiation spectra. The validity of the model and展开更多
Chemically synthesized ZnS thin film is found to be a good x-ray radiation sensor. We report the effect of annealing on the x-ray radiation detection sensitivity of a ZnS thin film synthesized by a chemical bath depos...Chemically synthesized ZnS thin film is found to be a good x-ray radiation sensor. We report the effect of annealing on the x-ray radiation detection sensitivity of a ZnS thin film synthesized by a chemical bath deposition technique. The chemically synthesized ZnS films are annealed at 333, 363 and 393K for 1 h. Structural analyses show that the lattice defects in the films decrease with annealing. Further, the band gap is also found to decrease from 3.38 to 3.21 eV after annealing at 393K. Current-voltage characteristics of the films are studied under dark and x-ray irradiation conditions. Due to the decrease of lattice defects and band gap, the conductivity under dark conditions is found to increase from 2.06 × 10^-6 to 1.69 × 10^-5 S/em, while that under x-ray irradiation increases from 4.13 × 10^-5 to 5.28 ×10^-5 S/cm. On the other hand, the x-ray radiation detection sensitivity of the films is found to decrease with annealing. This decrease of detection sensitivity is attributed to the decrease of the band gap as well as some structural and surface morphological changes occurring after annealing.展开更多
We have studied the gamma and X-ray radiation compatibility of Ti-based alloys such as Ti–37 Ta–26 Hf–13 Zr-24(wt%) [Alloy 1], Ti–40 Ta–22 Hf–11.7 Zr-26.3(wt%) [Alloy 2], Ti–45 Ta–18.4 Hf–10 Zr-26.6(wt%) [All...We have studied the gamma and X-ray radiation compatibility of Ti-based alloys such as Ti–37 Ta–26 Hf–13 Zr-24(wt%) [Alloy 1], Ti–40 Ta–22 Hf–11.7 Zr-26.3(wt%) [Alloy 2], Ti–45 Ta–18.4 Hf–10 Zr-26.6(wt%) [Alloy3], Ti–50 Ta–15 Hf–8 Zr-27(wt%) [Alloy 4], Ti–55 Ta–12 Hf–7 Zr-26(wt%) [Alloy 5], and Ti–60 Ta–10 Hf–5 Zr-25(wt%) [Alloy 6]. Gamma and X-ray radiation compatibility is studied by evaluating the mass attenuation coefficient,mean free path, HVL, TVL effective atomic number,effective electron density, exposure buildup factor, and relative dose. We have compared these parameters for studied alloys with that of arteries. The alloys Ti–55 Ta–12 Hf–7 Zr-26 and Ti–60 Ta–10 Hf–5 Zr-25 have added properties such as gamma/X-ray radiation compatibility,high elastic admissible strain, high mechanical strength,and excellent biocompatibility. Hence, we may suggest that, among Ti–Ta–Hf–Zr alloys, these alloys are best materials for coronary stent applications.展开更多
The light propagation through system a polarizer-analyzer is investigated on the basis of quantum conceptions about the nature of light. It is shown, that Malus law based on principles of classical electrodynamics not...The light propagation through system a polarizer-analyzer is investigated on the basis of quantum conceptions about the nature of light. It is shown, that Malus law based on principles of classical electrodynamics not completely takes into account all effects which can occur at the light propagation through system a polarizer-analyzer. The phenomenon of possible change of frequency of light in particular drops out, for example in the region of X-ray radiation. The deduction of Malus law based on quantum principles is given. For comparison the differential effective section of interaction of a photon and electron with take into account of rotation of a plane of polarization of a photon in Compton’s effect is found.展开更多
BACKGROUND: Bone marrow-derived mesenchymal stem cells (BMSCs) are a potentially useful source for cell replacement therapy following spinal cord injury. However, the homing characteristics of BMSCs in vivo remain ...BACKGROUND: Bone marrow-derived mesenchymal stem cells (BMSCs) are a potentially useful source for cell replacement therapy following spinal cord injury. However, the homing characteristics of BMSCs in vivo remain unclear. Low-dose radiation has been shown to promote homing of BMSCs to exposed sites. OBJECTIVE: To investigate the effects of low-dose local radiation to non-injured areas on the ability of human BMSCs to home to the injured mouse spinal cord, as well as recovery of spinal cord injury. DESIGN, TIME AND SE'I-FING: A randomized, controlled, animal experiment was performed at the Central Laboratory, Second Affiliated Hospital of Soochow University between October 2007 and October 2008. MATERIALS: BMSCs were isolated from four adult, human donors. METHODS: Fifty adult, female, Balb/c mice were subjected to adjusted weight-drop impact resulting in complete paraplegia. Three days later, mice were randomly assigned to a radiation + transplantation group (n = 23) and a transplantation group (n = 20). In total, 2 x 106 carboxyfluorescein diacetate succinimidyl ester-labeled BMSCs were injected into each mouse via the caudal vein. Mice in the radiation + transplantation group received 2.5 Gy local X-ray irradiation 2 hours before BMSCs injection. MAIN OUTCOME MEASURES: The homing of BMSCs to injured cord and irradiated skin after transplantation was observed by fluorescence microscope; the structure recovery of injured cord was assessed by magnetic resonance imaging. RESULTS: Compared with the transplantation group, at 24 hours after transplantation, the number of BMSCs was significantly increased in the injured area and the exposed site (P 〈 0.05), and inflammation and edema were significantly alleviated in the injured cord in the radiation + transplantation group. CONCLUSION: Local low-dose radiation has the potential to promote homing of BMSCs and recovery of spinal cord injury, although the radiated region was not injured area.展开更多
Caspases as critical components in cell signaling pathways have been proved to be involved in events such asapoptosis, cell growth and differentiation. Two distinct apoptotic pathways related to the Caspase cascade ha...Caspases as critical components in cell signaling pathways have been proved to be involved in events such asapoptosis, cell growth and differentiation. Two distinct apoptotic pathways related to the Caspase cascade have beenidentified; death receptor-induced apoptosis and mitochondrial stress-induced apoptosis. Death receptors triggerCaspase-8 and the mitochondria subsequently release apoptogenic factors (cytochrome c, Apaf-1, AIF), leading tothe activation of Caspase-9. The mitochondrial and death receptor apoptotic pathways are intimately connected[1].展开更多
