目的基于肿瘤基因图谱(the cancer genome atlas,TCGA)和人类蛋白质图谱(human protein atlas,HPA)数据库生物学信息,分析肝细胞癌(hepatocellular carcinoma,HCC)中YEATS2表达水平与临床预后及治疗价值。方法从TCGA数据库下载HCC的mRN...目的基于肿瘤基因图谱(the cancer genome atlas,TCGA)和人类蛋白质图谱(human protein atlas,HPA)数据库生物学信息,分析肝细胞癌(hepatocellular carcinoma,HCC)中YEATS2表达水平与临床预后及治疗价值。方法从TCGA数据库下载HCC的mRNA表达数据和临床资料,运用R软件分析YEATS2在HCC组织与正常组织间的表达情况,并通过HPA数据库对其蛋白表达差异进行初步验证。比较YEATS2在HCC各临床特征之间的表达差异,然后通过Kaplan-Meier法和COX回归分析评估其对HCC患者生存期的影响,并绘制受试者工作特征(receiveroperating characteristic,ROC)曲线,评价其诊断价值。利用基因本体论(gene ontology,GO)和京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)富集分析,探讨YEATS2在HCC中的生物学功能。通过“ESTIMATE”算法分析YEATS2表达与肿瘤微环境(tumor microenvironment,TME)的关系,并利用CIBERSORT评估其与肿瘤浸润免疫细胞(tumor-infiltrating immune cells,TIICs)的相关性。利用R包分析YEATS2表达水平与免疫检查点及药物敏感度的关系。结果在HCC组织中YEATS2的表达增加(P=4.96e-21),且表达水平与年龄、临床分期、病理分级和T分期相关(均P<0.05)。YEATS2高表达使HCC患者的总生存率(overall survival,OS)(P<0.001)和无进展生存期(progression free survival,FPS)(P=0.016)下降,COX回归结果显示,YEATS2表达水平与HCC患者的不良预后相关(OS:HR=2.167,95%CI:1.441~3.261,P=2.06e-04),其是HCC患者预测不良预后的独立危险因素(OS:HR=1.891,95%CI:1.243~2.877,P=0.003)。ROC曲线提示:1,3,5年AUC分别为0.677,0.622和0.612,具有良好预测能力。TCGA数据库共筛选出YEATS2高、低表达组的差异基因6764个,其中4094个基因在YEATS2高表达组中表达上调,2670个基因表达下调。GO和KEGG富集分析结果显示,YEATS2高表达组差异基因主要富集在免疫调节、细胞周期调控和药物耐药等通路。TME评分结果显示,YEATS2高表达组引起免疫评分减少(P<0.01)。YEATS2与TIICs相关性显示,YEATS2表达与M0型巨噬细胞浸润水平呈正相关(r=0.48,P<0.001),与CD8^(+)T细胞、浆细胞和单核细胞浸润水平呈负相关(r=-0.26,-0.29,-0.30,P=0.021,0.011,0.008),并与23种免疫检查点基因呈正相关(r=0.20~0.46,均P<0.05)。药物敏感度分析显示,YEATS2高表达组患者中卡博替尼、林西替尼、多柔比星和环巴胺的半抑制浓度(half maximal inhibitory concentration,IC50)高于低表达组患者(均P<0.01)。结论YEATS2在HCC中高表达,且表达水平与HCC患者的预后不良有关。YEATS2可作为HCC临床早期诊断、预后和免疫治疗的生物标志物,为临床诊疗提供新的思路。展开更多
When you are old is one of the most famous love poetry written by Irish Poet, William Butler Yeats. The paper elaborates deeply on one of the early love poetry of William Butler Yeats: When you are old. It gives an in...When you are old is one of the most famous love poetry written by Irish Poet, William Butler Yeats. The paper elaborates deeply on one of the early love poetry of William Butler Yeats: When you are old. It gives an introduction of W.B. Yeats and then discusses Yeats' s early love poetry and his muse as well as her influence in the love poetry; Then the poem When you are old is analyzed and in the meantime the original French version and the Chinese version were provided for readers' literary appreciation.展开更多
Yeats' lyrics of sublimation is one of his major concerns in his later years. Sublimation for Yeats is essentially the transmutation and elevation of bitterness and tragic facts of being into happiness, into tranq...Yeats' lyrics of sublimation is one of his major concerns in his later years. Sublimation for Yeats is essentially the transmutation and elevation of bitterness and tragic facts of being into happiness, into tranquility of mind, then into the emotionless emotion, as Yeats names it as "innocence". The process of sublimation enriches the creativity of Yeats as artist when he is confronted with severity of aging spiritually and physically.展开更多
The lyrics of transcendence by William Butler Yeats is to a greatextent a comprehensive interpretation of Yeats' views on poet ics and life.According to Yeats,transcendence is essentially a cold,lofty wisdom with ...The lyrics of transcendence by William Butler Yeats is to a greatextent a comprehensive interpretation of Yeats' views on poet ics and life.According to Yeats,transcendence is essentially a cold,lofty wisdom with which human beings could transcend their innate limitations,incompleteness as well as the secularities of existence,therefore achieving the mastery over one's fate.The thematic study of Yeats' lyrics of transcendence offers an unique approach to Yeats' philosophy in art and life.展开更多
"Passion as Defense" is one of the most profound themes in Yeats'later poems,Yeats' theory of passion as defense essentially suggests the emotional commitment to make life habitable in a disastrous w..."Passion as Defense" is one of the most profound themes in Yeats'later poems,Yeats' theory of passion as defense essentially suggests the emotional commitment to make life habitable in a disastrous world.Yeats in this sense employs passion to contend against pathos.With the victory over the tragedy of being,Yeats display the heroic quality as poet and man.展开更多
