OBJECTIVE: To assess the effectiveness and safety of Xianling Gubao(XLGB) Capsule in the treatment of osteoporotic fracture(OF). METHODS: Published articles from eight Chinese and English databases were searched from ...OBJECTIVE: To assess the effectiveness and safety of Xianling Gubao(XLGB) Capsule in the treatment of osteoporotic fracture(OF). METHODS: Published articles from eight Chinese and English databases were searched from inception to August 2017. Clinical trials were selected according to inclusion criteria and exclusion criteria. Risk evaluation tool was used to assess the quality of studies. Data was extracted and meta-analysis was performed by RevMan5.3 software. RESULTS: A total of 229 articles were searched, and 27 were included for study with 2292 samples,including 1152 cases in the experiment group and 1140 cases in the control group. For patients with four limbs OF,XLGB Capsule combined with manipulation reposition with plaster external fixation can shorten healing time of fracture[MD=–0.77, 95% CI(–1.25, –0.30)], increase bone mineral density(BMD) [MD=0.17, 95% CI(0.10, 0.25)], blood calcium content [MD=0.52, 95% CI(0.38, 0.64)], phosphorous content in serum [MD=0.28, 95% CI(0.21, 0.35)], and alkaline phosphatase content [SMD=–5.24, 95% CI(–3.45, –2.42)]. In the treatment of spine OF, XLGB Capsule had no significant effects on reducing re-fracture rate of non-surgical vertebral body, but it could postpone the interval time of refracture of non-surgical vertebral bodies [RR=0.71, 95% CI(0.23, 2.18)]. Combined treatment with XLGB Capsule could improve clinical effective rate [RR=1.17, 95% CI(1.11, 1.23)]. Both alone and combined application of XLGB Capsule could increase BMD and calcitonin content of patients with spine OF. Combined application of calcium or medicine that regulating calcium metabolism was faster in reducing Cobb angle of centrum kyphosis than application alone [MD=–2.68,95% CI(–3.72, –2.12)]. Alone or combined application showed no significant effects on osteoporotic pain. The adverse reactions reported in the study were mainly the digestive system damage. CONCLUSIONS: XLGB Capsule alone or combine with other western medicine had better efficacy in treating OF than western medicine treatment alone. However,there was potential bias in the included studies, so the conclusion still needed further high quality randomized controlled trials to improve the evidence level.展开更多
Objective:A typical case of Xianling Gubao(XLGB)Tablets-induced liver injury was systematically studied in the clinic and the laboratory.Methods:A patient with herb-induced liver injury(HILI)and a history of taking XL...Objective:A typical case of Xianling Gubao(XLGB)Tablets-induced liver injury was systematically studied in the clinic and the laboratory.Methods:A patient with herb-induced liver injury(HILI)and a history of taking XLGB Tablets before disease onset was engaged as the study subject,and the case was diagnosed according to the updated Roussel Uclaf Causality Assessment Method(RUCAM)and the integrated evidence chain(iEC)method recommended by the Guidelines for Diagnosis and Treatment of Herb-induced Liver Injury(HILI Guidelines).Results:Clinical history,biochemical indexes and imaging tests were used to exclude the influence of fundamental diseases and confusing liver diseases such as viral,alcoholic and autoimmune liver diseases on the diagnosis.Based on an investigation of the patient’s medication history,she was suspected to have HILI caused by XLGB Tablets,as the patient was only taking an oral preparation of XLGB Tablets,and the influence of other drugs on the diagnosis was excluded.This patient with alanine aminotransferase(ALT)3 upper limit of normal(ULN)and a calculated R of 6 was diagnosed with possible acute drug-induced hepatocellular injury.The relationship was considered“highly probable”(score of 9)using the updated RUCAM of 2016.Moreover,the fingerprint similarity between the preparation taken by the patient and a commercially available preparation was 0.99,suggesting that the patient was consuming XLGB Tablets rather than another drug.LC-MS technology and the Agilent Fake TCM-Drugs database were used to investigate the drug,and no chemical additions were found.Examination of the drug for pesticide residues,heavy metals,aflatoxins and other exogenous substances indicated compliance with the content limits of the Chinese Pharmacopoeia.Conclusion:In summary,the final diagnosis of XLGB-induced liver injury reached the clinical diagnosis of HILI and was acute severe hepatocellular injury type by the updated RUCAM and iEC.Therefore,this study provides scientific evidence regarding the causality evaluation of compound preparations of traditional Chinese medicines-induced liver injury.展开更多
