Contents ForewordⅠ.Political Rights Ⅱ.Civil Rights Ⅲ.Economic Rights Ⅳ.Social Rights Ⅴ.Cultural Rights Ⅵ.Environmental Rights Ⅶ.Right to Freedom of Religious Belief Ⅷ.Rights of Women,Children,the Elderly and D...Contents ForewordⅠ.Political Rights Ⅱ.Civil Rights Ⅲ.Economic Rights Ⅳ.Social Rights Ⅴ.Cultural Rights Ⅵ.Environmental Rights Ⅶ.Right to Freedom of Religious Belief Ⅷ.Rights of Women,Children,the Elderly and Disabled Foreword Realization of full human rights is an ideal,one that humankind has pursued for展开更多
Xinjiang, the largest province region in China,is located in the northwest of China.There are eight countries,such as Kazakhstan etc.that surround around Xinjiang. There are long land border lines and many developable...Xinjiang, the largest province region in China,is located in the northwest of China.There are eight countries,such as Kazakhstan etc.that surround around Xinjiang. There are long land border lines and many developable passes. Under the direction of total national development strategy of coastal and border opening, considering the advanced condition of location,the new spatial frontier trade pattern of 'multilevel and all-round position' has initially been formed.That is,to develop westwards market in Middle Asia,to enlarge southwards market in Pakistan and to open up northwards market in Mongolia.The great progress of border opening has been made in Xinjiang.At present, Xinjiang is catching the opportunity to adjust the industrial structure and regional allocation,enhance horizontal economic combination and cooperation,and strengthen the infrastructures construction.Therefore more solid material foundation ofborder opening will be formed for further enlarging.展开更多
Developmental dyslexia is a complex reading and writing disorder with strong genetic components. In previous genetic studies about dyslexia, a number of candidate genes have been identified. These include DCDC2, which...Developmental dyslexia is a complex reading and writing disorder with strong genetic components. In previous genetic studies about dyslexia, a number of candidate genes have been identified. These include DCDC2, which has repeatedly been associated with developmental dyslexia in various European and American populations. However, data regarding this relationship are varied according to population. The Uyghur people of China represent a Eurasian population with an interesting genetic profile. Thus, this group may provide useful information about the association between DCDC2 gene polymorphisms and dyslexia. In the current study, we examined genetic data from 392 Uyghur children aged 8–12 years old from the Xinjiang Uyghur Autonomous Region of China. Participants included 196 children with dyslexia and 196 grade-, age-, and gender-matched controls. DNA was isolated from oral mucosal cell samples and fourteen single nucleotide polymorphisms（rs6456593, rs1419228, rs34647318, rs9467075, rs793862, rs9295619, rs807701, rs807724, rs2274305, rs7765678, rs4599626, rs6922023, rs3765502, and rs1087266） in DCDC2 were screened via the SNPscan method. We compared SNP frequencies in five models（Codominant, Dominant, Recessive, Heterozygote advantage, and Allele） between the two groups by means of the chi-squared test. A single-locus analysis indicated that, with regard to the allele frequency of these polymorphisms, three SNPs（rs807724, rs2274305, and rs4599626） were associated with dyslexia. rs9467075 and rs2274305 displayed significant associations with developmental dyslexia under the dominant model. rs6456593 and rs6922023 were significantly associated with developmental dyslexia under the dominant model and in the heterozygous genotype. Additionally, we discovered that the T-G-C-T of the four-marker haplotype（rs9295619-rs807701-rs807724-rs2274305） and the T-A of the two-marker haplotype（rs3765502-1087266） were significantly different between cases and controls. Thus, we conclude that DCDC2 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children.展开更多
文摘Contents ForewordⅠ.Political Rights Ⅱ.Civil Rights Ⅲ.Economic Rights Ⅳ.Social Rights Ⅴ.Cultural Rights Ⅵ.Environmental Rights Ⅶ.Right to Freedom of Religious Belief Ⅷ.Rights of Women,Children,the Elderly and Disabled Foreword Realization of full human rights is an ideal,one that humankind has pursued for
文摘Xinjiang, the largest province region in China,is located in the northwest of China.There are eight countries,such as Kazakhstan etc.that surround around Xinjiang. There are long land border lines and many developable passes. Under the direction of total national development strategy of coastal and border opening, considering the advanced condition of location,the new spatial frontier trade pattern of 'multilevel and all-round position' has initially been formed.That is,to develop westwards market in Middle Asia,to enlarge southwards market in Pakistan and to open up northwards market in Mongolia.The great progress of border opening has been made in Xinjiang.At present, Xinjiang is catching the opportunity to adjust the industrial structure and regional allocation,enhance horizontal economic combination and cooperation,and strengthen the infrastructures construction.Therefore more solid material foundation ofborder opening will be formed for further enlarging.
基金funded by the National Natural Science Foundation of China,No.81360434
文摘Developmental dyslexia is a complex reading and writing disorder with strong genetic components. In previous genetic studies about dyslexia, a number of candidate genes have been identified. These include DCDC2, which has repeatedly been associated with developmental dyslexia in various European and American populations. However, data regarding this relationship are varied according to population. The Uyghur people of China represent a Eurasian population with an interesting genetic profile. Thus, this group may provide useful information about the association between DCDC2 gene polymorphisms and dyslexia. In the current study, we examined genetic data from 392 Uyghur children aged 8–12 years old from the Xinjiang Uyghur Autonomous Region of China. Participants included 196 children with dyslexia and 196 grade-, age-, and gender-matched controls. DNA was isolated from oral mucosal cell samples and fourteen single nucleotide polymorphisms（rs6456593, rs1419228, rs34647318, rs9467075, rs793862, rs9295619, rs807701, rs807724, rs2274305, rs7765678, rs4599626, rs6922023, rs3765502, and rs1087266） in DCDC2 were screened via the SNPscan method. We compared SNP frequencies in five models（Codominant, Dominant, Recessive, Heterozygote advantage, and Allele） between the two groups by means of the chi-squared test. A single-locus analysis indicated that, with regard to the allele frequency of these polymorphisms, three SNPs（rs807724, rs2274305, and rs4599626） were associated with dyslexia. rs9467075 and rs2274305 displayed significant associations with developmental dyslexia under the dominant model. rs6456593 and rs6922023 were significantly associated with developmental dyslexia under the dominant model and in the heterozygous genotype. Additionally, we discovered that the T-G-C-T of the four-marker haplotype（rs9295619-rs807701-rs807724-rs2274305） and the T-A of the two-marker haplotype（rs3765502-1087266） were significantly different between cases and controls. Thus, we conclude that DCDC2 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children.
