Systematic review and meta analysis of the TCM therapy of Fuzheng and Kangai combined with chemotherapy in treating advanced NSCLC

Objective:To systematically evaluate TCM of Fuzheng and Kangai combined with chemotherapy in the treatment of Advanced NSCLC,including the efficacy and effect on the quality of life of patients.Methods:Two researchers independently searched the literature of clinical trails from Jan.2010 until Jun.2020 in the Cochrane Library,Pubmed,Embase,CBM,CNKI,WanFang Data and VIP database.Also,they had been evaluated and extracted strictly by REVMAN 5.3.Results:A total of 1303 patients were included in 15 articles.The meta analysis shows that the TCM of Fuzheng and Kangai combined with chemotherapy can improve the objective response rate[OR=2.14,95%CI(1.67,2.74),P<0.00001],disease control rate[OR=2.54,95%CI(1.88,3.42),P<0.00001]and KPS score[OR=3.28,95%CI(1.92,5.60),P<0.0001],decrease the incidence rate of liver injury[OR=0.34,95%CI(0.21,0.54),P=0.003],hemoglobin reduction[OR=0.53,95%CI(0.28,1.01),P=0.05],leukopenia[OR=0.22,95%CI(0.13,0.39),P<0.00001],thrombocytopenia[OR=0.32,95%CI(0.21,0.50),P<0.00001],toxic effects on the digestive systems[OR=0.30,95%CI(0.19,0.46),P<0.00001].Conclusions:the experimental group was better than control one in short-term efficacy and KPS score.Furthermore,the experimental group can reduce the incidence rate of myelosuppression,toxicity of digestive system and liver.

Influence of TCM Therapy for Supplementing Pi(脾) and Nourishing Shen(肾) on Dendritic Cell Function in Patients with Chronic Hepatitis B Treated by Lamivudine

Objective:To observe the influence of traditional Chinese medicine(TCM) therapy for supplementing Pi(脾) and nourishing Shen(肾,SPNS) on dendritic cell function in patients with chronic hepatitis B (CHB) treated by lamivudine.Methods:Sixty CHB patients with positive HBeAg were equally randomized by digital table into two groups:the observation group and the control group.Patients in the control group were treated with lamivudine only,while patients in the observation group were treated with lamivudine combine...

Clinical Observation on Treatment of Moderate and Severe Periodical Mastalgia with TCM Hot-wet Compress Therapy

[Objectives] To observe the clinical therapeutic efficacy of local hot-wet compress therapy of digestion ointment prescription on the patients with moderate and severe mastalgia. [Methods] Firstly,60 patients with mastalgia were selected,and divided into the experimental group and control group( 30 cases for each group). The control group was treated with acupuncture at distal point,and the experimental group was treated with TCM local hot-wet compress therapy combined with acupuncture at distal point. Then,the clinical therapeutic efficacy of two groups was compared. [Results]The experimental group was superior to the control group in relieving the breast pain,improving emotional integral,reducing breast lumps,improving lump texture,and improving TCM syndrome integral( P < 0. 05). [Conclusions]The digestion ointment prescription local hot-wet compress therapy has a significant therapeutic effect on treatment of mastalgia and can significantly improve the breast pain symptom of patients.

Clinical Effects of the Qi-acupuncture Therapy of TCM on Portal Hypertension

Objective:To explore the effective prevention and treatment of portal hypertension(PH).Methods:A total of 220 patients who came to our hospital from March 2015 to October 2018 were treated.They were randomly divided into the treatment group and the control group,each with 110 cases.Before treatment,there was no significant differences in age,sex,clinical symptoms,signs,laboratory tests and color Doppler ultrasound related examinations between the 2 groups(P>0.05).Among them,the treatment group on the basis of traditional Chinese and Western medicine treatment in our hospital,the Qi-acupuncture therapy of TCM was added.The extra meridian acupoints along with acupoints were selected.The control group received conventional treatment with traditional Chinese and Western medicine in our hospital.Results:There were significant differences in clinical symptoms,signs and chemistry between groups after treatment(P<0.01).There were significant differences in test,color ultrasound related examination and so on(P<0.01).Those in the treatment group was significantly better than the control group(P<0.01).Conclusion:On the basis of the Qi-acupuncture therapy of TCM,selecting extra meridian acupoint and acupoints can effectively treat PH.