Selectively killing cancer without harming normal tissue is a fundamental challenge in cancer therapy. Elevatedoxidative stress and aberrant redox homeostasis are frequently observed in cancer cells compared with thei...Selectively killing cancer without harming normal tissue is a fundamental challenge in cancer therapy. Elevatedoxidative stress and aberrant redox homeostasis are frequently observed in cancer cells compared with their normalcell counterparts[1]. A small shift toward an oxidizing condition in cells may lead to elevated proliferation andinduction of adaptive response. However, a high oxidizing condition often results in cell injury and cell death.Persistent high level of reactive oxygen species (ROS) in cancer cells usually elicits increased cell proliferation andadaptive responses that may contribute to tumorigenesis, metastasis, and treatment resistance. However, normalcells may still maintain redox homeostasis through adaptive responses. Therefore, regulating intracellular redoxstate may represent an ideal strategy to selectively sensitize cancer cells to oxidative stress-inducing therapy, suchas radiotherapy.展开更多
Telomerase inhibitor MST-312 is a new compound derived from epigallocatechin gallate (EGCG)[1]. Our resultsdemonstrated that 4 M MST-312 not only showed lower cytotoxicity, but also inhibited telomerase activity inHe...Telomerase inhibitor MST-312 is a new compound derived from epigallocatechin gallate (EGCG)[1]. Our resultsdemonstrated that 4 M MST-312 not only showed lower cytotoxicity, but also inhibited telomerase activity inHepG2 cells. Therefore, in our experiments, 4 M MST-312 was chosen to study radiosensitization and relatedmechanisms. -H2AX foci are considered as an indicator of DNA damages[2]. The immunofluorescence stainingresults showed the number of -H2AX foci in the pretreatment with MST-312 followed by 2 Gy X-ray irradiationgroup. However, as shown in Fig. 1, the formation of Rad51 foci in the combined treatment group was blockedoutside the nuclear of HepG2 cells, when compared with the irradiation alone group. JC-1 staining showed thatMST-312 pretreatment, followed by X-ray irradiation, caused increase of the green/red fluorescence intensity ratio(ΔΨm) compared with X-ray irradiation alone. Meanwhile, MST-312 pretreatment followed by X-ray irradiationelevated expression of p53 protein and decreased expression of caspase-3 as well as fraction of Bcl-2 / Bax.展开更多
Applying the timing tools of kilohertz quasi-periodic oscillations(k Hz QPOs)and cross-correlations,we study the influence of the magnetosphere-disk relation on the X-ray radiation process of GX 17+2.First,as the spec...Applying the timing tools of kilohertz quasi-periodic oscillations(k Hz QPOs)and cross-correlations,we study the influence of the magnetosphere-disk relation on the X-ray radiation process of GX 17+2.First,as the spectral state track of X-ray emission evolves along the horizontal branch(HB),the magnetosphere-disk radii of the source derived by k Hz QPOs shrink from r~24 km to r~18 km,while its average X-ray intensities in≤10 ke V and in≥10 ke V show the opposite evolutional trends.Moreover,this branch has been detected with the anti-correlations between the low-/high-energy(e.g.,2–5 ke V/16–30 ke V)X-rays.We suggest that in HB there may exist an X-ray radiation transfer process at the disk radii near the neutron star(NS),i.e.,~5–10 km away from the surface,which probably originates from the interaction between the corona or jet with high-energy X-rays and accretion disk with low-energy X-rays.Second,as the source evolves along the normal branch(NB)and along the flaring branch(FB),their average X-ray intensities in all~2–30 ke V show the monotonously decreasing and monotonously increasing trends,respectively.In addition,these two branches are both dominated by the positive correlations between the low-and high-energy(e.g.,2–5 ke V/16–30 ke V)X-rays.Moreover,the evolution along NB is accompanied by the shrinking of the magnetosphere-disk radii from r~18 km to r~16 km.We ascribe these phenomena to that as the shrinking of the accretion disk radius,the piled up accretion matter around the NS surface may trigger the radiation that produces both the low-and high-energy X-rays simultaneously,and then form the branches of NB and FB.展开更多
Space objects such as spacecraft or missiles may be exposed to intense X-rays in outer space,leading to severe damage.The reinforcement of these objects to reduce the damage caused by X-ray irradiation is a significan...Space objects such as spacecraft or missiles may be exposed to intense X-rays in outer space,leading to severe damage.The reinforcement of these objects to reduce the damage caused by X-ray irradiation is a significant concern.The blow-off impulse(BOI)is a crucial physical quantity for investigating material damage induced by X-ray irradiation.However,the accurate calculation of BOI is challenging,particularly for large deformations of materials with complex configurations.In this study,we develop a novel two-dimensional particle-in-cell code,Xablation2D,to calculate BOIs under far-field X-ray irradiation.This significantly reduces the dependence of the numerical simulation on the grid shape.The reliability of this code is verified by simulation results from open-source codes,and the calculated BOIs are consistent with the experimental and analytical results.展开更多
