During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the mold.In which,the behavior of bubbles traversing the liquid slag serves as a rest...During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the mold.In which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid slag.In contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive information.Therefore,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding times.The results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles increases.In addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually decreases.In one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the large.These findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.展开更多
The paper presents experimental investigation results of crack pattern change in cement pastes caused by external sulfate attack(ESA).To visualize the formation and development of cracks in cement pastes under ESA,an ...The paper presents experimental investigation results of crack pattern change in cement pastes caused by external sulfate attack(ESA).To visualize the formation and development of cracks in cement pastes under ESA,an X-ray computed tomography(X-ray CT)was used,i e,the tomography system of Zeiss Xradia 510 versa.The results indicate that X-CT can monitor the development process and distribution characteristics of the internal cracks of cement pastes under ESA with attack time.In addition,the C3A content in the cement significantly affects the damage mode of cement paste specimens during sulfate erosion.The damage of ordinary Portland cement(OPC)pastes subjected to sulfate attack with high C3A content are severe,while the damage of sulfate resistant Portland cement(SRPC)pastes is much smaller than that of OPC pastes.Furthermore,a quadratic function describes the correlation between the crack volume fraction and development depth for two cement pastes immermed in sulfate solution.展开更多
Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage se...Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.展开更多
Working toward an efficient duration and timeline for the preconstruction phase should be one of the main objectives for project owners.Failing to plan for and coordinate preconstruction decisions in order to control ...Working toward an efficient duration and timeline for the preconstruction phase should be one of the main objectives for project owners.Failing to plan for and coordinate preconstruction decisions in order to control preconstruction duration and manage time variances can lead to financial insecurities,incomplete contract documents,permitting issues,and unrealistic schedules and resource allocation during this phase.To minimize time variances and ensure a productive decision-making process,project owners should be familiar with critical elements in a project that cause variances in the preconstruction phase timeline.In this study,the impacts of eleven critical preconstruction elements on time variances were analyzed.These eleven preconstruction elements are considered critical in how they impact time variances during the preconstruction phase.They were determined to be critical based either on significantly impacting time variance during the preconstruction phase or believed to be critical from findings from previous studies,however,the findings from this study showed no significant impact on the time variances.In most previous studies focusing on the elements impacting project schedules,data were collected by surveying construction professionals.In this study,objective and quantitative data related to project preconstruction elements were used as opposed to self-reported data.Using the results of this study,project owners and stakeholders will be able to evaluate the critical preconstruction elements impacting the timing of their projects and prioritize decisions related to the critical elements early on during the preconstruction phase.展开更多
The rapid advancement of information technology has heightened interest in complementary devices and circuits.Conventional p-type semiconductors often lack sufficient electrical performance,thus prompting the search f...The rapid advancement of information technology has heightened interest in complementary devices and circuits.Conventional p-type semiconductors often lack sufficient electrical performance,thus prompting the search for new materials with high hole mobility and long-term stability.Elemental tellurium(Te),featuring a one-dimensional chiral atomic structure,has emerged as a promising candidate due to its narrow bandgap,high hole mobility,and versatility in industrial applications,particularly in electronics and renewable energy.This review highlights recent progress in Te nanostructures and related devices,focusing on synthesis methods,including vapor deposition and hydrothermal synthesis,which produce Te nanowires,nanorods,and other nanostructures.Critical applications in photodetectors,gas sensors,and energy harvesting devices are discussed,with a special emphasis on their role within the internet of things(IoT)framework,a rapidly growing field that is reshaping our technological landscape.The prospects and potential applications of Te-based technologies are also highlighted.展开更多
Total hip arthroplasty for adults with sequelae from childhood hip disorders poses significant challenges due to altered anatomy.The paper published by Oommen et al reviews the essential management strategies for thes...Total hip arthroplasty for adults with sequelae from childhood hip disorders poses significant challenges due to altered anatomy.The paper published by Oommen et al reviews the essential management strategies for these complex cases.This article explores the integration of finite element analysis(FEA)to enhance surgical precision and outcomes.FEA provides detailed biomechanical insights,aiding in preoperative planning,implant design,and surgical technique optimization.By simulating implant configurations and assessing bone quality,FEA helps in customizing implants and evaluating surgical techniques like subtrochanteric shortening osteotomy.Advanced imaging techniques,such as 3D printing,virtual reality,and augmented reality,further enhance total hip arthroplasty precision.Future research should focus on validating FEA models,developing patient-specific simulations,and promoting multidisciplinary collaboration.Integrating FEA and advanced technologies in total hip arthroplasty can improve functional outcomes,reduce complications,and enhance quality of life for patients with childhood hip disorder sequelae.展开更多
