首先,设计了节点自适应传感半径调整算法(AASR,adaptive adjustment of sensing radius),通过节点自适应选择最佳的覆盖范围,有效地进行节点覆盖控制,减少节点能量虚耗,提高覆盖效率。其次,从调整效果、能量消耗和覆盖冗余度3个方面对...首先,设计了节点自适应传感半径调整算法(AASR,adaptive adjustment of sensing radius),通过节点自适应选择最佳的覆盖范围,有效地进行节点覆盖控制,减少节点能量虚耗,提高覆盖效率。其次,从调整效果、能量消耗和覆盖冗余度3个方面对节点自适应传感半径调整算法进行了模拟实验和分析。仿真结果表明,AASR能够有效提高节点生存时间,减少能量消耗,提高覆盖率。展开更多
Human intestinal bacteria play an important role in the metabolism of herbal medicines, leading to the variations in their pharmacological profile. The present study aimed to investigate the metabolism of Xiao-Cheng-Q...Human intestinal bacteria play an important role in the metabolism of herbal medicines, leading to the variations in their pharmacological profile. The present study aimed to investigate the metabolism of Xiao-Cheng-Qi decoction(XCQD) by human intestinal bacteria and to discover active component combination(ACC) contributing to the anti-inflammatory activity of XCQD. The water extract of XCQD was anaerobically incubated with human intestinal bacteria suspensions for 48 h at 37 °C. A liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry(LC-Q-TOF/MS) method was performed for identification of the metabolites. In addition, the anti-inflammatory effects of XCQD and biotransformed XCQD(XCQD-BT) were evaluated in vitro with cytokines in RAW264.7 cells induced by lipopolysaccharide(LPS). A total of 51 compounds were identified in XCQD and XCQD-BT. Among them, 20 metabolites were proven to be transformed by human intestinal bacteria. Significantly, a combination of 14 compounds was identified as ACC from XCQD-BT, which was as effective as XCQD in cell models of inflammation. In conclusion, this study provided an applicable method, based on intestinal bacterial metabolism, for identifying combinatory compounds responsible for a certain pharmacological activity of herbal medicines.展开更多
文摘首先,设计了节点自适应传感半径调整算法(AASR,adaptive adjustment of sensing radius),通过节点自适应选择最佳的覆盖范围,有效地进行节点覆盖控制,减少节点能量虚耗,提高覆盖效率。其次,从调整效果、能量消耗和覆盖冗余度3个方面对节点自适应传感半径调整算法进行了模拟实验和分析。仿真结果表明,AASR能够有效提高节点生存时间,减少能量消耗,提高覆盖率。
基金supported by the National Natural Science Foundation of China(No.81173471)
文摘Human intestinal bacteria play an important role in the metabolism of herbal medicines, leading to the variations in their pharmacological profile. The present study aimed to investigate the metabolism of Xiao-Cheng-Qi decoction(XCQD) by human intestinal bacteria and to discover active component combination(ACC) contributing to the anti-inflammatory activity of XCQD. The water extract of XCQD was anaerobically incubated with human intestinal bacteria suspensions for 48 h at 37 °C. A liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry(LC-Q-TOF/MS) method was performed for identification of the metabolites. In addition, the anti-inflammatory effects of XCQD and biotransformed XCQD(XCQD-BT) were evaluated in vitro with cytokines in RAW264.7 cells induced by lipopolysaccharide(LPS). A total of 51 compounds were identified in XCQD and XCQD-BT. Among them, 20 metabolites were proven to be transformed by human intestinal bacteria. Significantly, a combination of 14 compounds was identified as ACC from XCQD-BT, which was as effective as XCQD in cell models of inflammation. In conclusion, this study provided an applicable method, based on intestinal bacterial metabolism, for identifying combinatory compounds responsible for a certain pharmacological activity of herbal medicines.
