Context: The biochemical assessment is a real-time indicator of the state and evolution of an infection. Among other things, it makes it possible to determine the right moment when it becomes necessary to start or cha...Context: The biochemical assessment is a real-time indicator of the state and evolution of an infection. Among other things, it makes it possible to determine the right moment when it becomes necessary to start or change a treatment. Objective: The objective of this study is to present the Biological profile of People Living with HIV starting AntiRetroViral treatment in Kinshasa in the era of Dolutegravir. Methods: The present study is a descriptive cross-sectional to determine the biological profile of People Living with HIV (PLHIV) starting AntiRetroViral Treatment (ART). The patient inclusion period was from October 4, 2021 to February 15, 2022. Sixteen centers were included. A sample of 5 ml of blood was taken in a tube with EDTA. Patients were randomly included consecutively in the centers during consultations. The population was made up of adults aged over 18, infected with HIV and starting ART. The parameters of interest retained for the present study were: sex, age, hemoglobin level, blood sugar, urea, creatinine, transaminases, total cholesterol, triglycerides, proteins total, as well as amylase. Results: 119 patients were included in this study in accordance with the inclusion criteria;67 (56.3%) are female, giving a sex ratio of 1.29 in favor of women. The average age of the patients is 39.87 ± 12.36 years. The most represented age group is that of 36 to 45 years with 37 patients (31.9%). The mean values of the biological parameters of the patients at the start of ART are as follows: 31.61 ± 20.71 IU/L for ALT/SGPT, 25.81 ± 19.96 IU/L for AST/SGOT, 79.35 ± 49.49 IU/L for Amylase, 108.13 ± 62.17 mg/dl for Total Cholesterol, 2.77 ± 1.27 mg/dl for Creatinine, 72.53 ±22.23 mg/dl for Glycaemia, 10.30 ± 2.33 g/dl for Hemoglobin, 7.91 ± 1.75 g/dl for Total Protein, 131.23 ± 68.80 mg/dl for Triglycerides, and 33.61 ± 26.27 mg/dl for Urea. Conclusion: Mean values of PLHIV are, for the most part, within the normal range. The average creatinine is higher than the normal average value while the average total cholesterol is below the limit values.展开更多
Context: Despite the new recommendations “Test and Treat”, the virological and molecular parameters remain important information for Antiretroviral Treatment and adequate for monitoring of patients infected with HIV...Context: Despite the new recommendations “Test and Treat”, the virological and molecular parameters remain important information for Antiretroviral Treatment and adequate for monitoring of patients infected with HIV/AIDS. Objective: the Objective of this study is to present the virological and molecular profile of People Living with HIV starting Antiretroviral Therapy in Kinshasa in the era of the Dolutegravir. Methods: This was a transversal study to determine virological and molecular profile of People Living with HIV (PLHIV) starting an ARV Treatment. The patient’s inclusion period was from October 04, 2021 to February 15, 2022. A sample of 5 ml of blood was taken in a tube with EDTA anticoagulant for Molecular Biology analyzes (Viral Load and Sequencing) in all HIV patients, after reading and signing informed consent. The population was made up of adult patients over the age of 18, infected with HIV and starting ART. Results: 119 patients (56.3% of women) were included in this study, thus a sex-ratio of 1.29. The average age of patients included was 39.87 ± 12.36 years. The most represented age group is that of 36 to 45 with 37 patients (31.9%) followed by that from 26 to 35 years with 24 patients (20.7%). Out of 119 patients, 21 patients had an undetectable Viral Load (VL). The median value of VL was 4.16 log10 RNA copies/ml. 114 samples were successfully amplified. Subtype A was dominant with 23 cases (20.2%);followed by the subtype C and CRF02_AG each with 14.0%, and D (10.5 %). K65R (1.8%), T69P/N (4.4%), K70R (7.9%) and M184V (7.0%) mutations were listed as existing mutations for Nucleotide Transcriptase Inhibitors. Conclusion: 38 patients (31.93%) started the TARV with a positive virological prognosis. The subtype A remains dominant in Kinshasa with 23 cases (20.2%);followed by the subtype C and CRF02_AG each with 14.0%. For Inhibitors of Transcriptase Reverse Nucleotide;K65R, T69P/N, K70E/R and M184V mutations were found in patients’ naive of ARV Treatment.展开更多
