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A study on the treatment of chloasma with moxibustion based on the theory of“Yang transforming Qi,and Yin shaping”
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作者 Mi Yang Hong-Yi Lan +2 位作者 Hong Wu Xu Wang Xin-Ju Li 《Clinical Research Communications》 2024年第3期23-28,共6页
Background:“Yang Transforming Qi and Yin shaping”comes from“Plain Question Yin and Yang should be like the theory”.Chinese medicine believes that the imbalance of yin and yang is the cause of human diseases.One of... Background:“Yang Transforming Qi and Yin shaping”comes from“Plain Question Yin and Yang should be like the theory”.Chinese medicine believes that the imbalance of yin and yang is the cause of human diseases.One of the strengths of TCM in treating diseases is holistic regulation.The theory of“Yang transforming Qi,and Yin shaping”implies a strong holistic view.Chloasma,one of the common skin diseases,seriously affects the physical and mental health of patients due to its unclear etiology,difficult treatment and easy recurrence.The occurrence and development of chloasma are closely related to internal organs.This paper is based on the theory of internal meridian,“Yang transforming Qi,and Yin shaping”which attaches importance to the concept of“Yang Qi”,from a new understanding of the pathogenesis etiology of chloasma.Methods:The author believes that the incidence of the disease is the deficiency of Yang Qi,which can’t promote the movement of Qi and blood to nourish the face,resulting in tangible material condensation,so proposes that this disease needs to be promoted by Yang transforming Qi and warm to dissipate.Moxibustion belongs to the fire,and its warming effect can dissipate the tangible evil.Results:Combined with clinical practice and the theory of internal meridian,the author elaborated that moxibustion is one of the effective methods for treating chloasma,which provides a new way of thinking for the treatment of chloasma.Conclusion:“Yang Transforming Qi and Yin shaping”can be used to guide the treatment of chloasma. 展开更多
关键词 yang Transforming Qi and yin shaping MOXIBUSTION CHLOASMA
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Observation on the Nursing Effect of Ginger Moxibustion on Gastrointestinal Symptoms in Patients with Heart Failure Due to Yang Qi Deficiency
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作者 Yijing Wang 《Journal of Clinical and Nursing Research》 2024年第6期135-141,共7页
Objective:To evaluate the nursing measures and effects of ginger moxibustion in the treatment of heart failure(yang qi deficiency type)with gastrointestinal symptoms.Methods:86 patients with heart failure(yang qi defi... Objective:To evaluate the nursing measures and effects of ginger moxibustion in the treatment of heart failure(yang qi deficiency type)with gastrointestinal symptoms.Methods:86 patients with heart failure(yang qi deficiency type)accompanied by gastrointestinal symptoms who were admitted to the hospital between January 2023 and January 2024 were selected and divided into 43 cases in each group by random number table grouping;Group I implemented integrated care,while Group II adopted conventional care.The indicators of care were compared between the two groups.Results:After the nursing care,the digestive symptom scores of Group I were lower than those of Group I,and the psychological scores were lower than those of Group II(P<0.05).Conclusion:Ginger moxibustion can improve gastrointestinal symptoms and enhance the psychological health of patients with heart failure(yang qi deficiency type)with gastrointestinal symptoms. 展开更多
关键词 Ginger moxibustion yang qi deficiency heart failure Gastrointestinal symptoms
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Clinical Nursing Intervention of Moxibustion on Abdominal Distension Symptoms in Heart Failure (Heart and Kidney Yang Deficiency and Blood Stasis Blocking Collaterals Syndrome)
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作者 Tingcui Yan 《Journal of Clinical and Nursing Research》 2024年第6期142-147,共6页
Objective:To investigate the clinical nursing intervention effect of moxibustion on abdominal distension symptoms in heart failure(heart and kidney yang deficiency and blood stasis blocking collaterals syndrome).Metho... Objective:To investigate the clinical nursing intervention effect of moxibustion on abdominal distension symptoms in heart failure(heart and kidney yang deficiency and blood stasis blocking collaterals syndrome).Methods:62 patients with heart failure(heart and kidney yang deficiency and blood stasis blocking collaterals syndrome)admitted to our hospital from February 2023 to February 2024 were selected and divided into the observation group(n=31)and the control group(n=31)by using the random numerical table method.The control group adopted conventional nursing interventions,and the observation group received the nursing program of the control group with the addition of moxibustion nursing interventions.The