Does enhanced recovery after surgery programs improve clinical outcomes in liver cancer surgery?

Enhanced recovery after surgery(ERAS)programs have been widely applied in liver surgery since the publication of the first ERAS guidelines in 2016 and the new recommendations in 2022.Liver surgery is usually performed in oncological patients(liver metastasis,hepatocellular carcinoma,cholangiocarcinoma,etc.),but the real impact of liver surgery ERAS programs in oncological outcomes is not clearly defined.Theoretical advantages of ERAS programs are:ERAS decreases postoperative complication rates and has been demonstrated a clear relationship between complications and oncological outcomes;a better and faster posto-perative recovery should let oncologic teams begin chemotherapeutic regimens on time;prehabilitation and nutrition actions before surgery should also improve the performance status of the patients receiving chemotherapy.So,ERAS could be another way to improve our oncological results.We will discuss the literature about liver surgery ERAS focusing on its oncological implications and future investigations projects.

An Approach to Detect Structural Development Defects in Object-Oriented Programs

Structural development defects essentially refer to code structure that violates object-oriented design principles. They make program maintenance challenging and deteriorate software quality over time. Various detection approaches, ranging from traditional heuristic algorithms to machine learning methods, are used to identify these defects. Ensemble learning methods have strengthened the detection of these defects. However, existing approaches do not simultaneously exploit the capabilities of extracting relevant features from pre-trained models and the performance of neural networks for the classification task. Therefore, our goal has been to design a model that combines a pre-trained model to extract relevant features from code excerpts through transfer learning and a bagging method with a base estimator, a dense neural network, for defect classification. To achieve this, we composed multiple samples of the same size with replacements from the imbalanced dataset MLCQ1. For all the samples, we used the CodeT5-small variant to extract features and trained a bagging method with the neural network Roberta Classification Head to classify defects based on these features. We then compared this model to RandomForest, one of the ensemble methods that yields good results. Our experiments showed that the number of base estimators to use for bagging depends on the defect to be detected. Next, we observed that it was not necessary to use a data balancing technique with our model when the imbalance rate was 23%. Finally, for blob detection, RandomForest had a median MCC value of 0.36 compared to 0.12 for our method. However, our method was predominant in Long Method detection with a median MCC value of 0.53 compared to 0.42 for RandomForest. These results suggest that the performance of ensemble methods in detecting structural development defects is dependent on specific defects.

Preparedness training programs improved the emergency response and crucial outcomes among nursing students:a scoping review

Objective:The study aims to review and discuss the outcomes of emergency preparedness training programs among nursing students.Methods:A scoping review was conducted based on the guidelines of Arskey and O’Malley.Databases through PubMed,Science Direct,and Google Scholar were used to obtain the relevant articles within the scoping review.Results:The researchers found 1175 articles.After manual review,28 articles were identified and assessed.The review reported that the emergency preparedness training program significantly affects preparedness,knowledge,performance,self-efficacy,learning motivation,self-confidence,satisfaction,critical decision-making,and problem-solving.Conclusions:Emergency training effectively increases knowledge,skills,confidence,satisfaction,and team performance.

Effect of Xinjikang on left ventricular hypertrophy remodeling in hypertensive rats

Objective:To investigate the effects of Xinjikang on the left ventricular hypertrophy remodeling and myocardial activity in hypertension.Methods:Sixty Wistar rats were randomly divided into four groups.The pressure-loaded left ventricular hypertrophy model was established with abdominal aorta ligation method.Rats in A and B groups were intragastrically administered with physiological saline,while C and D groups were administered with Xinjikang and metoprolol,respectively.The changes in blood pressure.E/A ratio,myocardial pathological morphology,myocardial lipoperoxides and superoxide dismustase activity in four groups were observed and compared before and after treatment.Results:There were statistically significant differences in E/A ratio between C group after treatment and model group(P<0.05).while no difference was observed between A and D groups(P>0.05);after treatment the myocardial lipoperoxides and superoxide dismustase contents in C and D groups were improved significantly compared with model group(P<0.05).Conclusions:Xinjikang can improve myocardial injury,restore myocardial parenchyma and myocardial interstitial remodeling functions in hypertensive rats with the left ventricular hypertrophy.

