Spatial-temporal distribution and geochemistry of highly evolved Mesozoic granites in Great Xing’an Range,NE China:Discriminant criteria and geological significance

Highly evolved granite is an important sign of the mature continent crust and closely associated with deposits of rare metals.In this work,the authors undertake systematically zircon U-Pb ages and whole rock elemental data for highly evolved granitic intrusions from the Great Xing’an Range(GXR),NE China,to elucidate their discriminant criteria,spatial-temporal distribution,differentiation and geodynamic mecha-nism.Geochemical data of these highly evolved granites suggest that high w(SiO_(2))(>70%)and differentiation index(DI>88)could be quantified indicators,while strong Eu depletion,high TE_(1,3),lowΣREE and low Zr/Hf,Nb/Ta,K/Rb could only be qualitative indicators.Zircon U-Pb ages suggest that the highly evolved gran-ites in the GXR were mainly formed in Late Mesozoic,which can be divided into two major stages:Late Ju-rassic-early Early Cretaceous(162-136 Ma,peak at 138 Ma),and late Early Cretaceous(136-106 Ma,peak at 126 Ma).The highly evolved granites are mainly distributed in the central-southern GXR,and display a weakly trend of getting younger from northwest to southeast,meanwhile indicating the metallogenic potential of rare metals within the central GXR.The spatial-temporal distribution,combined with regional geological data,indicates the highly evolved Mesozoic granites in the GXR were emplaced in an extensional environ-ment,of which the Late Jurassic-early Early Cretaceous extension was related to the closure of the Mongol-Okhotsk Ocean and roll-back of the Paleo-Pacific Plate,while the late Early Cretaceous extension was mainly related to the roll-back of the Paleo-Pacific Plate.

Zircon U-Pb geochronology,geochemistry and tectonic implication of volcanic rocks from Manketouebo Formation in Keyihe area of northern Great Xing'an Range

Zircon U-Pb isotope dating and whole-rock geochemical analyses were undertaken for the rhyolite,rhyolitic lithic crystal tuff and dacitic tuff from the Manketouebo Formation in the Keyihe area,in order to constrain their genesis and tectonic significance.Zircon LA-ICP-MS U-Pb data indicate that the rhyolite and rhyolitic lithic crystal tuff were formed during 137±5 Ma and 143±1 Ma,respectively.These volcanic rocks have high SiO2(70.03%–76.46%)and K2O+Na2O(8.10%–9.52%)contents,but low CaO(0.03%–0.95%)and MgO(0.07%–0.67%)contents,which belong to the peraluminous and high-K calc-alkaline rocks.They are enriched in light rare earth elements(REEs),and exhibit fractionation of light over heavy REEs,withδEu values of 0.37–0.83.The volcanic rocks are enriched in LILEs(e.g.,Rb,U and K)and depleted in HFSEs(e.g.,Nb,Ti,P and Ta).The chemical composition suggests that these volcanic rocks formed by partial melting of crust material.Combined with previous regional research results,the authors consider that the volcanic rocks of the Manketouebo Formation in the Keyihe area were formed under an extensional environment related to the closure of the Mongolia–Okhotsk Ocean.

垦利碱蓬Suaeda kenliensis J.W.Xing sp.nov.--碱蓬属一新种

报道了中国碱蓬属植物一新种——垦利碱蓬Suaeda kenliensis J.W.Xing sp.nov.。该种与南方碱蓬Suaeda australis(R.Br.)Moq.相近,但系一年生,种子具圆盘状和卵形两种形状,直径约2～3mm,叶长可达5～7 cm,无不定根,与南方碱蓬相区别。垦利碱蓬生长于潮间带和海水周期性淹没处。耐高盐,区域内海水盐度为25,滩涂表层含盐量在退潮后经日晒蒸发可达60‰以上。常形成单一种群的红海滩植被景观。模式标本存:中国科学院海洋生物标本馆;编号:MBM286537。采集地:莱州湾垦利海域潮间带泥滩。采集人:邢军武、曲宁、钟芳。

The Implantation and Transmission of Plague Culture by the Five Plague Gods in Shuilu Murals

The Five Plague Gods(五瘟神) in the Shuilu(水陆) murals from the Ming and Qing dynasties exemplify a distinctive manifestation of plague gods image developed under the pedigree of Taoist gods.As a significant system for expelling disasters in Shuilu,the depiction of the Five Plague Gods prominently merges human beings and livestock.This shape form to a large extent,draws on the image of Nuo(傩),a figure reflecting an imagination of the host of plague pathogens.In terms of the numbers of gods,it aligns with the conceptual framework of Wu Xing(五行 the five elements),a foundational principle in traditional Chinese medicine.The internal cultural connection highlights the means of plague prevention and control in China,as well as the external reflection of plague culture.Through multi-dimensional interpretations with the double proof method,this article dissects the formation,core elements,and cultural characteristics of the beliefs in the Five Plague Gods reflected in the Shuilu murals,and transcends mere visual semantics,offering a deeper understanding of these complex cultural symbols.