The Guanfang large-scale W deposit is located in the W polymetallic ore concentration area of Bozhushan in southeastern Yunnan,China.Despite extensive research,the fluid evolution process of the deposit remains ambigu...The Guanfang large-scale W deposit is located in the W polymetallic ore concentration area of Bozhushan in southeastern Yunnan,China.Despite extensive research,the fluid evolution process of the deposit remains ambiguous,leading to controversy regarding its genesis.This study conducted a detailed field geological survey,with systematic sampling of the KT6 orebody,to delineate mineralization stages.Fine mineralogy work,including the use of CL images of scheelite,in-situ LA-ICP-MS trace elements,and Sr isotopes,was carried out on diff erent generations of scheelite formed in various stages.The findings identified the evolution of fluids in the mineralization process,shedding light on the genesis of the deposit.The study revealed four mineralization stages at the Guanfang W deposit:prograde skarn stage,retrograde skarn stage,quartz-sulfide stage,and carbonate-fluorite stage.Diff erent generations of scheelite(Sch I,Sch II,Sch III)were observed in the first three stages,displaying distinct chondrite-normalized REE patterns.The REE of Sch I mainly substituted into the Ca site by REE^(3+)+□_(Ca),and there may be a similar substitution of Nb for REE,whereas it is not the main substitution method.The REE of Sch II mainly enter the scheelite lattice in the form of REE 3++Na+,and there may be a substitution of Nb for REE isomorphism.In the early stage,The REE of Sch III was mainly replaced by Nb for REE isomorphism,while in the later stage,the replacement mode of REE^(3+)+□_(Ca)coexisted with it.The Mo content in scheelite,along with the corresponding Eu anomalies in both scheelite and garnet,collectively imply that the ore-forming fluids during various mineralization stages were predominantly oxidizing,with only slight reducibility observed in Sch II.The in-situ Sr isotope ratios of scheelite concentrates ranged from 0.7093 to 0.7153,resembling those of the Bozhushan granite,indicating a relationship between W mineralization and granite.In addition,the Y/Ho ratios of scheelite from various mineralization stages exhibit a narrow range(19-31),with a pronounced correlation between the contents of Y and Ho and a similar trend in their variation.This consistency suggests that the Guanfang deposit has undergone a uniform or comparable evolutionary process,implying a stable ore-forming fluid across diff erent mineralization stages.展开更多
Due to the high-order B-spline basis functions utilized in isogeometric analysis(IGA)and the repeatedly updating global stiffness matrix of topology optimization,Isogeometric topology optimization(ITO)intrinsically su...Due to the high-order B-spline basis functions utilized in isogeometric analysis(IGA)and the repeatedly updating global stiffness matrix of topology optimization,Isogeometric topology optimization(ITO)intrinsically suffers from the computationally demanding process.In this work,we address the efficiency problem existing in the assembling stiffness matrix and sensitivity analysis using B˙ezier element stiffness mapping.The Element-wise and Interaction-wise parallel computing frameworks for updating the global stiffness matrix are proposed for ITO with B˙ezier element stiffness mapping,which differs from these ones with the traditional Gaussian integrals utilized.Since the explicit stiffness computation formula derived from B˙ezier element stiffness mapping possesses a typical parallel structure,the presented GPU-enabled ITO method can greatly accelerate the computation speed while maintaining its high memory efficiency unaltered.Numerical examples demonstrate threefold speedup:1)the assembling stiffness matrix is accelerated by 10×maximumly with the proposed GPU strategy;2)the solution efficiency of a sparse linear system is enhanced by up to 30×with Eigen replaced by AMGCL;3)the efficiency of sensitivity analysis is promoted by 100×with GPU applied.Therefore,the proposed method is a promising way to enhance the numerical efficiency of ITO for both single-patch and multiple-patch design problems.展开更多
Sudden and unforeseen seismic failures of coal mine overburden(OB)dump slopes interrupt mining operations,cause loss of lives and delay the production of coal.Consideration of the spatial heterogeneity of OB dump mate...Sudden and unforeseen seismic failures of coal mine overburden(OB)dump slopes interrupt mining operations,cause loss of lives and delay the production of coal.Consideration of the spatial heterogeneity of OB dump materials is imperative for an adequate evaluation of the seismic stability of OB dump slopes.In this study,pseudo-static seismic stability analyses are carried out for an OB dump slope by considering the material parameters obtained from an insitu field investigation.Spatial heterogeneity is simulated through use of the random finite element method(RFEM)and the random limit equilibrium method(RLEM)and a comparative study is presented.Combinations of horizontal and vertical spatial correlation lengths were considered for simulating isotropic and anisotropic random fields within the OB dump slope.Seismic performances of the slope have been reported through the probability of failure and reliability index.It was observed that the RLEM approach overestimates failure probability(P_(f))by considering seismic stability with spatial heterogeneity.The P_(f)was observed to increase with an increase in the coefficient of variation of friction angle of the dump materials.Further,it was inferred that the RLEM approach may not be adequately applicable for assessing the seismic stability of an OB dump slope for a horizontal seismic coefficient that is more than or equal to 0.1.展开更多