Non-pharmacological therapy of TCM for the treatment of essential hypertension

Non-pharmacotogicat treatment is an important means to control hypertension, with many advantages such as tow cost, tess medication, stable btood pressure, tess compHcations, and improved prognosis. This article reviews the research progress of non-drug treatment of hypertension in Chinese medicine in the past five years, and evaluates traditional Chinese medicine such as TCM Qigong, Wuhuo opera, Ba Duanjin and Taijiquan, and Chinese medicine acupuncture, moxibustion, massage, apptication, acupoint embedding and other traditional Chinese medicine. The effect of external treatment in hypertension control provides guidance for non-drug therapy to control hypertension.

保元汤加味联合揿针治疗射血分数保留心力衰竭临床观察

目的:观察保元汤加味联合揿针治疗射血分数保留心力衰竭的临床疗效。方法:将60例射血分数保留心力衰竭患者按照随机数字表法分为两组各30例。对照组予西药治疗,治疗组在对照组基础上予保元汤加味配合揿针,疗程均为4周。比较两组治疗前后中医证候积分、心功能疗效、舒张早期二尖瓣瓣口血流峰值速度/二尖瓣瓣环舒张早期速度(E/e')、左室射血分数(LVEF)、6分钟步行试验(6MWT)、B型脑钠肽(BNP)、尿酸(UA)水平。结果:治疗组心功能疗效为93.33%,明显优于对照组的70.00%(P﹤0.05);治疗后两组各单项症状积分均较治疗前下降(P﹤0.05),治疗组中医证候积分低于对照组(P﹤0.05);与治疗前相比治疗组E/e'水平、BNP均较前下降(P﹤0.05),且均低于对照组(P﹤0.05);与治疗前相比治疗组LVEF、6MWT水平较前提高(P﹤0.05),且高于对照组(P﹤0.05);对照组UA较前明显上升(P﹤0.01),治疗组UA较前无明显变化(P﹥0.05),较对照组明显下降(P﹤0.05)。结论:保元汤加味联合揿针配合常规西药治疗能明显改善射血分数保留心力衰竭患者临床症状、心功能,明显提高患者运动耐量、预防利尿剂导致的尿酸升高。

“高知”群体更信赖中医吗?

背景越来越多的证据表明,年轻的、高学历的、来自经济发达地区的“高知”人群正成为中医药的主要使用群体。目的本研究拟依据技术接受整合(UTAUT)模型,采用变量中心与个体中心相结合的方法,更深入地探究国民中医接受度的影响因素。将人口学、慢性疾病、健康素养、传统文化认同、科学思维等变量纳入考量,聚焦家长是否愿意让孩子接受中医儿科治疗。方法2023年7—9月,使用自搭建的DiggMind在线心理测评平台发放问卷进行调查,通过方便取样的方式选取广东省的幼儿园、小学、中学各1所,对717名家长进行问卷调查。收集家长的人口学变量(性别、年龄、学历、职业、户籍、患慢性疾病),采用6级Likert量表(分数越高代表“越符合自身情况”)测量UTAUT模型的6个维度及3个影响因素变量(健康素养、传统文化认同和科学思维)。使用路径分析、潜在剖面分析和Logistic回归分析对数据进行统计。结果UTAUT模型对中医儿科使用意向与行为的解释率高达72%。通过对效果期望、社会影响、便利条件、风险认知、使用意向、使用行为UTAUT模型6个维度进行潜在剖面分析,结果显示将样本分成4个亚组的方案相对最优,将本研究样本划分出“抵制组”“持疑组”“认同组”“坚信组”4个中医接受程度逐步递增的亚型。家长的科学思维和传统文化认同对中医儿科接受态度有正向作用(P<0.05),而学历、户籍类型、职业声望等变量的影响无统计学意义(P>0.05)。结论本研究揭示出真正促进“高知”群体信赖中医药文化的是他们身上所具备的良好品质而非学历、职业、户籍等外在因素,为现代科学理论与传统医学实践之间的融合搭建了桥梁。