Chinese investigation and research in Southern Ocean physical oceanography and meteorology during the Chinese Polar Programs 2011–2015

Within the context of developing a research presence in the Antarctic region, the first phase of the Chinese Polar Programs covered the period 2011-2015, which almost coincided with the 12th Five-Year Plan （2011-2015）. For the promotion of full understanding of the progress of Chinese expeditions and research in Antarctica, the observations and achievements of cruises during 2011-2015 are summarized in this paper. Four Antarctic cruises （28th-31st） were performed in the Prydz Bay and Antarctic Peninsula regions during the first phase of the Polar Programs. These cruises performed systemic collections of physical oceanographic and meteorological data to support further research on the ice-ocean-atmosphere interactions in Antarctica. Overall, 248 CTD/LADCP stations, 66 microstructure profiles, 507 XBT/XCTDs, 181 air sounding balloons, 58000 total gaseous mercury （TGM） concentrations, 452 aerosol samples, 294 atmospheric samples, 11 moorings, and 28 surface drifters were acquired or deployed during the four cruises. Using these extensive observations and other data, Chinese scientists have achieved new recognition in the fields of Southern Ocean physical oceanography and meteorology, as well as in other interdisciplinary subjects. These studies, which have been associated with scientific techniques, instrumentation, ocean circulation, water mass formation, energy transformation, and carbon uptake, have elucidated the dynamic mechanisms and potential effects of climate change in Antarctica. Finally, some observations based on experience gained during previous Chinese Antarctic Research and Expedition campaigns are summarized with advice for the improvement of future investigations in the Antarctic region.

Effects of mindfulness-based intervention programs on sleep among people with common mental disorders:A systematic review and meta-analysis

BACKGROUND Sleep problems are particularly prevalent in people with depression or anxiety disorder.Although mindfulness has been suggested as an important component in alleviating insomnia,no comprehensive review and meta-analysis has been conducted to evaluate the effects of different mindfulness-based intervention(MBI)programs on sleep among people with depression or anxiety disorder.AIM To compare the effects of different MBI programs on sleep among people with depression or anxiety disorder.METHODS Related publications in Embase,Medline,PubMed and PsycINFO databases were systematically searched from January 2010 to June 2020 for randomised controlled trials.Data were synthesized using a random-effects or a fixed-effects model to analyse the effects of various MBI programs on sleep problems among people with depression or anxiety disorder.The fixed-effects model was used when heterogeneity was negligible,and the random-effects model was used when heterogeneity was significant to calculate the standardised mean differences(SMDs)and 95%confidence intervals(CIs).RESULTS We identified 397 articles,of which 10 randomised controlled trials,involving a total of 541 participants,were included in the meta-analysis.Studies of internet mindfulness meditation intervention(IMMI),mindfulness meditation(MM),mindfulness-based cognitive therapy(MBCT),mindfulness-based stress reduction(MBSR)and mindfulness-based touch therapy(MBTT)met the inclusion criteria.The greatest effect sizes are reported in favour of MBTT,with SMDs of-1.138(95%CI:-1.937 to-0.340;P=0.005),followed by-1.003(95%CI:-1.645 to-0.360;P=0.002)for MBCT.SMDs of-0.618(95%CI:-0.980 to-0.257;P=0.001)and-0.551(95%CI:-0.842 to-0.260;P<0.0001)were reported for IMMI and MBSR in the pooling trials,respectively.Significant effects on sleep problem improvement are shown in all reviewed MBI programs,except MM,for which the effect size was shown to be nonsignificant.CONCLUSION All MBI programs(MBTT,MBCT,IMMI and MBSR),except MM,are effective options to improve sleep problems among people with depression or anxiety disorder.

Reasons Behind the Growing Popularity of Sino-Foreign Cooperative Educational Programs

The continuously expanding program scale and increasing student enrollment number of Sino-foreign cooperative educational programs in recent years have demonstrated their increasing acceptance among Chinese students.This paper aims to explore and analyze the reasons behind the growing popularity of Sino-foreign joint educational programs.

Development and evaluation of local communities incentive programs for improving the traditional forest management:A case study of Northern Zagros forests,Iran

We examined the local community incentive programs to improve traditional forest management in three forested villages in Baneh city, Kurdistan province in the northern Zagros forests of western Iran. Zagros forests cover 6.07 million ha and support rich plant and animal diversity. Changes in local community social and economic sys-tems and the inefficiency of traditional forest management led to a criti-cal situation in the stability of forest regeneration in recent decades. Due to a shortage of productive and arable lands and resulting unemployment and poverty, people overexploited the Zagros forests. Outside interven-tion in traditional forest management creates conflicts between local peoples and forest management organizations. To achieve sustainable forest management, including forest resources conservation and im-provement of natural resource based livelihoods of communities, it is desirable to implement Forestry Incentive Programs （FIP） based on the important functions of forests. Detailed information on the so-cio-economics of communities, the effect of forests on local livelihoods, and lists of products extracted from the forest were obtained from a sur-vey of local communities though questionnaire, interview and observa-tion. We studied 276 households in three villages and completed 76 ques-tionnaires by householders in the quantitative analysis. Sampling was performed by simple random sampling （SRS）. The needs of rural com-munities, such as livestock husbandry, mainly arise from the characteris-tics and environmental features of villages. We identified the driving forces, pressures, status, impacts and responses （DPSIR） to design incen-tive programs, by DPSIR analysis and interaction analysis. Evaluation of local community benefits from forests showed that in order to improve forest management, 319 dollars per year would be needed by each family as an incentive in 2010 to prevent lopping and firewood collecting, the main causes of forest degradation.

