[Objectives]The paper was to investigate the clinical effects of Zhenwu Decoction combined with Tingli Dazao Xiefei Decoction in the treatment of chronic heart failure with edema syndrome due to yang deficiency.[Metho...[Objectives]The paper was to investigate the clinical effects of Zhenwu Decoction combined with Tingli Dazao Xiefei Decoction in the treatment of chronic heart failure with edema syndrome due to yang deficiency.[Methods]Eighty patients with chronic heart failure were randomly divided into 2 groups(control group and treatment group),with 40 cases in each group.The patients in the control group were treated with conventional western medicine for 14 d,and the patients in the treatment group were treated with Zhenwu Decoction and Tingli Dazhao Xiefeng Decoction on the basis of the control group for 14 d.The curative effect of traditional Chinese medicine(TCM)syndrome score,left ventricular ejection fraction(LVEF),plasma N-terminal brain natruretic peptide precursor(NT-proBNP)and New York Heart Association(NYHA)functional class were compared between the two groups before and after treatment.Minnesota living with heart failure questionnaire in the principle of Chinese civilization and traditional medicine characteristics(C-MLHF)at admission and 1 month after discharge were compared between the two groups.[Results]After treatment,the total effective rate of TCM syndrome score in the treatment group was 82.50%,and that in the control group was 67.50%.The curative effect of TCM syndrome score in the treatment group was better than that in the control group(P<0.05).After treatment the LVEF in both groups was increased compared with that before treatment,and the NT-proBNP level was decreased compared with that before treatment(P<0.05),and those in the treatment group were better than those in the control group.The total effective rate of cardiac function in the treatment group was 87.50%,and that in the control group was 65.00%.The improvement of cardiac function in the treatment group was better than that in the control group(P<0.05).One month after discharge,C-MLHF scores in both groups were decreased compared with those before treatment,and that in the treatment group was lower than in the control group(P<0.05).[Conclusions]Zhenwu Decoction combined with Tingli Dazao Xiefei Decoction based on traditional western medicine treatment could improve the clinical efficacy,symptoms and quality of life of patients in the treatment of chronic heart failure with edema syndrome due to yang deficiency.展开更多
[Objectives]The action mechanism of Tingli Dazao Xiefei Decoction in the treatment of COPD was explored by the network pharmacology and molecular docking technology.[Methods]The TCMSP database was used to perform acti...[Objectives]The action mechanism of Tingli Dazao Xiefei Decoction in the treatment of COPD was explored by the network pharmacology and molecular docking technology.[Methods]The TCMSP database was used to perform active ingredient screening and target prediction on Chinese medicines contained in Tingli Dazao Xiefei Decoction,and COPD-related targets were searched through disease databases.Common targets of Tingli Dazao Xiefei Decoction and COPD were imported into Metascape database for GO analysis and KEGG pathway enrichment analysis.The STRING database was used to perform PPI analysis on common targets,and core targets were screened through the Cytoscape software.The Pymol,AutoDockTools,Vina and other software were used for molecular docking of some core targets and ingredients.[Results]From Tingli Dazao Xiefei Decoction,26 active ingredients which shared 211 common targets and 22 core targets with COPD,were screened out.Enrichment analysis revealed a total of 1892 biological processes,78 cell components,152 molecular functions,and 164 signal paths.The molecular docking of part of the core targets and corresponding ingredients obtained better results.[Conclusions]Tingli Dazao Xiefei Decoction treats COPD through multiple targets and multiple pathways,revealing its mechanism for treating COPD.展开更多
目的:观察小柴胡汤合葛根芩连汤加减治疗慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)稳定期肺脾气虚兼湿热证的临床疗效。方法:对2021年7月~2022年3月的COPD稳定期肺脾气虚兼湿热证患者78例行回顾性分析,依据治疗差...目的:观察小柴胡汤合葛根芩连汤加减治疗慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)稳定期肺脾气虚兼湿热证的临床疗效。方法:对2021年7月~2022年3月的COPD稳定期肺脾气虚兼湿热证患者78例行回顾性分析,依据治疗差异分为对照组39例(予常规西药治疗)和试验组39例(予常规西药+小柴胡汤合葛根芩连汤加减治疗)。对比两组临床疗效、证候积分、肺功能[第1秒用力呼气容积(Force the expiratory volume for the first second,FEV 1 )、第1秒用力呼气容积/用力肺活量(Force the expiratory volume for the first second/Forced Vital Capacity,FEV 1 /FVC)]、6min步行距离(6minute walking distance,6MWD)、慢阻肺生活质量量表(COPD Assessment Test,CAT)及安全性。结果:对照组、试验组总疗效率分别为74.36%、92.31%,试验组总疗效率更高( P <0.05)。两组治疗后,证候总积分均下降,但试验组证候总积分下降幅度更大( P <0.05)。两组治疗后FEV 1 、FEV 1 /FVC值均上升,且试验组比对照组高( P <0.05)。两组治疗后6MWD的距离均延长,且试验组明显长于对照组( P <0.05)。两组治疗后CAT评分(包括咳嗽、咳痰、胸闷、睡眠、情绪、精力评分)均降低,且试验组明显低于对照组( P <0.05)。治疗期间,对照组不良反应总发生率为2.56%(1/39),试验组不良反应总发生率为5.12%(2/39),两组不良反应总发生率相比较,差异无统计学意义( P >0.05)。结论:小柴胡汤合葛根芩连汤加减治疗可改善COPD稳定期肺脾气虚兼湿热证的患者生活质量、肺功能,提高临床疗效。展开更多
基金"Outstanding Innovative Talents Support Program"of Heilongjiang University of Chinese Medicine(051267).