Geochemical Characteristics and Geological Significance of Early Permian Baya'ertuhushuo Gabbro in South Great Xing'an Range

Field geological investigation and geochemical analysis are carried out on Baya＇ertuhushuo Gabbro in South Great Xing＇an Range. Field investigation reveals that the gabbro is a magmatic intrusion rather than a component of an ophiolite suite as previously thought. Zircon laser ablation inductively coupled plasma mass spectroscopy （LA-ICP-MS） U-Pb dating indicates the gabbro was formed in 274-275 Ma, just as the widespread volcanic rocks of Dashizhai Formation （P1d）, monzogranites and miarolitic alkali-feldspar granites in the study area. The gabbro has SiO2 content between 47.23 wt% and 50.17 wt%, high MgO and FeOT contents of 6.95-11.29 wt% and 7.32- 12.24wt%, respectively, and it belongs to low-K tholeiitic series in the SiO2-K2O diagram. The Chondrite-normalized rare earth element （REE） patterns and primitive mantle-normalized spider diagrams of the gabbro are similar to those of Normal Mid-Ocean Ridge Basalt （N-MORB） except for the enrichment of large ion lithophfle elements （LILE）, such as Rb, Ba and K. In trace element tectonic discriminative diagrams, the samples are mainly plotted in the N-MORB field, and Zircon in situ Lu-Hf isotopic analysis also indicates the gabbro originated from depleted mantle. Through synthetic studies of the geochemical characteristics and petrogenesis of Baya＇ertuhushuo gabbro, volcanic rocks of Dashizhai Formation and granitoids in the area, it is suggested that the early Permian magmatism in the Xilinhot-Xiwuqi area formed in the tectonic setting of asthenosphere upwelling, which was caused by breaking-off of the subducted Paleo-Asian Ocean slab.

Early Cretaceous Adakitic Rocks in the Northern Great Xing’an Range, NE China: Implications for the Final Closure of Mongol-Okhotsk Ocean and Regional Extensional Setting

A large amount of igneous rocks in NE China formed in an extensional setting during Late Mesozoic. However, there is still controversy about how the Mongol-Okhotsk Ocean and the Paleo-Pacific Ocean effected the lithosphere in NE China. In this paper, we carried out a comprehensive study for andesites from the Keyihe area using LA-ICP-MS zircon UPb dating and geochemical and Hf isotopic analysis to investigate the petrogenesis and tectonic setting of these andesites. The U-Pb dating yields an Early Cretaceous crystallization age of 128.3±0.4 Ma. Geochemically, the andesites contain high Sr(686-930 ppm) and HREE contents, low Y(11.9-19.8 ppm) and Yb(1.08-1.52 ppm) contents, and they therefore have high Sr/Y(42-63) and La/Yb(24-36) ratios, showing the characteristics of adakitic rocks. Moreover, they exhibit high K2O/Na2O ratios(0.57-0.81), low Mg O contents(0.77-3.06 wt%), low Mg# value(17-49) and negative εHf(t) values(-1.7 to-8.5) with no negative Eu anomalies, indicating that they are not related to the oceanic plate subduction. Based on the geochemical and isotopic data provided in this paper and regional geological data, it can be concluded that the Keyihe adakitic rocks were affected by the Mongol-Okhotsk tectonic regime, forming in a transition setting from crustal thickening to regional extension thinning. They were derived from the partial melting of the thickened lower crust. The closure of the Mongol-Okhotsk Ocean may finish in early Early Cretaceous, followed by the collisional orogenic process. The southern part region of its suture belt was in a post-orogenic extensional setting in the late Early Cretaceous.

