选择性凝血因子XI抑制剂在血栓性疾病治疗中的临床研究进展

血栓性疾病是当今社会的一个重要医疗问题,动脉内血栓形成是引起心肌梗死、缺血性脑卒中、急性肢体缺血的最常见原因,静脉内血栓则可能导致肢体缺血坏死及肺栓塞等严重后果,这些疾病每年共导致全球1000多万人死亡,占所有疾病死亡的50%以上,在过去的20年内,这一比例更是增加了25%~35%[1]。目前,抗凝剂是预防和治疗血栓形成的主要手段之一。

Numerical Simulation of Dynamic Response of an Existing Subway Station Subjected to Internal Blast Loading

In order to design and retrofit a subway station to resist an internal blast, the distribution of blast loading and its effects on structures should be investigated firstly. In this paper, the behavior of a typical subway station subjected to different internal blast Ioadings was analyzed. It briefly introduced the geometric characteristics and material constitutive model of an existing two-layer and three-span frame subway station. Then three cases of different explosive charges were consid- ered to analyze the dynamic responses of the structure. Finally, the maximum principal stress, dis- placement and velocity of the columns in the three cases were obtained and discussed. It con- cluded that the responses of the columns are sensitive to the charge of explosive and the distance from the detonation. It＇s also found that the stairs between the two layers have significant effects on the distribution of the maximum principal stress of the columns in the upper layer. The explicit dynamic nonlinear finite element software ANSYS/LS-DYNA was used in this study.

Multi-approach analysis of maximum riverbed scour depth above subway tunnel

When subway tunnels are routed underneath rivers, riverbed scour may expose the structure, with potentially severe consequences. Thus, it is important to identify the maximum scour depth to ensure that the designed buried depth is adequate. There are a range of methods that may be applied to this problem, including the fluvial process analysis method, geological structure analysis method, scour formula method, scour model experiment method, and numerical simulation method. However, the application ranges and forecasting precision of these methods vary considerably. In order to quantitatively analyze the characteristics of the different methods, a subway tunnel passing underneath a river was selected, and the aforementioned five methods were used to forecast the maximum scour depth. The fluvial process analysis method was used to characterize the river regime and evolution trend, which were the baseline for examination of the scour depth of the riverbed. The results obtained from the scour model experiment and the numerical simulation methods are reliable; these two methods are suitable for application to tunnel projects passing underneath rivers. The scour formula method was less accurate than the scour model experiment method; it is suitable for application to lower risk projects such as pipelines. The results of the geological structure analysis had low precision; the method is suitable for use as a secondary method to assist other research methods. To forecast the maximum scour depth of the riverbed above the subway tunnel, a combination of methods is suggested, and the appropriate analysis method should be chosen with respect to the local conditions.

Numerical Simulation of Dynamic Response of an Existing Subway Station Subjected to Internal Blast Loading

In order to design and retrofit a subway station to resist an internal blast, the distribution of blast loading and its effects on structures should be investigated firstly. In this paper, the behav-ior of a typical subway station subjected to different internal blast loadings was analyzed. It briefly introduced the geometric characteristics and material constitutive model of an existing two-layer and three-span frame subway station. Then three cases of different explosive charges were consid-ered to analyze the dynamic responses of the structure. Finally, the maximum principal stress, dis-placement and velocity of the columns in the three cases were obtained and discussed. It con-cluded that the responses of the columns are sensitive to the charge of explosive and the distance from the detonation. It’s also found that the stairs between the two layers have significant effects on the distribution of the maximum principal stress of the columns in the upper layer. The explicit dynamic nonlinear finite element software——ANSYS/LS-DYNA was used in this study.

Assessment of the Influence of Tunnel Settlement on Operational Performance of Subway Vehicles

In the realm of subway shield tunnel operations,the impact of tunnel settlement on the operational performance of subway vehicles is a crucial concern.This study introduces an advanced analytical model to investigate rail geometric deformations caused by settlement within a vehicle-track-tunnel coupled system.The model integrates the geometric deformations of the track,attributed to settlement,as track irregularities.A novel“cyclic model”algorithm was employed to enhance computational efficiency without compromising on precision,a claim that was rigorously validated.The model’s capability extends to analyzing the time-history responses of vehicles traversing settlement-affected areas.The research primarily focuses on how settlement wavelength,amplitude,and vehicle speed influence operational performance.Key findings indicate that an increase in settlement wavelength can improve vehicle performance,whereas a rise in amplitude can degrade it.The study also establishes settlement thresholds,based on vehicle operation comfort and safety.These insights are pivotal for maintaining and enhancing the safety and efficiency of subway systems,providing a valuable framework for urban infrastructure management and long-term maintenance strategies in metropolitan transit systems.