Objective:To study the effect of Xianling Gubao-assisted surgical treatment on postoperative healing, calcium and phosphorus contents as well as bone metabolism in elderly women with Colles fracture.Methods:A total of...Objective:To study the effect of Xianling Gubao-assisted surgical treatment on postoperative healing, calcium and phosphorus contents as well as bone metabolism in elderly women with Colles fracture.Methods:A total of 96 elderly female patients with Colles fracture treated in our hospital between June 2013 and December 2015 were selected and randomly divided into two groups, the observation group of patients received Xianling Gubao capsule combined with manual reduction and plaster external fixation therapy, and control group of patients only received reduction and external fixation therapy. The fracture healing time was followed up after treatment, and 3 months after treatment, serum was collected to determine the content of calcium-phosphorus metabolism indexes and bone metabolism indexes.Results:The fracture healing time of observation group was significantly shorter than that of control group;1 month and 3 months after treatment, serum Ca, P, ALP, IGF-1, PDGF, BGP and PICP levels of both groups were significantly higher than those before treatment while CTX-1, tPINP and TRACP-5b levels were significantly lower than those before treatment;serum Ca, P, ALP, IGF-1, PDGF, BGP and PICP levels of observation group after treatment were significantly higher than those of control group while CTX-1, tPINP and TRACP-5b levels were significantly lower than those of control group.Conclusion:Adjuvant Xianling Gubao capsule therapy can promote the Colles fracture healing in elderly women, also improve calcium-phosphorus metabolism, promote bone formation and inhibit bone resorption.展开更多
Objective:To explore the repair and treatment effect of Quan Du Zhong capsule on necrosis of femoral head in dogs.Methods:Totally 12 beagles were randomly divided into normal group,model group,Quan Du Zhong capsule gr...Objective:To explore the repair and treatment effect of Quan Du Zhong capsule on necrosis of femoral head in dogs.Methods:Totally 12 beagles were randomly divided into normal group,model group,Quan Du Zhong capsule group and Xianlinggubao capsule group,with three in each group.In addition to the normal group,the other groups established the femoral head necrosis model by liquid nitrogen alternative freezing.The normal group and the model group did not have any intervention during the modeling period,and the Quan Du Zhong group began to receive the Quan Du Zhong by gavage on the day of modeling;Xianlinggubao capsule group was given Xianlinggubao capsule by gavage once a day for 12 consecutive weeks on the day of modeling.The levels of VEGF and bFGF in the blood vessels of each group at the 12th week were compared,and the ratios of BMD,BS/BV,BV/TV,Tb.Th,Tb.N were measured by Micro CT,and the expressions of Bcl-2,Bax,Caspase-3 proteins were detected by immune reaction.Results:1.Compared with the normal group,the level of serum VEGF and bFGF in the model group decreased after 12 weeks of modeling(P<0.05);Compared with the model group,the levels of serum VEGF and bFGF water in the Xianlinggubao capsule group and the Quan Du Zhong capsule group increased on average at the 12th week of modeling,with statistical difference(P<0.05).The level of the Quan Du Zhong capsule group was the highest,followed by the Xianlinggubao capsule group.2.Compared with the normal group,BMD,BS/BV,BV/TV,Tb.Th and Tb.N in the model group were lower,and Tb.SP were higher,the results