nursing effectiveness,quality of life scores,and nursing satisfaction were compared between the two groups.Results:The nursing effectiveness of the observation group was significantly higher than the control group(P<0.05);the quality of life score of the observation group was significantly higher than the control group(P<0.05);the nursing satisfaction of the observation group was significantly higher than that of the control group(P<0.05).Conclusion:The use of moxibustion nursing intervention in patients with heart failure(heart and kidney yang deficiency and blood stasis blocking collaterals syndrome)can effectively relieve the symptoms of abdominal distension,improve patients'quality of life,and increase nursing satisfaction,which has promotion and application values. 展开更多
关键词 MOXIBUSTION heart failure heart and kidney yang deficiency and blood stasis blocking collaterals syndrome Abdominal distension Nursing intervention
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On the Possible Structures of Electron and Proton
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作者 Wei-Xing Xu 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2024年第4期1734-1742,共9页
In this work, the possible structures of electron and proton have been explored. Based on the potential expressions of electron and proton, we found that the electron and proton share the similar structure inside re a... In this work, the possible structures of electron and proton have been explored. Based on the potential expressions of electron and proton, we found that the electron and proton share the similar structure inside re and rn. And within re and rn, the conventional charge concept stops working, the same charge repelling force doesn’t exist anymore and as a result, the requirement of charge conservation is automatically removed. Whereas beyond re and rn, the potential expressions of electron and proton obey the point charge potentials as we normally understand. Therefore, the conventional charge concept can be applied and the requirement of charge conservation takes effect. Furthermore, a possible mechanism for the creations of electric monopole and magnetic monopole is discussed. In addition, to compare the particle size in micro-world, the balloon criterion is proposed. By this balloon criterion, the proton is determined about 10 times bigger than electron. From the physical picture about electron and proton described above, the stabilities of electron and proton can be explained quite well. 展开更多
关键词 Electromagnetic Spacetime Quantum Mechanics ELECTRON PROTON Standard Model Particle Physics yin-yang Philosophy Electric Monopole Magnetic Monopole Charge Conservation
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Differential Effects of Yin- and Yang-Chinese Tonifying Herbs on Innate and Adaptive Immunity
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作者 Hoi Yan Leung Kam Ming Ko 《Chinese Medicine》 2023年第2期68-78,共11页
The present study investigated the effect of treatment with methanolic extracts of Yin- and Yang-Chinese tonifying herbs on concanavalin A (Con A)/lipopolysaccharide (LPS)-stimulated splenocyte proliferation (adaptive... The present study investigated the effect of treatment with methanolic extracts of Yin- and Yang-Chinese tonifying herbs on concanavalin A (Con A)/lipopolysaccharide (LPS)-stimulated splenocyte proliferation (adaptive immunity) and natural killer (NK) cell activity (innate immunity) in an ex vivo mouse model. The results indicated that while treatment with most Yin herbal extracts potentiated the Con A/LPS-stimulated splenocyte proliferation, only Yang (but not Yin) herbal extracts stimulated NK cell activity. The differential effects of Yin- and Yang-Chinese tonifying herbs on innate and adaptive immunity are consistent with the Chinese medicine theory which depicts the Yin and Yang functional components of Zheng Qi (vital energy), with the Yang component being responsible for the first line of defense against invading microorganisms (i.e., innate immunity) and the Yin oner serving as a follow-up defensive response (adaptive immunity). 展开更多
关键词 yin yang Innate Immunity Adaptive Immunity Natural Killer Cell Activity Splenocyte Proliferation
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Acupuncture Treating Heart Diseases Based on Sixty JiaZi and Eight Palaces <br/>—Mathematical Reasoning of Treatment Principle Based on Yin Yang Wu Xing Theory in Traditional Chinese Medicine (V)
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作者 Yingshan Zhang Yan Li Chunyun Guo 《Chinese Medicine》 2021年第3期118-184,共67页
