OBJECTIVE: To assess the effectiveness and safety of Xianling Gubao(XLGB) Capsule in the treatment of osteoporotic fracture(OF). METHODS: Published articles from eight Chinese and English databases were searched from ...OBJECTIVE: To assess the effectiveness and safety of Xianling Gubao(XLGB) Capsule in the treatment of osteoporotic fracture(OF). METHODS: Published articles from eight Chinese and English databases were searched from inception to August 2017. Clinical trials were selected according to inclusion criteria and exclusion criteria. Risk evaluation tool was used to assess the quality of studies. Data was extracted and meta-analysis was performed by RevMan5.3 software. RESULTS: A total of 229 articles were searched, and 27 were included for study with 2292 samples,including 1152 cases in the experiment group and 1140 cases in the control group. For patients with four limbs OF,XLGB Capsule combined with manipulation reposition with plaster external fixation can shorten healing time of fracture[MD=–0.77, 95% CI(–1.25, –0.30)], increase bone mineral density(BMD) [MD=0.17, 95% CI(0.10, 0.25)], blood calcium content [MD=0.52, 95% CI(0.38, 0.64)], phosphorous content in serum [MD=0.28, 95% CI(0.21, 0.35)], and alkaline phosphatase content [SMD=–5.24, 95% CI(–3.45, –2.42)]. In the treatment of spine OF, XLGB Capsule had no significant effects on reducing re-fracture rate of non-surgical vertebral body, but it could postpone the interval time of refracture of non-surgical vertebral bodies [RR=0.71, 95% CI(0.23, 2.18)]. Combined treatment with XLGB Capsule could improve clinical effective rate [RR=1.17, 95% CI(1.11, 1.23)]. Both alone and combined application of XLGB Capsule could increase BMD and calcitonin content of patients with spine OF. Combined application of calcium or medicine that regulating calcium metabolism was faster in reducing Cobb angle of centrum kyphosis than application alone [MD=–2.68,95% CI(–3.72, –2.12)]. Alone or combined application showed no significant effects on osteoporotic pain. The adverse reactions reported in the study were mainly the digestive system damage. CONCLUSIONS: XLGB Capsule alone or combine with other western medicine had better efficacy in treating OF than western medicine treatment alone. However,there was potential bias in the included studies, so the conclusion still needed further high quality randomized controlled trials to improve the evidence level.展开更多
Objective:To study the effect of Xianling Gubao-assisted surgical treatment on postoperative healing, calcium and phosphorus contents as well as bone metabolism in elderly women with Colles fracture.Methods:A total of...Objective:To study the effect of Xianling Gubao-assisted surgical treatment on postoperative healing, calcium and phosphorus contents as well as bone metabolism in elderly women with Colles fracture.Methods:A total of 96 elderly female patients with Colles fracture treated in our hospital between June 2013 and December 2015 were selected and randomly divided into two groups, the observation group of patients received Xianling Gubao capsule combined with manual reduction and plaster external fixation therapy, and control group of patients only received reduction and external fixation therapy. The fracture healing time was followed up after treatment, and 3 months after treatment, serum was collected to determine the content of calcium-phosphorus metabolism indexes and bone metabolism indexes.Results:The fracture healing time of observation group was significantly shorter than that of control group;1 month and 3 months after treatment, serum Ca, P, ALP, IGF-1, PDGF, BGP and PICP levels of both groups were significantly higher than those before treatment while CTX-1, tPINP and TRACP-5b levels were significantly lower than those before treatment;serum Ca, P, ALP, IGF-1, PDGF, BGP and PICP levels of observation group after treatment were significantly higher than those of control group while CTX-1, tPINP and TRACP-5b levels were significantly lower than those of control group.Conclusion:Adjuvant Xianling Gubao capsule therapy can promote the Colles fracture healing in elderly women, also improve calcium-phosphorus metabolism, promote bone formation and inhibit bone resorption.展开更多