Doped elements in alloys significantly impact their performance.Conventional methods usually sputter the surface material of the sample,or their performance is limited to the surface of alloys owing to their poor pene...Doped elements in alloys significantly impact their performance.Conventional methods usually sputter the surface material of the sample,or their performance is limited to the surface of alloys owing to their poor penetration ability.The X-ray K-edge subtraction(KES)method exhibits great potential for the nondestructive in situ detection of element contents in alloys.However,the signal of doped elements usually deteriorates because of the strong absorption of the principal component and scattering of crystal grains.This in turn prevents the extensive application of X-ray KES imaging to alloys.In this study,methods were developed to calibrate the linearity between the grayscale of the KES image and element content.The methods were aimed at the sensitive analysis of elements in alloys.Furthermore,experiments with phantoms and alloys demonstrated that,after elaborate calibration,X-ray KES imaging is capable of nondestructive and sensitive analysis of doped elements in alloys.展开更多
The particle morphological properties,such as sphericity,concavity and convexity,of a granular assembly significantly affect its macroscopic and microscopic compressive behaviors under isotropic loading condition.Howe...The particle morphological properties,such as sphericity,concavity and convexity,of a granular assembly significantly affect its macroscopic and microscopic compressive behaviors under isotropic loading condition.However,limited studies on investigating the microscopic behavior of the granular assembly with real particle shapes under isotropic compression were reported.In this study,X-ray computed tomography(mCT)and discrete element modeling(DEM)were utilized to investigate isotropic compression behavior of the granular assembly with regard to the particle morphological properties,such as particle sphericity,concavity and interparticle frictions.The mCT was first used to extract the particle morphological parameters and then the DEM was utilized to numerically investigate the influences of the particle morphological properties on the isotropic compression behavior.The image reconstruction from mCT images indicated that the presented particle quantification algorithm was robust,and the presented microscopic analysis via the DEM simulation demonstrated that the particle surface concavity significantly affected the isotropic compression behavior.The observations of the particle connectivity and local void ratio distribution also provided insights into the granular assembly under isotropic compression.Results found that the particle concavity and interparticle friction influenced the most of the isotropic compression behavior of the granular assemblies.展开更多
Large areas of muddy sediments on the coastal shelves of China provide important samples for studying climate and ecological changes. Analysis of a large number of such samples, which is essential for systematic study...Large areas of muddy sediments on the coastal shelves of China provide important samples for studying climate and ecological changes. Analysis of a large number of such samples, which is essential for systematic study on environmental information recorded in mud areas because of complicated sedimentary environment and variable sedimentary rate, requires a fast and economical method. In this study, we investigated the potential of X-ray fluorescence core scanner (XRFS), a fast analytical instrument for measuring the elemental concentrations of muddy sediments, and observed a significant correlation between the element concentrations of muddy sediments determined by regular X-ray fluorescence spectrometer (XRF) and XRFS, respectively. The correlations are mainly determined by excitation energy of elements, but also influenced by solubility of element ions. Furthermore, we found a striking link between A1 concentrations and marine-originated organic carbon (MOC), a proxy of marine primary productivity. This indicates that MOC is partly controlled by sedimentary characteristics. Therefore, XRFS method has a good potential in fast analysis of a large number of muddy sediment samples, and it can also be used to calibrate MOC in ecological study of coastal seas.展开更多
The X-ray fluorescence(XRF)core scanning method is widely applied in studies of sedimentary paleoenvironments due to its convenient pretreatment,nondestructive characteristics,fast execution,continuous scanning,and hi...The X-ray fluorescence(XRF)core scanning method is widely applied in studies of sedimentary paleoenvironments due to its convenient pretreatment,nondestructive characteristics,fast execution,continuous scanning,and high resolution.XRF core scanning for sediments is commonly used in the studies on the South China Sea.This study compares XRF-scanned intensities and measured inductively coupled plasma(ICP)elemental contents of core CS11 in the northeast South China Sea deep basin.The results show that the analyzed elements can be separated into three classes.Class I includes elements with high correlation coefficients,such as Ca,Sr,and Zr;Class II contains elements with average correlation coefficients,such as Fe,Mn,Ti,and Cu;and Class III comprises elements with low correlation coefficients,such as K,Ni,Zn,Rb,and Al.In the South China Sea deep basin,pore water,compaction,and grain size have weak effects on the elemental intensities and contents of short core sediments.Hence,for elements with high correlation coefficients,a linear relationship model can be established by the least-squares method,in which the converted XRF intensities are approximately equal to the measured ICP contents.Based on the established log-ratio calibration model,the resulting ln(K/Ca),ln(Ti/Ca),ln(Fe/Ca),and ln(Zr/Ca)values generally display the same variation trends as the measured curves.The elemental contents and ratios produced by the linear model via the least-squares method and the log-ratio calibration model are expected to provide high-resolution data support for future paleoenvironmental research on the South China Sea deep basin.展开更多