were statistically significant(P<0.05).Compared with the model group,the BMD,BV/TV,Tb.Th and Tb.N of Xianlinggubao capsule group and the total eucommia capsule group increased,while the BS/BV and Tb.SP decreased(P<0.05).3.The Quan Du Zhong capsule group and Xianlinggubao capsule group could significantly increase the expression of bcl-2 protein in the femoral head of dogs,which was significantly different from the model group(P<0.05).The expression of bax protein in the femoral head of dogs in the Quan Du Zhong capsule group and the Xianlinggubao capsule group was significantly reduced compared with the model group(P<0.05).The expression of caspase-3 protein in the femoral head of dogs was significantly reduced in the Quan Du Zhong capsule group and Xianlinggubao capsule group,which was significantly different from the model group(P<0.05).Conclusion:Quan Du Zhong capsule can increase the expression of VEGF and bFGF in serum,increase the expression of bcl-2,inhibit the expression of bax,and reduce the expression of caspase-3,which plays a synergistic role in the treatment of avascular necrosis of the femoral head,and has potential targets.展开更多
目的探究仙灵骨葆胶囊联合阿仑膦酸钠治疗老年骨质疏松性压缩性骨折的临床效果。方法研究纳入77例老年骨质疏松性压缩性骨折患者,以随机数字表法将77例患者分成对照组(38例)与观察组(39例),对照组患者采用手术、术后服用阿仑膦酸钠治疗...目的探究仙灵骨葆胶囊联合阿仑膦酸钠治疗老年骨质疏松性压缩性骨折的临床效果。方法研究纳入77例老年骨质疏松性压缩性骨折患者,以随机数字表法将77例患者分成对照组(38例)与观察组(39例),对照组患者采用手术、术后服用阿仑膦酸钠治疗,观察组患者在对照组治疗的基础上联合应用仙灵骨葆胶囊,比较2组患者的治疗效果及不良反应和并发症的发生率;比较治疗前后视觉模拟评分(visual analogue scale,VAS)、活动能力评分及日本骨科协会评估治疗分数(Japanese orthopaedic association scores,JOA)、椎体高度变化及后凸角度、骨钙素(bone Gla-protein,BGP)和骨碱性磷酸酶(bone alkaline phosphatase,BALP)水平及骨密度(bone mineral density,BMD);比较生活质量综合评定问卷(generic quality of life inventory 74,GQOL-74)评分。结果与对照组(81.58%)相比,观察组的有效率(97.44%)更高(P<0.05);观察组与对照组患者不良反应和并发症的发生情况比较,差异无统计学意义(P>0.05);治疗后2组患者的VAS、活动能力评分、JOA、BGP、BALP、BMD、GQOL-74评分均改善,与对照组相比,观察组患者VAS、活动能力评分、JOA、BGP、BALP、BMD、GQOL-74评分的改善更加明显(P<0.05)。结论仙灵骨葆胶囊联合阿仑膦酸钠治疗老年骨质疏松性压缩性骨折的临床效果显著,患者恢复较好,生活质量得到提升。展开更多
文摘OBJECTIVE: To assess the effectiveness and safety of Xianling Gubao(XLGB) Capsule in the treatment of osteoporotic fracture(OF). METHODS: Published articles from eight Chinese and English databases were searched from inception to August 2017. Clinical trials were selected according to inclusion criteria and exclusion criteria. Risk evaluation tool was used to assess the quality of studies. Data was extracted and meta-analysis was performed by RevMan5.3 software. RESULTS: A total of 229 articles were searched, and 27 were included for study with 2292 samples,including 1152 cases in the experiment group and 1140 cases in the control group. For patients with four limbs OF,XLGB Capsule combined with manipulation reposition with plaster external fixation can shorten healing time of fracture[MD=–0.77, 95% CI(–1.25, –0.30)], increase bone mineral density(BMD) [MD=0.17, 95% CI(0.10, 0.25)], blood calcium content [MD=0.52, 95% CI(0.38, 0.64)], phosphorous content in serum [MD=0.28, 95% CI(0.21, 0.35)], and alkaline phosphatase content [SMD=–5.24, 95% CI(–3.45, –2.42)]. In the treatment of spine OF, XLGB Capsule had no significant effects on reducing re-fracture rate of non-surgical vertebral body, but it could postpone the interval time of refracture of non-surgical vertebral bodies [RR=0.71, 95% CI(0.23, 2.18)]. Combined treatment with XLGB Capsule could improve clinical effective rate [RR=1.17, 95% CI(1.11, 1.23)]. Both alone and combined application of XLGB Capsule could increase BMD and calcitonin content of patients with spine OF. Combined application of calcium or medicine that regulating calcium metabolism was faster in reducing Cobb angle of centrum kyphosis than application alone [MD=–2.68,95% CI(–3.72, –2.12)]. Alone or combined application showed no significant effects on osteoporotic pain. The adverse reactions reported in the study were mainly the digestive system damage. CONCLUSIONS: XLGB Capsule alone or combine with other western medicine had better efficacy in treating OF than western medicine treatment alone. However,there was potential bias in the included studies, so the conclusion still needed further high quality randomized controlled trials to improve the evidence level.