This paper attempts to analyze the symbolism that is embodied in"Sailing to Byzantium"and to further understand the spiritual freedom W. B. Yeats expressed in the poem. Studying the contrasts of the symbols ...This paper attempts to analyze the symbolism that is embodied in"Sailing to Byzantium"and to further understand the spiritual freedom W. B. Yeats expressed in the poem. Studying the contrasts of the symbols and the eternity and holy spirit carried by Byzantium, we can understand Yeats' life philosophy, and finally reach his spiritual freedom which perpetuates itself in art.展开更多
Using Sabina J. Mtiller＇s theory of myth, this paper will analyze the deconstruction and revision of myths in The Green Helmet. Irish mythology, as described by M^iller, has in its inheritance a myth of Ireland being...Using Sabina J. Mtiller＇s theory of myth, this paper will analyze the deconstruction and revision of myths in The Green Helmet. Irish mythology, as described by M^iller, has in its inheritance a myth of Ireland being personified in an image of a woman, a goddess of the land. This Ireland-as-woman image, as well as Irish heroism and their fighting spirit will be investigated in Yeats＇ drama to show its simplification and to mock its nature. The analysis will also give an insight into the diversified and complex image of the Irish nation.展开更多
As ＂the greatest poet in the 20th century＂, Yeats is always a hot topic among academic community. The question whether Yeats is the ＂last romantic＂ or the first Modernist remains controversial for a long time in a...As ＂the greatest poet in the 20th century＂, Yeats is always a hot topic among academic community. The question whether Yeats is the ＂last romantic＂ or the first Modernist remains controversial for a long time in academic field. Whether critics term Yeats a modernist or not, they generally agree that the poems produced in his late creative period are definitively modernist works. This paper targets Yeats＇s realization of poetic modernization through his mask theory applied in ＂Crazy Jane＂ poems. It discusses the poetic movement in the beginning of the 20th century, the poetic theory Yeats proposed and instances Yeats＇s mask theory as the manifestation of his poetic modernization. The author argues that with his innovation in verse writing particularly demonstrated by application of mask theory in ＂Crazy Jane＂ poems, Yeats unquestionably played a very important role in Anglo-American modernist poetry.展开更多
As a central issue in stylistics, foregrounding, which can be achieved by deviation and overregularity at every linguistic level, can give readers more innovative and ingenious perspective on appreciation of text. W. ...As a central issue in stylistics, foregrounding, which can be achieved by deviation and overregularity at every linguistic level, can give readers more innovative and ingenious perspective on appreciation of text. W. B. Yeats＇ Leda and the Swan is a poem deserving close reading and attention. The analysis from sound patterning, meter and rhythm, verbal repetition endows the poem with some novel and new aesthetic significance展开更多
W.B.Yeats(1865-1939),Noble Prize winner for literature in 1923,is an influential Irish poet,playwright and critic.This paper will discuss that Yeats is devoted to seek and construct Irish cultural identity in his poet...W.B.Yeats(1865-1939),Noble Prize winner for literature in 1923,is an influential Irish poet,playwright and critic.This paper will discuss that Yeats is devoted to seek and construct Irish cultural identity in his poetry because of the Irish cultural and identity crisis as well as his own identity anxiety.Yeats endeavours to establish a distinctly Irish cultural identity through reviving Irish traditional folklore,myths and legends,hybridising English language,and absorbing oriental culture in his poetry.展开更多
William Butler Yeats(1865-1939),the winner of Nobel Prize for Literature,has attracted extensive research attention from academia in recent years.This paper aims to discuss various myths Yeats uses in his poetic creat...William Butler Yeats(1865-1939),the winner of Nobel Prize for Literature,has attracted extensive research attention from academia in recent years.This paper aims to discuss various myths Yeats uses in his poetic creation,focusing on the analysis of the multiple application of myth,including myths performing as the mythic themes of the worldly,the spiritual,and the emotional,as poetic images,as emotional and intellectual symbols,and as political metaphors.展开更多