Although laser-induced breakdown spectroscopy(LIBS),as a fast on-line analysis technology,has great potential and competitiveness in the analysis of chemical composition and proximate analysis results of coal in therm...Although laser-induced breakdown spectroscopy(LIBS),as a fast on-line analysis technology,has great potential and competitiveness in the analysis of chemical composition and proximate analysis results of coal in thermal power plants,the measurement repeatability of LIBS needs to be further improved due to the difficulty in controlling the stability of the generated plasmas at present.In this paper,we propose a novel x-ray fluorescence(XRF) assisted LIBS method for high repeatability analysis of coal quality,which not only inherits the ability of LIBS to directly analyze organic elements such as C and H in coal,but also uses XRF to make up for the lack of stability of LIBS in determining other inorganic ash-forming elements.With the combination of elemental lines in LIBS and XRF spectra,the principal component analysis and the partial least squares are used to establish the prediction model and perform multi-elemental and proximate analysis of coal.Quantitative analysis results show that the relative standard deviation(RSD) of C is 0.15%,the RSDs of other elements are less than 4%,and the standard deviations of calorific value,ash content,sulfur content and volatile matter are 0.11 MJ kg,0.17%,0.79% and 0.41%respectively,indicating that the method has good repeatability in determination of coal quality.This work is helpful to accelerate the development of LIBS in the field of rapid measurement of coal entering the power plant and on-line monitoring of coal entering the furnace.展开更多
We develop an element-specific x-ray microscopy method by using Zernike phase contrast imaging near absorption edges, where a real part of refractive index changes abruptly. In this method two phase contrast images ar...We develop an element-specific x-ray microscopy method by using Zernike phase contrast imaging near absorption edges, where a real part of refractive index changes abruptly. In this method two phase contrast images are subtracted to obtain the target element: one is at the absorption edge of the target element and the other is near the absorption edge. The x-ray exposure required by this method is expected to be significantly lower than that of conventional absorption-based x-ray elemental imaging methods. Numerical calculations confirm the advantages of this highly efficient imaging method.展开更多
X-ray fluorescence spectrometry was used to detect the content of eight elements in metal coating smeared on waste plastics,and effects of sample cups,elements in plastic substrate,and interaction of elements in metal...X-ray fluorescence spectrometry was used to detect the content of eight elements in metal coating smeared on waste plastics,and effects of sample cups,elements in plastic substrate,and interaction of elements in metal coating on detection results were analyzed. The results show that the RSD of the method used to detect element content in the metal coating smeared on the waste plastics ranged from 0.008% to 0.044%; the determination range of the eight elements was 0.002%-52.0%,and their detection limit ranged from 0.0002% to 0.0008%. The determination results of X-ray fluorescence spectrometry were consistent with that of ICP-AES. The method can provide technical support for the determination of damage and pollution caused by metal coating smeared on waste plastics.展开更多
Earth’s magnetopause is a thin boundary separating the shocked solar wind plasma from the magnetospheric plasmas,and it is also the boundary of the solar wind energy transport to the magnetosphere.Soft X-ray imaging ...Earth’s magnetopause is a thin boundary separating the shocked solar wind plasma from the magnetospheric plasmas,and it is also the boundary of the solar wind energy transport to the magnetosphere.Soft X-ray imaging allows investigation of the large-scale magnetopause by providing a two-dimensional(2-D)global view from a satellite.By performing 3-D global hybrid-particle-in-cell(hybrid-PIC)simulations,we obtain soft X-ray images of Earth’s magnetopause under different solar wind conditions,such as different plasma densities and directions of the southward interplanetary magnetic field.In all cases,magnetic reconnection occurs at low latitude magnetopause.The soft X-ray images observed by a hypothetical satellite are shown,with all of the following identified:the boundary of the magnetopause,the cusps,and the magnetosheath.Local X-ray emissivity in the magnetosheath is characterized by large amplitude fluctuations(up to 160%);however,the maximum line-of-sight-integrated X-ray intensity matches the tangent directions of the magnetopause well,indicating that these fluctuations have limited impact on identifying the magnetopause boundary in the X-ray images.Moreover,the magnetopause boundary can be identified using multiple viewing geometries.We also find that solar wind conditions have little effect on the magnetopause identification.The Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission will provide X-ray images of the magnetopause for the first time,and our global hybrid-PIC simulation results can help better understand the 2-D X-ray images of the magnetopause from a 3-D perspective,with particle kinetic effects considered.展开更多
The Soft X-ray Imager(SXI)is part of the scientific payload of the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission.SMILE is a joint science mission between the European Space Agency(ESA)and the Chinese...The Soft X-ray Imager(SXI)is part of the scientific payload of the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission.SMILE is a joint science mission between the European Space Agency(ESA)and the Chinese Academy of Sciences(CAS)and is due for launch in 2025.SXI is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the SMILE orbit.SXI is sensitive to the soft X-rays produced by the Solar Wind Charge eXchange(SWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s exosphere.SWCX provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field lines.The sensitivity of the SXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of SMILE will enable such movements to be tracked for segments lasting many hours.SXI is led by the University of Leicester in the United Kingdom(UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United States.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.52274315 and 52374320)the Fundamental Research Funds for the Central Universities(Nos.FRF-TP-22-011A1 and FRF-DF22-16)。
文摘During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the mold.In which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid slag.In contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive information.Therefore,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding times.The results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles increases.In addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually decreases.In one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the large.These findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.