According to the textual research into the historical documents dominated by archives yearly, as well as the verification with several other kinds of data, the later or earlier starting time of the rainy seasons in Yu...According to the textual research into the historical documents dominated by archives yearly, as well as the verification with several other kinds of data, the later or earlier starting time of the rainy seasons in Yunnan during 1711-1982 has been reconstructed. The analysis indicates that there are obvious fluctuations in the starting date of the rainy seasons in Yunnan in a year or years, and long fluctuation on the decadal scale. The rainy season comes earlier in the early 18th century, later in the 19th century and earlier again in the 20th century. This reflects to a certain degree the gradual change of the summer monsoon in Yunnan. There exists an obvious quasi-3 years cycle, which is related to EI-Nino＇s quasi-3 years cycle, and a 11.3-year cycle which is notably related to the 11-year cycle of the solar activity of starting date of the rainy seasons in Yunnan. Meanwhile, the dissertation finds that the EI-Nino is very important to the starting date of the rainy seasons in Yunnan. The starting date of the rainy seasons in Yunnan often comes later or normally in the year of EI-Nino. However, there is an obvious imperfect period in such influence, which in turn may mean that there is a certain fluctuation in the effect of ENSO on Asian summer monsoon.展开更多
The starting flow due to a suddenly applied pressure gradient in a parallel plate channel which is rotating as a system is studied. Exact analytic series solutions to the unsteady Navier-Stokes equations are found by ...The starting flow due to a suddenly applied pressure gradient in a parallel plate channel which is rotating as a system is studied. Exact analytic series solutions to the unsteady Navier-Stokes equations are found by both the Laplace transform method and the separation of parameters method, the latter is shown to be superior. Rotation not only induces a secondary transverse flow but also alters the character of the transient flow rate and velocity profiles. Back flow and inertial oscillations occur, especially at higher rota- tion rates.展开更多
In order to study the application of dual clutch transmission （DCT） on tracked vehicles, a simulation moclel and two control methods were performed for starting analysis. Based on a certain transmission of an existi...In order to study the application of dual clutch transmission （DCT） on tracked vehicles, a simulation moclel and two control methods were performed for starting analysis. Based on a certain transmission of an existing tracked vehicle, a DCT structure was proposed. Matlab/Simulink was a dopted as a platform to develop the simulation model. The engine speed was controlled to follow the target speed as a launch strategy. Two control methods, a proportional integral derivative （ PID ） control method and a fuzzy control method, were proposed to control the engine throttle and oil pressure in order to track the target engine speed. Simulation results show that either the PID control or fuzzy control method can improve the starting performance compared with no loop control meth od. Fuzzy control method can lead a better starting quality compared with PID control method.展开更多
When the induction motor is fed from the PWM VSI inverter, with and without torque enhancing function, the variations of the starting torque and the starting current versus the starting frequency are analyzed, base...When the induction motor is fed from the PWM VSI inverter, with and without torque enhancing function, the variations of the starting torque and the starting current versus the starting frequency are analyzed, based on the steady state equivalent circuit of the induction motor.The corresponding expressions are derived, and the corresponding curves are also drawn, from which the initial starting frequency range can be determined properly and easily. The initial starting frequency range is the common range, in which the starting torque should be high enough and the starting current low enough.Some other useful formulas are also derived.These results are significant for electrical drive designers to make the starting schemes. The effects of the increase of the stator and the rotor resistances on the starting torque and the initial starting frequency range are also discussed, which is caused by the skin effects of the high order harmonics present in the PWM inverter output voltage.展开更多
The purpose of this paper is to study the critical sand starting velocity and transformation law of flow pattern based on gas-water-sand three-phase flow in an inclined pipe.Firstly,the indoor simulation experiment sy...The purpose of this paper is to study the critical sand starting velocity and transformation law of flow pattern based on gas-water-sand three-phase flow in an inclined pipe.Firstly,the indoor simulation experiment system of gas-water-sand three-phase flow was used to test the conversion law of flow pattern based upon the different gas void fraction.Secondly,the influence of slug bubbles on sand migration was investigated according to distinctive hole deviation angles,gas void fraction and sand concentration.Finally,the critical sand starting velocity was tested based on dissimilar hole deviation angles,gas void fraction,sand concentration and sand particle size,and then the influence of the abovementioned key parameters on the sand starting velocity was debated based on the force analysis of the sand particles.The