目的研究中药明目五子汤联合针刺治疗肝肾阴虚型水样液缺乏性干眼症的临床效果。方法选取2017年1月—2020年7月浙江中医药大学附属宁波市中医院接收的60例肝肾阴虚型干眼症患者,随机分为A组和B组,每组30例。A组采用中药明目五子汤治疗,...目的研究中药明目五子汤联合针刺治疗肝肾阴虚型水样液缺乏性干眼症的临床效果。方法选取2017年1月—2020年7月浙江中医药大学附属宁波市中医院接收的60例肝肾阴虚型干眼症患者,随机分为A组和B组,每组30例。A组采用中药明目五子汤治疗,B组在A组的基础上给予针刺疗法。比较2组患者的泪液分泌测试(Schirmer I test,SIT)、泪膜破裂时间(Tear film break up time,BUT)、白细胞介素-6(Interleukin-6,IL-6)、干眼症积分及角膜染色评分。结果B组治疗后的SIT、BUT优于A组,IL-6水平和干眼症积分低于A组,差异均有统计学意义(P<0.05)。结论中药明目五子汤联合针刺治疗肝肾阴虚型干眼症,能改善患者的内膜稳定性和干眼症症状,值得临床推广。展开更多
Objective： To observe the effects of electroacupuncture （EA） at the Conception Vessel on proliferation and differentiation of the nerve stem cells in the inferior zone of the lateral ventricle in cerebral ischemia ...Objective： To observe the effects of electroacupuncture （EA） at the Conception Vessel on proliferation and differentiation of the nerve stem cells in the inferior zone of the lateral ventricle in cerebral ischemia rats. Methods： The model rats were prepared by occlusion of the middle cerebral artery for 2 hours and then by reperfusion. They were randomly divided into two groups： a control group and an EA group. Changes in differentiation and proliferation of the nerve stem cells were observed 7, 14 and 28 days after successful modeling. Results： As compared with the 7-day control group （C-7d group）, there was no significant difference （P〉0.05） in the numbers of 5-bromodeoxyuridine （Brdu） positive cells, Brdu/GFAP, Brdu/Nestin and Brdu/Nse double-labeled cells in the inferior zone of the lateral ventricle in the EA group 7 days after modeling. However, in the 14-day EA group （R-14d group） and the 28-day EA group （R-28d group）, the numbers of Brdu positive cells and Brdu/GFAE Brdu/Nestin, Brdu/Nse double-labeled cells significantly increased as compared respectively with the 14-day control （C-14d group） and the 28-day control （C-28d） group （P〈0.05 or P〈0.01）. Conclusions： EA at the Conception Vessel promotes differentiation and proliferation of the nerve stem cells in the inferior zone of the lateral ventricle in the cerebral ischemia rats, and may stimulate differentiation of the proliferous nerve stem cells towards the astrocvtes.展开更多
文摘目的研究中药明目五子汤联合针刺治疗肝肾阴虚型水样液缺乏性干眼症的临床效果。方法选取2017年1月—2020年7月浙江中医药大学附属宁波市中医院接收的60例肝肾阴虚型干眼症患者,随机分为A组和B组,每组30例。A组采用中药明目五子汤治疗,B组在A组的基础上给予针刺疗法。比较2组患者的泪液分泌测试(Schirmer I test,SIT)、泪膜破裂时间(Tear film break up time,BUT)、白细胞介素-6(Interleukin-6,IL-6)、干眼症积分及角膜染色评分。结果B组治疗后的SIT、BUT优于A组,IL-6水平和干眼症积分低于A组,差异均有统计学意义(P<0.05)。结论中药明目五子汤联合针刺治疗肝肾阴虚型干眼症,能改善患者的内膜稳定性和干眼症症状,值得临床推广。
文摘Objective： To observe the effects of electroacupuncture （EA） at the Conception Vessel on proliferation and differentiation of the nerve stem cells in the inferior zone of the lateral ventricle in cerebral ischemia rats. Methods： The model rats were prepared by occlusion of the middle cerebral artery for 2 hours and then by reperfusion. They were randomly divided into two groups： a control group and an EA group. Changes in differentiation and proliferation of the nerve stem cells were observed 7, 14 and 28 days after successful modeling. Results： As compared with the 7-day control group （C-7d group）, there was no significant difference （P〉0.05） in the numbers of 5-bromodeoxyuridine （Brdu） positive cells, Brdu/GFAP, Brdu/Nestin and Brdu/Nse double-labeled cells in the inferior zone of the lateral ventricle in the EA group 7 days after modeling. However, in the 14-day EA group （R-14d group） and the 28-day EA group （R-28d group）, the numbers of Brdu positive cells and Brdu/GFAE Brdu/Nestin, Brdu/Nse double-labeled cells significantly increased as compared respectively with the 14-day control （C-14d group） and the 28-day control （C-28d） group （P〈0.05 or P〈0.01）. Conclusions： EA at the Conception Vessel promotes differentiation and proliferation of the nerve stem cells in the inferior zone of the lateral ventricle in the cerebral ischemia rats, and may stimulate differentiation of the proliferous nerve stem cells towards the astrocvtes.