When You Are Old is a famous poem written by Yeats to his infatuation Maud Gonne. The paper analyzes the poem in the following aspects: the conflicting elements, rhythm, the opposition and unity of form and content in...When You Are Old is a famous poem written by Yeats to his infatuation Maud Gonne. The paper analyzes the poem in the following aspects: the conflicting elements, rhythm, the opposition and unity of form and content in the text to reveal the theme thoroughly: to be beyond sorrow, then to be eternal in love and life.展开更多
M. L. Rosenthal is an authority on William Butler Yeats, Ezra Pound, and T. S. Eliot and their poems. In his review book on the three poets, Sailing into the Unknown： Yeats, Pound and Eliot, his close and provocative...M. L. Rosenthal is an authority on William Butler Yeats, Ezra Pound, and T. S. Eliot and their poems. In his review book on the three poets, Sailing into the Unknown： Yeats, Pound and Eliot, his close and provocative analysis indicates the features of the three poets＇ representative works respectively. This article tries to sum up the main contents of each chapter of this review book and make a comment on the significance of his reviews as a whole.展开更多
Many of W.B. Yeats' s poems are inspired and influenced by Maud Gonne, as his love of the life, whose images have been changing from hi"sRose"with beauty and untouchability to"Helen"with destru...Many of W.B. Yeats' s poems are inspired and influenced by Maud Gonne, as his love of the life, whose images have been changing from hi"sRose"with beauty and untouchability to"Helen"with destructive power and"Phoenix"with spiritual eternity during different Irish historical and social backgrounds. By analyzing three selected poems, this paper reveals that Yeats' s creating of the images of Maud Gonne is not single but multiple, which are not only concerned with the eulogy of her beauty but also her powerful mind and faithful dedication towards Irish national independence and liberation.展开更多
Yeats'poems are famous for the use of symbolism.His symbolism is characterized by continuous development,which can be roughly divided into three phases:the early phase-from 1889 to 1904,the middle phase-from 1919 ...Yeats'poems are famous for the use of symbolism.His symbolism is characterized by continuous development,which can be roughly divided into three phases:the early phase-from 1889 to 1904,the middle phase-from 1919 to 1925,and the late phase-the years after 1925.We can see poems with different characters of symbolism in his different phases.In this paper,three poems are to be chosen to show his transmutation of symbolism.展开更多
文摘When you are old is one of the most famous love poetry written by Irish Poet, William Butler Yeats. The paper elaborates deeply on one of the early love poetry of William Butler Yeats: When you are old. It gives an introduction of W.B. Yeats and then discusses Yeats' s early love poetry and his muse as well as her influence in the love poetry; Then the poem When you are old is analyzed and in the meantime the original French version and the Chinese version were provided for readers' literary appreciation.
文摘Yeats' lyrics of sublimation is one of his major concerns in his later years. Sublimation for Yeats is essentially the transmutation and elevation of bitterness and tragic facts of being into happiness, into tranquility of mind, then into the emotionless emotion, as Yeats names it as "innocence". The process of sublimation enriches the creativity of Yeats as artist when he is confronted with severity of aging spiritually and physically.
文摘The lyrics of transcendence by William Butler Yeats is to a greatextent a comprehensive interpretation of Yeats' views on poet ics and life.According to Yeats,transcendence is essentially a cold,lofty wisdom with which human beings could transcend their innate limitations,incompleteness as well as the secularities of existence,therefore achieving the mastery over one's fate.The thematic study of Yeats' lyrics of transcendence offers an unique approach to Yeats' philosophy in art and life.
文摘"Passion as Defense" is one of the most profound themes in Yeats'later poems,Yeats' theory of passion as defense essentially suggests the emotional commitment to make life habitable in a disastrous world.Yeats in this sense employs passion to contend against pathos.With the victory over the tragedy of being,Yeats display the heroic quality as poet and man.