The parasitic hydrogen evolution reaction(HER)in the negative half-cell of vanadium redox flow batteries(VRFBs)causes severe efficiency losses.Thus,a deeper understanding of this process and the accompanying bubble fo...The parasitic hydrogen evolution reaction(HER)in the negative half-cell of vanadium redox flow batteries(VRFBs)causes severe efficiency losses.Thus,a deeper understanding of this process and the accompanying bubble formation is crucial.This benchmarking study locally analyzes the bubble distribution in thick,porous electrodes for the first time using deep learning-based image segmentation of synchrotron X-ray micro-tomograms.Each large three-dimensional data set was processed precisely in less than one minute while minimizing human errors and pointing out areas of increased HER activity in VRFBs.The study systematically varies the electrode potential and material,concluding that more negative electrode potentials of-200 m V vs.reversible hydrogen electrode(RHE)and lower cause more substantial bubble formation,resulting in bubble fractions of around 15%–20%in carbon felt electrodes.Contrarily,the bubble fractions stay only around 2%in an electrode combining carbon felt and carbon paper.The detected areas with high HER activity,such as the border subregion with more than 30%bubble fraction in carbon felt electrodes,the cutting edges,and preferential spots in the electrode bulk,are potential-independent and suggest that larger electrodes with a higher bulk-to-border ratio might reduce HER-related performance losses.The described combination of electrochemical measurements,local X-ray microtomography,AI-based segmentation,and 3D morphometric analysis is a powerful and novel approach for local bubble analysis in three-dimensional porous electrodes,providing an essential toolkit for a broad community working on bubble-generating electrochemical systems.展开更多
Cell behavior is affected by nanostructured surface,but it remains unknown how ionizing radiation af-fects cells on nanostructured surface.This paper reports an experimental investigation of X-ray radiation induced da...Cell behavior is affected by nanostructured surface,but it remains unknown how ionizing radiation af-fects cells on nanostructured surface.This paper reports an experimental investigation of X-ray radiation induced damage of cells placed on an array of vertically aligned silicon nanowires.X-ray photoelectrons and secondary electrons produced from nanowire array are measured and compared to those from flat silicon substrate.The cell functions including morphology,viability,adhesion and proliferation have been examined and found to be drastically affected when cells are exposed to X-ray radiation,compared to those sitting on flat substrate and those only exposed to X-ray.The enhanced cell damage on nanowires upon X-ray exposure is attributed to nanowire enhanced production of photoelectrons including Auger electrons and secondary electrons,which have high escaping probability from sharp tips of nanowires.The escaped photoelectrons ionize water molecules and generate hydroxyl free radicals that can damage DNAs of cells.An inference of this work is that the contrast in scanning electron microscopy is useful in assessing the effects of nanomaterials for enhanced X-ray radiation therapy.展开更多
The effects of ionizing and displacement irradiation of high-energy x-ray and 2-MeV proton on GaN thin films were investigated and compared in this study.The electrical properties of both P-GaN and N-GaN,separated fro...The effects of ionizing and displacement irradiation of high-energy x-ray and 2-MeV proton on GaN thin films were investigated and compared in this study.The electrical properties of both P-GaN and N-GaN,separated from power devices,were gauged for fundamental analysis.It was found that the electrical properties of P-GaN were improved as a consequence of the disruption of the Mg-H bond induced by high-dose x-ray irradiation,as indicated by the Hall and circular transmission line model.Specifically,under a 100-Mrad(Si)x-ray dose,the specific contact resistance pc of P-GaN decreased by 30%,and the hole carrier concentration increased significantly.Additionally,the atom displacement damage effect of a 2-MeV proton of 1×10^(13)p/cm^(2)led to a significant degradation of the electrical properties of P-GaN,while those of N-GaN remained unchanged.P-GaN was found to be more sensitive to irradiation than N-GaN thin film.The effectiveness of x-ray irradiation in enhancing the electrical properties of P-GaN thin films was demonstrated in this study.展开更多
This study presents a new method for characterizing the thermal lattice deformation of a monochromator with high precision under service conditions and first reports the operando measurements of nanoscale thermal latt...This study presents a new method for characterizing the thermal lattice deformation of a monochromator with high precision under service conditions and first reports the operando measurements of nanoscale thermal lattice deformation on a double-crystal monochromator at different incident powers.The nanoscale thermal lattice deformation of the monochromator first crystal was obtained by analyzing the intensity of the distorted DuMond diagrams.DuMond diagrams of the 333 diffraction index,sensitive to lattice deformation,were obtained directly using a 2D detector and an analyzer crystal orthogonal to the monochromator.With increasing incident power and power density,the maximum height of the lattice deformation increased from 3.2 to 18.5 nm,and the deformation coefficient of the maximum height increased from 1.1 to 3.2 nm/W.The maximum relative standard deviation was 4.2%,and the maximum standard deviation was 0.1 nm.Based on the measured thermal deformations,the flux saturation phenomenon and critical point for the linear operation of the monochromator were predicted with increasing incident power.This study provides a simple solution to the problem of the lower precision of synchrotron radiation monochromator characterizations compared to simulations.展开更多
Modern trends in beam-driven radiation sources include the interaction of Cherenkov wakefields in open-ended circular waveguides with complicated dielectric linings, with a three-layer dielectric capillary recently pr...Modern trends in beam-driven radiation sources include the interaction of Cherenkov wakefields in open-ended circular waveguides with complicated dielectric linings, with a three-layer dielectric capillary recently proposed to reduce radiation divergence being a representative example [Opt. Lett. 45 5416(2020)]. We present a rigorous approach that allows for an analytical description of the electromagnetic processes that occur when the structure is excited by a single waveguide TM mode. In other words, the corresponding canonical waveguide diffraction problem is solved in a rigorous formulation. This is a continuation of our previous papers which considered simpler cases with a homogeneous or two-layer dielectric filling. Here we use the same analytical approach based on the Wiener–Hopf–Fock technique and deal with the more complicated case of a three-layer dielectric lining. Using the obtained rigorous solution, we discuss the possibility of manipulating the far-field radiation pattern using a third layer made of a low permittivity material.展开更多