终末期肝病模型-XI评分对急性心肌梗死冠状动脉支架植入术后患者预后的预测价值

目的 探讨终末期肝病模型-XI(MELD-XI)评分对急性心肌梗死患者冠状动脉支架植入术后的预后的预测价值。方法 回顾性收集2021年1月至2022年12月于内蒙古医科大学附属医院收治的急性心肌梗死患者226例,根据入院时MELD-XI评分,将患者分为高MELD-XI评分组和低MELD-XI评分组,每组各113例。比较两组患者近、远期预后。结果 与低MELD-XI评分组比较,高MELD-XI评分组患者左室射血分数(LVEF)显著降低[(51.67±7.91)%vs.(60.91±5.91)%],(P<0.001);N末端脑钠肽前体(NT-proBNP)显著增高(822.87±462.38) vs.(701.84±338.21)ng/L,(P=0.026)。与低MELD-XI评分组比较,高MELD-XI评分组患者不良结局事件的发生率显著增高(16.81%vs. 6.19%,P=0.012)。MELD-XI评分对急性心肌梗死冠状动脉支架植入术后不良结局事件具有一定的预测价值,曲线下面积为0.732,95%CI:0.671~0.798,(P<0.001)。结论 MELD-XI对于预测急性心肌梗死患者预后具有一定的参考价值。

Flexible Policies for Subway Construction

GoodnewskeepspouringinforBeding'sl,.b.aVconstructioninrecentdays.AttheEconomic&TradeTalksbetweenthemainlandandHongkongSARheldonOctober28,1999inthecapital,theBeijingMunicipalGovernmentannouncedaboldplantobuildthreeexpressrailways-SubwayNo.13,SubwayNo...

System and Realization Path of Xi Jinping's Eco-poverty Alleviation Concept under the Vision of Green Development

Since the 18 th National Congress of the Communist Party of China,General Secretary Xi Jinping delivered a series of speeches on ecological environment and poverty governance,forming the Xi Jinping's eco-poverty alleviation ideology.In this paper,the Xi Jinping's eco-poverty alleviation ideology is taken as the research object.Using the methods of literature analysis and comparative analysis,the origin of eco-poverty alleviation theory is explored from the common prosperity theory and the theory of ecological capital,and the practice foundation is found out from practical cases.The relationship between the ecological damage and poverty is systematically analyzed,and the mechanism of ecological poverty is explored in detail.The basic connotation of Xi Jinping's eco-poverty alleviation is expounded,and it consists of three parts:guiding ideology layer,implementation layer,and guarantee layer.By perfecting and innovating the market mechanism,social management mechanism,performance evaluation mechanism,integration mechanism with other poverty alleviation methods,and ecological immigration mechanism of ecological poverty,the realization of Xi Jinping's eco-poverty alleviation concept could be guaranteed.

A Comparative Study of the English Translations of“Chun Ye Xi Yu”From the Perspective of Register Theory

Ancient poetry is an irreplaceable component of Chinese culture and an invaluable asset in China’s cultural heritage.With the rapid development of globalization and informatization,Chinese poem is attracting more and more interests and focuses as one part of China’s cultural soft power which plays an important role on spreading traditional Chinese culture.Systemic functional linguistics mainly explores the essence,entailment,system and structure of language from the perspective of social culture,especially the relationship between context and discourse.Therefore,the paper applies the register theory to Chinese poem translations of Xu Yuanchong and Yang Xianyi of“Chun Ye Xi Yu”in order to compare two translated texts from three aspects of field,tenor,and mode,and examine the expression of the connotation of the original poem between the two translations.

English Translation of Chinese Natural Ecological Discourse:A Corpus-based Case Study on Xi Jinping:The Governance of China

Amid the increasingly severe global natural eco-environment,it is necessary to build a natural ecological civilization by constructing an ecological civilization discourse.Against this background,this study compiles a corpus of natural ecological discourse in the English translation of Xi Jinping:The Governance of China(short for Xi).By using Wordsmith and AntConc,this study explores the linguistic features of the ecological discourse in English translation of Xi in the following dimensions,including high-frequency words,keywords,word collocations,concordance lines.This study aims to analyze the concepts and attitudes towards natural ecology,so as to provide certain valuable insights for the construction of China’s discourse on natural ecological civilization.The study found that the natural ecology discourse involving in the English translation of Xi turned out to be ecologically beneficial.

