Objective: To analyze the potential mechanism of Xinyi San in treating rhinitis through network pharmacology. Methods: In the database of Traditional Chinese Medicine Systems Pharmacology (TCMSP), chemical composition...Objective: To analyze the potential mechanism of Xinyi San in treating rhinitis through network pharmacology. Methods: In the database of Traditional Chinese Medicine Systems Pharmacology (TCMSP), chemical composition and potential targets of Xinyi San were got, and the target genes of rhinitis of Xinyi San were extracted from GeneCards databases. Then we constructed protein-protein interactions (PPI) network of target genes, and then analyzed the Key genes in GO analysis and KEGG analysis. Results: We got 97 components, 53 potential therapeutic targets, 1009 GO items and 92 pathways in our study. The main pathways included Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, PI3K-Akt signaling pathway, Human cytomegalovirus infection, Prostate cancer, etc. Conclusion: Xinyi San plays a role in treating rhinitis through multiple components, multiple targets and multiple pathways.展开更多
Objective: To study the molecular mechanism of Xinyi San for the treatment of senile rhinitis by applying network pharmacological analysis technology. Methods: The effective components and corresponding targets of Xin...Objective: To study the molecular mechanism of Xinyi San for the treatment of senile rhinitis by applying network pharmacological analysis technology. Methods: The effective components and corresponding targets of Xinyi San were collected by TCMSP. The targets of senile rhinitis were collected by the Genecards database. The potential target of Xinyi San in the treatment of senile rhinitis was obtained by Venn analysis. Cytoscape 3.7.2 the software constructs the relationship network model of “disease-single drug-active ingredient-action target”. Protein protein interaction (PPI) network was constructed by using a string database. R4.1.1 software was used for GO function enrichment analysis and KEGG pathway enrichment analysis. Results: In this study, we obtained 158 active ingredients, 40 potential therapeutic targets, 74 GO projects, and 99 pathways. Major pathways include Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, PI3K-Akt signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways of neurodegeneration-multiple diseases, etc. Conclusion: Xinyi San has the characteristics of multi-component, multi-target, and multi-channel in the treatment of senile rhinitis. This study provides a basis for the in-depth study of Xinyi San.展开更多
[Objectives]This study was conducted to establish characteristic chromatograms of of the volatile oil of Xinyi Biyan Pills by gas chromatography,discover possible problems in the production processes of different manu...[Objectives]This study was conducted to establish characteristic chromatograms of of the volatile oil of Xinyi Biyan Pills by gas chromatography,discover possible problems in the production processes of different manufacturers,and further improve the quality control methods.[Methods]The volatile oil in samples was extracted and tested by gas chromatography to collect chromatograms,which were analyze and evaluated by the similarity evaluation software of chromatographic fingerprints of traditional Chinese medicine.[Results]Nineteen common peaks were calibrated in the characteristic chromatograms;and the characteristic chromatograms of samples produced by different manufacturers were obviously different.[Conclusions]Controlling the volatile components in Xinyi Biyan Pills by the established characteristic chromatograms of GC is accurate and feasible,and can be used as a quality control method for Xinyi Biyan Pills.展开更多
Objective: To analyze the potential mechanism of Xinyi San in treating nasal polyposis through network pharmacology. Methods: We Screened the active components and targets of Xinyi San by TCMSP database, and disease t...Objective: To analyze the potential mechanism of Xinyi San in treating nasal polyposis through network pharmacology. Methods: We Screened the active components and targets of Xinyi San by TCMSP database, and disease targets through GeneCards database. We constructed “disease-single drug-component-target” network through software Cytoscape 3.7.2 and constructed PPI network through STRING database. GO function and KEGG pathway enrichment were analyzed to predict its mechanism. Results: We got 162 components, 69 therapeutic targets, 88 GO items and 135 pathways. The main pathways include Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, Kaposi sarcoma-associated herpesvirus infection, Hepatitis B, Human cytomegalovirus infection, etc. Conclusion: This study preliminarily revealed the active components, targets and pathways of Xinyi San in treating nasal polyposis.展开更多