Transarterial radioembolization or selective internal radiation therapy(SIRT)has emerged as a minimally invasive approach for the treatment of tumors.This percutaneous technique involves the local,intra-arterial deliv...Transarterial radioembolization or selective internal radiation therapy(SIRT)has emerged as a minimally invasive approach for the treatment of tumors.This percutaneous technique involves the local,intra-arterial delivery of radioactive microspheres directly into the tumor.Historically employed as a palliative measure for liver malignancies,SIRT has gained traction over the past decade as a potential curative option,mirroring the increasing role of radiation segmentectomy.The latest update of the BCLC hepatocellular carcinoma guidelines recognizes SIRT as an effective treatment modality comparable to other local ablative methods,particularly well-suited for patients where surgical resection or ablation is not feasible.Radiation segmentectomy is a more selective approach,aiming to deliver high-dose radiation to one to three specific hepatic segments,while minimizing damage to surrounding healthy tissue.Future research efforts in radiation segmentectomy should prioritize optimizing radiation dosimetry and refining the technique for super-selective administration of radiospheres within the designated hepatic segments.展开更多
As interest in double perovskites is growing,especially in applications like photovoltaic devices,understanding their mechanical properties is vital for device durability.Despite extensive exploration of structure and...As interest in double perovskites is growing,especially in applications like photovoltaic devices,understanding their mechanical properties is vital for device durability.Despite extensive exploration of structure and optical properties,research on mechanical aspects is limited.This article builds a vacancyordered double perovskite model,employing first-principles calculations to analyze mechanical,bonding,electronic,and optical properties.Results show Cs_(2)Hfl_(6),Cs_(2)SnBr_(6),Cs_(2)SnI_(6),and Cs_(2)PtBr_(6)have Young's moduli below 13 GPa,indicating flexibility.Geometric parameters explain flexibility variations with the changes of B and X site composition.Bonding characteristic exploration reveals the influence of B and X site electronegativity on mechanical strength.Cs_(2)SnBr_(6)and Cs_(2)PtBr_(6)are suitable for solar cells,while Cs_(2)HfI_(6)and Cs_(2)TiCl_(6)show potential for semi-transparent solar cells.Optical property calculations highlight the high light absorption coefficients of up to 3.5×10^(5) cm^(-1)for Cs_(2)HfI_(6)and Cs_(2)TiCl_(6).Solar cell simulation shows Cs_(2)PtBr_(6)achieves 22.4%of conversion effciency.Cs_(2)ZrCl_(6)holds promise for ionizing radiation detection with its 3.68 eV bandgap and high absorption coefficient.Vacancy-ordered double perovskites offer superior flexibility,providing valuable insights for designing stable and flexible devices.This understanding enhances the development of functional devices based on these perovskites,especially for applications requiring high stability and flexibility.展开更多
This article presents illustrations of an extended model of the electron to visualize how it spins and radiates in the external magnetic field. A time-varying magnetic field B produces a rotational induced electric fi...This article presents illustrations of an extended model of the electron to visualize how it spins and radiates in the external magnetic field. A time-varying magnetic field B produces a rotational induced electric field E which rotates (spins) the electron about its axis. In time-constant magnetic field: the electron radiates the cyclotron radiation. In time-varying magnetic field: synchrotron radiation is generated. The couplings between spin, acceleration and radiation will be discussed.展开更多
In Part I of this paper, an inequality satisfied by the vacuum energy density of the universe was derived using an indirect and heuristic procedure. The derivation is based on a proposed thought experiment, according ...In Part I of this paper, an inequality satisfied by the vacuum energy density of the universe was derived using an indirect and heuristic procedure. The derivation is based on a proposed thought experiment, according to which an electron is accelerated to a constant and relativistic speed at a distance L from a perfectly conducting plane. The charge of the electron was represented by a spherical charge distribution located within the Compton wavelength of the electron. Subsequently, the electron is incident on the perfect conductor giving rise to transition radiation. The energy associated with the transition radiation depends on the parameter L. It was shown that an inequality satisfied by the vacuum energy density will emerge when the length L is pushed to cosmological dimensions and the product of the radiated energy, and the time duration of emission is constrained by Heisenberg’s uncertainty principle. In this paper, a similar analysis is conducted with a chain of electrons oscillating sinusoidally and located above a conducting plane. In the thought experiment presented in this paper, the behavior of the energy radiated by the chain of oscillating electrons is studied in the frequency domain as a function of the length L of the chain. It is shown that when the length L is pushed to cosmological dimensions and the energy radiated within a single burst of duration of half a period of oscillation is constrained by the fact that electromagnetic energy consists of photons, an inequality satisfied by the vacuum energy density emerges as a result. The derived inequality is given by where is the vacuum energy density. This result is consistent with the measured value of the vacuum energy density, which is 5.38 × 10<sup>-10</sup> J/m. The result obtained here is in better agreement with experimental data than the one obtained in Part I of this paper with time domain radiation.展开更多
基金supported by the National Natural Science Foundation of China(No.12205289).
