120 pearl oysters （Pinctada martensii） were randomly sampled from F1 population, and shell length, shell width, shell height, shell weight and total weight of each sample were measured. Correlation and path analysis...120 pearl oysters （Pinctada martensii） were randomly sampled from F1 population, and shell length, shell width, shell height, shell weight and total weight of each sample were measured. Correlation and path analysis were conducted on the basis of measurement data. The results showed that shell length, shell width, shell height, shell weight and total weight were significantly correlated （P 〈 0.05）. Total weight was significantly and positively correlated with shell weight （r = 0.8970）, shell height （r = 0.6974）, shell width （r = 0.6521） and shell length （r = 0.5486）. Shell weight, shell height, shell width and shell length had positive and direct effects on total wet weight, with the values of 0.6356, 0.1872, 0.1814 and 0.0599, respectively. The results indicated that growth traits （shell length, shell width, shell height, shell weight and total wet weigh） of the F1 population could be improved by direct or indirect selection.展开更多
Alzheimer＇s disease, the leading cause of dementia in the elderly, is a complex neurodegenerative disorder which leads to a progressive decline in cognitive functions. A rapid screening model is highly demanded for i...Alzheimer＇s disease, the leading cause of dementia in the elderly, is a complex neurodegenerative disorder which leads to a progressive decline in cognitive functions. A rapid screening model is highly demanded for identification and evaluation of novel anti-Alzheimer＇s disease drugs from a large numbers of compounds. Until now, numerous studies utilized zebrafish model for drug discovery. Since aluminum can induce a similar biological activity in zebrafish as in Alzheimer patients, in this study, we developed a novel animal model using 3 to 5 day post-fertilization larval zebrafish by optimizing the doses and duration of aluminum chloride exposure. Six anti-Alzheimer＇s disease drugs with a variety of mechanisms were tested to validate the newly developed zebrafish model. Importantly, Rivastigmine, ThT, Flurbiprofen and AM-117 could increase the value of Dyskinesia Recovery Rate by 53.4-64%, 169.4-200%, 54.5-96% and 70.9-121%, respectively. Rivastigmine, Memantine, ThT, Flurbiprofen, Rosiglitazone and AM-117 improved the value of Response Efficiency by 86.6-175.1%, 28.2-66.6%, 127.2-236.5%, 118.3-323.7%, 26.6-140.8% and 70.2-161.4%, respectively. Our results suggest that the zebrafish model developed in this study could be a useful tool for high throughput screening of potential novel anti-Alzheimer＇s disease leading compounds targeting acetylcholinesterase, N-methyl-D-aspartic acid receptor, γ-secretase, peroxisome proliferator-activated receptor-γand amyloid-β.展开更多
To understand the effect of climate change on constitutive antioxidant and biochemical metabolites in Western Himalayas, five medicinal herbs were selected and grown at two altitudes in Jammu(305 m) and Srinagar(1730 ...To understand the effect of climate change on constitutive antioxidant and biochemical metabolites in Western Himalayas, five medicinal herbs were selected and grown at two altitudes in Jammu(305 m) and Srinagar(1730 m) with subtropical and temperate climates, respectively.Significant variations were observed in phenols and flavonoids in Hypericum perforatum L., Matricaria chamomilla L., Thymus vulgaris L., Cynara cardunculus L. and Echinacea purpurea L. growing at two locations. High altitude temperate site show variable(up to 13 fold) increase in their content.Proteins(1.3- 1.8 times), sugars(2.8- 4.1 times) and free amino acid(1.04- 1.22 times) were also higher at Srinagar(1730 m). Within these plants, H.perforatum and M. chamomilla have shown higher accumulation of phenols, xanthophylls and proline even at subtropical environment in Jammu(305 m)suggesting potential for increasing their geographical area. The results demonstrate that changing environmental conditions significantly affect the bioactive constituents, which accumulate as a defence strategy by these temperate plants. Their medicinal significance during climate change scenario has also been discussed.展开更多
A decorated ruthenium catalyst was prepared by the coprecipitation method and used for the selective hydrogenation of maleic anhydride(MA) to γ-butyrolactone(GBL). The as-prepared catalyst was characterized by XRD, T...A decorated ruthenium catalyst was prepared by the coprecipitation method and used for the selective hydrogenation of maleic anhydride(MA) to γ-butyrolactone(GBL). The as-prepared catalyst was characterized by XRD, TGDTG and N2 adsorption techniques. The characterization tests revealed that the catalyst carrier was composed of monoclinic zirconia(m-ZrO2) and hydroxyl cobalt oxide(CoO(OH)). The hydrogenation results showed that the content of CoO(OH), the reaction temperature, the hydrogen pressure and the reaction time significantly affected the catalytic selectivity to GBL. The promotional effect of CoO(OH) was remarkable, which led to an obvious increase in GBL selectivity. An 100% MA conversion and 92.0% selectivity to GBL were achieved over the Ru/ZrO2-CoO(OH)(35%) catalyst in water solvent under the conditions involving a reaction temperature of 180 ℃, a hydrogen pressure of 3.0 MPa, and a reaction time of 6 h.展开更多
基金grants of the Guangdong Marine and Fishery Bureau(No.B02068)Guangdong Ocean University(No.E06031).