experimental results illustrated that when the gas void fraction was less than 5%,it was bubbly flow.When it increased from 5%to 30%,the bubbly flow and slug flow coexisted.When it was between 30%and 50%,the slug flow and agitated flow coexisted.When it reached 50%,it was agitated flow.Providing that the hole deviation angle was 90°,the phenomenon of overall migration and wavelike migration on the surface of sand bed was observed.On the contrary,the phenomenon of rolling and jumping migration was recognized.The critical sand starting velocity was positively correlated with the hole deviation angle and sand particle size,but negatively associated with the gas void fraction and sand concentration.This research can provide a certain reference for sand-starting production in the field of petroleum engineering.展开更多
基金National Natural Science Foundation of China(Nos.U2037601,51821001)Key Basic Research Project of the National Basic Strengthening Plan,China(No.2022-xxxx-ZD-093-xx)。
文摘Context: The biochemical assessment is a real-time indicator of the state and evolution of an infection. Among other things, it makes it possible to determine the right moment when it becomes necessary to start or change a treatment. Objective: The objective of this study is to present the Biological profile of People Living with HIV starting AntiRetroViral treatment in Kinshasa in the era of Dolutegravir. Methods: The present study is a descriptive cross-sectional to determine the biological profile of People Living with HIV (PLHIV) starting AntiRetroViral Treatment (ART). The patient inclusion period was from October 4, 2021 to February 15, 2022. Sixteen centers were included. A sample of 5 ml of blood was taken in a tube with EDTA. Patients were randomly included consecutively in the centers during consultations. The population was made up of adults aged over 18, infected with HIV and starting ART. The parameters of interest retained for the present study were: sex, age, hemoglobin level, blood sugar, urea, creatinine, transaminases, total cholesterol, triglycerides, proteins total, as well as amylase. Results: 119 patients were included in this study in accordance with the inclusion criteria;67 (56.3%) are female, giving a sex ratio of 1.29 in favor of women. The average age of the patients is 39.87 ± 12.36 years. The most represented age group is that of 36 to 45 years with 37 patients (31.9%). The mean values of the biological parameters of the patients at the start of ART are as follows: 31.61 ± 20.71 IU/L for ALT/SGPT, 25.81 ± 19.96 IU/L for AST/SGOT, 79.35 ± 49.49 IU/L for Amylase, 108.13 ± 62.17 mg/dl for Total Cholesterol, 2.77 ± 1.27 mg/dl for Creatinine, 72.53 ±22.23 mg/dl for Glycaemia, 10.30 ± 2.33 g/dl for Hemoglobin, 7.91 ± 1.75 g/dl for Total Protein, 131.23 ± 68.80 mg/dl for Triglycerides, and 33.61 ± 26.27 mg/dl for Urea. Conclusion: Mean values of PLHIV are, for the most part, within the normal range. The average creatinine is higher than the normal average value while the average total cholesterol is below the limit values.
文摘Context: Despite the new recommendations “Test and Treat”, the virological and molecular parameters remain important information for Antiretroviral Treatment and adequate for monitoring of patients infected with HIV/AIDS. Objective: the Objective of this study is to present the virological and molecular profile of People Living with HIV starting Antiretroviral Therapy in Kinshasa in the era of the Dolutegravir. Methods: This was a transversal study to determine virological and molecular profile of People Living with HIV (PLHIV) starting an ARV Treatment. The patient’s inclusion period was from October 04, 2021 to February 15, 2022. A sample of 5 ml of blood was taken in a tube with EDTA anticoagulant for Molecular Biology analyzes (Viral Load and Sequencing) in all HIV patients, after reading and signing informed consent. The population was made up of adult patients over the age of 18, infected with HIV and starting ART. Results: 119 patients (56.3% of women) were included in this study, thus a sex-ratio of 1.29. The average age of patients included was 39.87 ± 12.36 years. The most represented age group is that of 36 to 45 with 37 patients (31.9%) followed by that from 26 to 35 years with 24 patients (20.7%). Out of 119 patients, 21 patients had an undetectable Viral Load (VL). The median value of VL was 4.16 log10 RNA copies/ml. 114 samples were successfully amplified. Subtype A was dominant with 23 cases (20.2%);followed by the subtype C and CRF02_AG each with 14.0%, and D (10.5 %). K65R (1.8%), T69P/N (4.4%), K70R (7.9%) and M184V (7.0%) mutations were listed as existing mutations for Nucleotide Transcriptase Inhibitors. Conclusion: 38 patients (31.93%) started the TARV with a positive virological prognosis. The subtype A remains dominant in Kinshasa with 23 cases (20.2%);followed by the subtype C and CRF02_AG each with 14.0%. For Inhibitors of Transcriptase Reverse Nucleotide;K65R, T69P/N, K70E/R and M184V mutations were found in patients’ naive of ARV Treatment.