Image Mathematics—Mathematical Intervening Principle Based on “Yin Yang Wu Xing” Theory in Traditional Chinese Mathematics (I)

By using mathematical reasoning, this paper demonstrates the mathematical intervening principle: “Virtual disease is to fill his mother but real disease is to rush down his son” (虚则补其母, 实则泄其子) and “Strong inhibition of the same time, support the weak” (抑强扶弱) based on “Yin Yang Wu Xing” Theory in image mathematics of Traditional Chinese Mathematics (TCMath). We defined generalized relations and generalized reasoning, introduced the concept of steady multilateral systems with two non-compatibility relations, and discussed its energy properties. Later based on the intervention principle in image mathematics of TCMath and treated the research object of the image mathematics as a steady multilateral system, it has been proved that the mathematical intervening principle is true. The kernel of this paper is the existence and reasoning of the non-compatibility relations in steady multilateral systems, and it accords with the oriental thinking model.

Recognition of Early Paleozoic Magmatisms in the Supposed Proterozoic Basements of Zhalantun, Great Xing’an Range, NE China

The Zhalantun terrane from the Xing’an massif, northeast China, was used to be considered as Proterozoic basements. However, amounts of detrital zircon ages from the meta-sedimentary rocks deny the existence of Precambrian basements recently. Notably, magmatic rocks were barely reported to limit the exact ages of the Zhalantun basements. In this study, we collected rhyolite, gabbro and quartz diorite for zircon in-situ U-Pb isotopic dating, which yield crystallization ages of ~505 Ma, ~447 Ma and ~125 Ma, respectively. Muscovite schist and siltstone define maximum depositional ages of ~499 Ma and ~489 Ma, respectively. Additionally, these dated supracrustal rocks and plutons also yield ancient detrital/xenocryst zircon ages of ~600-1000 Ma, ~1600-2220 Ma, ~2400 Ma, ~2600-2860 Ma. Based on the whole-rock major and trace element compositions, the ~505 Ma rhyolites display high SiO2 and alkaline contents, low Fe2O3T, TiO2 and Al2O3, and relatively high Mg O and Mg#, which exhibit calc-alkaline characteristics. These rhyolites yield fractionated REE patterns and negative Nb, Ta, Ti, Sr, P and Eu anomalies and positive Zr anomalies. The geochemistry, petrology and Lu-Hf isotopes imply that rhyolites were derived from the partial melting of continental basalt induced by upwelling of sub-arc mantle magmas, and then experienced fractional crystallization of plagioclase, which points to a continental arc regime. The ~447 Ma gabbros exhibit low Si O2 and alkaline contents, high Fe2 O3 T, Ti O2, Mg O and Mg#. They show minor depletions of La and Ce, flat MREE and HREE patterns, and negative Nb, Ta, Zr and Hf anomalies. Both sub-arc mantle and N-MORB-like mantle were involved in the formation of the gabbros, indicative of a probable back-arc basin tectonic setting. Given that, the previously believed Proterozoic supracrustal rocks and several plutons from the Zhalantun Precambrian basements were proved to be Paleozoic to Mesozoic rocks, among which these Paleozoic magmatic rocks were generally related to subduction regime. So far, none Proterozoic rocks have been identified from the Zhalantun Precambrian basement, though some ~600-3210 Ma ancient detrital/xenocryst zircons were reported. Combined with ancient zircon ages and newly reported ~2.5 Ga and ~1.8 Ga granites from the south of the Zhalantun, therefore, the Precambrian rocks probably once exposed in the Zhalantun while they were re-worked and consumed during later long tectonic evolutionary history, resulting in absence of Precambrian rocks in the Zhalantun.

Origin of C type adakite magmas in the NE Xing＇an block, NE China and tectonic implication

In this paper, we report new whole-rock geochemical and zircon U-Pb data for monzogranites in the NE Xing＇an block. These data constrained the petrogenesis of C type （high Sr/Y） adakitic rocks and showed the spatial extent of the influence of the Mongol-Okhostsk ocean tectonic regime and the collision between the Jiamusi Massif and Songliao Terrane. New zircon laser-ablation inductivity coupled plasma mass spectrometry （LA-ICP-MS） U-Pb data indicated that the monzogranites in the studied area were emplaced in the Early Jurassic （～ 180 Ma）. These rocks were characterized by unusally high SiO2 （≥67.49）, and Sr （461-759 ppm）, but strikingly low Y （4.63-8.06 ppm） and HREE （∑HREE = 3.83-6.49 ppm, Yb = 0.5-0.77 ppm） contents, with therefore high Sr/Y （67.2-119） and （La/Yb）N （29.7-41.5） ratios, showing the geochemical characteristics of C type adakitic granite. The data displayed negligible Eu anomalies （Eu/Eu^＊ =0.77-1.08）, LREE-enriched and pronounced negative Nb and Ta anomalies. The C-type adakites in the studied area were most likely derived from the partial melting of a thickened lower continental curst. The magma source is most likely dominated by amphibolites and garnet amphibolites. In combination with previously-reported data from igneous rocks from the Mesozoic in NE China, we conclude that the Xing＇ an block was influenced by the Mongol-Okhotsk subduction tectonic system, and experiences compressive settings from the amalgamation of the Jiamusi block in the east of the CAOB.

