Visible light-mediated site-specific C(sp^(3))-H xanthylation of amides has been accomplished using N-xanthylamides.The N-centered radicals generated by light initiation of N-xanthylamide substrates undergo 1,5-hydrog...Visible light-mediated site-specific C(sp^(3))-H xanthylation of amides has been accomplished using N-xanthylamides.The N-centered radicals generated by light initiation of N-xanthylamide substrates undergo 1,5-hydrogen atom transfer to form benzylic or alkyl radical intermediates under metal-and catalyst-free conditions.This method exhibits a broad substrate scope,high functional group tolerance,and high regioselectivity.Furthermore,this strategy provides straightforward access to a range of derivatives through the subsequent elaboration of the xanthate group.展开更多
基金We acknowledge financial support from the National Natural Science Foundation of China(No.21602144)the Scientific Research Project of the Education Department of Hubei Province(No.Q20211503)the Science and Technology Program of Sichuan Province(No.2021ZYD0064).
文摘Visible light-mediated site-specific C(sp^(3))-H xanthylation of amides has been accomplished using N-xanthylamides.The N-centered radicals generated by light initiation of N-xanthylamide substrates undergo 1,5-hydrogen atom transfer to form benzylic or alkyl radical intermediates under metal-and catalyst-free conditions.This method exhibits a broad substrate scope,high functional group tolerance,and high regioselectivity.Furthermore,this strategy provides straightforward access to a range of derivatives through the subsequent elaboration of the xanthate group.