文摘With the advancement in X-ray astronomical detection technology,various celestial polarization detection projects have been initiated.To meet the calibration requirements of polarimeters on the ground,a polarized X-ray radiation facility was designed for this study.The design was based on the principle that X-rays incident at 45°on a crystal produce polarized X-rays,and a second crystal was used to measure the polarization of the X-rays produced by the facility after rotation.The effects of different diaphragm sizes on the degree of polarization were compared,and the facility produced X-rays with polarization degrees of up to 99.55±0.96%using LiF200 and LiF220 crystals.This result revealed that the polarization of incident X-rays is one of the factors affecting the diffraction efficiency of crystals.The replacement of different crystals can satisfy the calibration requirements of polarized X-ray detectors with more energy points in the energy range(4-10)keV.In the future,the facility should be placed in a vacuum environment to meet the calibration requirements at lower energies.
文摘An X-ray radiation source with approximately constant radiation temperature is realized by irradiating golden hohlraum with a shaped laser pulse. A simple theoretical model based on power balance is used to design the shape of the drive laser pulse. Experiments are carried out on the Shenguang III prototype laser facility, and the experimentM results are presented for radiation sources with the flat-top lasting about 2.5 ns at two different peak temperatures of about 150 eV and 170 eV, respectively, including the the drive laser pulses and the time integrated possible improvements are discussed. time histories of the temperatures, the shapes of radiation spectra. The validity of the model and
文摘Chemically synthesized ZnS thin film is found to be a good x-ray radiation sensor. We report the effect of annealing on the x-ray radiation detection sensitivity of a ZnS thin film synthesized by a chemical bath deposition technique. The chemically synthesized ZnS films are annealed at 333, 363 and 393K for 1 h. Structural analyses show that the lattice defects in the films decrease with annealing. Further, the band gap is also found to decrease from 3.38 to 3.21 eV after annealing at 393K. Current-voltage characteristics of the films are studied under dark and x-ray irradiation conditions. Due to the decrease of lattice defects and band gap, the conductivity under dark conditions is found to increase from 2.06 × 10^-6 to 1.69 × 10^-5 S/em, while that under x-ray irradiation increases from 4.13 × 10^-5 to 5.28 ×10^-5 S/cm. On the other hand, the x-ray radiation detection sensitivity of the films is found to decrease with annealing. This decrease of detection sensitivity is attributed to the decrease of the band gap as well as some structural and surface morphological changes occurring after annealing.
文摘We have studied the gamma and X-ray radiation compatibility of Ti-based alloys such as Ti–37 Ta–26 Hf–13 Zr-24(wt%) [Alloy 1], Ti–40 Ta–22 Hf–11.7 Zr-26.3(wt%) [Alloy 2], Ti–45 Ta–18.4 Hf–10 Zr-26.6(wt%) [Alloy3], Ti–50 Ta–15 Hf–8 Zr-27(wt%) [Alloy 4], Ti–55 Ta–12 Hf–7 Zr-26(wt%) [Alloy 5], and Ti–60 Ta–10 Hf–5 Zr-25(wt%) [Alloy 6]. Gamma and X-ray radiation compatibility is studied by evaluating the mass attenuation coefficient,mean free path, HVL, TVL effective atomic number,effective electron density, exposure buildup factor, and relative dose. We have compared these parameters for studied alloys with that of arteries. The alloys Ti–55 Ta–12 Hf–7 Zr-26 and Ti–60 Ta–10 Hf–5 Zr-25 have added properties such as gamma/X-ray radiation compatibility,high elastic admissible strain, high mechanical strength,and excellent biocompatibility. Hence, we may suggest that, among Ti–Ta–Hf–Zr alloys, these alloys are best materials for coronary stent applications.
文摘The light propagation through system a polarizer-analyzer is investigated on the basis of quantum conceptions about the nature of light. It is shown, that Malus law based on principles of classical electrodynamics not completely takes into account all effects which can occur at the light propagation through system a polarizer-analyzer. The phenomenon of possible change of frequency of light in particular drops out, for example in the region of X-ray radiation. The deduction of Malus law based on quantum principles is given. For comparison the differential effective section of interaction of a photon and electron with take into account of rotation of a plane of polarization of a photon in Compton’s effect is found.
基金a Project for Nuclear Military Personal Health Assessment and Radiation Damage Treat-ment, No. 616010305
文摘BACKGROUND: Bone marrow-derived mesenchymal stem cells (BMSCs) are a potentially useful source for cell replacement therapy following spinal cord injury. However, the homing characteristics of BMSCs in vivo remain unclear. Low-dose radiation has been shown to promote homing of BMSCs to exposed sites. OBJECTIVE: To investigate the effects of low-dose local radiation to non-injured areas on the ability of human BMSCs to home to the injured mouse spinal cord, as well as recovery of spinal cord injury. DESIGN, TIME AND SE'I-FING: A randomized, controlled, animal experiment was performed at the Central Laboratory, Second Affiliated Hospital of Soochow University between October 2007 and October 2008. MATERIALS: BMSCs were isolated from four adult, human donors. METHODS: Fifty adult, female, Balb/c mice were subjected to adjusted weight-drop impact resulting in complete paraplegia. Three days later, mice were randomly assigned to a radiation + transplantation group (n = 23) and a transplantation group (n = 20). In total, 2 x 106 carboxyfluorescein diacetate succinimidyl ester-labeled BMSCs were injected into each mouse via the caudal vein. Mice in the radiation + transplantation group received 2.5 Gy local X-ray irradiation 2 hours before BMSCs injection. MAIN OUTCOME MEASURES: The homing of BMSCs to injured cord and irradiated skin after transplantation was observed by fluorescence microscope; the structure recovery of injured cord was assessed by magnetic resonance imaging. RESULTS: Compared with the transplantation group, at 24 hours after transplantation, the number of BMSCs was significantly increased in the injured area and the exposed site (P 〈 0.05), and inflammation and edema were significantly alleviated in the injured cord in the radiation + transplantation group. CONCLUSION: Local low-dose radiation has the potential to promote homing of BMSCs and recovery of spinal cord injury, although the radiated region was not injured area.