Effects of meteorological factors on the defoliation dynamics of the larch caterpillar(Dendrolimus superans Butler)in the Great Xing’an boreal forests

Larch caterpillars are widely distributed in the Great Xing’an boreal forests;however,the relationship between caterpillar defoliation dynamics and climatic factors is poorly understood.The aims of this study are to investigate the primary weather conditions that might influence forest defoliation and to identify the most important life stage of the larch caterpillar at which forest defoliation might be mitigated by incorporating more inhibitory influences from climatic factors.The life cycle of the larch caterpillar was partitioned into four stages and multiple linear regression and mixed effect models were combined with a relative weight analysis approach to evaluate the importance and influence of meteorological variables on defoliation dynamics.The results show that warmer temperatures in growing seasons and overwintering periods can increase the defoliation area,while rainy and humid growing seasons decrease the defoliation area.Total precipitation during the early instar larval period had the greatest power to explain the variance in defoliation dynamics and had a very strong inhibitory effect,followed by the accumulative temperatures of the late instar larval period which had a positive impact,and precipitation during the middle instar larval period which had a negative impact.Weather conditions during the early instar larval period had the greatest influence on the area defoliated and accounted for 40%of the explained variance.This study demonstrates that climatic warming and drying will increase the risk of larch caterpillar outbreaks in the Great Xing’an Mountains.

Felsic Igneous Rocks in the Hua'aobaote Pb-Zn-Ag Polymetallic Orefield,Southern Great Xing'an Range:Genesis,Metallogenetic and Tectonic Significance

The Hua’aobaote Pb-Zn-Ag Polymetallic orefield is situated in the southern section of the Great Xing’an Range(GXAR),which has experienced extensive magmatism.Since the Paleozoic,there are two stages of magmatism in Hua’aobaote orefield occurred in the Paleozoic and Mesozoic.The Mesozoic magmatism is of great significance for the PbZn-Ag Polymetallic mineralization in Hua’aobaote orefield.In this study,new geochemical data was obtained to discuss the timing and petrogenesis of the magmatic rocks and its geodynamic and metallogenic significance.Zircon U-Pb ages reveal that the felsic igneous rocks from the Hua’aobaote orefield were formed in the Early Permian(294.8±3.2 Ma)and Early Cretaceous(132.6±1.4 Ma).Geochemically,the Early Permian granodiorite porphyrite is characterized by high Sr/Y(42-63)ratios and Mg^(#)(62.24-70.74)values and low heavy rare earth element(HREE)(5.09-6.79 ppm)contents.The granodiorite porphyrite is also characterized by depleted Sr-Nd initial isotopic signatures[ε_(Nd)(t)=5.91-7.59,(^(87)Sr/^(86)Sr)i=0.7029-0.7030],exhibiting adakitic characteristics.The Early Cretaceous granite porphyry and rhyolite are A-type felsic igneous rocks,and demonstrate high SiO_(2),Na_(2)O+K_(2)O and rare earth element(REE)contents,low CaO and MgO contents,low(^(87)Sr/^(86)Sr)i ratios(0.7044-0.7058),and positive ε_(Nd)(t)values(2.57-4.65).Whole-rock Pb isotopic compositions in granodiorite porphyrite are:206Pb/204Pb=17.631-18.149,^(207)Pb/^(204)Pb=15.422-15.450,and ^(208)Pb/^(204)Pb=37.325-37.729.The granite porphyry and rhyolite have initial ^(206)Pb/^(204)Pb,^(207)Pb/^(204)Pb,and ^(208)Pb/^(204)Pb ratios of 18.106-19.309,15.489-15.539,and 37.821-38.05,respectively.Sr-Nd-Pb isotopic evidence suggests that the Early Permian granodiorite porphyrite is likely to derive from slab melts and modified by peridotitic mantle wedge in the subduction tectonic setting of the Paleo-Asian Ocean.The Early Cretaceous A-type felsic igneous rocks were derived from juvenile lower crust,accompanied by limited crustal contamination and various degree of fractional crystallisation during magma emplacement.The Early Cretaceous magmatism and related mineralization were formed in a post-orogenic tectonic setting that attributed to the closure of the Mongol-Okhotsk Ocean.Pb isotopic data for the various rock units in the study area indicate that the Mesozoic magma source contributed substantial Pb,Zn,and Ag to the Hua’aobaote deposit.

