Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS)...Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).展开更多
可截取签名允许签名人根据需要,在不与原始签名人交互的情况下删除已签名中的敏感数据块,并为截取后的数据计算一个公开并且可验证的签名.目前大多数可截取签名方案都是基于传统数论的困难假设构造的,鉴于量子计算机可能构成的威胁,构...可截取签名允许签名人根据需要,在不与原始签名人交互的情况下删除已签名中的敏感数据块,并为截取后的数据计算一个公开并且可验证的签名.目前大多数可截取签名方案都是基于传统数论的困难假设构造的,鉴于量子计算机可能构成的威胁,构造能够抵抗量子计算攻击的可截取签名方案尤为重要.因此基于格的Ring-SIS(ring short integer solution)问题,提出一种理想格上基于身份的可截取签名方案,证明了该方案在选择身份和消息攻击下存在不可伪造性和隐私性.理论分析和效率分析表明,相较于同类方案,该方案在功能性上同时具备身份认证、隐私性和抗量子攻击等多种功能,用户公钥尺寸更短、安全性更高、算法耗时更低.展开更多
Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiqu...Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of SUMOylation.We used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other cancers.We demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by nutlin-3.This underscores the intricate relationship between natural compounds such as nutlin-3 and immune regulation.Using comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma progression.We also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic simulation.Nutlin-3a inhibited glioma cell proliferation and activated the p53 pathway.Its efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or exercise.Experiments using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway regulation.Notably,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing cells.These results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma management.Our research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.展开更多
可证数据持有方案(Provable Data Possession, PDP)可以让用户在不下载全部数据的情况下验证其外包数据是否完好无损。为了提高外包数据的可用性和安全性,许多用户将数据的多个副本存储在单云服务器上,但是单云服务器在发生故障或者其...可证数据持有方案(Provable Data Possession, PDP)可以让用户在不下载全部数据的情况下验证其外包数据是否完好无损。为了提高外包数据的可用性和安全性,许多用户将数据的多个副本存储在单云服务器上,但是单云服务器在发生故障或者其他意外情况时,用户存储的数据副本也会遭到破坏因而无法恢复原始数据。同时,许多可证数据持有方案依赖于公钥基础设施(Public Key Infrastructure, PKI)技术,存在密钥管理问题。此外,现有的可证数据持有方案大多是在用户端使用密钥对数据进行处理。由于用户端的安全意识较弱或者安全设置较低,密钥可能会有泄露的风险。恶意云一旦获得了用户端的密钥,就可以通过伪造虚假的数据持有证明来隐藏数据丢失的事件。基于上述问题,提出了一种基于身份的密钥隔离的多云多副本可证数据持有方案(Identity-Based Key-Insulated Provable Multi-Copy Data Possession in Multi-Cloud Storage, IDKIMC-PDP)。基于身份的可证数据持有方案消除了公钥基础设施技术中复杂的证书管理。多云多副本确保了即使在某个云服务器上的副本被篡改或者被破坏的情况下,用户仍然可以从其他云服务器上获取副本并恢复数据。同时,方案中使用了密钥隔离技术实现了前向和后向安全。即使某一时间段内的密钥泄露,其他时间段内云存储审计的安全性也不会受到影响。给出了该方案的正式定义、系统模型和安全模型;在标准困难问题下,给出了该方案的安全性证明。安全性分析表明,IDKIMC-PDP方案具有强抗密钥泄露性、可检测性以及数据块标签和证明的不可伪造性。实验结果表明,与现有的多云多副本相关方案相比,IDKIMC-PDP方案具有相对较高的效率。展开更多
基金supported by NIH grants(R01NS125074,R01AG083164,and R21NS127177)(to YL).
文摘Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).
文摘可截取签名允许签名人根据需要,在不与原始签名人交互的情况下删除已签名中的敏感数据块,并为截取后的数据计算一个公开并且可验证的签名.目前大多数可截取签名方案都是基于传统数论的困难假设构造的,鉴于量子计算机可能构成的威胁,构造能够抵抗量子计算攻击的可截取签名方案尤为重要.因此基于格的Ring-SIS(ring short integer solution)问题,提出一种理想格上基于身份的可截取签名方案,证明了该方案在选择身份和消息攻击下存在不可伪造性和隐私性.理论分析和效率分析表明,相较于同类方案,该方案在功能性上同时具备身份认证、隐私性和抗量子攻击等多种功能,用户公钥尺寸更短、安全性更高、算法耗时更低.
基金supported by Project of the Health Shanghai Initiative Special Fund(Medical-Sports Integration,Creating a New Model of Exercise for Health),No.JKSHZX-2022-02(to SC).
文摘Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of SUMOylation.We used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other cancers.We demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by nutlin-3.This underscores the intricate relationship between natural compounds such as nutlin-3 and immune regulation.Using comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma progression.We also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic simulation.Nutlin-3a inhibited glioma cell proliferation and activated the p53 pathway.Its efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or exercise.Experiments using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway regulation.Notably,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing cells.These results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma management.Our research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.