Sustainable Urban Mobility: (A)Synchrony between Subway Systems

The present study analyses the differences between the subways systems of two cities, Lisbon (Portugal) and Brasília (Brazil), verifying the extent to which their subway systems are spatially integrated with the respective urban fabric-which would promote a better synchrony in terms of economy and sustainability. For interpreting the data, the methodology and tools of the Theory of the Social Logic of Space were used, by means of axial maps, researching the relationship between the constructed and empty (public spaces) areas of the urban structures. Based on the findings, meaningful differences between the subway systems and the configuration of urban spaces were observed, as a product of specific design matrixes. In Lisbon, the mobility associated to the subway seems to be encouraged by the integration of the system with the potential for movement provided by the urban tissue (making the secondary centralities articulated with the subway stations more dynamic). In Brasilia, however, there are several difficulties for such mobility, due to the predominant role of the empty spaces in the city which weakens the gathering potential of such areas, despite the fact that such articulation with secondary centralities is also present there.

达芬奇机器人(Xi)辅助下直肠前切除术(NOSES-Ⅳ式)

达芬奇机器人(Xi)系统联合经自然腔道取标本(NOSES)在直肠癌手术中的应用日益成熟和普遍.二者的结合充分发挥了各自的优势,将层面的游离,淋巴的清扫,血管的解剖,神经的保护和无菌、微创理念贯穿始终.因此,机器人下的手术操作,规范的手术流程,经自然腔道取标本的微创模式,为程序化的直肠癌根治手术带来了新的进步.

Construction Technology of Pile Foundation for Subway Tunnel Crossing Bridge

Urban infrastructure has become more complex with the rapid development of urban transportation networks.In urban environments with limited space,construction of facilities like subways and bridges may mutually influence each other,especially when subway construction requires passing under bridges.In such cases,pile foundation replacement technology is often necessary.However,this technology is highly specialized,with a lengthy and risky construction period,and high costs.Personnel must be proficient in key technical aspects to ensure construction quality.This article discusses the technical principle,construction process,and core technology of pile foundation replacement,along with the application of this technology in subway tunnel crossing bridge projects,supported by engineering examples for reference.

Automatic Sensing and Detection for Subway Tunnel Pathologies

Subway tunnels often suffer from surface pathologies such as cracks,corrosion,fractures,peeling,water and sand infiltration,and sudden hazards caused by foreign object intrusions.Installing a mobile visual pathology sensing system at the front end of operating trains is a critical measure to ensure subway safety.Taking leakage as the typical pathology,a tunnel pathology automatic visual detection method based on Deeplabv3+(ASTPDS)was proposed to achieve automatic and high-precision detection and pixel-level morphology extraction of pathologies.Compared with similar methods,this approach showed significant advantages and achieved a detection accuracy of 93.12%,surpassing FCN and U-Net.Moreover,it also exceeded the recall rates for detecting leaks of FCN and U-Net by 8.33%and 8.19%,respectively.

Discussion on Construction Technology of Subway Tunnel Expansion under Bridge Foundation

As the urban populations grow,the number and size of subway construction projects are increasing while also meeting higher construction standards.So,subway construction projects must have a better understanding of construction technology.This article focuses on the construction technology of the subway tunnel expansion under the bridge foundation.By analyzing the engineering characteristics of the bridge foundation and using a project as an example,this article provides a detailed discussion of the construction process of tunnel expansion under a bridge foundation.This article aims to serve as a reference for subway tunnel construction in China to ensure the key points of construction technology are understood,thus improving construction quality and laying a solid technical foundation for the sustainable development of urban rail engineering.