基金supported by the National Natural Science Foundation of China(No.82174071).
文摘Objective:A typical case of Xianling Gubao(XLGB)Tablets-induced liver injury was systematically studied in the clinic and the laboratory.Methods:A patient with herb-induced liver injury(HILI)and a history of taking XLGB Tablets before disease onset was engaged as the study subject,and the case was diagnosed according to the updated Roussel Uclaf Causality Assessment Method(RUCAM)and the integrated evidence chain(iEC)method recommended by the Guidelines for Diagnosis and Treatment of Herb-induced Liver Injury(HILI Guidelines).Results:Clinical history,biochemical indexes and imaging tests were used to exclude the influence of fundamental diseases and confusing liver diseases such as viral,alcoholic and autoimmune liver diseases on the diagnosis.Based on an investigation of the patient’s medication history,she was suspected to have HILI caused by XLGB Tablets,as the patient was only taking an oral preparation of XLGB Tablets,and the influence of other drugs on the diagnosis was excluded.This patient with alanine aminotransferase(ALT)3 upper limit of normal(ULN)and a calculated R of 6 was diagnosed with possible acute drug-induced hepatocellular injury.The relationship was considered“highly probable”(score of 9)using the updated RUCAM of 2016.Moreover,the fingerprint similarity between the preparation taken by the patient and a commercially available preparation was 0.99,suggesting that the patient was consuming XLGB Tablets rather than another drug.LC-MS technology and the Agilent Fake TCM-Drugs database were used to investigate the drug,and no chemical additions were found.Examination of the drug for pesticide residues,heavy metals,aflatoxins and other exogenous substances indicated compliance with the content limits of the Chinese Pharmacopoeia.Conclusion:In summary,the final diagnosis of XLGB-induced liver injury reached the clinical diagnosis of HILI and was acute severe hepatocellular injury type by the updated RUCAM and iEC.Therefore,this study provides scientific evidence regarding the causality evaluation of compound preparations of traditional Chinese medicines-induced liver injury.
文摘Objective:To study the effect of Xianling Gubao-assisted surgical treatment on postoperative healing, calcium and phosphorus contents as well as bone metabolism in elderly women with Colles fracture.Methods:A total of 96 elderly female patients with Colles fracture treated in our hospital between June 2013 and December 2015 were selected and randomly divided into two groups, the observation group of patients received Xianling Gubao capsule combined with manual reduction and plaster external fixation therapy, and control group of patients only received reduction and external fixation therapy. The fracture healing time was followed up after treatment, and 3 months after treatment, serum was collected to determine the content of calcium-phosphorus metabolism indexes and bone metabolism indexes.Results:The fracture healing time of observation group was significantly shorter than that of control group;1 month and 3 months after treatment, serum Ca, P, ALP, IGF-1, PDGF, BGP and PICP levels of both groups were significantly higher than those before treatment while CTX-1, tPINP and TRACP-5b levels were significantly lower than those before treatment;serum Ca, P, ALP, IGF-1, PDGF, BGP and PICP levels of observation group after treatment were significantly higher than those of control group while CTX-1, tPINP and TRACP-5b levels were significantly lower than those of control group.Conclusion:Adjuvant Xianling Gubao capsule therapy can promote the Colles fracture healing in elderly women, also improve calcium-phosphorus metabolism, promote bone formation and inhibit bone resorption.