An SQP algorithm for mathematical programs with nonlinear complementarity constraints

In this paper, we describe a successive approximation and smooth sequential quadratic programming （SQP） method for mathematical programs with nonlinear complementarity constraints （MPCC）. We introduce a class of smooth programs to approximate the MPCC. Using an 11 penalty function, the line search assures global convergence, while the superlinear convergence rate is shown under the strictly complementary and second-order sufficient conditions. Moreover, we prove that the current iterated point is an exact stationary point of the mathematical programs with equilibrium constraints （MPEC） when the algorithm terminates finitely.

A new smoothing technique for mathematical programs with equilibrium constraints

A kind of mathematical programs with equilibrium constraints （MPEC） is studied. By using the idea of successive approximation, a smoothing nonlinear programming, which is equivalent to the MPEC problem, is proposed. Thereby, it is ensured that some classical optimization methods can be applied for the MPEC problem. In the end, two algorithm models are proposed with the detail analysis of the global convergence.

Household Disposal and Recycling of Medication in Saudi Arabia: A Call for Introducing Drug Take-Back Programs

Background: Inappropriate disposal practices of medicinal products by households can harm nature. Alternatively, passing unused medications to friends and family members can have undesirable consequences as the quality of the product is in question. Objective: To investigate the disposal and recycling practices of medicinal products by households in Saudi Arabia. Methods: A cross-sectional questionnaire designed to investigate disposal and recycling practices aimed at households in Saudi Arabia. Phone interviews were conducted with healthcare providers from hospitals and community pharmacies as well as medical charity representatives. A thorough search (Jun-September 2020) for disposal and recycling policies was performed on the Saudi Food and Drug Authority (SFDA) and the Ministry of Health websites. Results: More than 900 participants were included in this study. Approximately 40% of respondents claimed to follow the SFDA recommendations for the disposal of unwanted medications in the wastebasket, whilst ≥6% preferred disposal via the toilet. On the other hand, 10% and 5% of households donated their unwanted over-the-counter and prescription-only medication products, respectively, to a person in need, without referring to healthcare professionals. Interviews with healthcare providers and medical charities revealed no drug take-back programs were currently available for households. The SFDA website provides a brief guide on the disposal of unwanted or expired medication. Conclusions: The absence of a clear drug disposal policy for households has created a gap allowing incorrect disposal practices that may lead to harming patients and/or the environment. The launching of drug take-back programs may lead to the provision of a clear consensus of governing bodies and healthcare providers on patient guidance for a safe drug disposal policy.

SHFuzz:A Hybrid Fuzzing Method Assisted by Static Analysis for Binary Programs

Fuzzing is an effective technique to find security bugs in programs by quickly exploring the input space of programs.To further discover vulnerabilities hidden in deep execution paths,the hybrid fuzzing combines fuzzing and concolic execution for going through complex branch conditions.In general,we observe that the execution path which comes across more and complex basic blocks may have a higher chance of containing a security bug.Based on this observation,we propose a hybrid fuzzing method assisted by static analysis for binary programs.The basic idea of our method is to prioritize seed inputs according to the complexity of their associated execution paths.For this purpose,we utilize static analysis to evaluate the complexity of each basic block and employ the hardware trace mechanism to dynamically extract the execution path for calculating the seed inputs’weights.The key advantage of our method is that our system can test binary programs efficiently by using the hardware trace and hybrid fuzzing.To evaluate the effectiveness of our method,we design and implement a prototype system,namely SHFuzz.The evaluation results show SHFuzz discovers more unique crashes on several real-world applications and the LAVA-M dataset when compared to the previous solutions.