文摘Caspases as critical components in cell signaling pathways have been proved to be involved in events such asapoptosis, cell growth and differentiation. Two distinct apoptotic pathways related to the Caspase cascade have beenidentified; death receptor-induced apoptosis and mitochondrial stress-induced apoptosis. Death receptors triggerCaspase-8 and the mitochondria subsequently release apoptogenic factors (cytochrome c, Apaf-1, AIF), leading tothe activation of Caspase-9. The mitochondrial and death receptor apoptotic pathways are intimately connected[1].
文摘Selectively killing cancer without harming normal tissue is a fundamental challenge in cancer therapy. Elevatedoxidative stress and aberrant redox homeostasis are frequently observed in cancer cells compared with their normalcell counterparts[1]. A small shift toward an oxidizing condition in cells may lead to elevated proliferation andinduction of adaptive response. However, a high oxidizing condition often results in cell injury and cell death.Persistent high level of reactive oxygen species (ROS) in cancer cells usually elicits increased cell proliferation andadaptive responses that may contribute to tumorigenesis, metastasis, and treatment resistance. However, normalcells may still maintain redox homeostasis through adaptive responses. Therefore, regulating intracellular redoxstate may represent an ideal strategy to selectively sensitize cancer cells to oxidative stress-inducing therapy, suchas radiotherapy.
基金Key Program of National Natural Science Foundation of China (U1432248), National Natural Science Foundationof China (11175222, 11205219), Western Talent Program of Chinese Academy of Sciences (Y460040XB0, Y160180XB0).
文摘Telomerase inhibitor MST-312 is a new compound derived from epigallocatechin gallate (EGCG)[1]. Our resultsdemonstrated that 4 M MST-312 not only showed lower cytotoxicity, but also inhibited telomerase activity inHepG2 cells. Therefore, in our experiments, 4 M MST-312 was chosen to study radiosensitization and relatedmechanisms. -H2AX foci are considered as an indicator of DNA damages[2]. The immunofluorescence stainingresults showed the number of -H2AX foci in the pretreatment with MST-312 followed by 2 Gy X-ray irradiationgroup. However, as shown in Fig. 1, the formation of Rad51 foci in the combined treatment group was blockedoutside the nuclear of HepG2 cells, when compared with the irradiation alone group. JC-1 staining showed thatMST-312 pretreatment, followed by X-ray irradiation, caused increase of the green/red fluorescence intensity ratio(ΔΨm) compared with X-ray irradiation alone. Meanwhile, MST-312 pretreatment followed by X-ray irradiationelevated expression of p53 protein and decreased expression of caspase-3 as well as fraction of Bcl-2 / Bax.
基金supported by the National Natural Science Foundation of China(Grant Nos.12163001,U1938117 and U1731238)the Guizhou Provincial Science and Technology Foundation(Grant No.[2020]1Y016)。
文摘Applying the timing tools of kilohertz quasi-periodic oscillations(k Hz QPOs)and cross-correlations,we study the influence of the magnetosphere-disk relation on the X-ray radiation process of GX 17+2.First,as the spectral state track of X-ray emission evolves along the horizontal branch(HB),the magnetosphere-disk radii of the source derived by k Hz QPOs shrink from r~24 km to r~18 km,while its average X-ray intensities in≤10 ke V and in≥10 ke V show the opposite evolutional trends.Moreover,this branch has been detected with the anti-correlations between the low-/high-energy(e.g.,2–5 ke V/16–30 ke V)X-rays.We suggest that in HB there may exist an X-ray radiation transfer process at the disk radii near the neutron star(NS),i.e.,~5–10 km away from the surface,which probably originates from the interaction between the corona or jet with high-energy X-rays and accretion disk with low-energy X-rays.Second,as the source evolves along the normal branch(NB)and along the flaring branch(FB),their average X-ray intensities in all~2–30 ke V show the monotonously decreasing and monotonously increasing trends,respectively.In addition,these two branches are both dominated by the positive correlations between the low-and high-energy(e.g.,2–5 ke V/16–30 ke V)X-rays.Moreover,the evolution along NB is accompanied by the shrinking of the magnetosphere-disk radii from r~18 km to r~16 km.We ascribe these phenomena to that as the shrinking of the accretion disk radius,the piled up accretion matter around the NS surface may trigger the radiation that produces both the low-and high-energy X-rays simultaneously,and then form the branches of NB and FB.