基金Funded by Chinese National Natural Science Foundation of China(No.U2006224)。
文摘The paper presents experimental investigation results of crack pattern change in cement pastes caused by external sulfate attack(ESA).To visualize the formation and development of cracks in cement pastes under ESA,an X-ray computed tomography(X-ray CT)was used,i e,the tomography system of Zeiss Xradia 510 versa.The results indicate that X-CT can monitor the development process and distribution characteristics of the internal cracks of cement pastes under ESA with attack time.In addition,the C3A content in the cement significantly affects the damage mode of cement paste specimens during sulfate erosion.The damage of ordinary Portland cement(OPC)pastes subjected to sulfate attack with high C3A content are severe,while the damage of sulfate resistant Portland cement(SRPC)pastes is much smaller than that of OPC pastes.Furthermore,a quadratic function describes the correlation between the crack volume fraction and development depth for two cement pastes immermed in sulfate solution.
基金supported by the National Natural Science Foundation of China, No.61932008Natural Science Foundation of Shanghai, No.21ZR1403200 (both to JC)。
文摘Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.
文摘Working toward an efficient duration and timeline for the preconstruction phase should be one of the main objectives for project owners.Failing to plan for and coordinate preconstruction decisions in order to control preconstruction duration and manage time variances can lead to financial insecurities,incomplete contract documents,permitting issues,and unrealistic schedules and resource allocation during this phase.To minimize time variances and ensure a productive decision-making process,project owners should be familiar with critical elements in a project that cause variances in the preconstruction phase timeline.In this study,the impacts of eleven critical preconstruction elements on time variances were analyzed.These eleven preconstruction elements are considered critical in how they impact time variances during the preconstruction phase.They were determined to be critical based either on significantly impacting time variance during the preconstruction phase or believed to be critical from findings from previous studies,however,the findings from this study showed no significant impact on the time variances.In most previous studies focusing on the elements impacting project schedules,data were collected by surveying construction professionals.In this study,objective and quantitative data related to project preconstruction elements were used as opposed to self-reported data.Using the results of this study,project owners and stakeholders will be able to evaluate the critical preconstruction elements impacting the timing of their projects and prioritize decisions related to the critical elements early on during the preconstruction phase.
基金supported by a fellowship award from the Research Grants Council of the Hong Kong Special Administrative Region,China(CityU RFS2021−1S04)the Innovation and Technology Fund(MHP/044/23)from the Innovation and Technology Commission of the Hong Kong Government Special Administrative Region,China.
文摘The rapid advancement of information technology has heightened interest in complementary devices and circuits.Conventional p-type semiconductors often lack sufficient electrical performance,thus prompting the search for new materials with high hole mobility and long-term stability.Elemental tellurium(Te),featuring a one-dimensional chiral atomic structure,has emerged as a promising candidate due to its narrow bandgap,high hole mobility,and versatility in industrial applications,particularly in electronics and renewable energy.This review highlights recent progress in Te nanostructures and related devices,focusing on synthesis methods,including vapor deposition and hydrothermal synthesis,which produce Te nanowires,nanorods,and other nanostructures.Critical applications in photodetectors,gas sensors,and energy harvesting devices are discussed,with a special emphasis on their role within the internet of things(IoT)framework,a rapidly growing field that is reshaping our technological landscape.The prospects and potential applications of Te-based technologies are also highlighted.
文摘Total hip arthroplasty for adults with sequelae from childhood hip disorders poses significant challenges due to altered anatomy.The paper published by Oommen et al reviews the essential management strategies for these complex cases.This article explores the integration of finite element analysis(FEA)to enhance surgical precision and outcomes.FEA provides detailed biomechanical insights,aiding in preoperative planning,implant design,and surgical technique optimization.By simulating implant configurations and assessing bone quality,FEA helps in customizing implants and evaluating surgical techniques like subtrochanteric shortening osteotomy.Advanced imaging techniques,such as 3D printing,virtual reality,and augmented reality,further enhance total hip arthroplasty precision.Future research should focus on validating FEA models,developing patient-specific simulations,and promoting multidisciplinary collaboration.Integrating FEA and advanced technologies in total hip arthroplasty can improve functional outcomes,reduce complications,and enhance quality of life for patients with childhood hip disorder sequelae.