This paper investigated aqueous chemistry for two geothermal spring groups responsive and sensitive to flow fluctuations induced by earthquakes. Quake monitorings are favored for their being in residential areas with ...This paper investigated aqueous chemistry for two geothermal spring groups responsive and sensitive to flow fluctuations induced by earthquakes. Quake monitorings are favored for their being in residential areas with well-preserved natural flow systems in Xinyi City＇s Xijiang Hot Springs and Fengshun County＇s Shihu Hot Spring. The hot springs are typical in temperatures and flow rates in southern China＇s Guangdong Province. Physical and chemical conditions deep down in the heat sources are important constraints on earthquake, fluid flow, reactive solute transport and heat transfer, but remain challenging to address via field observations and numerical experiments. In this paper, we made daily and annual observations on flow rates, temperature, and/or aqueous chemistry. We employed strontium isotopes as tracers for the water sources, equilibrium phase diagram for K-feldspar and albite stability, and Na-K-Mg diagram for heat reservoir temperatures. The abundant sulfite content in Xi- jiang Hot Springs is discussed. Our main finding are that the deep fault springs are characterized by low reduction-oxidation potential at around -200- -150 mV and relatively large daily flow variations. The resuits provide scientific background features on the field sites regarding earthquake monitoring and predictions and geothermal reservoir.展开更多
Objective: To observe the therapeutic effect of composite Xinyi ae rosol (复方辛夷雾化剂, XYA) in treating asthma and its influence on asthma relat ed cytokines in serum and sputum of patients with mild or moderate br...Objective: To observe the therapeutic effect of composite Xinyi ae rosol (复方辛夷雾化剂, XYA) in treating asthma and its influence on asthma relat ed cytokines in serum and sputum of patients with mild or moderate bronchial ast hma.Methods: Sixty patients were divided randomly into the treated gr oup and the control group, 30 in each group. They were treated with XYA and Salb utamol aerosol (SA) respectively by spray inhalation once a day for seven days a s one therapeutic course to observe the antiasthmatic effect of the treatment. Changes of lung function and the levels of tumor necrosis factor α (TNF-α) , interleukine-2 receptor (IL-2R) and interleukine-8 (IL-8) in serum and sputum were observed before and after treatment using enzyme linked immunos orbent assay (ELISA). Levels of TNF-α, IL-2R andIL-8 in the sputum of part of the patients in the treatment group were also observed.Results: In the treated group, 6 patients had the asthma clinica lly controlled after treatment, 12 were markedly alleviated, 9 alleviated and 3 remained unchanged, while in the control group, the respective numbers were 4, 6 , 15 and 5. The controlled-markedly effective rate of XYA was 60.0%, which wa s significantly better than that of SA (33.3%, P <0.05). The one second forc ed expiratory volume percent (FEV1%) and peek expiratory flow rate (PEFR) improv ed significantly and the levels of TNF-α, IL-2R and IL-8 in serum decr eased noticeably in both groups after treatment ( P <0.05 or P <0.01), but the improvement in the treated group was more significant as compared with tho se in the control group ( P <0.05). The levels of TNF-α, IL-2R and IL -8 in sputum considerably lowered also after XYA treatment ( P <0.01).Conclusion: XYA could regulate the related cytokines in patient s with mild or moderate bronchial asthma, and reduce the releasing of inflammato ry factors, which is consistent with the improvement of lung functions, so as to ease the airway inflammation chiefly exhibited as cell infiltration in bron chi.展开更多
文摘Objective: To analyze the potential mechanism of Xinyi San in treating rhinitis through network pharmacology. Methods: In the database of Traditional Chinese Medicine Systems Pharmacology (TCMSP), chemical composition and potential targets of Xinyi San were got, and the target genes of rhinitis of Xinyi San were extracted from GeneCards databases. Then we constructed protein-protein interactions (PPI) network of target genes, and then analyzed the Key genes in GO analysis and KEGG analysis. Results: We got 97 components, 53 potential therapeutic targets, 1009 GO items and 92 pathways in our study. The main pathways included Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, PI3K-Akt signaling pathway, Human cytomegalovirus infection, Prostate cancer, etc. Conclusion: Xinyi San plays a role in treating rhinitis through multiple components, multiple targets and multiple pathways.
文摘Objective: To study the molecular mechanism of Xinyi San for the treatment of senile rhinitis by applying network pharmacological analysis technology. Methods: The effective components and corresponding targets of Xinyi San were collected by TCMSP. The targets of senile rhinitis were collected by the Genecards database. The potential target of Xinyi San in the treatment of senile rhinitis was obtained by Venn analysis. Cytoscape 3.7.2 the software constructs the relationship network model of “disease-single drug-active ingredient-action target”. Protein protein interaction (PPI) network was constructed by using a string database. R4.1.1 software was used for GO function enrichment analysis and KEGG pathway enrichment analysis. Results: In this study, we obtained 158 active ingredients, 40 potential therapeutic targets, 74 GO projects, and 99 pathways. Major pathways include Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, PI3K-Akt signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways of neurodegeneration-multiple diseases, etc. Conclusion: Xinyi San has the characteristics of multi-component, multi-target, and multi-channel in the treatment of senile rhinitis. This study provides a basis for the in-depth study of Xinyi San.
基金Guangxi Key R&D Program Project (GK AB19110027).