文摘[Objectives]The paper was to investigate the clinical effects of Zhenwu Decoction combined with Tingli Dazao Xiefei Decoction in the treatment of chronic heart failure with edema syndrome due to yang deficiency.[Methods]Eighty patients with chronic heart failure were randomly divided into 2 groups(control group and treatment group),with 40 cases in each group.The patients in the control group were treated with conventional western medicine for 14 d,and the patients in the treatment group were treated with Zhenwu Decoction and Tingli Dazhao Xiefeng Decoction on the basis of the control group for 14 d.The curative effect of traditional Chinese medicine(TCM)syndrome score,left ventricular ejection fraction(LVEF),plasma N-terminal brain natruretic peptide precursor(NT-proBNP)and New York Heart Association(NYHA)functional class were compared between the two groups before and after treatment.Minnesota living with heart failure questionnaire in the principle of Chinese civilization and traditional medicine characteristics(C-MLHF)at admission and 1 month after discharge were compared between the two groups.[Results]After treatment,the total effective rate of TCM syndrome score in the treatment group was 82.50%,and that in the control group was 67.50%.The curative effect of TCM syndrome score in the treatment group was better than that in the control group(P<0.05).After treatment the LVEF in both groups was increased compared with that before treatment,and the NT-proBNP level was decreased compared with that before treatment(P<0.05),and those in the treatment group were better than those in the control group.The total effective rate of cardiac function in the treatment group was 87.50%,and that in the control group was 65.00%.The improvement of cardiac function in the treatment group was better than that in the control group(P<0.05).One month after discharge,C-MLHF scores in both groups were decreased compared with those before treatment,and that in the treatment group was lower than in the control group(P<0.05).[Conclusions]Zhenwu Decoction combined with Tingli Dazao Xiefei Decoction based on traditional western medicine treatment could improve the clinical efficacy,symptoms and quality of life of patients in the treatment of chronic heart failure with edema syndrome due to yang deficiency.
文摘[Objectives]The action mechanism of Tingli Dazao Xiefei Decoction in the treatment of COPD was explored by the network pharmacology and molecular docking technology.[Methods]The TCMSP database was used to perform active ingredient screening and target prediction on Chinese medicines contained in Tingli Dazao Xiefei Decoction,and COPD-related targets were searched through disease databases.Common targets of Tingli Dazao Xiefei Decoction and COPD were imported into Metascape database for GO analysis and KEGG pathway enrichment analysis.The STRING database was used to perform PPI analysis on common targets,and core targets were screened through the Cytoscape software.The Pymol,AutoDockTools,Vina and other software were used for molecular docking of some core targets and ingredients.[Results]From Tingli Dazao Xiefei Decoction,26 active ingredients which shared 211 common targets and 22 core targets with COPD,were screened out.Enrichment analysis revealed a total of 1892 biological processes,78 cell components,152 molecular functions,and 164 signal paths.The molecular docking of part of the core targets and corresponding ingredients obtained better results.[Conclusions]Tingli Dazao Xiefei Decoction treats COPD through multiple targets and multiple pathways,revealing its mechanism for treating COPD.
文摘目的:观察小柴胡汤合葛根芩连汤加减治疗慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)稳定期肺脾气虚兼湿热证的临床疗效。方法:对2021年7月~2022年3月的COPD稳定期肺脾气虚兼湿热证患者78例行回顾性分析,依据治疗差异分为对照组39例(予常规西药治疗)和试验组39例(予常规西药+小柴胡汤合葛根芩连汤加减治疗)。对比两组临床疗效、证候积分、肺功能[第1秒用力呼气容积(Force the expiratory volume for the first second,FEV 1 )、第1秒用力呼气容积/用力肺活量(Force the expiratory volume for the first second/Forced Vital Capacity,FEV 1 /FVC)]、6min步行距离(6minute walking distance,6MWD)、慢阻肺生活质量量表(COPD Assessment Test,CAT)及安全性。结果:对照组、试验组总疗效率分别为74.36%、92.31%,试验组总疗效率更高( P <0.05)。两组治疗后,证候总积分均下降,但试验组证候总积分下降幅度更大( P <0.05)。两组治疗后FEV 1 、FEV 1 /FVC值均上升,且试验组比对照组高( P <0.05)。两组治疗后6MWD的距离均延长,且试验组明显长于对照组( P <0.05)。两组治疗后CAT评分(包括咳嗽、咳痰、胸闷、睡眠、情绪、精力评分)均降低,且试验组明显低于对照组( P <0.05)。治疗期间,对照组不良反应总发生率为2.56%(1/39),试验组不良反应总发生率为5.12%(2/39),两组不良反应总发生率相比较,差异无统计学意义( P >0.05)。结论:小柴胡汤合葛根芩连汤加减治疗可改善COPD稳定期肺脾气虚兼湿热证的患者生活质量、肺功能,提高临床疗效。