<span style="font-family:Verdana;">Theory</span><span style="font-family:Verdana;" "=""> of Sixty JiaZi (60 </span><span style="font-family:Verdana;&q... <span style="font-family:Verdana;">Theory</span><span style="font-family:Verdana;" "=""> of Sixty JiaZi (60 </span><span style="font-family:Verdana;">甲子</span><span style="font-family:;" "=""><span style="font-family:Verdana;">) is useful in understanding a human body disease. By using mathematical reasoning based on Yin Yang Wu Xing Theory in Traditional Chinese Medicine (TCM), this paper demonstrates the treatment principle: “seize the momentum of development, hasten </span><span style="font-family:Verdana;">lucky</span> <span style="font-family:Verdana;">avoids</span><span style="font-family:Verdana;"> disaster” (</span></span><span style="font-family:Verdana;">顺势而为</span><span style="font-family:Verdana;" "="">, </span><span style="font-family:Verdana;">趋吉避凶</span><span style="font-family:;" "=""><span style="font-family:Verdana;">). Sixty </span><span style="font-family:Verdana;">JiaZi</span><span style="font-family:Verdana;"> is hidden behind eight palaces. The first or second transfer law of human body energies of Sixty JiaZi changes according to the different blood pH values of a human body whether in the normal range or not, respectively, assuming that the range of blood pH values of a human </span><span style="font-family:Verdana;">body</span><span style="font-family:Verdana;"> is divided into four parts from small to large. Both second and third are for a healthy human body. Both the </span><span style="font-family:Verdana;">root-cause</span><span style="font-family:Verdana;"> and symptoms come from the first transfer law of human body energies. And both first and fourth are for an unhealthy human body. Both the </span><span style="font-family:Verdana;">root-cause</span><span style="font-family:Verdana;"> and symptoms come from the second transfer law of human body energies. The treating disease of a human body should protect and maintain the balance of two incompatibility relations: the loving relationship and the killing relationship. As an application, acupuncture is used to treat atrial premature beats as congenital heart disease.</span></span> 展开更多
关键词 Traditional Chinese Medicine (TCM) yin yang Wu Xing theory Steady Multilateral Systems Incompatibility Relations Side Effects Medical and Drug Resistance Problem
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Acupuncture Treating Heart Disease Based on Eight Palaces or Eight Veins <br/>—Mathematical Reasoning of Treatment Principle Based on Yin Yang Wu Xing Theory in Traditional Chinese Medicine (IV) 被引量:1
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作者 Yingshan Zhang Yan Li Chunyun Guo 《Chinese Medicine》 2021年第3期47-117,共71页
Theory<span><span><span style="font-family:;" "=""> of eight palaces (</span></span></span><span><span><span style="font-family:宋体;&qu... Theory<span><span><span style="font-family:;" "=""> of eight palaces (</span></span></span><span><span><span style="font-family:宋体;">八宫</span></span></span><span><span><span style="font-family:;" "="">) or eight veins (</span></span></span><span><span><span style="font-family:宋体;">八脉</span></span></span><span><span><span style="font-family:;" "="">) is useful in understanding the basic sick subsystems that may be to fall ills as the <span>root-cause</span>. By using mathematical reasoning based on Yin Yang Wu Xing Theory in Traditional Chinese Medicine (TCM), this paper demonstrates the treatment principle: “Even if all changed, it is hard to change one’s nature” (</span></span></span><span><span><span style="font-family:宋体;">江山易改</span></span></span><span><span><span style="font-family:;" "="">, </span></span></span><span><span><span style="font-family:宋体;">本性难移</span></span></span><span><span><span style="font-family:;" "="">). The eight palaces or eight veins can be used to diagnose basic sick subsystems that may be to fall ills as the <span>root-cause</span>. The first or second transfer law of human body energies of the eight palaces or eight veins according to the different blood pH values of a human body whether in the normal range or not,</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">respectively,</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">assuming</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">that the range of blood pH value is divided into four parts from small to large. Both second and third are for a healthy human body. Both the <span>root-cause</span> and symptoms come from the first transfer law of human body energies. And both first and fourth are for an unhealthy human body. Both the <span>root-cause</span> and symptoms come from the second transfer law of human body energies. A disease treatment should protect and maintain the balance of two incompatibility relations: the loving relationship and the killing relationship. As an application, acupuncture is used to treat atrial premature beats as <span>a congenital</span> heart disease.</span></span></span> 展开更多
关键词 Traditional Chinese Medicine (TCM) yin yang Wu Xing theory Steady Multilateral Systems Incompatibility Relations Side Effects Medical and Drug Resistance Problem
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Yin Yang: A New Perspective in Understanding the Development of Religion in Contemporary China