杜梨LRR-XI-a亚家族的鉴定及调控腐烂病抗性的成员筛选

为探究LRR-XI-a基因家族在杜梨免疫系统中的作用机制,基于GDR数据库的杜梨基因组数据鉴定了杜梨LRR-XI-a家族成员,经进化特征、基因重复事件和表达模式分析筛选了响应腐烂病信号的成员,并结合果实瞬时表达和抗性基因表达分析对部分成员的功能进行了初步分析。结果表明,杜梨LRR-XI-a基因家族包含91个成员,进化上可分为6个亚组。基因重复分析结果表明,杜梨中GroupⅠ成员数的迅速增加可能由串联复制(TD)和全基因组复制(WGD)共同导致,而GroupⅥ成员的增加仅由WGD所致。顺式作用元件分析结果表明,杜梨LRR-XI-a亚组Ⅱ和Ⅵ可能主要参与杜梨对非生物逆境信号的响应,而其余4个亚组同时参与对生物和非生物逆境信号的响应。表达分析结果表明,LRR-XI-4和LRR-XI-5在腐烂病侵染后呈不同程度的上调表达,其中LRR-XI-5上调表达量可达对照的586倍以上。果实瞬时表达分析结果表明,过表达LRR-XI-4和LRR-XI-5降低了梨果实对腐烂病的抗性,抑制了JA信号通路基因的表达,但激活了超敏反应响应基因的表达。综上,基因重复导致杜梨LRR-XI-a家族成员发生迅速增加;LRR-XI-a家族成员响应不同的生物胁迫和非生物胁迫;LRR-XI-4和LRR-XI-5通过激活超敏反应(HR)相关基因的表达负调控腐烂病抗性,可作为后期腐烂病抗性研究的候选基因。本研究结果为后续开展梨抗病机理研究和分子育种奠定了基础。

牛凝血因子XI基因15bp插入突变的分子检测及基因频率分析

牛凝血因子XI基因第9外显子15bp插入突变是近年在日本和牛中发现的一种遗传缺陷,导致凝血因子活性降低。为了分析该缺陷基因在我国牛群中的携带频率,本研究开发了能灵敏检测该突变的2种新方法,即毛细管电泳法和等位基因特异性扩增法,并检测了我国引进的和牛种公牛、1个含和牛血液的杂交育种群和商品群、4个国内地方品种(鲁西牛、延边牛、蒙古牛、复州牛)、2个培育品种(中国荷斯坦牛、新疆褐牛)和6个国外品种(西门塔尔、夏洛来、利木赞、安格斯、蒙贝利亚、挪威红牛)样品共452头份。结果显示,在和牛、含和牛血液的杂交育种群及商品群中突变基因频率分别为0.182、0.389和0.242,在延边牛中发现1头携带者,而在其余群体中均未检出,推测该突变可能只存在于东北亚和我国东北地区牛群中。今后我国在引进和牛用于杂交改良以及本地牛选育中需要对该突变进行分子检测和逐步淘汰,从而降低不利等位基因的频率。

The Study on Tourist Destination Tourism Image Perception and Evaluation in Xi'an City

[Objective] The aim was to explore the tourist destination image measurement method, and have an empirical study on Xi＇an City. [Method] With combination of non-structural and structured approach to design questionnaires, tourism image of Xi＇an was explored using the SPSS software from both the qualitative and quantitative analyses. [Result] Xi＇an tourism images serve a heritage historical monuments atmosphere with the Terracotta Warriors, City Wall, Big Wild Goose Pagoda,Huaqing Hot Springs, presenting a positive feeling among tourists in general. In the dissemination of travel, tourism infrastructure construction, tourism transportation,travel services have negative effects on the image of Xi＇an tourism. [Conclusion]The evaluation on the tourism resources is highly spoken of by tourists than the scenic spot, indicating that despite high visibility of tourism resources in Xi＇an, it has not formed strong core competitiveness and a complete tourism industrial chain. It is necessary to take the right marketing strategies to enhance tourist familiarity to Xi＇an. Tourists demands, therefore, should be well considered in developing Xi＇an scenic spots and new tourism products and projects be focused on to improve tourists＇ satisfaction.

Development Strategies for Modern Agricultural Logistics in Xi'an Based on Systematic Diynamics

[Objective] The devlopmental stratagies for modern agricultural logistics industry in Xi’an were studied based on system dynamics.[Method] By dint of system dynamics,reality analysis and relevant data were applied to support the exploration of each factor for the development of modern agricultural logistics industry.In the meantime,according to the concrete data,the systematic dynamics model was set up based on the third party logistics and Xi’an agricultural economy cooperation.In addition,each influencing factor was expounded.[Result] The agricultural production,logistics requirement and logistics supply in Xi’an City were increasing;the idea of reducing the cost through improving agricultural logistics requirement was not ideal;the increasing input to agricultural logistics can reduce cost and can promote the development of economy;the third party increasing investment can reduce cost and accelerate economic development.[Conclusion] It provided theoretical basis for the adjustment of economic structure.

The Preliminary Study of Certain Pharmacological Effects of Xi Xin Oil

细辛油能松弛兔离体主动脉条,使去甲肾上腺素所致主动脉收缩的量效曲线右移并效能降低;使离体兔耳灌流量减少;能延长小鼠常压耐缺氧时间;用其1/2 LD_(50)之剂量腹腔注射给药3天,可致小鼠骨髓微核形成增加。