叙事护理联合五行音乐之角调式乐曲干预肝气郁结型维持性血液透析患者焦虑、抑郁的效果

目的:探讨叙事护理联合五行音乐之角调式乐曲干预肝气郁结型维持性血液透析(MHD)患者焦虑、抑郁的临床效果。方法:选取浙江中医药大学附属第一医院2021年1月~2023年1月收治的90例肝气郁结型MHD患者为研究对象,随机分为对照组、五行音乐组与联合组各30例,对照组实施常规护理干预,五行音乐组在对照组基础上增加五行音乐之角调式乐曲干预,联合组在五行音乐组基础上增加叙事护理干预。比较三组干预前后焦虑情绪、抑郁情绪、睡眠质量及中医症状评分变化。结果:干预6周、12周后,联合组汉密尔顿焦虑量表(HAMA)评分低于五行音乐组和对照组,五行音乐组低于对照组(P<0.05)。干预6周、12周后,联合组汉密尔顿抑郁量表(HAMD)评分低于五行音乐组与对照组,五行音乐组低于对照组(P<0.05)。干预6周、12周后,联合组匹兹堡睡眠质量指数量表(PSQI)评分低于五行音乐组与对照组,五行音乐组低于对照组(P<0.05)。干预12周后,联合组失眠多梦、沉默寡言、善太息中医症状评分均低于五行音乐组和对照组,五行音乐组均低于对照组(P<0.05)。结论:叙事护理联合五行音乐之角调式乐曲能有效改善肝气郁结型MHD患者焦虑、抑郁情绪及睡眠质量,减轻中医症状。

中药干预相关信号通路治疗局灶节段肾小球硬化型肾病的研究进展

局灶节段肾小球硬化(focal segmental glomerulosclerosis,FSGS)型肾病是一种常见的肾小球疾病,是导致终末期肾病的主要原因。中药可通过干预磷脂酰肌醇3激酶(phosphoinositide 3-kinase,PI3K)/蛋白激酶B(protein kinase B,PKB,又称AKT)信号通路、核转录因子-κB(nuclear factor-κB,NF-κB)信号通路、转化生长因子-β(transforming growth factor-β,TGF-β)信号通路、β-catenin信号通路、Notch信号通路、核转录因子红系2相关因子2(nuclear factor-erythroid 2-related factor 2,Nrf2)信号通路、沉默信息调节因子(silence infor-mation regulator,SIRT)信号通路等减少细胞外基质积累和上皮-间质转化,减少活性氧和炎症因子的产生、激活自噬、修复裂孔隔膜相关蛋白减轻FSGS型肾病的足细胞损伤。尽管中药调控相关信号通路治疗FSGS型肾病有很多优势,但目前中药干预FSGS型肾病信号传导的研究还处于前期阶段,且多停留在动物实验阶段,存在研究内容不足、研究方法差异较大、缺乏统一的FSGS型肾病中医指南或共识等问题。今后,应将基础实验与临床研究相结合进行验证,进一步明确中药发挥治疗作用的相关机制,同时,在动物实验中选用中药复方时应根据辨证论治的思维进行选择,更利于提高疗效及作用机制探讨。除此之外,非中药疗法如火龙罐、艾灸、推拿等也对FSGS型肾病治疗有一定的疗效,未来可从非药物疗法的作用机制进行探讨。

通窍活血汤联合针刺治疗颅内动脉瘤介入栓塞术后头痛临床观察

目的:观察通窍活血汤联合针刺治疗颅内动脉瘤介入栓塞术后头痛的临床疗效。方法:选择符合纳入标准的颅内动脉瘤患者60例,随机分为两组各30例。对照组予西药治疗,治疗组在对照组基础上予通窍活血汤联合针刺治疗,比较两组临床疗效、头痛评分、神经功能评分(nationalInstitute of health stroke scale,NIHSS)、血清指标及不良反应发生情况。结果:治疗组临床总有效率为96.67%,明显高于对照组的73.33%(P﹤0.05);治疗后,治疗组头痛评分及NIHSS评分显著低于对照组(P﹤0.05);且治疗组血清指标水平显著低于对照组(P﹤0.05)。结论:通窍活血汤联合针刺治疗颅内动脉瘤介入栓塞术后引起的头痛症状具有良好的临床疗效,可以改善患者神经功能评分、头痛评分、NIHSS评分及血清指标。

Effects of Huayu Xiaozheng Therapy on Recurrence of Multiple Endometrial Polyps After Electrotomy

