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Anticancer Activity of Total Flavonoids Isolated from Xianhe Yanling Recipe(仙鹤延龄方) 被引量:2
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作者 刘培勋 高境 +3 位作者 陈毓杰 龙伟 沈秀 唐卫生 《Chinese Journal of Integrative Medicine》 SCIE CAS 2011年第6期459-463,共5页
Objective:To investigate the anticancer activity of the total flavonoids isolated from a herbal formula,Xianhe Yanling Recipe(仙鹤延龄方),a recipe commonly used in cancer patients in China.Methods: The in vitro an... Objective:To investigate the anticancer activity of the total flavonoids isolated from a herbal formula,Xianhe Yanling Recipe(仙鹤延龄方),a recipe commonly used in cancer patients in China.Methods: The in vitro anticancer activity of the total flavonoids was determined using the 3-(4,5-dimethylthiazole-2-yl)-2,5- diphenyltetrazolium bromide(MTT) assay on three cancer cell lines:MCF-7(a human breast adenocarcinoma cell line),HepG-2(a human hepatocellular carcinoma cell line) and ES-2(a human ovarian cancer cell line). The in vivo anticancer effect of the total flavonoids was assessed in a mouse tumor model bearing H22-induced hepatocellular carcinoma,and cisplatin was used as a positive control.Results:The total flavonoids exerted a powerful inhibitory effect on the three cell lines,with 50%inhibiting concentrations(IC_(50)) of 24.948,31.569 and 6.923μg/mL,respectively.In vivo studies showed that the total flavonoids had dose-dependent inhibitory effects on hepatocellular carcinoma in mice.Conclusion:The total flavonoids from Xianhe Yanling Recipe have potential anticancer activity,and further researches and development are warranted. 展开更多
关键词 ANTICANCER flavonoids xianhe Yanling Recipe 3-(4 5-dimethylthiazole-2-yl)-2 5-diphenyltetrazolium bromide assay in vivo
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