基金suppor ted by Yunnan Major Scientific and Technological Projects(Grant No.202202AG050006)the Personnel Training Project of Kunming University of Science and Technology(Grant No.KKZ3202221022)。
文摘The Guanfang large-scale W deposit is located in the W polymetallic ore concentration area of Bozhushan in southeastern Yunnan,China.Despite extensive research,the fluid evolution process of the deposit remains ambiguous,leading to controversy regarding its genesis.This study conducted a detailed field geological survey,with systematic sampling of the KT6 orebody,to delineate mineralization stages.Fine mineralogy work,including the use of CL images of scheelite,in-situ LA-ICP-MS trace elements,and Sr isotopes,was carried out on diff erent generations of scheelite formed in various stages.The findings identified the evolution of fluids in the mineralization process,shedding light on the genesis of the deposit.The study revealed four mineralization stages at the Guanfang W deposit:prograde skarn stage,retrograde skarn stage,quartz-sulfide stage,and carbonate-fluorite stage.Diff erent generations of scheelite(Sch I,Sch II,Sch III)were observed in the first three stages,displaying distinct chondrite-normalized REE patterns.The REE of Sch I mainly substituted into the Ca site by REE^(3+)+□_(Ca),and there may be a similar substitution of Nb for REE,whereas it is not the main substitution method.The REE of Sch II mainly enter the scheelite lattice in the form of REE 3++Na+,and there may be a substitution of Nb for REE isomorphism.In the early stage,The REE of Sch III was mainly replaced by Nb for REE isomorphism,while in the later stage,the replacement mode of REE^(3+)+□_(Ca)coexisted with it.The Mo content in scheelite,along with the corresponding Eu anomalies in both scheelite and garnet,collectively imply that the ore-forming fluids during various mineralization stages were predominantly oxidizing,with only slight reducibility observed in Sch II.The in-situ Sr isotope ratios of scheelite concentrates ranged from 0.7093 to 0.7153,resembling those of the Bozhushan granite,indicating a relationship between W mineralization and granite.In addition,the Y/Ho ratios of scheelite from various mineralization stages exhibit a narrow range(19-31),with a pronounced correlation between the contents of Y and Ho and a similar trend in their variation.This consistency suggests that the Guanfang deposit has undergone a uniform or comparable evolutionary process,implying a stable ore-forming fluid across diff erent mineralization stages.
基金supported by the National Key R&D Program of China(2023YFB2504601)National Natural Science Foundation of China(52205267).
文摘Due to the high-order B-spline basis functions utilized in isogeometric analysis(IGA)and the repeatedly updating global stiffness matrix of topology optimization,Isogeometric topology optimization(ITO)intrinsically suffers from the computationally demanding process.In this work,we address the efficiency problem existing in the assembling stiffness matrix and sensitivity analysis using B˙ezier element stiffness mapping.The Element-wise and Interaction-wise parallel computing frameworks for updating the global stiffness matrix are proposed for ITO with B˙ezier element stiffness mapping,which differs from these ones with the traditional Gaussian integrals utilized.Since the explicit stiffness computation formula derived from B˙ezier element stiffness mapping possesses a typical parallel structure,the presented GPU-enabled ITO method can greatly accelerate the computation speed while maintaining its high memory efficiency unaltered.Numerical examples demonstrate threefold speedup:1)the assembling stiffness matrix is accelerated by 10×maximumly with the proposed GPU strategy;2)the solution efficiency of a sparse linear system is enhanced by up to 30×with Eigen replaced by AMGCL;3)the efficiency of sensitivity analysis is promoted by 100×with GPU applied.Therefore,the proposed method is a promising way to enhance the numerical efficiency of ITO for both single-patch and multiple-patch design problems.
基金the financial support provided by MHRD,Govt.of IndiaCoal India Limited for providing financial assistance for the research(Project No.CIL/R&D/01/73/2021)the partial financial support provided by the Ministry of Education,Government of India,under SPARC project(Project No.P1207)。
文摘Sudden and unforeseen seismic failures of coal mine overburden(OB)dump slopes interrupt mining operations,cause loss of lives and delay the production of coal.Consideration of the spatial heterogeneity of OB dump materials is imperative for an adequate evaluation of the seismic stability of OB dump slopes.In this study,pseudo-static seismic stability analyses are carried out for an OB dump slope by considering the material parameters obtained from an insitu field investigation.Spatial heterogeneity is simulated through use of the random finite element method(RFEM)and the random limit equilibrium method(RLEM)and a comparative study is presented.Combinations of horizontal and vertical spatial correlation lengths were considered for simulating isotropic and anisotropic random fields within the OB dump slope.Seismic performances of the slope have been reported through the probability of failure and reliability index.It was observed that the RLEM approach overestimates failure probability(P_(f))by considering seismic stability with spatial heterogeneity.The P_(f)was observed to increase with an increase in the coefficient of variation of friction angle of the dump materials.Further,it was inferred that the RLEM approach may not be adequately applicable for assessing the seismic stability of an OB dump slope for a horizontal seismic coefficient that is more than or equal to 0.1.
基金supported by the National Key Research and Development Program of China(Nos.2017YFA0403801,2017YFA0206004,2018YFC1200204)the National Natural Science Foundation of China(NSFC)(Nos.81430087,11775297,U1932205).
文摘Doped elements in alloys significantly impact their performance.Conventional methods usually sputter the surface material of the sample,or their performance is limited to the surface of alloys owing to their poor penetration ability.The X-ray K-edge subtraction(KES)method exhibits great potential for the nondestructive in situ detection of element contents in alloys.However,the signal of doped elements usually deteriorates because of the strong absorption of the principal component and scattering of crystal grains.This in turn prevents the extensive application of X-ray KES imaging to alloys.In this study,methods were developed to calibrate the linearity between the grayscale of the KES image and element content.The methods were aimed at the sensitive analysis of elements in alloys.Furthermore,experiments with phantoms and alloys demonstrated that,after elaborate calibration,X-ray KES imaging is capable of nondestructive and sensitive analysis of doped elements in alloys.