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作者 CHU YI, Lu 《Cultural and Religious Studies》 2014年第2期78-93,共16页
The Taoism on Yin Yang has influenced the Orientalists' perception concerning the types of relation among all existence in the universe for cenalries. It maintains that a society is comprised of countless antagonisti... The Taoism on Yin Yang has influenced the Orientalists' perception concerning the types of relation among all existence in the universe for cenalries. It maintains that a society is comprised of countless antagonistic components or conflicting social players, including religious institutions and the Chinese government. All existence is charged with two great forces, simply known as Yin and Yang. These two great forces are opposite-but-complementary to each other. They determine how social players interact to avoid chaos and destructions, so balance and harmony are established and maintained in society. In other words, Yin Yang helps the social players to form a harmonious relationship with one and another by weakening or strengthening their inner inherited Yin-or-Yang elements according to timing and conditions. Drawing on recent research on Yin Yang as a novel approach in understanding business-related issues in contemporary China, such concept is also relevant to understand the development of religion in China. 展开更多
关键词 RELIGION China TAOISM yin yang
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The Reality and Application of Yin and Yang
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作者 Wutong Song Hongxin Cao 《Chinese Medicine》 CAS 2022年第2期23-31,共9页
Ancient Chinese philosophers discovered Yin and Yang and the laws of Yin and Yang movement during their exploration and practice of nature more than two thousand years ago, and applied them to life, science, philosoph... Ancient Chinese philosophers discovered Yin and Yang and the laws of Yin and Yang movement during their exploration and practice of nature more than two thousand years ago, and applied them to life, science, philosophy and medicine, playing an important role in the achievement of ancient Chinese civilization. Through historical changes, yin and yang have gradually been regarded as a concept or theory, thus making it difficult for people to understand the connotation of Yin-Yang and make new discoveries and progress. Nowadays, many scholars in China and the West are interested in studying the treasures of ancient Chinese civilization. We illustrate the actual function of Yin and Yang by explaining the essential state of matter, the law of physical movement, the transformation of energy, and then illustrate the practical application in life and science. In conclusion, yin-yang is a key to unlocking the treasures of traditional Chinese civilization, which can help to bring into play its original values, and continue to provide new insights and directions for the development of modern science and the advancement of humanities. 展开更多
关键词 yin and yang Material Properties Physical Movement Energy Transformation Practical Applications
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The combined efficacy of warming Yang therapy and Western of dilated cardiomyopathy with heart medicine the treatment failure:a meta-analysis
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作者 Shan-Fu Chen Jian-Zhong Pang +1 位作者 You Zhai Ying-Qiang Zhao 《Drug Combination Therapy》 2020年第3期137-148,共12页
Background:To evaluate the clinical efficacy of oral administration of Chinese medicines with warming Yang effects and Western medicine in the treatment of heart failure caused by dilated cardiomyopathy.Methods:Seven ... Background:To evaluate the clinical efficacy of oral administration of Chinese medicines with warming Yang effects and Western medicine in the treatment of heart failure caused by dilated cardiomyopathy.Methods:Seven databases including Chinese National Knowledge Infrastructure,Weipu database,Wanfang database,China Biomedical Literature Service System,Cochrane library,PubMed,and Embase were searched.The search date was from established to October 2019.Randomized clinical trials of dilated cardiomyopathy patients with heart failure under the combination treatment of Chinese medicines with warming Yang effects and Western medicine were included.We then assessed the methodological quality of included literatures,extracted valid data and conducted systematically evaluation according to the Cochrane systematic review method.Outcome index included clinical efficacy,left ventricular ejection fraction,and brain natriuretic peptide.Results:Meta-analysis results showed that the clinical effective rate was higher in the combination group than that in the control group(RR=1.24,95%CI(1.14,1.34),P<0.01).In addition,the combination group could improve left ventricular ejection fraction compared with the control group(Std.MD=0.85,95%CI(0.69,1.01),P<0.01).However,the meta-analysis of brain natriuretic peptide levels showed that the included literatures have higher heterogeneity and the meta-analysis results were unstable.So the results of brain natriuretic peptide were abandoned.Conclusion:Oral administration of Chinese medicines with warming Yang effects combined with Western medicine is better than Western medicine alone in improving clinical effect and left ventricular ejection fraction,but it is not clear whether brain natriuretic peptide can be improved.Because the quality of the included studies is not high and inconsistent outcome index,more standardized and rigorous randomized double-blind controlled trials are needed to validate and guide clinical use. 展开更多