文摘120 pearl oysters （Pinctada martensii） were randomly sampled from F1 population, and shell length, shell width, shell height, shell weight and total weight of each sample were measured. Correlation and path analysis were conducted on the basis of measurement data. The results showed that shell length, shell width, shell height, shell weight and total weight were significantly correlated （P 〈 0.05）. Total weight was significantly and positively correlated with shell weight （r = 0.8970）, shell height （r = 0.6974）, shell width （r = 0.6521） and shell length （r = 0.5486）. Shell weight, shell height, shell width and shell length had positive and direct effects on total wet weight, with the values of 0.6356, 0.1872, 0.1814 and 0.0599, respectively. The results indicated that growth traits （shell length, shell width, shell height, shell weight and total wet weigh） of the F1 population could be improved by direct or indirect selection.
基金Acknowledgments The authors thank the National Natural Science Foundation of China （81302646）, Natural Science Foundation of Zhejiang Province （LQ13H300002）, Science Technology Department of Zhejiang Province （2015F50015） and Health and Family Planning commission of Zhejiang Province （XKQ-010-001 and 2013KYB070） for financial support.
文摘Alzheimer＇s disease, the leading cause of dementia in the elderly, is a complex neurodegenerative disorder which leads to a progressive decline in cognitive functions. A rapid screening model is highly demanded for identification and evaluation of novel anti-Alzheimer＇s disease drugs from a large numbers of compounds. Until now, numerous studies utilized zebrafish model for drug discovery. Since aluminum can induce a similar biological activity in zebrafish as in Alzheimer patients, in this study, we developed a novel animal model using 3 to 5 day post-fertilization larval zebrafish by optimizing the doses and duration of aluminum chloride exposure. Six anti-Alzheimer＇s disease drugs with a variety of mechanisms were tested to validate the newly developed zebrafish model. Importantly, Rivastigmine, ThT, Flurbiprofen and AM-117 could increase the value of Dyskinesia Recovery Rate by 53.4-64%, 169.4-200%, 54.5-96% and 70.9-121%, respectively. Rivastigmine, Memantine, ThT, Flurbiprofen, Rosiglitazone and AM-117 improved the value of Response Efficiency by 86.6-175.1%, 28.2-66.6%, 127.2-236.5%, 118.3-323.7%, 26.6-140.8% and 70.2-161.4%, respectively. Our results suggest that the zebrafish model developed in this study could be a useful tool for high throughput screening of potential novel anti-Alzheimer＇s disease leading compounds targeting acetylcholinesterase, N-methyl-D-aspartic acid receptor, γ-secretase, peroxisome proliferator-activated receptor-γand amyloid-β.
基金financial support to the present study by Council of Scientific and Industrial Research (CSIR)Government of India,under CSIR- networking project (BSC-0109) on ‘Plant Diversity: Studying adaptation biologyunderstanding/exploiting medicinally important plants for useful bioactives (SIMPLE)
文摘To understand the effect of climate change on constitutive antioxidant and biochemical metabolites in Western Himalayas, five medicinal herbs were selected and grown at two altitudes in Jammu(305 m) and Srinagar(1730 m) with subtropical and temperate climates, respectively.Significant variations were observed in phenols and flavonoids in Hypericum perforatum L., Matricaria chamomilla L., Thymus vulgaris L., Cynara cardunculus L. and Echinacea purpurea L. growing at two locations. High altitude temperate site show variable(up to 13 fold) increase in their content.Proteins(1.3- 1.8 times), sugars(2.8- 4.1 times) and free amino acid(1.04- 1.22 times) were also higher at Srinagar(1730 m). Within these plants, H.perforatum and M. chamomilla have shown higher accumulation of phenols, xanthophylls and proline even at subtropical environment in Jammu(305 m)suggesting potential for increasing their geographical area. The results demonstrate that changing environmental conditions significantly affect the bioactive constituents, which accumulate as a defence strategy by these temperate plants. Their medicinal significance during climate change scenario has also been discussed.
基金the financial support from the Natural Science Foundation of China(No.21303139)the Key Fund Project of Educational Department of Sichuan Province(No.14ZA0126)the Open Project of Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province(No.CSPC2013-1)
文摘A decorated ruthenium catalyst was prepared by the coprecipitation method and used for the selective hydrogenation of maleic anhydride(MA) to γ-butyrolactone(GBL). The as-prepared catalyst was characterized by XRD, TGDTG and N2 adsorption techniques. The characterization tests revealed that the catalyst carrier was composed of monoclinic zirconia(m-ZrO2) and hydroxyl cobalt oxide(CoO(OH)). The hydrogenation results showed that the content of CoO(OH), the reaction temperature, the hydrogen pressure and the reaction time significantly affected the catalytic selectivity to GBL. The promotional effect of CoO(OH) was remarkable, which led to an obvious increase in GBL selectivity. An 100% MA conversion and 92.0% selectivity to GBL were achieved over the Ru/ZrO2-CoO(OH)(35%) catalyst in water solvent under the conditions involving a reaction temperature of 180 ℃, a hydrogen pressure of 3.0 MPa, and a reaction time of 6 h.
