This study aimed to evaluate the efficacy of comprehensive therapy based on traditional Chinese medicine （TCM） patterns on older patients with chronic obstructive pulmonary disease （COPD） through a four- center, o...This study aimed to evaluate the efficacy of comprehensive therapy based on traditional Chinese medicine （TCM） patterns on older patients with chronic obstructive pulmonary disease （COPD） through a four- center, open-label, randomized controlled trial. Patients were divided into the trial group treated using conventional western medicine and Bu-Fei Jian-Pi granules, Bu-Fei Yi-Shen granules, and Yi-Qi Zi-Shen granules based on TCM patterns respectively; and the control group treated using conventional western medicine. A total of 136 patients ≥ 65 years completed the study, with 63 patients comprising the trial group and 73 comprising the control group. After the six-month treatment and the 12-month follow-up period, significant differences were observed between the trial and control groups in the following aspects： frequency of acute exacerbation （P ≤ 0.040）, duration of acute exacerbation （P = 0.034）, symptoms （P ≤ 0.034）, 6-min walking distance （6MWD） （P ≤ 0.039）, dyspnea scale （P ≤ 0.036）; physical domain （P ≤ 0.019）, psychological domain （P ≤ 0.033）, social domain （P ≤ 0.020）, and environmental domain （P ≤ 0.044） of the WHOQOL-BREF questionnaire; and daily living ability domain （P ≤ 0.007）, social activity domain （P ≤ 0.018）, depression symptoms domain （P ≤ 0.025）, and anxiety symptoms domain （P ≤ 0.037） of the COPD-QOL. No differences were observed between the trial and control groups with regard to FVC, FEV1, and FEV1%.展开更多
文摘This study aimed to evaluate the efficacy of comprehensive therapy based on traditional Chinese medicine （TCM） patterns on older patients with chronic obstructive pulmonary disease （COPD） through a four- center, open-label, randomized controlled trial. Patients were divided into the trial group treated using conventional western medicine and Bu-Fei Jian-Pi granules, Bu-Fei Yi-Shen granules, and Yi-Qi Zi-Shen granules based on TCM patterns respectively; and the control group treated using conventional western medicine. A total of 136 patients ≥ 65 years completed the study, with 63 patients comprising the trial group and 73 comprising the control group. After the six-month treatment and the 12-month follow-up period, significant differences were observed between the trial and control groups in the following aspects： frequency of acute exacerbation （P ≤ 0.040）, duration of acute exacerbation （P = 0.034）, symptoms （P ≤ 0.034）, 6-min walking distance （6MWD） （P ≤ 0.039）, dyspnea scale （P ≤ 0.036）; physical domain （P ≤ 0.019）, psychological domain （P ≤ 0.033）, social domain （P ≤ 0.020）, and environmental domain （P ≤ 0.044） of the WHOQOL-BREF questionnaire; and daily living ability domain （P ≤ 0.007）, social activity domain （P ≤ 0.018）, depression symptoms domain （P ≤ 0.025）, and anxiety symptoms domain （P ≤ 0.037） of the COPD-QOL. No differences were observed between the trial and control groups with regard to FVC, FEV1, and FEV1%.