基金Knowledge Innovation Program of CAS, No.KZCX3-SW-321-3Key Project of the Ministry of Education of China, No.01JAZJD770008
文摘According to the textual research into the historical documents dominated by archives yearly, as well as the verification with several other kinds of data, the later or earlier starting time of the rainy seasons in Yunnan during 1711-1982 has been reconstructed. The analysis indicates that there are obvious fluctuations in the starting date of the rainy seasons in Yunnan in a year or years, and long fluctuation on the decadal scale. The rainy season comes earlier in the early 18th century, later in the 19th century and earlier again in the 20th century. This reflects to a certain degree the gradual change of the summer monsoon in Yunnan. There exists an obvious quasi-3 years cycle, which is related to EI-Nino＇s quasi-3 years cycle, and a 11.3-year cycle which is notably related to the 11-year cycle of the solar activity of starting date of the rainy seasons in Yunnan. Meanwhile, the dissertation finds that the EI-Nino is very important to the starting date of the rainy seasons in Yunnan. The starting date of the rainy seasons in Yunnan often comes later or normally in the year of EI-Nino. However, there is an obvious imperfect period in such influence, which in turn may mean that there is a certain fluctuation in the effect of ENSO on Asian summer monsoon.
文摘The starting flow due to a suddenly applied pressure gradient in a parallel plate channel which is rotating as a system is studied. Exact analytic series solutions to the unsteady Navier-Stokes equations are found by both the Laplace transform method and the separation of parameters method, the latter is shown to be superior. Rotation not only induces a secondary transverse flow but also alters the character of the transient flow rate and velocity profiles. Back flow and inertial oscillations occur, especially at higher rota- tion rates.
基金Supported by Defense Advanced Research Support Project(62301030303)111 Project(B08043)
文摘In order to study the application of dual clutch transmission （DCT） on tracked vehicles, a simulation moclel and two control methods were performed for starting analysis. Based on a certain transmission of an existing tracked vehicle, a DCT structure was proposed. Matlab/Simulink was a dopted as a platform to develop the simulation model. The engine speed was controlled to follow the target speed as a launch strategy. Two control methods, a proportional integral derivative （ PID ） control method and a fuzzy control method, were proposed to control the engine throttle and oil pressure in order to track the target engine speed. Simulation results show that either the PID control or fuzzy control method can improve the starting performance compared with no loop control meth od. Fuzzy control method can lead a better starting quality compared with PID control method.
文摘When the induction motor is fed from the PWM VSI inverter, with and without torque enhancing function, the variations of the starting torque and the starting current versus the starting frequency are analyzed, based on the steady state equivalent circuit of the induction motor.The corresponding expressions are derived, and the corresponding curves are also drawn, from which the initial starting frequency range can be determined properly and easily. The initial starting frequency range is the common range, in which the starting torque should be high enough and the starting current low enough.Some other useful formulas are also derived.These results are significant for electrical drive designers to make the starting schemes. The effects of the increase of the stator and the rotor resistances on the starting torque and the initial starting frequency range are also discussed, which is caused by the skin effects of the high order harmonics present in the PWM inverter output voltage.
基金supporting by the Youth Program of National Natural Science Foundation of China(52104012)the China Postdoctoral Science Foundation(2021M693494)+2 种基金the Key Program of the National Natural Science Foundation of China(51734010)the Key Natural Science Projects of Scientific Research Plan in Colleges and Universities of Xinjiang Uygur Autonomous Region(XJEDU2021I028)the Strategic Cooperation Technology Projects of CNPC and CUPB(ZLZX2020-01-01)
文摘The purpose of this paper is to study the critical sand starting velocity and transformation law of flow pattern based on gas-water-sand three-phase flow in an inclined pipe.Firstly,the indoor simulation experiment system of gas-water-sand three-phase flow was used to test the conversion law of flow pattern based upon the different gas void fraction.Secondly,the influence of slug bubbles on sand migration was investigated according to distinctive hole deviation angles,gas void fraction and sand concentration.Finally,the critical sand starting velocity was tested based on dissimilar hole deviation angles,gas void fraction,sand concentration and sand particle size,and then the influence of the abovementioned key parameters on the sand starting velocity was debated based on the force analysis of the sand particles.The experimental results illustrated that when the gas void fraction was less than 5%,it was bubbly flow.When it increased from 5%to 30%,the bubbly flow and slug flow coexisted.When it was between 30%and 50%,the slug flow and agitated flow coexisted.When it reached 50%,it was agitated flow.Providing that the hole deviation angle was 90°,the phenomenon of overall migration and wavelike migration on the surface of sand bed was observed.On the contrary,the phenomenon of rolling and jumping migration was recognized.The critical sand starting velocity was positively correlated with the hole deviation angle and sand particle size,but negatively associated with the gas void fraction and sand concentration.This research can provide a certain reference for sand-starting production in the field of petroleum engineering.
