[Objectives]To explore the use of Xiao’er Kechuanling Oral Liquid combined with Tulobuterol Patch on the basis of comprehensive treatment,compare it with the combined aerosol inhalation of terbutaline,ipratropium bro...[Objectives]To explore the use of Xiao’er Kechuanling Oral Liquid combined with Tulobuterol Patch on the basis of comprehensive treatment,compare it with the combined aerosol inhalation of terbutaline,ipratropium bromide and budesonide which are commonly used in clinic,and observe the curative effect in the treatment of acute bronchiolitis and the effect on serum IL-4 and IL-8.[Methods]80 children with acute bronchiolitis were randomly divided into observation group(n=40)and control group(n=40),and both groups were given routine comprehensive treatment.The observation group was treated with Xiao’er Kechuanling Oral Liquid combined with Tulobuterol Patch and budesonide,while the control group was treated with combined aerosol inhalation of terbutaline,ipratropium bromide and budesonide.The curative effect of the two groups was observed;the remission duration of cough,wheezing,dyspnea and nocturnal wheezing,and the disappearance time of wheezing rales and moist rales were observed in the two groups;the treatment course of intravenous infusion of methylprednisolone sodium succinate,oxygen inhalation time,sputum suction times and hospitalization time were observed in the two groups;the changes of serum IL-4 and IL-8 were observed before and after treatment in the two groups;the adverse drug reactions were observed.[Results](i)The total effective rate of the two groups was 100%(P>0.05),but the cure rate of the observation group(72.5%)was significantly higher than that of the control group(42.5%)(P<0.01).(ii)The disappearance time of cough,wheezing rales and moist rales and hospitalization time in the observation group were significantly shorter than those in the control group(P<0.01),the remission duration of nocturnal wheezing in the observation group was shorter than that in the control group(P<0.05),and the remission duration of wheezing and dyspnea in the control group was slightly longer than that in the control group(P>0.05).(iii)There was no significant difference(P>0.05)in serum IL-4 and serum IL-8 between the two groups before and after treatment.After treatment,the levels of serum IL-4 and IL-8 in the observation group and the control group were significantly lower than those before treatment in the observation group and the control group.[Conclusions]On the basis of comprehensive treatment,the use of Xiao’er Kechuanling Oral Liquid combined with Tulobuterol Patch in the treatment of acute bronchiolitis could reduce the effect of nocturnal wheezing on sleep,reduce the levels of serum IL-4 and IL-8,and significantly improve adverse symptoms.展开更多
目的探讨小儿定喘口服液联合甲泼尼龙治疗重症支气管哮喘的临床疗效。方法选取2015年2月—2016年2月在西电集团医院呼吸内科接受治疗的小儿重症支气管哮喘患者86例,随机分成对照组和治疗组,每组各43例。对照组患儿静脉滴注注射用甲泼尼...目的探讨小儿定喘口服液联合甲泼尼龙治疗重症支气管哮喘的临床疗效。方法选取2015年2月—2016年2月在西电集团医院呼吸内科接受治疗的小儿重症支气管哮喘患者86例,随机分成对照组和治疗组,每组各43例。对照组患儿静脉滴注注射用甲泼尼龙琥珀酸钠,1 mg/kg加入到5%葡萄糖溶液250 m L中,1次/d。治疗组在对照组的基础上口服小儿定喘口服液,3-6岁患儿10 m L/次,7-10岁患儿15 m L/次,10岁以上患儿20 m L/次,均为3次/d。所有患儿均连续治疗2周。比较两组临床疗效、肺功能变化、动脉血气指标、临床症状和体征消失时间以及肿瘤坏死因子α（TNF-α）、白介素-8（IL-8）和免疫球蛋白E（Ig E）表达水平。结果治疗后,对照组和治疗组总有效率分别为81.40%和95.35%,两组比较差异有统计学意义（P〈0.05）。治疗后,两组一秒用力呼气容积（FEV1）、最大呼气流量（PEF）、用力肺活量（FVC）和FEV1/FVC均较同组治疗前显著升高,同组比较差异具有统计学意义（P〈0.05）;且治疗组这些观察指标显著高于对照组,两组比较差异具有统计学意义（P〈0.05）。治疗后,两组氧分压（p O2）和血氧饱和度（Sp O2）升高,二氧化碳分压（p CO2）较治疗前下降,同组治疗前后差异具有统计学意义（P〈0.05）;且治疗组这些观察指标显著优于对照组,两组比较差异具有统计学意义（P〈0.05）。治疗后,治疗组患儿喘憋消失时间和肺部哮鸣音消失时间短于对照组,两组比较差异具有统计学意义（P〈0.05）。治疗后,两组患儿TNF-α、IL-8和Ig E表达水平均下降,同组治疗前后差异具有统计学意义（P〈0.05）;且治疗组这些观察指标水平低于对照组,两组比较差异具有统计学意义（P〈0.05）。结论小儿定喘口服液联合甲泼尼龙治疗重症支气管哮喘的疗效显著,可有效改善患儿肺功能及降低血清炎性因子水平,具有一定的临床推广应用价值。展开更多
基金Supported by Scientific Research Project of the Department of Health of Guangxi Zhuang Autonomous Region(Z2015215)Development,Popularization and Application Project of Appropriate Medical and HealthTechnology in Guangxi(S2018015).
