Yingzhaosu B (1), coexisting with Yingzhaosu A (2) which is an antimalarialprinciple in the traditional Chinese herbal medicine Yingzhao (Artabotrys uncina-tus (L.) Merr.), is a polyhydroxy bisabolene compound. Althou...Yingzhaosu B (1), coexisting with Yingzhaosu A (2) which is an antimalarialprinciple in the traditional Chinese herbal medicine Yingzhao (Artabotrys uncina-tus (L.) Merr.), is a polyhydroxy bisabolene compound. Although its structure wasproposed by Liang and coworkers in 1979, the stereochemistry remained unsettled.From biogenetic viewpoint, it is reasonable to assume that the configuration of 4-Cin Yingzhaosu B is S as that in Yingzhaosu A. Recently, the synthesis of degrada展开更多
Yingzhaosu D (1), coexisting with Yingzhaosu A (2) which is an antimalarial principlein a traditional Chinese herbal medicine Yingzhao (Artabotrys uncinatus L. Merr.), has shownto be a new polyhydroxy sesquiterpene. W...Yingzhaosu D (1), coexisting with Yingzhaosu A (2) which is an antimalarial principlein a traditional Chinese herbal medicine Yingzhao (Artabotrys uncinatus L. Merr.), has shownto be a new polyhydroxy sesquiterpene. We have previously reported the synthesis of Ying-zhaosu A (2) and shown that the configuration at C-4 is S. It is therefore reasonable to as-sume that the corresponding carbon atom in Yingzhaosu D has the same absolute configura-tion. Herein we report an effective method to prepare Yingzhaosu D and its three stereo-展开更多
基金Project supported by the National Natural Science Foundation of China and National Key Laboratory of Bioorganic and Natural Products Chemistry of SIOC.
文摘Yingzhaosu B (1), coexisting with Yingzhaosu A (2) which is an antimalarialprinciple in the traditional Chinese herbal medicine Yingzhao (Artabotrys uncina-tus (L.) Merr.), is a polyhydroxy bisabolene compound. Although its structure wasproposed by Liang and coworkers in 1979, the stereochemistry remained unsettled.From biogenetic viewpoint, it is reasonable to assume that the configuration of 4-Cin Yingzhaosu B is S as that in Yingzhaosu A. Recently, the synthesis of degrada
基金Project supported by the National Natural Science Foundation of China.
文摘Yingzhaosu D (1), coexisting with Yingzhaosu A (2) which is an antimalarial principlein a traditional Chinese herbal medicine Yingzhao (Artabotrys uncinatus L. Merr.), has shownto be a new polyhydroxy sesquiterpene. We have previously reported the synthesis of Ying-zhaosu A (2) and shown that the configuration at C-4 is S. It is therefore reasonable to as-sume that the corresponding carbon atom in Yingzhaosu D has the same absolute configura-tion. Herein we report an effective method to prepare Yingzhaosu D and its three stereo-