Objective:To investigate the preventive effect of Huayu Xiaozheng therapy method of traditional Chinese medicine on the recurrence of multiple endometrial polyps after hysteroscopic electro resection.Methods:A total of 120 patients with blood stasis diagnosed with multiple endometrial polyps after hysteroscopic electroresection were divided into Traditional Chinese medicine group(38 people),Manyuele group(27 people),contraceptive pill group(34 people)and control group(21 people),and the endometrial thickness,polyp recurrence cases and TCM syndrome points were observed in 4 groups after treatment in 3 months,6 months and 12 months..Results:The endometrial thickness was statistically significant(P<0.05)before and after treatment in the Chinese medicine group,the Manyuele group and the contraceptive group,and the endometrial thickness was statistically significant(P<0.05)in the 1 year after treatment,and the endometrial thickness of the Chinese medicine group was compared with the contraceptive group and the Manyuele group in the 1 year after treatment,and the difference was not statistically significant.The differences in TCM symptoms in the Chinese medicine treatment group were statistically significant compared with those in the contraceptive group and the Manyuele group(P<0.05).The recurrence rate of polyps in the 1 year after treatment was statistically significant compared with the control group(P<0.05),and the difference between the three groups was not statistically significant(P>0.05).Conclusion:The traditional Chinese medicine stasis elimination method has a preventive effect on the recurrence of endometrial polyps,and its preventive effect is no different from that of Western medicine,and can significantly improve clinical symptoms.

理气平胃丸治疗寒热错杂型功能性消化不良疗效观察

目的:观察理气平胃丸治疗寒热错杂型功能性消化不良的临床疗效。方法:将符合纳入标准的80例功能性消化不良患者随机分为两组各40例,对照组予抑制胃酸分泌、保护消化道黏膜、调节胃肠道功能等对症治疗,治疗组在对照组基础上予理气平胃丸治疗,两组均以2周为1个疗程,连续治疗2个疗程。治疗后比较两组临床疗效。结果:治疗组临床总有效率92.5%,对照组临床总有效率72.5%,治疗组临床疗效优于对照组(P﹤0.05);治疗后两组患者中医证候积分、SAS评分、SDS评分均较治疗前降低,且治疗组优于对照组(P﹤0.05)。结论:理气平胃丸治疗寒热错杂型功能性消化不良临床疗效好,可以改善患者临床症状,并且在一定程度上可以改善患者焦虑状态和抑郁状态。

瓜萎薤白半夏汤合涤痰汤对冠心病PCI术后患者心肌灌注及心血管不良事件的影响

目的:观察瓜萎薤白半夏汤合涤痰汤对冠心病经皮冠状动脉介入(PCI)术后患者心肌灌注及心血管不良事件的影响。方法:选88例冠心病经皮冠状动脉介入术后患者,随机分为两组各44例。对照组予常规治疗,治疗组在对照组基础上加用瓜萎薤白半夏汤合涤痰汤治疗。两组均持续治疗8周,比较两组临床疗效。结果:治疗组总有效率93.18%,对照组总有效率77.27%,两组比较,差异有统计学意义(P﹤0.05)。治疗后,两组心绞痛发作次数及持续时间均低于治疗前(P﹤0.05),且治疗组低于对照组(P﹤0.05);两组各项心肌灌注指标水平均低于治疗前(P﹤0.05),且治疗组低于对照组(P﹤0.05)。治疗组术后心血管不良事件发生率为9.09%,对照组为29.55%,两组比较,差异有统计学意义(P﹤0.05)。结论:瓜萎薤白半夏汤合涤痰汤用于治疗冠心病经皮冠状动脉介入术后患者疗效较佳,可明显改善心肌灌注状态,降低心血管不良事件发生风险。

EXTREMELY HIGH FREQUENCY (EHF) PUNCTURE THERAPY AND SYNDROMES OF TRADITIONAL CHINESE MEDICINE

ExtremeIy high frequency (EHF) puncture is a new method of treatment based uponbiological effects of low power electromagnetic waves of millimetric band and acupuncture theory oftraditional Chinese medicine (TCM). It is non-invasive, painless and effective. Extensiveness and variety of the specific sensations (Deqi phenomenon) during EHF-puncture re-flect intensive reactions of the patient’s organism and provide individualization of therapy. EHF-puncture is a step of integration of traditional Chinese with modern Western medicines.

Treatment of 140 cerebral palsied children with a combined method based on traditional Chinese medicine(TCM)and western medicine

Objective:To observe and evaluate a method that is effective and practical for treatment of cerebral palsied(CP)children in China.Method:The patient's age and disease type and individual specific conditions were considered in choosingtherapy methods accordingly:Chinese herbs,acupuncture,auricnlar seed pressure,point finger pressing,massage,orthopedichand manipulation,physiotherapy,occupational therapy,language therapy,etc.Meanwhile we created a new CP treatment modelthat combines hospitalized treatment with family therapy.Results:The majority of CP patients improved greatly in motor andsocial adaptation capacities after treatment.Wilcoxon paired rank sum test analysis showed that there were significant differencesbetween the data before and after treatment(P<0.01).Conclusion:This combined therapy method,based on traditional Chinesemedicine and western medicine plus family supplemental therapy,is an effective and practical treatment strategy for CP children inChina.