Magmatic Evolution and Mineralization Process of the Super-Large Shihuiyao Rb–Nb–Ta Deposit,Southern Great Xing'an Range,China

Rare metal ore reserves are an important strategic resource, and their metallogenic mechanism and mineralization studies have also been received widespread international attention.

New Discovery of the Late Triassic Terrigenous Sediments in the Great Xing＇＇an Range Region,NE China and its Geological Significance

Objective The Great Xing＇an Range is located in the eastern section of Central Asian Orogenic Belt（CAOB）.As a superposed position of multiple tectonic domains,its structural evoIlution has always been a focused issue of geological research.

Study of seasonal snow cover influencing the ground thermal regime on western flank of Da Xing'anling Mountains,northeastern China

Although many studies relevant to snow cover and permafrost have focused on alpine, arctic, and subarctic areas, there is still a lack of understanding of the influences of seasonal snow cover on the thermal regime of the soils in permafrost regions in the mid-latitudes and boreal regions, such as that on the westem flank of the Da Xing＇anling （Hinggan） Mountains, northeastern China. This paper gives a detailed analysis on meteorological data series from 2001 to 2010 provided by the Gen＇he Weather Station, which is located in a talik of discontinuous permafrost zone and with sparse meadow on the observation field. It is inferred that snow cover is important for the ground thermal regime in the middle Da Xing＇anling Mountains. Snow cover of 10-cm in thickness and five to six months in duration （generally November to next March） can reduce the heat loss from the ground to the atmosphere by 28%, and by 71% if the snow depth increases to 36 cm. Moreover, the occurrence of snow cover resulted in mean annual ground surface temperatures 4.7-8.2℃ higher than the mean annual air temperatures recorded at the Gen＇he Weather Station, The beginning date for stable snow cover establishment （SE date） and the initial snow depth （SDi） also had a great influences on the ground freezing process. Heavy snowfall before ground surface freeze-up could postpone and retard the freezing process in Gen＇he. As a result, the duration of ground freezing was shortened by at least 20 days and the maximum depth of frost penetration was as much as 90 cm shallower.

Evolution Rules and Spatial Features of Traditional Settlements in Fukou Xing Region

As one of the eight Taihang passes,Fukou Xing is located in the south of the Taihang Mountains and has been an important passage for Shanxi and Hebei in history.Taking traditional settlements in Fukou Xing Region as research object,using the Advanced Spaceborne Thermal Emission and Reflection Radiometer(ASTER) Global Digital Elevation Model(GDEM)(remote sensing measurement of elevation data) and GIS platform,this paper made a quantitative study on traditional settlement space in mountain environment of this region,and studied space parameters including elevation,terrain,aspect,and boundary,observed and summarized the spatial features.In addition,based on the local chronicles of Ming and Qing dynasties,it mutually verified the quantitative conclusions and qualitative cognition,analyzed the evolution rules of traditional settlements in Fukou Xing region,and finally obtained new understandings of spatial features of traditional settlements in Fukou Xing region.

The Cu-Mo Mineralization of the Late Jurassic Porphyry in the Northern Great Xing'an Range: Constraints from Zircon U-Pb Ages of the Ore-Causative Granites

The Great Xing’an Range(GXAR)is one of the most important metallogenic belts in China.Previous study has shown that porphyry Cu-Mo deposit distributed in the northern Great Xing’an Range formed mainly in two stages:(1)Early Ordovician,such as Duobaoshan and Tongshan deposits(Liu et al.,2017);2)Triassic-Early Jurassic,including Wunugetushan,Taipingchuan and Badaguan deposits(Tang et al.,2016).In recent years,two potential porphyry Cu-Mo deposits,Huoluotai and Xiaokele,were discovered in the Erguna Block,northern GXAR(Figs.1a–b).However,the ore formation ages and regional metallogenic regularity are ambiguous due to the lack of isotopic ages.Two zircon U-Pb ages from the ore-causative granites were reported in this paper,with the aims to constrain the metallogenic ages and provide evidence for study of the regional metallogenic regularity and ore prospect prediction.