基金the Universidad Nacional de San Agustín(UNSA)through the joint Center for Mining Sustainability with the Colorado School of Mines is highly acknowledged.
文摘The particle morphological properties,such as sphericity,concavity and convexity,of a granular assembly significantly affect its macroscopic and microscopic compressive behaviors under isotropic loading condition.However,limited studies on investigating the microscopic behavior of the granular assembly with real particle shapes under isotropic compression were reported.In this study,X-ray computed tomography(mCT)and discrete element modeling(DEM)were utilized to investigate isotropic compression behavior of the granular assembly with regard to the particle morphological properties,such as particle sphericity,concavity and interparticle frictions.The mCT was first used to extract the particle morphological parameters and then the DEM was utilized to numerically investigate the influences of the particle morphological properties on the isotropic compression behavior.The image reconstruction from mCT images indicated that the presented particle quantification algorithm was robust,and the presented microscopic analysis via the DEM simulation demonstrated that the particle surface concavity significantly affected the isotropic compression behavior.The observations of the particle connectivity and local void ratio distribution also provided insights into the granular assembly under isotropic compression.Results found that the particle concavity and interparticle friction influenced the most of the isotropic compression behavior of the granular assemblies.
基金supported by the National Basic Research Program of China(2010CB428902)National Natural Science Foundation of China(40876088)
文摘Large areas of muddy sediments on the coastal shelves of China provide important samples for studying climate and ecological changes. Analysis of a large number of such samples, which is essential for systematic study on environmental information recorded in mud areas because of complicated sedimentary environment and variable sedimentary rate, requires a fast and economical method. In this study, we investigated the potential of X-ray fluorescence core scanner (XRFS), a fast analytical instrument for measuring the elemental concentrations of muddy sediments, and observed a significant correlation between the element concentrations of muddy sediments determined by regular X-ray fluorescence spectrometer (XRF) and XRFS, respectively. The correlations are mainly determined by excitation energy of elements, but also influenced by solubility of element ions. Furthermore, we found a striking link between A1 concentrations and marine-originated organic carbon (MOC), a proxy of marine primary productivity. This indicates that MOC is partly controlled by sedimentary characteristics. Therefore, XRFS method has a good potential in fast analysis of a large number of muddy sediment samples, and it can also be used to calibrate MOC in ecological study of coastal seas.
基金This study was jointly supported by the National Natural Science Foundation of China(Nos.41576058 and 41976192)the Project of China Geological Survey(No.DD20191010)+2 种基金the Shandong Provincial Natural Science Foundation of China(No.ZR2020MD061)the Open Foundation of the State Key Laboratory of Loess and Quaternary Geology(Nos.SKLLQG1707 and SKLLQG1805)the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB40000000).
文摘The X-ray fluorescence(XRF)core scanning method is widely applied in studies of sedimentary paleoenvironments due to its convenient pretreatment,nondestructive characteristics,fast execution,continuous scanning,and high resolution.XRF core scanning for sediments is commonly used in the studies on the South China Sea.This study compares XRF-scanned intensities and measured inductively coupled plasma(ICP)elemental contents of core CS11 in the northeast South China Sea deep basin.The results show that the analyzed elements can be separated into three classes.Class I includes elements with high correlation coefficients,such as Ca,Sr,and Zr;Class II contains elements with average correlation coefficients,such as Fe,Mn,Ti,and Cu;and Class III comprises elements with low correlation coefficients,such as K,Ni,Zn,Rb,and Al.In the South China Sea deep basin,pore water,compaction,and grain size have weak effects on the elemental intensities and contents of short core sediments.Hence,for elements with high correlation coefficients,a linear relationship model can be established by the least-squares method,in which the converted XRF intensities are approximately equal to the measured ICP contents.Based on the established log-ratio calibration model,the resulting ln(K/Ca),ln(Ti/Ca),ln(Fe/Ca),and ln(Zr/Ca)values generally display the same variation trends as the measured curves.The elemental contents and ratios produced by the linear model via the least-squares method and the log-ratio calibration model are expected to provide high-resolution data support for future paleoenvironmental research on the South China Sea deep basin.