文摘[Objectives]This study was conducted to establish characteristic chromatograms of of the volatile oil of Xinyi Biyan Pills by gas chromatography,discover possible problems in the production processes of different manufacturers,and further improve the quality control methods.[Methods]The volatile oil in samples was extracted and tested by gas chromatography to collect chromatograms,which were analyze and evaluated by the similarity evaluation software of chromatographic fingerprints of traditional Chinese medicine.[Results]Nineteen common peaks were calibrated in the characteristic chromatograms;and the characteristic chromatograms of samples produced by different manufacturers were obviously different.[Conclusions]Controlling the volatile components in Xinyi Biyan Pills by the established characteristic chromatograms of GC is accurate and feasible,and can be used as a quality control method for Xinyi Biyan Pills.
文摘Objective: To analyze the potential mechanism of Xinyi San in treating nasal polyposis through network pharmacology. Methods: We Screened the active components and targets of Xinyi San by TCMSP database, and disease targets through GeneCards database. We constructed “disease-single drug-component-target” network through software Cytoscape 3.7.2 and constructed PPI network through STRING database. GO function and KEGG pathway enrichment were analyzed to predict its mechanism. Results: We got 162 components, 69 therapeutic targets, 88 GO items and 135 pathways. The main pathways include Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, Kaposi sarcoma-associated herpesvirus infection, Hepatitis B, Human cytomegalovirus infection, etc. Conclusion: This study preliminarily revealed the active components, targets and pathways of Xinyi San in treating nasal polyposis.
基金supported in part by 211 startup fund to the first author by China University of Geosciences (Wuhan)
文摘This paper investigated aqueous chemistry for two geothermal spring groups responsive and sensitive to flow fluctuations induced by earthquakes. Quake monitorings are favored for their being in residential areas with well-preserved natural flow systems in Xinyi City＇s Xijiang Hot Springs and Fengshun County＇s Shihu Hot Spring. The hot springs are typical in temperatures and flow rates in southern China＇s Guangdong Province. Physical and chemical conditions deep down in the heat sources are important constraints on earthquake, fluid flow, reactive solute transport and heat transfer, but remain challenging to address via field observations and numerical experiments. In this paper, we made daily and annual observations on flow rates, temperature, and/or aqueous chemistry. We employed strontium isotopes as tracers for the water sources, equilibrium phase diagram for K-feldspar and albite stability, and Na-K-Mg diagram for heat reservoir temperatures. The abundant sulfite content in Xi- jiang Hot Springs is discussed. Our main finding are that the deep fault springs are characterized by low reduction-oxidation potential at around -200- -150 mV and relatively large daily flow variations. The resuits provide scientific background features on the field sites regarding earthquake monitoring and predictions and geothermal reservoir.
文摘Objective: To observe the therapeutic effect of composite Xinyi ae rosol (复方辛夷雾化剂, XYA) in treating asthma and its influence on asthma relat ed cytokines in serum and sputum of patients with mild or moderate bronchial ast hma.Methods: Sixty patients were divided randomly into the treated gr oup and the control group, 30 in each group. They were treated with XYA and Salb utamol aerosol (SA) respectively by spray inhalation once a day for seven days a s one therapeutic course to observe the antiasthmatic effect of the treatment. Changes of lung function and the levels of tumor necrosis factor α (TNF-α) , interleukine-2 receptor (IL-2R) and interleukine-8 (IL-8) in serum and sputum were observed before and after treatment using enzyme linked immunos orbent assay (ELISA). Levels of TNF-α, IL-2R andIL-8 in the sputum of part of the patients in the treatment group were also observed.Results: In the treated group, 6 patients had the asthma clinica lly controlled after treatment, 12 were markedly alleviated, 9 alleviated and 3 remained unchanged, while in the control group, the respective numbers were 4, 6 , 15 and 5. The controlled-markedly effective rate of XYA was 60.0%, which wa s significantly better than that of SA (33.3%, P <0.05). The one second forc ed expiratory volume percent (FEV1%) and peek expiratory flow rate (PEFR) improv ed significantly and the levels of TNF-α, IL-2R and IL-8 in serum decr eased noticeably in both groups after treatment ( P <0.05 or P <0.01), but the improvement in the treated group was more significant as compared with tho se in the control group ( P <0.05). The levels of TNF-α, IL-2R and IL -8 in sputum considerably lowered also after XYA treatment ( P <0.01).Conclusion: XYA could regulate the related cytokines in patient s with mild or moderate bronchial asthma, and reduce the releasing of inflammato ry factors, which is consistent with the improvement of lung functions, so as to ease the airway inflammation chiefly exhibited as cell infiltration in bron chi.