文摘[Objectives]To explore the use of Xiao’er Kechuanling Oral Liquid combined with Tulobuterol Patch on the basis of comprehensive treatment,compare it with the combined aerosol inhalation of terbutaline,ipratropium bromide and budesonide which are commonly used in clinic,and observe the curative effect in the treatment of acute bronchiolitis and the effect on serum IL-4 and IL-8.[Methods]80 children with acute bronchiolitis were randomly divided into observation group(n=40)and control group(n=40),and both groups were given routine comprehensive treatment.The observation group was treated with Xiao’er Kechuanling Oral Liquid combined with Tulobuterol Patch and budesonide,while the control group was treated with combined aerosol inhalation of terbutaline,ipratropium bromide and budesonide.The curative effect of the two groups was observed;the remission duration of cough,wheezing,dyspnea and nocturnal wheezing,and the disappearance time of wheezing rales and moist rales were observed in the two groups;the treatment course of intravenous infusion of methylprednisolone sodium succinate,oxygen inhalation time,sputum suction times and hospitalization time were observed in the two groups;the changes of serum IL-4 and IL-8 were observed before and after treatment in the two groups;the adverse drug reactions were observed.[Results](i)The total effective rate of the two groups was 100%(P>0.05),but the cure rate of the observation group(72.5%)was significantly higher than that of the control group(42.5%)(P<0.01).(ii)The disappearance time of cough,wheezing rales and moist rales and hospitalization time in the observation group were significantly shorter than those in the control group(P<0.01),the remission duration of nocturnal wheezing in the observation group was shorter than that in the control group(P<0.05),and the remission duration of wheezing and dyspnea in the control group was slightly longer than that in the control group(P>0.05).(iii)There was no significant difference(P>0.05)in serum IL-4 and serum IL-8 between the two groups before and after treatment.After treatment,the levels of serum IL-4 and IL-8 in the observation group and the control group were significantly lower than those before treatment in the observation group and the control group.[Conclusions]On the basis of comprehensive treatment,the use of Xiao’er Kechuanling Oral Liquid combined with Tulobuterol Patch in the treatment of acute bronchiolitis could reduce the effect of nocturnal wheezing on sleep,reduce the levels of serum IL-4 and IL-8,and significantly improve adverse symptoms.
文摘目的探讨小儿定喘口服液联合甲泼尼龙治疗重症支气管哮喘的临床疗效。方法选取2015年2月—2016年2月在西电集团医院呼吸内科接受治疗的小儿重症支气管哮喘患者86例,随机分成对照组和治疗组,每组各43例。对照组患儿静脉滴注注射用甲泼尼龙琥珀酸钠,1 mg/kg加入到5%葡萄糖溶液250 m L中,1次/d。治疗组在对照组的基础上口服小儿定喘口服液,3-6岁患儿10 m L/次,7-10岁患儿15 m L/次,10岁以上患儿20 m L/次,均为3次/d。所有患儿均连续治疗2周。比较两组临床疗效、肺功能变化、动脉血气指标、临床症状和体征消失时间以及肿瘤坏死因子α（TNF-α）、白介素-8（IL-8）和免疫球蛋白E（Ig E）表达水平。结果治疗后,对照组和治疗组总有效率分别为81.40%和95.35%,两组比较差异有统计学意义（P〈0.05）。治疗后,两组一秒用力呼气容积（FEV1）、最大呼气流量（PEF）、用力肺活量（FVC）和FEV1/FVC均较同组治疗前显著升高,同组比较差异具有统计学意义（P〈0.05）;且治疗组这些观察指标显著高于对照组,两组比较差异具有统计学意义（P〈0.05）。治疗后,两组氧分压（p O2）和血氧饱和度（Sp O2）升高,二氧化碳分压（p CO2）较治疗前下降,同组治疗前后差异具有统计学意义（P〈0.05）;且治疗组这些观察指标显著优于对照组,两组比较差异具有统计学意义（P〈0.05）。治疗后,治疗组患儿喘憋消失时间和肺部哮鸣音消失时间短于对照组,两组比较差异具有统计学意义（P〈0.05）。治疗后,两组患儿TNF-α、IL-8和Ig E表达水平均下降,同组治疗前后差异具有统计学意义（P〈0.05）;且治疗组这些观察指标水平低于对照组,两组比较差异具有统计学意义（P〈0.05）。结论小儿定喘口服液联合甲泼尼龙治疗重症支气管哮喘的疗效显著,可有效改善患儿肺功能及降低血清炎性因子水平,具有一定的临床推广应用价值。