基金supported by National Energy R&D Center of Petroleum Refining Technology of China(RIPP,SINOPEC)National Key Research and Development Program of China(No.2017YFA0304203)+5 种基金Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China(No.IRT_17R70)National Natural Science Foundation of China(Nos.61975103,61875108,61775125 and 11434007)Industrial Application Innovation Project(No.627010407)Scientific and Technological Innovation Project of Shanxi Gemeng US-China Clean Energy R&D Center Co.,Ltd111 Project(D18001)Fund for Shanxi‘1331KSC’。
文摘Although laser-induced breakdown spectroscopy(LIBS),as a fast on-line analysis technology,has great potential and competitiveness in the analysis of chemical composition and proximate analysis results of coal in thermal power plants,the measurement repeatability of LIBS needs to be further improved due to the difficulty in controlling the stability of the generated plasmas at present.In this paper,we propose a novel x-ray fluorescence(XRF) assisted LIBS method for high repeatability analysis of coal quality,which not only inherits the ability of LIBS to directly analyze organic elements such as C and H in coal,but also uses XRF to make up for the lack of stability of LIBS in determining other inorganic ash-forming elements.With the combination of elemental lines in LIBS and XRF spectra,the principal component analysis and the partial least squares are used to establish the prediction model and perform multi-elemental and proximate analysis of coal.Quantitative analysis results show that the relative standard deviation(RSD) of C is 0.15%,the RSDs of other elements are less than 4%,and the standard deviations of calorific value,ash content,sulfur content and volatile matter are 0.11 MJ kg,0.17%,0.79% and 0.41%respectively,indicating that the method has good repeatability in determination of coal quality.This work is helpful to accelerate the development of LIBS in the field of rapid measurement of coal entering the power plant and on-line monitoring of coal entering the furnace.
基金supported by the National Basic Research Program of China(Grant No.2012CB825801)the National Natural Science Foundation of China(Grant Nos.11505188,and 11305173)
文摘We develop an element-specific x-ray microscopy method by using Zernike phase contrast imaging near absorption edges, where a real part of refractive index changes abruptly. In this method two phase contrast images are subtracted to obtain the target element: one is at the absorption edge of the target element and the other is near the absorption edge. The x-ray exposure required by this method is expected to be significantly lower than that of conventional absorption-based x-ray elemental imaging methods. Numerical calculations confirm the advantages of this highly efficient imaging method.
基金Supported by Project of Ningbo Entry-Exit Inspection and Quarantine Bureau(K21-2013)
文摘X-ray fluorescence spectrometry was used to detect the content of eight elements in metal coating smeared on waste plastics,and effects of sample cups,elements in plastic substrate,and interaction of elements in metal coating on detection results were analyzed. The results show that the RSD of the method used to detect element content in the metal coating smeared on the waste plastics ranged from 0.008% to 0.044%; the determination range of the eight elements was 0.002%-52.0%,and their detection limit ranged from 0.0002% to 0.0008%. The determination results of X-ray fluorescence spectrometry were consistent with that of ICP-AES. The method can provide technical support for the determination of damage and pollution caused by metal coating smeared on waste plastics.
基金supported by the National Natural Science Foundation of China(NNSFC)grants 42074202,42274196Strategic Priority Research Program of Chinese Academy of Sciences grant XDB41000000ISSI-BJ International Team Interaction between magnetic reconnection and turbulence:From the Sun to the Earth。
文摘Earth’s magnetopause is a thin boundary separating the shocked solar wind plasma from the magnetospheric plasmas,and it is also the boundary of the solar wind energy transport to the magnetosphere.Soft X-ray imaging allows investigation of the large-scale magnetopause by providing a two-dimensional(2-D)global view from a satellite.By performing 3-D global hybrid-particle-in-cell(hybrid-PIC)simulations,we obtain soft X-ray images of Earth’s magnetopause under different solar wind conditions,such as different plasma densities and directions of the southward interplanetary magnetic field.In all cases,magnetic reconnection occurs at low latitude magnetopause.The soft X-ray images observed by a hypothetical satellite are shown,with all of the following identified:the boundary of the magnetopause,the cusps,and the magnetosheath.Local X-ray emissivity in the magnetosheath is characterized by large amplitude fluctuations(up to 160%);however,the maximum line-of-sight-integrated X-ray intensity matches the tangent directions of the magnetopause well,indicating that these fluctuations have limited impact on identifying the magnetopause boundary in the X-ray images.Moreover,the magnetopause boundary can be identified using multiple viewing geometries.We also find that solar wind conditions have little effect on the magnetopause identification.The Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission will provide X-ray images of the magnetopause for the first time,and our global hybrid-PIC simulation results can help better understand the 2-D X-ray images of the magnetopause from a 3-D perspective,with particle kinetic effects considered.
基金funding and support from the United Kingdom Space Agency(UKSA)the European Space Agency(ESA)+5 种基金funded and supported through the ESA PRODEX schemefunded through PRODEX PEA 4000123238the Research Council of Norway grant 223252funded by Spanish MCIN/AEI/10.13039/501100011033 grant PID2019-107061GB-C61funding and support from the Chinese Academy of Sciences(CAS)funding and support from the National Aeronautics and Space Administration(NASA)。
文摘The Soft X-ray Imager(SXI)is part of the scientific payload of the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission.SMILE is a joint science mission between the European Space Agency(ESA)and the Chinese Academy of Sciences(CAS)and is due for launch in 2025.SXI is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the SMILE orbit.SXI is sensitive to the soft X-rays produced by the Solar Wind Charge eXchange(SWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s exosphere.SWCX provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field lines.The sensitivity of the SXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of SMILE will enable such movements to be tracked for segments lasting many hours.SXI is led by the University of Leicester in the United Kingdom(UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United States.