基金supported by the National Science Foundation of China(No.12347103)the Fundamental Research Funds for the Central Universities(No.226-2022-00216)。
文摘Space objects such as spacecraft or missiles may be exposed to intense X-rays in outer space,leading to severe damage.The reinforcement of these objects to reduce the damage caused by X-ray irradiation is a significant concern.The blow-off impulse(BOI)is a crucial physical quantity for investigating material damage induced by X-ray irradiation.However,the accurate calculation of BOI is challenging,particularly for large deformations of materials with complex configurations.In this study,we develop a novel two-dimensional particle-in-cell code,Xablation2D,to calculate BOIs under far-field X-ray irradiation.This significantly reduces the dependence of the numerical simulation on the grid shape.The reliability of this code is verified by simulation results from open-source codes,and the calculated BOIs are consistent with the experimental and analytical results.
基金financial support through a KekuléPh.D.fellowship by the Fonds der Chemischen Industrie(FCI)support from the China Scholarship Council(No.202106950013)。
文摘The parasitic hydrogen evolution reaction(HER)in the negative half-cell of vanadium redox flow batteries(VRFBs)causes severe efficiency losses.Thus,a deeper understanding of this process and the accompanying bubble formation is crucial.This benchmarking study locally analyzes the bubble distribution in thick,porous electrodes for the first time using deep learning-based image segmentation of synchrotron X-ray micro-tomograms.Each large three-dimensional data set was processed precisely in less than one minute while minimizing human errors and pointing out areas of increased HER activity in VRFBs.The study systematically varies the electrode potential and material,concluding that more negative electrode potentials of-200 m V vs.reversible hydrogen electrode(RHE)and lower cause more substantial bubble formation,resulting in bubble fractions of around 15%–20%in carbon felt electrodes.Contrarily,the bubble fractions stay only around 2%in an electrode combining carbon felt and carbon paper.The detected areas with high HER activity,such as the border subregion with more than 30%bubble fraction in carbon felt electrodes,the cutting edges,and preferential spots in the electrode bulk,are potential-independent and suggest that larger electrodes with a higher bulk-to-border ratio might reduce HER-related performance losses.The described combination of electrochemical measurements,local X-ray microtomography,AI-based segmentation,and 3D morphometric analysis is a powerful and novel approach for local bubble analysis in three-dimensional porous electrodes,providing an essential toolkit for a broad community working on bubble-generating electrochemical systems.
基金supported by a Director’s New Innovator Award from National Institute of Health(No.1DP2EB016572).
文摘Cell behavior is affected by nanostructured surface,but it remains unknown how ionizing radiation af-fects cells on nanostructured surface.This paper reports an experimental investigation of X-ray radiation induced damage of cells placed on an array of vertically aligned silicon nanowires.X-ray photoelectrons and secondary electrons produced from nanowire array are measured and compared to those from flat silicon substrate.The cell functions including morphology,viability,adhesion and proliferation have been examined and found to be drastically affected when cells are exposed to X-ray radiation,compared to those sitting on flat substrate and those only exposed to X-ray.The enhanced cell damage on nanowires upon X-ray exposure is attributed to nanowire enhanced production of photoelectrons including Auger electrons and secondary electrons,which have high escaping probability from sharp tips of nanowires.The escaped photoelectrons ionize water molecules and generate hydroxyl free radicals that can damage DNAs of cells.An inference of this work is that the contrast in scanning electron microscopy is useful in assessing the effects of nanomaterials for enhanced X-ray radiation therapy.
文摘The effects of ionizing and displacement irradiation of high-energy x-ray and 2-MeV proton on GaN thin films were investigated and compared in this study.The electrical properties of both P-GaN and N-GaN,separated from power devices,were gauged for fundamental analysis.It was found that the electrical properties of P-GaN were improved as a consequence of the disruption of the Mg-H bond induced by high-dose x-ray irradiation,as indicated by the Hall and circular transmission line model.Specifically,under a 100-Mrad(Si)x-ray dose,the specific contact resistance pc of P-GaN decreased by 30%,and the hole carrier concentration increased significantly.Additionally,the atom displacement damage effect of a 2-MeV proton of 1×10^(13)p/cm^(2)led to a significant degradation of the electrical properties of P-GaN,while those of N-GaN remained unchanged.P-GaN was found to be more sensitive to irradiation than N-GaN thin film.The effectiveness of x-ray irradiation in enhancing the electrical properties of P-GaN thin films was demonstrated in this study.
基金National Natural Science Foundation of China(No.12205360)Shanghai Pilot Program for Basic Research-Chinese Academy of Science,Shanghai Branch(No.JCYJ-SHFY-2021-010).
文摘This study presents a new method for characterizing the thermal lattice deformation of a monochromator with high precision under service conditions and first reports the operando measurements of nanoscale thermal lattice deformation on a double-crystal monochromator at different incident powers.The nanoscale thermal lattice deformation of the monochromator first crystal was obtained by analyzing the intensity of the distorted DuMond diagrams.DuMond diagrams of the 333 diffraction index,sensitive to lattice deformation,were obtained directly using a 2D detector and an analyzer crystal orthogonal to the monochromator.With increasing incident power and power density,the maximum height of the lattice deformation increased from 3.2 to 18.5 nm,and the deformation coefficient of the maximum height increased from 1.1 to 3.2 nm/W.The maximum relative standard deviation was 4.2%,and the maximum standard deviation was 0.1 nm.Based on the measured thermal deformations,the flux saturation phenomenon and critical point for the linear operation of the monochromator were predicted with increasing incident power.This study provides a simple solution to the problem of the lower precision of synchrotron radiation monochromator characterizations compared to simulations.
