Objective: To explore the effect of Yanhuning in combined with azithromycin on the inflammatory cytokines and immunological function in children with mycoplasma pneumonia. Methods: A total of 130 children with mycopla...Objective: To explore the effect of Yanhuning in combined with azithromycin on the inflammatory cytokines and immunological function in children with mycoplasma pneumonia. Methods: A total of 130 children with mycoplasma pneumonia were included in the study and randomized into the treatment group (n=65) and the control group (n=65). The patients in the control group were given azithromycin. On the above basis, the patients in the treatment group were given Yanhuning. The patients in the two groups were continuously treated for 7 d. The levels of serum inflammatory cytokines and immunological function indicators before and after treatment in the two groups were detected and compared. Results: When compared with before treatment, the serum IL-2 level after treatment in the two groups was significantly elevated, while IL-4, IL-10, IL-13, IL-6, TNF-α, and IFN-γ levels were significantly reduced;moreover, the improvement in the treatment group was significantly superior to that in the control group. When compared with before treatment, CD3+, CD4+, and CD4+/CD8+ after treatment in the two groups were significantly elevated, and those in the treatment group were significantly higher than those in the control group, while CD8+ was significantly reduced, but the comparison between the two groups was not statistically significant. When compared with before treatment, RBC-C3bR after treatment in the two groups was significantly elevated, while RBC-ICR was significantly reduced;moreover, the improvement in the treatment group was significantly superior to that in the control group. Conclusions: Yanhuning in combined with azithromycin in the treatment of mycoplasma pneumonia in children can significantly enhance the immunological function, and reduce the inflammatory reaction, with an effect significantly superior to that by single application of azithromycin.展开更多
目的系统评价注射用炎琥宁与α-干扰素治疗小儿上呼吸道感染的有效性和安全性,为临床应用提供循证医学证据。方法计算机检索CBM、CNKI、VIP、WanFang Data等数据库,纳入注射用炎琥宁与α-干扰素治疗小儿上呼吸道感染的随机对照试验(RCT...目的系统评价注射用炎琥宁与α-干扰素治疗小儿上呼吸道感染的有效性和安全性,为临床应用提供循证医学证据。方法计算机检索CBM、CNKI、VIP、WanFang Data等数据库,纳入注射用炎琥宁与α-干扰素治疗小儿上呼吸道感染的随机对照试验(RCT)或半随机对照试验(qRCT),检索时间为建库至今,对符合纳入标准的研究进行质量评价,并使用Rev Man 5.3软件进行Meta分析。结果共纳入10项研究,合计1104例患儿。Meta分析结果显示,注射用炎琥宁与α-干扰素治疗小儿呼吸系统感染可以显著提高患儿的总有效率(OR=4.99,95%CI:3.22~7.74,P<0.01),缩短退热时间(MD=-1.39,95%CI:-1.87^-0.92,P<0.01)、咳嗽消失时间(MD=-1.54,95%CI:-2.25^-0.83,P<0.01)、鼻塞流涕消失时间(MD=-1.65,95%CI:-2.35^-0.95,P<0.01)。结论注射用炎琥宁与α-干扰素治疗小儿呼吸系统感染疗效较好,可明显缩短患儿退热时间、咳嗽消失时间、鼻塞流涕消失时间。展开更多
文摘Objective: To explore the effect of Yanhuning in combined with azithromycin on the inflammatory cytokines and immunological function in children with mycoplasma pneumonia. Methods: A total of 130 children with mycoplasma pneumonia were included in the study and randomized into the treatment group (n=65) and the control group (n=65). The patients in the control group were given azithromycin. On the above basis, the patients in the treatment group were given Yanhuning. The patients in the two groups were continuously treated for 7 d. The levels of serum inflammatory cytokines and immunological function indicators before and after treatment in the two groups were detected and compared. Results: When compared with before treatment, the serum IL-2 level after treatment in the two groups was significantly elevated, while IL-4, IL-10, IL-13, IL-6, TNF-α, and IFN-γ levels were significantly reduced;moreover, the improvement in the treatment group was significantly superior to that in the control group. When compared with before treatment, CD3+, CD4+, and CD4+/CD8+ after treatment in the two groups were significantly elevated, and those in the treatment group were significantly higher than those in the control group, while CD8+ was significantly reduced, but the comparison between the two groups was not statistically significant. When compared with before treatment, RBC-C3bR after treatment in the two groups was significantly elevated, while RBC-ICR was significantly reduced;moreover, the improvement in the treatment group was significantly superior to that in the control group. Conclusions: Yanhuning in combined with azithromycin in the treatment of mycoplasma pneumonia in children can significantly enhance the immunological function, and reduce the inflammatory reaction, with an effect significantly superior to that by single application of azithromycin.
文摘目的系统评价注射用炎琥宁与α-干扰素治疗小儿上呼吸道感染的有效性和安全性,为临床应用提供循证医学证据。方法计算机检索CBM、CNKI、VIP、WanFang Data等数据库,纳入注射用炎琥宁与α-干扰素治疗小儿上呼吸道感染的随机对照试验(RCT)或半随机对照试验(qRCT),检索时间为建库至今,对符合纳入标准的研究进行质量评价,并使用Rev Man 5.3软件进行Meta分析。结果共纳入10项研究,合计1104例患儿。Meta分析结果显示,注射用炎琥宁与α-干扰素治疗小儿呼吸系统感染可以显著提高患儿的总有效率(OR=4.99,95%CI:3.22~7.74,P<0.01),缩短退热时间(MD=-1.39,95%CI:-1.87^-0.92,P<0.01)、咳嗽消失时间(MD=-1.54,95%CI:-2.25^-0.83,P<0.01)、鼻塞流涕消失时间(MD=-1.65,95%CI:-2.35^-0.95,P<0.01)。结论注射用炎琥宁与α-干扰素治疗小儿呼吸系统感染疗效较好,可明显缩短患儿退热时间、咳嗽消失时间、鼻塞流涕消失时间。
文摘目的:系统评价炎琥宁注射剂治疗流行性腮腺炎的疗效,探索省增补基本药物循证评价的有效方式,为新版基本药物目录遴选提供参考。方法:计算机检索Pub Med、中国期刊全文数据库(CJFD)、万方数据库、中文科技期刊数据库(VIP),收集炎琥宁注射剂单用或者联合其他阳性药物(试验组)对比其他阳性药物(对照组)治疗流行性腮腺炎的随机对照试验(RCT),采用改良的Jadad评分量表评价质量后,提取有效数据采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入26项RCT,合计2 613例患者。Meta分析结果显示,试验组患者总有效率[OR=5.28,95%CI(3.92,7.11),P<0.001]显著高于对照组,退热时间[MD=-1.97,95%CI(-2.83,-1.12),P<0.001]、肿胀消退时间[MD=-2.05,95%CI(-2.53,-1.58),P<0.001]、疼痛消失时间[MD=-1.39,95%CI(-2.02,-0.75),P<0.001]均显著短于对照组,差异均有统计学意义。结论:炎琥宁注射剂治疗流行性腮腺炎疗效较好,可显著缩短患者退热时间、肿胀消退时间和疼痛消失时间。