Therapy of acute severe pancreatitis awaits further improvement

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Research Progress of Non-drug Therapy of Traditional Chinese Medicine in the Treatment of Obese Polycystic Ovary Syndrome

Polycystic ovarian syndrome(PCOS)as a relatively common clinical reproductive endocrine disease,the incidence is increasing year by year and the treatment is difficult,among which obese PCOS accounts for nearly 50%of the total.In recent years,non-drug therapy of traditional Chinese medicine(TCM)has been effective in the treatment of PCOS.This article summarizes the relevant literature in the past ten years from acupuncture,acupoint embedding,moxibustion,and auricular points,and observes the effects of TCM non-drug therapy on endocrine and glucose and lipid metabolism in obese PCOS patients.The impact of various indicators such as body mass index,body mass index,etc.,and discuss the problems in such treatments,as well as put forward suggestions to achieve the purpose of better guiding the clinical treatment of obese PCOS.

Traditional Chinese medicine five-tone therapy

From the perspective of the application of medical value orientation music therapy, this paper summarized the ancient Chinese sound therapy, such as shaman music therapy and five-tone therapy. It also compared five-tone therapy with Tibetan Singing bowl music therapy. The ancient music therapy is a kind of medical means which is oriented to the treatment effect. At first, it was mainly based on the music medical behavior of Taoist, and then gradually evolved into the modern treatment application of folk pentatonic therapy. On the basis of inheritance and development of ancient traditional music treatment, contemporary medicine proposed a new individualized music treatment. Therefore, the theory of five-tone therapy has updated the research on traditional Chinese music treatment theory and system, and will provide reference for the establishment of accurate music treatment system in the future.

Progress of research on massage therapy for sub-health conditions

Sub-health state is a kind of low-quality state between health and disease, and will lead to disease if not intervened in time. As one of the external treatment options in traditional Chinese medicine (TCM), massage therapy has achieved an ideal curative effect in the treatment of the sub-health state. This paper summarizes the articles on massage treatment for the treatment of patients in the sub-health state from the past decade. It mainly includes the current understanding of sub-health, treatment ideas and specific methods, as well as clinical classification of treatment modalities. From the perspective of treatment ideas and specific methods, most massage therapies are performed under the guidance of the holistic concept of TCM, and the concept of treatment based on syndrome differentiation (four diagnostic methods of TCM: inspection, auscultation, inquiry, and palpation). In this treatment, not only are the therapeutic functions of meridians and acupoints emphasized, but the selection of the therapeutic time is also performed according to the "Ziwuliuzhu" and the "Lingguibafa"(the acupuncture method based on time in ancient China). According to the different clinical symptoms of sub-health, it can be divided into three types: physical sub-health, psychological sub-health, and social adaptive sub-health. Massage therapy eliminates pain, relieves physical fatigue, and has a good therapeutic effect on physical sub-health. It can alleviate anxiety and depression, promote psychosomatic pleasure of patients, and has a satisfactory regulatory effect on the psychological sub-health symptoms. However, basic research on using modern medical theories and the means to explain its mechanism of action is relatively weak. Therefore, only constantly improving the quality of clinical observation and strengthening basic research can provide more and better evidence for the clinical application of massage therapy in treating the symptoms of the sub-health status.

Brief introduction to the historical development and therapeutic effects of cupping therapy in traditional Chinese medicine

Cupping therapy (CT) is an ancient traditional and complementary medicine practice. Recently, there has been a growing evidence of its potential benefits in the treatment of various diseases. The CT has been constantly developing with the emergence of various modern and improved cupping devices. It is now evident that cupping could adjust the Qi, blood, Yin and Yang, dredge the meridian, as well as relieve the effect of illness, achieve fitness and relative equilibrium of Yin-Yang. It exerts its effects through the negative pressure suction via the mechanical and thermal stimulations, and the negative pressure effects induced by cupping. This article gives an overview of CT practice, its historical development, as well as its therapeutic effects and mechanism. Furthermore, a new and updated classification of CT was briefly introduced.