基金supported by the Russian Science Foundation(Grant No.18-72-10137)。
文摘Modern trends in beam-driven radiation sources include the interaction of Cherenkov wakefields in open-ended circular waveguides with complicated dielectric linings, with a three-layer dielectric capillary recently proposed to reduce radiation divergence being a representative example [Opt. Lett. 45 5416(2020)]. We present a rigorous approach that allows for an analytical description of the electromagnetic processes that occur when the structure is excited by a single waveguide TM mode. In other words, the corresponding canonical waveguide diffraction problem is solved in a rigorous formulation. This is a continuation of our previous papers which considered simpler cases with a homogeneous or two-layer dielectric filling. Here we use the same analytical approach based on the Wiener–Hopf–Fock technique and deal with the more complicated case of a three-layer dielectric lining. Using the obtained rigorous solution, we discuss the possibility of manipulating the far-field radiation pattern using a third layer made of a low permittivity material.
文摘Transarterial radioembolization or selective internal radiation therapy(SIRT)has emerged as a minimally invasive approach for the treatment of tumors.This percutaneous technique involves the local,intra-arterial delivery of radioactive microspheres directly into the tumor.Historically employed as a palliative measure for liver malignancies,SIRT has gained traction over the past decade as a potential curative option,mirroring the increasing role of radiation segmentectomy.The latest update of the BCLC hepatocellular carcinoma guidelines recognizes SIRT as an effective treatment modality comparable to other local ablative methods,particularly well-suited for patients where surgical resection or ablation is not feasible.Radiation segmentectomy is a more selective approach,aiming to deliver high-dose radiation to one to three specific hepatic segments,while minimizing damage to surrounding healthy tissue.Future research efforts in radiation segmentectomy should prioritize optimizing radiation dosimetry and refining the technique for super-selective administration of radiospheres within the designated hepatic segments.
基金supported by the National Natural Science Foundation of China(62305261,62305262)the Natural Science Foundation of Shaanxi Province(2024JC-YBMS-021,2024JC-YBMS-788,2023-JC-YB-065,2023-JC-QN-0693,2022JQ-652)+1 种基金the Xi’an Science and Technology Bureau of University Service Enterprise Project(23GXFW0043)the Cross disciplinary Research and Cultivation Project of Xi’an University of Architecture and Technology(2023JCPY-17)。
文摘As interest in double perovskites is growing,especially in applications like photovoltaic devices,understanding their mechanical properties is vital for device durability.Despite extensive exploration of structure and optical properties,research on mechanical aspects is limited.This article builds a vacancyordered double perovskite model,employing first-principles calculations to analyze mechanical,bonding,electronic,and optical properties.Results show Cs_(2)Hfl_(6),Cs_(2)SnBr_(6),Cs_(2)SnI_(6),and Cs_(2)PtBr_(6)have Young's moduli below 13 GPa,indicating flexibility.Geometric parameters explain flexibility variations with the changes of B and X site composition.Bonding characteristic exploration reveals the influence of B and X site electronegativity on mechanical strength.Cs_(2)SnBr_(6)and Cs_(2)PtBr_(6)are suitable for solar cells,while Cs_(2)HfI_(6)and Cs_(2)TiCl_(6)show potential for semi-transparent solar cells.Optical property calculations highlight the high light absorption coefficients of up to 3.5×10^(5) cm^(-1)for Cs_(2)HfI_(6)and Cs_(2)TiCl_(6).Solar cell simulation shows Cs_(2)PtBr_(6)achieves 22.4%of conversion effciency.Cs_(2)ZrCl_(6)holds promise for ionizing radiation detection with its 3.68 eV bandgap and high absorption coefficient.Vacancy-ordered double perovskites offer superior flexibility,providing valuable insights for designing stable and flexible devices.This understanding enhances the development of functional devices based on these perovskites,especially for applications requiring high stability and flexibility.
文摘This article presents illustrations of an extended model of the electron to visualize how it spins and radiates in the external magnetic field. A time-varying magnetic field B produces a rotational induced electric field E which rotates (spins) the electron about its axis. In time-constant magnetic field: the electron radiates the cyclotron radiation. In time-varying magnetic field: synchrotron radiation is generated. The couplings between spin, acceleration and radiation will be discussed.
文摘In Part I of this paper, an inequality satisfied by the vacuum energy density of the universe was derived using an indirect and heuristic procedure. The derivation is based on a proposed thought experiment, according to which an electron is accelerated to a constant and relativistic speed at a distance L from a perfectly conducting plane. The charge of the electron was represented by a spherical charge distribution located within the Compton wavelength of the electron. Subsequently, the electron is incident on the perfect conductor giving rise to transition radiation. The energy associated with the transition radiation depends on the parameter L. It was shown that an inequality satisfied by the vacuum energy density will emerge when the length L is pushed to cosmological dimensions and the product of the radiated energy, and the time duration of emission is constrained by Heisenberg’s uncertainty principle. In this paper, a similar analysis is conducted with a chain of electrons oscillating sinusoidally and located above a conducting plane. In the thought experiment presented in this paper, the behavior of the energy radiated by the chain of oscillating electrons is studied in the frequency domain as a function of the length L of the chain. It is shown that when the length L is pushed to cosmological dimensions and the energy radiated within a single burst of duration of half a period of oscillation is constrained by the fact that electromagnetic energy consists of photons, an inequality satisfied by the vacuum energy density emerges as a result. The derived inequality is given by where is the vacuum energy density. This result is consistent with the measured value of the vacuum energy density, which is 5.38 × 10<sup>-10</sup> J/m. The result obtained here is in better agreement with experimental data than the one obtained in Part I of this paper with time domain radiation.