Perceptions of Beach Stewards and Information Needs for Shorebird Stopover Sites Vary as a Function of Visitor Interests: Improving Stewardship Programs in Coastal Landscapes

Many studies have demonstrated that some of the activities of people can disturb nesting and foraging birds, particularly along coasts and estuaries. Some managers respond to human disturbance of sensitive species by closing beaches, but most have stewards monitor and restrict access to beaches or portions of beaches. Yet little is known about the type of visitor or their perceptions of beach stewards. This paper explores the general acceptance of beach stewards and their role in conservation of red knots (Calidris canutus rufa), other shorebirds, and horseshoe crabs (Limulus polyphemus) along the Delaware Bay (New Jersey) beaches by interviewing 279 visitors during the stopover period. While most people came to see the shorebird and horseshoe crab spectacle (60%), many came for the scenery, tranquility, and recreation. Just over half of the people interviewed said that the stewards were helpful (58%), although most of those that answered this question later said that they provided conservation value (86%), but only 40% said they relied on the stewards for information. On a Likert rating scale of 1 to 5 (the highest value), the mean rating for whether it was important for stewards to be present was 3.87 ± 0.09, and the rating for the presence of stewards who can provide information was 3.71 ± 0.11. In contrast, protection of shorebirds was rated a mean of 4.79 ± 0.04. There were significant visitor type differences in how important stewards were, but not in the importance of stewards who can provide information. Fishermen, recreationists, and people coming for scenery and tranquility rated the presence of stewards higher than those visitors who were interested in either shorebirds or crabs (or both). Ratings also differed significantly as a function of age and gender;older adults and females rated characteristics higher than did people under 30 years and males. Information needs identified by stewards are also discussed. These data can be used by the managers developing a strategy for conservation of shorebirds and other species sensitive to disturbance, and for the implementation of an effective stewardship program.

Nutrition Programs through Public Health Centers in Korea

In the peroid of confusion after the Korean War, there was an absolute shortage in the volume of food. The intake of energy and all other nutrients fell short of the recommended dietary intake. To solve the food shortage, there were many food assistant programs through the government channel. With the economic developments during past years, now, there are enough foods for everyone. Thus, food assistant program, which has been the only nutrition program in the government, is no longer needed except for low-income families.Currently, there are not enough nutrition programs in the government. In 1994, about 30 public health center start nutrition programs with the help of Korean Dietetic Association.In this study, kinds of nutrition programs, age, sex and number of participants, the content of programs are studied. The effects of nutrition programs are partially evaluated.Also, problems with current nutrition programs are discussed. Finally, future directions of nutrition programs in the public health centers are discussed

Applications of Molecular Markers in Fruit Crops for Breeding Programs—A Review

Selection and use of molecular markers for evaluation of DNA polymorphism in plants are couple of the most important approaches in the field of molecular genetics.The assessment of genetic diversity using morphological markers is not sufficient due to little differentiating traits among the species,genera or their individuals.Morphological markers are not only highly influenced by environmental factors but skilled assessment is also prerequisite to find the variations in plant genetic resources.Therefore,molecular markers are considered as efficient tools for detailed DNA based characterization of fruit crops.Molecular markers provide new directions to the efforts of plant breeders particularly in genetic variability,gene tags,gene localization,taxonomy,genetic diversity,phylogenetic analysis and also play an important role to decrease the time required for development of new and excellent cultivars.The success of molecular markers technology in genetic improvement programs depends on the close relationship among the plant breeders,biotechnologists,skilled manpower and good financial support.The present review describes application and success of molecular markers technology used for genetic improvement in different fruit crops.

A Trace-state Based Approach to Specification and Design of Parallel Programs

In this paper they deal with the issue of specification and design of parallel communicatingprocesses. A trace-state based model is introduced to describe the behaviour of concurrent programs. They presenta formal system based on that model to achieve hierarchical and modular development and verification methods. Anumber of refinement rules are used to decompose the specification into smaller ones and calculate program fromthe

Study of Impacts of Small Business Innovation Research Programs

The development and commercialization of new technologies are important to the global economy. In this paper, the author first addresses Small Business Innovation Research （SBIR） background ; then, implicitly defines SBIR ; finally, I also analyze the impacts of smaU business innovation research programs. There are four aspects ： entrepreneurial orientation; environmental factors; organizational factors and performanee.

2018 MOFCOM Academic Education Programs

The Academic Education Programs sponsored by the Ministry of Commerce of China is designed to nurture high-end business officials and managerial personnel from recipient countries, offering one-year and two-year master programs as well as three-year doctoral programs for those working in the applied fields of government, trade, foreign affairs, agriculture, technology, education, culture and health.

A review of obstacles and facilitating factors of implementing Clinical Ladder Programs in nursing

Clinical Ladder Programs is to develop different training programs according to different levels of nurses’management.The purpose is to improve nurses’sense of professional identity,professional and technical capabilities,and determine salary levels,so as to fully mobilize nurses’enthusiasm.This article reviews the current status of the application of Clinical Ladder Programs in clinical nursing around the world,and understands the obstacles and facilitating factors that affect the implementation of Clinical Ladder Programs,in order to provide a reference for establishing a perfect hierarchical nurse training model in China.