Objective:To explore the repair and treatment effect of Quan Du Zhong capsule on necrosis of femoral head in dogs.Methods:Totally 12 beagles were randomly divided into normal group,model group,Quan Du Zhong capsule gr...Objective:To explore the repair and treatment effect of Quan Du Zhong capsule on necrosis of femoral head in dogs.Methods:Totally 12 beagles were randomly divided into normal group,model group,Quan Du Zhong capsule group and Xianlinggubao capsule group,with three in each group.In addition to the normal group,the other groups established the femoral head necrosis model by liquid nitrogen alternative freezing.The normal group and the model group did not have any intervention during the modeling period,and the Quan Du Zhong group began to receive the Quan Du Zhong by gavage on the day of modeling;Xianlinggubao capsule group was given Xianlinggubao capsule by gavage once a day for 12 consecutive weeks on the day of modeling.The levels of VEGF and bFGF in the blood vessels of each group at the 12th week were compared,and the ratios of BMD,BS/BV,BV/TV,Tb.Th,Tb.N were measured by Micro CT,and the expressions of Bcl-2,Bax,Caspase-3 proteins were detected by immune reaction.Results:1.Compared with the normal group,the level of serum VEGF and bFGF in the model group decreased after 12 weeks of modeling(P<0.05);Compared with the model group,the levels of serum VEGF and bFGF water in the Xianlinggubao capsule group and the Quan Du Zhong capsule group increased on average at the 12th week of modeling,with statistical difference(P<0.05).The level of the Quan Du Zhong capsule group was the highest,followed by the Xianlinggubao capsule group.2.Compared with the normal group,BMD,BS/BV,BV/TV,Tb.Th and Tb.N in the model group were lower,and Tb.SP were higher,the results were statistically significant(P<0.05).Compared with the model group,the BMD,BV/TV,Tb.Th and Tb.N of Xianlinggubao capsule group and the total eucommia capsule group increased,while the BS/BV and Tb.SP decreased(P<0.05).3.The Quan Du Zhong capsule group and Xianlinggubao capsule group could significantly increase the expression of bcl-2 protein in the femoral head of dogs,which was significantly different from the model group(P<0.05).The expression of bax protein in the femoral head of dogs in the Quan Du Zhong capsule group and the Xianlinggubao capsule group was significantly reduced compared with the model group(P<0.05).The expression of caspase-3 protein in the femoral head of dogs was significantly reduced in the Quan Du Zhong capsule group and Xianlinggubao capsule group,which was significantly different from the model group(P<0.05).Conclusion:Quan Du Zhong capsule can increase the expression of VEGF and bFGF in serum,increase the expression of bcl-2,inhibit the expression of bax,and reduce the expression of caspase-3,which plays a synergistic role in the treatment of avascular necrosis of the femoral head,and has potential targets.展开更多
文摘OBJECTIVE: To assess the effectiveness and safety of Xianling Gubao(XLGB) Capsule in the treatment of osteoporotic fracture(OF). METHODS: Published articles from eight Chinese and English databases were searched from inception to August 2017. Clinical trials were selected according to inclusion criteria and exclusion criteria. Risk evaluation tool was used to assess the quality of studies. Data was extracted and meta-analysis was performed by RevMan5.3 software. RESULTS: A total of 229 articles were searched, and 27 were included for study with 2292 samples,including 1152 cases in the experiment group and 1140 cases in the control group. For patients with four limbs OF,XLGB Capsule combined with manipulation reposition with plaster external fixation can shorten healing time of fracture[MD=–0.77, 95% CI(–1.25, –0.30)], increase bone mineral density(BMD) [MD=0.17, 95% CI(0.10, 0.25)], blood calcium content [MD=0.52, 95% CI(0.38, 0.64)], phosphorous content in serum [MD=0.28, 95% CI(0.21, 0.35)], and alkaline phosphatase content [SMD=–5.24, 95% CI(–3.45, –2.42)]. In the treatment of spine OF, XLGB Capsule had no significant effects on reducing re-fracture rate of non-surgical vertebral body, but it could postpone the interval time of refracture of non-surgical vertebral bodies [RR=0.71, 95% CI(0.23, 2.18)]. Combined treatment with XLGB Capsule could improve clinical effective rate [RR=1.17, 95% CI(1.11, 1.23)]. Both alone and combined application of XLGB Capsule could increase BMD and calcitonin content of patients with spine OF. Combined application of calcium or medicine that regulating calcium metabolism was faster in reducing Cobb angle of centrum kyphosis than application alone [MD=–2.68,95% CI(–3.72, –2.12)]. Alone or combined application showed no significant effects on osteoporotic pain. The adverse reactions reported in the study were mainly the digestive system damage. CONCLUSIONS: XLGB Capsule alone or combine with other western medicine had better efficacy in treating OF than western medicine treatment alone. However,there was potential bias in the included studies, so the conclusion still needed further high quality randomized controlled trials to improve the evidence level.