文摘This paper attempts to analyze the symbolism that is embodied in"Sailing to Byzantium"and to further understand the spiritual freedom W. B. Yeats expressed in the poem. Studying the contrasts of the symbols and the eternity and holy spirit carried by Byzantium, we can understand Yeats' life philosophy, and finally reach his spiritual freedom which perpetuates itself in art.
文摘Using Sabina J. Mtiller＇s theory of myth, this paper will analyze the deconstruction and revision of myths in The Green Helmet. Irish mythology, as described by M^iller, has in its inheritance a myth of Ireland being personified in an image of a woman, a goddess of the land. This Ireland-as-woman image, as well as Irish heroism and their fighting spirit will be investigated in Yeats＇ drama to show its simplification and to mock its nature. The analysis will also give an insight into the diversified and complex image of the Irish nation.
文摘As ＂the greatest poet in the 20th century＂, Yeats is always a hot topic among academic community. The question whether Yeats is the ＂last romantic＂ or the first Modernist remains controversial for a long time in academic field. Whether critics term Yeats a modernist or not, they generally agree that the poems produced in his late creative period are definitively modernist works. This paper targets Yeats＇s realization of poetic modernization through his mask theory applied in ＂Crazy Jane＂ poems. It discusses the poetic movement in the beginning of the 20th century, the poetic theory Yeats proposed and instances Yeats＇s mask theory as the manifestation of his poetic modernization. The author argues that with his innovation in verse writing particularly demonstrated by application of mask theory in ＂Crazy Jane＂ poems, Yeats unquestionably played a very important role in Anglo-American modernist poetry.
文摘As a central issue in stylistics, foregrounding, which can be achieved by deviation and overregularity at every linguistic level, can give readers more innovative and ingenious perspective on appreciation of text. W. B. Yeats＇ Leda and the Swan is a poem deserving close reading and attention. The analysis from sound patterning, meter and rhythm, verbal repetition endows the poem with some novel and new aesthetic significance
文摘W.B.Yeats(1865-1939),Noble Prize winner for literature in 1923,is an influential Irish poet,playwright and critic.This paper will discuss that Yeats is devoted to seek and construct Irish cultural identity in his poetry because of the Irish cultural and identity crisis as well as his own identity anxiety.Yeats endeavours to establish a distinctly Irish cultural identity through reviving Irish traditional folklore,myths and legends,hybridising English language,and absorbing oriental culture in his poetry.
文摘William Butler Yeats(1865-1939),the winner of Nobel Prize for Literature,has attracted extensive research attention from academia in recent years.This paper aims to discuss various myths Yeats uses in his poetic creation,focusing on the analysis of the multiple application of myth,including myths performing as the mythic themes of the worldly,the spiritual,and the emotional,as poetic images,as emotional and intellectual symbols,and as political metaphors.
文摘When You Are Old is a famous poem written by Yeats to his infatuation Maud Gonne. The paper analyzes the poem in the following aspects: the conflicting elements, rhythm, the opposition and unity of form and content in the text to reveal the theme thoroughly: to be beyond sorrow, then to be eternal in love and life.
文摘M. L. Rosenthal is an authority on William Butler Yeats, Ezra Pound, and T. S. Eliot and their poems. In his review book on the three poets, Sailing into the Unknown： Yeats, Pound and Eliot, his close and provocative analysis indicates the features of the three poets＇ representative works respectively. This article tries to sum up the main contents of each chapter of this review book and make a comment on the significance of his reviews as a whole.
文摘Many of W.B. Yeats' s poems are inspired and influenced by Maud Gonne, as his love of the life, whose images have been changing from hi"sRose"with beauty and untouchability to"Helen"with destructive power and"Phoenix"with spiritual eternity during different Irish historical and social backgrounds. By analyzing three selected poems, this paper reveals that Yeats' s creating of the images of Maud Gonne is not single but multiple, which are not only concerned with the eulogy of her beauty but also her powerful mind and faithful dedication towards Irish national independence and liberation.
文摘Yeats'poems are famous for the use of symbolism.His symbolism is characterized by continuous development,which can be roughly divided into three phases:the early phase-from 1889 to 1904,the middle phase-from 1919 to 1925,and the late phase-the years after 1925.We can see poems with different characters of symbolism in his different phases.In this paper,three poems are to be chosen to show his transmutation of symbolism.
