[Objectives]To observe the effect of Xianlinggubao Capsule on osteoporotic vertebral compression fracture(OVCF)in rabbits and the influence mechanism of the repair of fractures.[Methods]Female June age 30 rabbits were...[Objectives]To observe the effect of Xianlinggubao Capsule on osteoporotic vertebral compression fracture(OVCF)in rabbits and the influence mechanism of the repair of fractures.[Methods]Female June age 30 rabbits were randomly divided into control group,model control group and Xianlinggubao group.After bilateral ovariectomy,the model control group and Xianlinggubao group were injected with dexamethasone continuously for 4 weeks,and then the OVCF compound model was established by surgery.The Xianlinggubao group was treated with Xianlinggubao at a dose of 300 mg/(kg·d)for 60 d,while the blank control group and the model control group were treated with the same amount of normal saline for 60 d.The number of blood vessels and the expression of bone morphogenetic protein-2(BMP-2)were detected by immunohistochemical staining and the bone mineral density(BMD)in the callus of the third lumbar fracture area of rabbits was measured.The content of serum phosphorus(P),alkaline phosphatase(ALP)and total calcium(TCa)in rabbit venous blood were measured by automatic biochemical analyzer.The content of vascular endothelial growth factor(VEGF)and platelet-derived growth factor(PDGF)in rabbit venous blood were measured by ELISA kit.[Results]The number of blood vessels and the expression of BMP-2 in the callus of the third lumbar fracture area of rabbits was high in Xianlinggubao group,the content of serum P,ALP,TCa,VEGF and PDGF was obviously increased,BMD was obviously increased,the bone microstructure of the third lumbar vertebrae fracture area of rabbits was basically restored.Compared with the model control group(P<0.05),the difference was statistically significant.[Conclusions]Xianlinggubao Capsule can increase calcium and phosphorus deposition,promote the formation of blood vessels in the fracture area of OVCF in rabbits,and have a strong repair effect on OVCF in rabbits.展开更多
目的系统评价仙灵骨葆胶囊辅助治疗骨质疏松性疼痛的疗效和安全性,以期为临床提供循证参考。方法检索中文科技期刊全文数据库(CNKI)、维普数据库、万方数据库,收集仙灵骨葆胶囊治疗骨质疏松性疼痛的随机对照试验(RCT),评价文献质量并提...目的系统评价仙灵骨葆胶囊辅助治疗骨质疏松性疼痛的疗效和安全性,以期为临床提供循证参考。方法检索中文科技期刊全文数据库(CNKI)、维普数据库、万方数据库,收集仙灵骨葆胶囊治疗骨质疏松性疼痛的随机对照试验(RCT),评价文献质量并提取数据,采用Rev Man 5.3软件进行Meta分析。结果共纳入6项RCT,合计530例患者。Meta分析结果显示,总有效率[RR=1.27,95%CI(1.16,1.40),P<0.000 01],差异具有统计学意义;治疗后疼痛VAS评分[RR=-1.54,95%CI(-2.40,-0.68),P<0.05],差异具有统计学意义;安全性[RR=0.6,95%CI(0.17,2.07),P>0.05],差异无统计学意义。结论仙灵骨葆胶囊辅助治疗骨质疏松性疼痛临床疗效优于对照组,治疗后疼痛程度明显减轻,且联合使用仙灵骨葆胶囊并未增加不良反应的发生。但由于本研究为二次研究,该结论仍有待于进一步证实。展开更多
基金Supported by Shiyan Taihe Hospital Project(2021JJXM084)General Project of Hubei Provincial Health and Health Commission(ZY2021M006).
文摘[Objectives]To observe the effect of Xianlinggubao Capsule on osteoporotic vertebral compression fracture(OVCF)in rabbits and the influence mechanism of the repair of fractures.[Methods]Female June age 30 rabbits were randomly divided into control group,model control group and Xianlinggubao group.After bilateral ovariectomy,the model control group and Xianlinggubao group were injected with dexamethasone continuously for 4 weeks,and then the OVCF compound model was established by surgery.The Xianlinggubao group was treated with Xianlinggubao at a dose of 300 mg/(kg·d)for 60 d,while the blank control group and the model control group were treated with the same amount of normal saline for 60 d.The number of blood vessels and the expression of bone morphogenetic protein-2(BMP-2)were detected by immunohistochemical staining and the bone mineral density(BMD)in the callus of the third lumbar fracture area of rabbits was measured.The content of serum phosphorus(P),alkaline phosphatase(ALP)and total calcium(TCa)in rabbit venous blood were measured by automatic biochemical analyzer.The content of vascular endothelial growth factor(VEGF)and platelet-derived growth factor(PDGF)in rabbit venous blood were measured by ELISA kit.[Results]The number of blood vessels and the expression of BMP-2 in the callus of the third lumbar fracture area of rabbits was high in Xianlinggubao group,the content of serum P,ALP,TCa,VEGF and PDGF was obviously increased,BMD was obviously increased,the bone microstructure of the third lumbar vertebrae fracture area of rabbits was basically restored.Compared with the model control group(P<0.05),the difference was statistically significant.[Conclusions]Xianlinggubao Capsule can increase calcium and phosphorus deposition,promote the formation of blood vessels in the fracture area of OVCF in rabbits,and have a strong repair effect on OVCF in rabbits.
文摘目的系统评价仙灵骨葆胶囊辅助治疗骨质疏松性疼痛的疗效和安全性,以期为临床提供循证参考。方法检索中文科技期刊全文数据库(CNKI)、维普数据库、万方数据库,收集仙灵骨葆胶囊治疗骨质疏松性疼痛的随机对照试验(RCT),评价文献质量并提取数据,采用Rev Man 5.3软件进行Meta分析。结果共纳入6项RCT,合计530例患者。Meta分析结果显示,总有效率[RR=1.27,95%CI(1.16,1.40),P<0.000 01],差异具有统计学意义;治疗后疼痛VAS评分[RR=-1.54,95%CI(-2.40,-0.68),P<0.05],差异具有统计学意义;安全性[RR=0.6,95%CI(0.17,2.07),P>0.05],差异无统计学意义。结论仙灵骨葆胶囊辅助治疗骨质疏松性疼痛临床疗效优于对照组,治疗后疼痛程度明显减轻,且联合使用仙灵骨葆胶囊并未增加不良反应的发生。但由于本研究为二次研究,该结论仍有待于进一步证实。