关键词 Dilated cardiomyopathy heart failure Warming yang META-ANALYSIS LVEF BNP
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Research on Sports Health System from the perspective of Yin-Yang and Balance
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作者 Jiaqi Kou 《International Journal of Technology Management》 2017年第1期35-37,共3页
Traditional sports health is an integral part of Chinese culture, Chinese civilization is accompanied by a process to produce, to grow up. It has self-cultivation, physical ? tness and longevity effect. Unfortunately... Traditional sports health is an integral part of Chinese culture, Chinese civilization is accompanied by a process to produce, to grow up. It has self-cultivation, physical ? tness and longevity effect. Unfortunately, despite thousands of years of traditional sports health practice, the formation of a rich health ideas, but these traditional sports health mind, like scattered pearls scattered in the literature and practice of traditional sports health, without to pick up a bunch of dressed form traditional sports regimen thought a monograph system. Based on this, the present study the history of ideas as a starting point for a study of traditional sports and health aspects of the history of ideas, aimed at the formation of traditional sports and health history of ideas monographs, traditional sports for the rich theory of health and promote the further development of traditional sports health theoretical system of scientific value. We life philosophy, yin and yang sports concept of yin and yang as the number concept of yin and yang concept of information four angles, analyzes the theory of Yin and Yang. 展开更多
关键词 yin and yang balance perspective HEALTH sports system ANALYTIC
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Research on the Flexible Yoga Training Mode based on Yin and Yang Theory of Dialectical Thinking Pattern
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作者 Xueyan Li 《International Journal of Technology Management》 2015年第11期55-57,共3页
In this research paper, we conduct research on the flexible yoga training mode based on Yin and Yang theory of dialectical thinking pattern. Yoga become modem young people are increasingly keen on sports exercise prog... In this research paper, we conduct research on the flexible yoga training mode based on Yin and Yang theory of dialectical thinking pattern. Yoga become modem young people are increasingly keen on sports exercise program, at the same time, as more ferocious originated in India yoga culture, even beyond the native of the popularity of the tai chi culture in China, in view of this kind of social cultural phenomenon, the author think it is necessary to carry out the two of fitness culture contrast research, to more deep understanding from angle of culturology of tai chi chuan and the Indian yoga in development in our country, as well as the similarities and differences of inheritance, development and research of its better to provide theoretical reference. We discuss the combination of the cutures and propose the flexible yoga training mode which is innovative. 展开更多
关键词 Yoga Training yin and yang Dialectical Thinking Pattern Flexible Yoga.
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Assessment of Ankylosing Spondylitis Based on the Theory of Yin and Yang in Traditional Chinese Medicine
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作者 Yuan Cheng Jichao Yin +3 位作者 Xinglv Hu Penggang Xu Yingchun Liu Chengxiang Lei 《Journal of Clinical and Nursing Research》 2021年第5期33-36,共4页
The theory of yin and yang in Chinese medicine signifies everything and can be used to divide everything in the world.The diagnosis and assessment of ankylosing spondylitis in Western medicine can also be divided by y... The theory of yin and yang in Chinese medicine signifies everything and can be used to divide everything in the world.The diagnosis and assessment of ankylosing spondylitis in Western medicine can also be divided by yin and yang.The current technologies used in Western medicine for detecting ankylosing spondylitis is summarized,divided,and reasoned with the philosophical views of yin and yang in traditional Chinese medicine. 展开更多
关键词 Traditional Chinese medicine Ankylosing spondylitis yin and yang theory