Mathematical Reasoning of Treatment Principle Based on “Yin Yang Wu Xing” Theory in Traditional Chinese Medicine

By using mathematical reasoning, this paper demonstrates the treatment principle: “Virtual disease is to fill his mother but real disease is to rush down his son” and “Strong inhibition of the same time, support the weak” based on “Yin Yang Wu Xing” Theory in Traditional Chinese Medicine (TCM). We defined two kinds of opposite relations and one kind of equivalence relation, introduced the concept of steady multilateral systems with two non-compatibility relations, and discussed its energy properties. Later based on the treatment of TCM and treated the healthy body as a steady multilateral system, it has been proved that the treatment principle is true. The kernel of this paper is the existence and reasoning of the non-compatibility relations in steady multilateral systems, and it accords with the oriental thinking model.

Supercritical extracts of forest fuels in Great Xing＇an Mountains

Extracts are important components of fuels. Fatty-extracts with high heating value （HV） are hypothe- sized by researchers as positively related to the HV of fuels. The Soxhlet extractor is typically used to extract fatty-extracts but it has shortcomings, including long processing time （8-10 h） and the requirement for large amounts of organic solvent. Supercritical extraction is an alternate and useful technique for extraction of natural products. However, published studies rarely discuss the relationship between extracts and HV. In this study, we assessed the supercritical extracts （SUE） of forest fuels in the Great Xing＇an Mountains. Our results indicated that the optimum conditions for extraction of SuEs were 40-60 mesh, 40-50 MPa, 45℃, 80 min and a CO2 flow rate of 1.5-2.0 dm3/min. The Soxhlet extracts contents and the SuE contents were all related to HV. However, R2 of the coniferous samples （0.8499） and needle samples （0.9722） demonstrated that the correlation between HV and the SuE content was closer. We conclude that supercritical fatty-extracts provide a useful index of the HV of fuels, especially coniferous fuels. SuE data can be used in fire management, for example to estimate the rate of fire spread or fire intensity.

Mathematical Reasoning of Treatment Principle Based on “Yin Yang Wu Xing” Theory in Traditional Chinese Medicine (II)

By using mathematical reasoning, this paper demonstrates the treatment principle: “Do not treat a disease after it has occurred. But treat the disease before it will occur” (不治已病治未病) based on “Yin Yang Wu Xing” Theory in Traditional Chinese Medicine (TCM). We defined generalized relations and reasoning, introduced the concept of generalized steady multilateral systems, and discussed its energy properties. Later based on the treatment of TCM and treated the healthy body as a steady multilateral system, it has been proved that the treatment principle above is true. The kernel of this paper is the existence and reasoning of the non-compatibility relations in steady multilateral systems, and it accords with the oriental thinking model.

A Network Pharmacology Study on the Effects of Ma Xing Shi Gan Decoction on Influenza

Objective Pharmacological methods were used to screen targets and signaling pathways of Ma Xing Shi Gan Decoction(MXSGD)during influenza treatments,and mechanisms underlying antiinfluenza effects were elucidated.Methods The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)and relevant literature were searched under predefined conditions to identify the main compounds and their targets.Interactions between the target proteins were predicted using the STRING database.Gene Ontology(GO)functional enrichment analyses and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses were performed on the core targets involved in the influenza protein-protein interaction(PPI)network,using WebGestalt and the reactome database.iGEMDOCK was used for molecular docking of receptors and ligands to produce docking scores,and the results were visualized using Autodock and PyMOL.Results In total,126 major compounds and their respective targets were screened.355 influenza target proteins and 1221 influenza protein interactions were predicted using the STRING database.Influenza-related signaling pathways were strongly enriched in pharmacodynamic targets of MXSGD such as cytokine signaling in immune system and signaling by interleukin.The main biological process was response to the stimulates.Molecular docking results showed that RELALicochalcone A docking elicited by MXSGD,was superior to that of other target proteins and active compounds,suggesting that the docking site is also the main effector site of MXSGD during influenza treatments.Conclusions The results showed that MXSGD exerts antiinfluenza effects by interfering with virus adsorption,inhibiting virus proliferation,influencing immune functions and protecting host cells,which may prevent inflammation-induced tissue damage.