基金Liaoning Provincial Science and Technology Plan Project(No.2017225043)。
文摘Objective:To explore the repair and treatment effect of Quan Du Zhong capsule on necrosis of femoral head in dogs.Methods:Totally 12 beagles were randomly divided into normal group,model group,Quan Du Zhong capsule group and Xianlinggubao capsule group,with three in each group.In addition to the normal group,the other groups established the femoral head necrosis model by liquid nitrogen alternative freezing.The normal group and the model group did not have any intervention during the modeling period,and the Quan Du Zhong group began to receive the Quan Du Zhong by gavage on the day of modeling;Xianlinggubao capsule group was given Xianlinggubao capsule by gavage once a day for 12 consecutive weeks on the day of modeling.The levels of VEGF and bFGF in the blood vessels of each group at the 12th week were compared,and the ratios of BMD,BS/BV,BV/TV,Tb.Th,Tb.N were measured by Micro CT,and the expressions of Bcl-2,Bax,Caspase-3 proteins were detected by immune reaction.Results:1.Compared with the normal group,the level of serum VEGF and bFGF in the model group decreased after 12 weeks of modeling(P<0.05);Compared with the model group,the levels of serum VEGF and bFGF water in the Xianlinggubao capsule group and the Quan Du Zhong capsule group increased on average at the 12th week of modeling,with statistical difference(P<0.05).The level of the Quan Du Zhong capsule group was the highest,followed by the Xianlinggubao capsule group.2.Compared with the normal group,BMD,BS/BV,BV/TV,Tb.Th and Tb.N in the model group were lower,and Tb.SP were higher,the results were statistically significant(P<0.05).Compared with the model group,the BMD,BV/TV,Tb.Th and Tb.N of Xianlinggubao capsule group and the total eucommia capsule group increased,while the BS/BV and Tb.SP decreased(P<0.05).3.The Quan Du Zhong capsule group and Xianlinggubao capsule group could significantly increase the expression of bcl-2 protein in the femoral head of dogs,which was significantly different from the model group(P<0.05).The expression of bax protein in the femoral head of dogs in the Quan Du Zhong capsule group and the Xianlinggubao capsule group was significantly reduced compared with the model group(P<0.05).The expression of caspase-3 protein in the femoral head of dogs was significantly reduced in the Quan Du Zhong capsule group and Xianlinggubao capsule group,which was significantly different from the model group(P<0.05).Conclusion:Quan Du Zhong capsule can increase the expression of VEGF and bFGF in serum,increase the expression of bcl-2,inhibit the expression of bax,and reduce the expression of caspase-3,which plays a synergistic role in the treatment of avascular necrosis of the femoral head,and has potential targets.
文摘目的探究仙灵骨葆胶囊联合阿仑膦酸钠治疗老年骨质疏松性压缩性骨折的临床效果。方法研究纳入77例老年骨质疏松性压缩性骨折患者,以随机数字表法将77例患者分成对照组(38例)与观察组(39例),对照组患者采用手术、术后服用阿仑膦酸钠治疗,观察组患者在对照组治疗的基础上联合应用仙灵骨葆胶囊,比较2组患者的治疗效果及不良反应和并发症的发生率;比较治疗前后视觉模拟评分(visual analogue scale,VAS)、活动能力评分及日本骨科协会评估治疗分数(Japanese orthopaedic association scores,JOA)、椎体高度变化及后凸角度、骨钙素(bone Gla-protein,BGP)和骨碱性磷酸酶(bone alkaline phosphatase,BALP)水平及骨密度(bone mineral density,BMD);比较生活质量综合评定问卷(generic quality of life inventory 74,GQOL-74)评分。结果与对照组(81.58%)相比,观察组的有效率(97.44%)更高(P<0.05);观察组与对照组患者不良反应和并发症的发生情况比较,差异无统计学意义(P>0.05);治疗后2组患者的VAS、活动能力评分、JOA、BGP、BALP、BMD、GQOL-74评分均改善,与对照组相比,观察组患者VAS、活动能力评分、JOA、BGP、BALP、BMD、GQOL-74评分的改善更加明显(P<0.05)。结论仙灵骨葆胶囊联合阿仑膦酸钠治疗老年骨质疏松性压缩性骨折的临床效果显著,患者恢复较好,生活质量得到提升。