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Discussion on the Application of Warm Yang to Promote Qi Transformation in Acne Mastitis from“Yang Promotes Qi Transformation and Yin Promotes Forming”
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作者 Yupei Chen Zhenlin Chen Pu Zhang 《Journal of Clinical and Nursing Research》 2021年第6期155-158,共4页
“Yang promotes Qi transformation and Yin promotes forming”maintains the normal progress of human life activities,which is an important embodiment of human vitality.The dysfunction of“Yang promotes Qi transformation... “Yang promotes Qi transformation and Yin promotes forming”maintains the normal progress of human life activities,which is an important embodiment of human vitality.The dysfunction of“Yang promotes Qi transformation and Yin promotes forming”leads to the coagulation of pathological products such as phlegm and blood stasis in the breast meridian,resulting in the occurrence of acne mastitis.In clinical treatment,we should take“warm Yang to promote Qi transformation”as the treatment principle,and add or subtract according to the specific situation. 展开更多
关键词 yang promotes Qi transformation and yin promotes formation Warm yang to promote Qi transformation Acne mastitis
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Therapy of Suppressing Yang and Astringing Yin for the Treatment of Cancer-Related Insomnia
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作者 Ranpei Zhu Xu Sun Yuling Zheng 《Chinese Medicine and Natural Products》 2022年第1期11-18,共8页
The pathogenesis of can cer-related in som nia(CRI)mainly in eludes,first,the flow of cancerous toxin leading to the disorder of visceral qi;second,cancer-related radiotherapy and chemotherapy belonging to"exogen... The pathogenesis of can cer-related in som nia(CRI)mainly in eludes,first,the flow of cancerous toxin leading to the disorder of visceral qi;second,cancer-related radiotherapy and chemotherapy belonging to"exogenous pathogenic factors"to a certain extent,which can further aggravate visceral disorders.The therapeutic principle of Chinese medicine is to tranquilize the mind on the basis of regulating viscera,suppressing yang,and astringing yin.On this theoretical basis,Professor Zheng Yuling created a representative prescription of Zhenjing Anshen Granules(镇静安神颗粒)which can achieve the co-regulation of the heart,liver,and kidney,tranquilizing the mind and nourishing the blood.Clinically,the selection of prescriptions and medicines needs to be considered due to factors such as different treatment stages and differ-ences in patients'constitutions. 展开更多
关键词 cancer related insomnia(CRI) suppressing yang and astringing yin Zhenjing Anshen Granules syndrome differentiation and treatment Yuling Zheng
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The Heart of Liuli:Chang Yi and Loretta Yang Hui-shan
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作者 Diana Freundl 《大美术》 2007年第10期144-147,共4页
All images courtesy of the artists■Loretta Yang Hui-shan (杨惠姗) and Chang Yi (张毅) are inseparable.They have done everything together,including giving up stardom 20 years ago to pursue a career in contemporary gla... All images courtesy of the artists■Loretta Yang Hui-shan (杨惠姗) and Chang Yi (张毅) are inseparable.They have done everything together,including giving up stardom 20 years ago to pursue a career in contemporary glass art.With two Golden Horse awards and a prize from the 展开更多
关键词 In the heart of Liuli:Chang Yi and Loretta yang Hui-shan
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Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang 被引量:8
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作者 Hong-Sheng Zhou Bing Z.Carter Michael Andreeff 《Cancer Biology & Medicine》 SCIE CAS CSCD 2016年第2期248-259,共12页
Acute myeloid leukemia (AML) is characterized by the accumulation of circulating immature blasts that exhibit uncontrolled growth, lack the ability to undergo normal differentiation, and have decreased sensitivity t... Acute myeloid leukemia (AML) is characterized by the accumulation of circulating immature blasts that exhibit uncontrolled growth, lack the ability to undergo normal differentiation, and have decreased sensitivity to apoptosis. Accumulating evidence shows the bone marrow (BM) niche is critical to the maintenance and retention of hematopoietic stem cells (HSC), including leukemia stem cells (LSC), and an increasing number of studies have demonstrated that crosstalk between LSC and the stromal cells associated with this niche greatly influences leukemia initiation, progression, and response to therapy. Undeniably, stromal cells in the BM niche provide a sanctuary in which LSC can acquire a drug-resistant phenotype and thereby evade chemotherapy- induced death. Yin and Yang, the ancient Chinese philosophical concept, vividly portrays the intricate and dynamic interactions between LSC and the BM niche. In fact, LSC-induced microenvironmental reprogramming contributes significantly to leukemogenesis. Thus, identifying the critical signaling pathways involved in these interactions will contribute to target optimization and combinatorial drug treatment strategies to overcome acquired drug resistance and prevent relapse following therapy. In this review, we describe some of the critical signaling pathways mediating BM niche-LSC interaction, including SDFI/CXCL12, Wnt/β-catenin, VCAM/VLA-4/NF-κB, CD44, and hypoxia as a newly-recognized physical determinant of resistance, and outline therapeutic strategies for overcoming these resistance factors. 展开更多