文摘Objective:To study the effect of Xianling Gubao-assisted surgical treatment on postoperative healing, calcium and phosphorus contents as well as bone metabolism in elderly women with Colles fracture.Methods:A total of 96 elderly female patients with Colles fracture treated in our hospital between June 2013 and December 2015 were selected and randomly divided into two groups, the observation group of patients received Xianling Gubao capsule combined with manual reduction and plaster external fixation therapy, and control group of patients only received reduction and external fixation therapy. The fracture healing time was followed up after treatment, and 3 months after treatment, serum was collected to determine the content of calcium-phosphorus metabolism indexes and bone metabolism indexes.Results:The fracture healing time of observation group was significantly shorter than that of control group;1 month and 3 months after treatment, serum Ca, P, ALP, IGF-1, PDGF, BGP and PICP levels of both groups were significantly higher than those before treatment while CTX-1, tPINP and TRACP-5b levels were significantly lower than those before treatment;serum Ca, P, ALP, IGF-1, PDGF, BGP and PICP levels of observation group after treatment were significantly higher than those of control group while CTX-1, tPINP and TRACP-5b levels were significantly lower than those of control group.Conclusion:Adjuvant Xianling Gubao capsule therapy can promote the Colles fracture healing in elderly women, also improve calcium-phosphorus metabolism, promote bone formation and inhibit bone resorption.
基金Liaoning Provincial Science and Technology Plan Project(No.2017225043)。
文摘Objective:To explore the repair and treatment effect of Quan Du Zhong capsule on necrosis of femoral head in dogs.Methods:Totally 12 beagles were randomly divided into normal group,model group,Quan Du Zhong capsule group and Xianlinggubao capsule group,with three in each group.In addition to the normal group,the other groups established the femoral head necrosis model by liquid nitrogen alternative freezing.The normal group and the model group did not have any intervention during the modeling period,and the Quan Du Zhong group began to receive the Quan Du Zhong by gavage on the day of modeling;Xianlinggubao capsule group was given Xianlinggubao capsule by gavage once a day for 12 consecutive weeks on the day of modeling.The levels of VEGF and bFGF in the blood vessels of each group at the 12th week were compared,and the ratios of BMD,BS/BV,BV/TV,Tb.Th,Tb.N were measured by Micro CT,and the expressions of Bcl-2,Bax,Caspase-3 proteins were detected by immune reaction.Results:1.Compared with the normal group,the level of serum VEGF and bFGF in the model group decreased after 12 weeks of modeling(P<0.05);Compared with the model group,the levels of serum VEGF and bFGF water in the Xianlinggubao capsule group and the Quan Du Zhong capsule group increased on average at the 12th week of modeling,with statistical difference(P<0.05).The level of the Quan Du Zhong capsule group was the highest,followed by the Xianlinggubao capsule group.2.Compared with the normal group,BMD,BS/BV,BV/TV,Tb.Th and Tb.N in the model group were lower,and Tb.SP were higher,the results were statistically significant(P<0.05).Compared with the model group,the BMD,BV/TV,Tb.Th and Tb.N of Xianlinggubao capsule group and the total eucommia capsule group increased,while the BS/BV and Tb.SP decreased(P<0.05).3.The Quan Du Zhong capsule group and Xianlinggubao capsule group could significantly increase the expression of bcl-2 protein in the femoral head of dogs,which was significantly different from the model group(P<0.05).The expression of bax protein in the femoral head of dogs in the Quan Du Zhong capsule group and the Xianlinggubao capsule group was significantly reduced compared with the model group(P<0.05).The expression of caspase-3 protein in the femoral head of dogs was significantly reduced in the Quan Du Zhong capsule group and Xianlinggubao capsule group,which was significantly different from the model group(P<0.05).Conclusion:Quan Du Zhong capsule can increase the expression of VEGF and bFGF in serum,increase the expression of bcl-2,inhibit the expression of bax,and reduce the expression of caspase-3,which plays a synergistic role in the treatment of avascular necrosis of the femoral head,and has potential targets.