关键词 Bone marrow niche leukemia stem cell acute myeloid leukemia yin and yang
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Transcriptional dysregulation in neurodegenerative diseases:who tipped the balance of Yin Yang 1 in the brain? 被引量:1
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作者 Zhefan Stephen Chen Ho Yin Edwin Chan 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第7期1148-1151,共4页
Yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including neurons.It controls neuronal differentiation,as well as neuronal specification and migration... Yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including neurons.It controls neuronal differentiation,as well as neuronal specification and migration during the development of the mammalian nervous system.Besides,YY1 also mediates the transcription of genes that are required for neuronal survival.An impairment of the transcriptional function of YY1 causes neuronal death.This review summarizes recent research findings that unveil the dysfunction of YY1 in multiple neurodegenerative disorders.The expression of disease proteins perturbs the function of YY1 via distinct molecular mechanisms,including recruitment to protein aggregates,protein degradation and aberrant nuclear/cytoplasmic shuttling.Understanding the pathogenic roles of YY1 will further broaden our knowledge of the disease mechanisms in distinct neurodegenerative disorders. 展开更多
关键词 Alzheimer’s disease amyotrophic lateral SCLEROSIS neurodegeneration PROTEIN aggregates recruitment PROTEIN degradation SUBCELLULAR localization TRANSCRIPTIONAL regulation yin yang 1
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Mathematical Reasoning of Treatment Principle Based on “Yin Yang Wu Xing” Theory in Traditional Chinese Medicine 被引量:5
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作者 Yingshan Zhang 《Chinese Medicine》 2011年第1期6-15,共10页
By using mathematical reasoning, this paper demonstrates the treatment principle: “Virtual disease is to fill his mother but real disease is to rush down his son” and “Strong inhibition of the same time, support th... By using mathematical reasoning, this paper demonstrates the treatment principle: “Virtual disease is to fill his mother but real disease is to rush down his son” and “Strong inhibition of the same time, support the weak” based on “Yin Yang Wu Xing” Theory in Traditional Chinese Medicine (TCM). We defined two kinds of opposite relations and one kind of equivalence relation, introduced the concept of steady multilateral systems with two non-compatibility relations, and discussed its energy properties. Later based on the treatment of TCM and treated the healthy body as a steady multilateral system, it has been proved that the treatment principle is true. The kernel of this paper is the existence and reasoning of the non-compatibility relations in steady multilateral systems, and it accords with the oriental thinking model. 展开更多
关键词 Traditional Chinese Medicine yin yang WU Xing” theORY STEADY Multilateral Systems Opposite RELATIONS Side Effects Medical and Drug Resistance Problem
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Mathematical Reasoning of Treatment Principle Based on “Yin Yang Wu Xing” Theory in Traditional Chinese Medicine (II) 被引量:4
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作者 Yingshan Zhang 《Chinese Medicine》 2011年第4期158-170,共13页
By using mathematical reasoning, this paper demonstrates the treatment principle: “Do not treat a disease after it has occurred. But treat the disease before it will occur” (不治已病治未病) based on “Yin Yang Wu X... By using mathematical reasoning, this paper demonstrates the treatment principle: “Do not treat a disease after it has occurred. But treat the disease before it will occur” (不治已病治未病) based on “Yin Yang Wu Xing” Theory in Traditional Chinese Medicine (TCM). We defined generalized relations and reasoning, introduced the concept of generalized steady multilateral systems, and discussed its energy properties. Later based on the treatment of TCM and treated the healthy body as a steady multilateral system, it has been proved that the treatment principle above is true. The kernel of this paper is the existence and reasoning of the non-compatibility relations in steady multilateral systems, and it accords with the oriental thinking model. 展开更多
关键词 Traditional Chinese Medicine (TCM) yin yang WU Xing” theORY STEADY Multilateral Systems Opposite Relations SIDE-EFFECTS Medical and Drug Resistance Problem
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