Preliminary basic research and clinical findings have demonstrated that electroacupuncture ther- apy exhibits positive effects in ameliorating depression. However, most studies of the underlying mechanism are at the s...Preliminary basic research and clinical findings have demonstrated that electroacupuncture ther- apy exhibits positive effects in ameliorating depression. However, most studies of the underlying mechanism are at the single gene level; there are few reports regarding the mechanism at the whole-genome level. Using a rat genomic gene-chip, we profiled hippocampal gene expression changes in rats after electroacupuncture therapy. Electroacupuncture therapy alleviated depres- sion-related manifestations in the model rats. Using gene-chip analysis, we demonstrated that electroacupuncture at Baihui （DU20） and Yintang （EX-HN3） regulates the expression of 21 genes. Real-time PCR showed that the genes Vgf, lgf2, Trnp32, Loc500373, Hifla, Folrl, Nrnb, and Rtn were upregulated or downregulated in depression and that their expression tended to nor- malize after electroacupuncture therapy. These results indicate that electroacupuncture at Baihui and Yintang modulates depression by regulating the expression of particular genes.展开更多
Insomnia prevalence may reach up to 30%of the population considering at least one of the following criteria:difficulty in falling asleep,difficulty in remaining asleep,waking up too early,not repairing sleep or bad sl...Insomnia prevalence may reach up to 30%of the population considering at least one of the following criteria:difficulty in falling asleep,difficulty in remaining asleep,waking up too early,not repairing sleep or bad sleep quality,followed by daily consequences of lack of sleep such as lack of attention or stress.Several studies have reported the use of acupuncture as a therapeutic alternative for insomnia treatment showing important results such as anxiety decrease,improvement of sleep quality,decrease of daily consequences of insomnia,among others.The aim of this project was to use acupuncture as treatment for insomnia using the points Shenmen(神门HT7),Taiyuan(太渊LU9),Neiguan(内关PC6)and Yintang(印堂EX-HN3).After the signing of the TCLE,the patient answered a questionnaire during sessions 1,5 and10.The patient received insomnia treatment through puncture of the following points:HT7,LU9,PC6 and EX-HN3.The patient reported a significant improve in the sleep quality after the first sessions and absence of the symptoms after the tenth session.Therefore we conclude that the stimulation of these acupoints is useful in the insomnia treatment.展开更多
基金supported by the National Natural Science Foundation of China,No.81273847
文摘Preliminary basic research and clinical findings have demonstrated that electroacupuncture ther- apy exhibits positive effects in ameliorating depression. However, most studies of the underlying mechanism are at the single gene level; there are few reports regarding the mechanism at the whole-genome level. Using a rat genomic gene-chip, we profiled hippocampal gene expression changes in rats after electroacupuncture therapy. Electroacupuncture therapy alleviated depres- sion-related manifestations in the model rats. Using gene-chip analysis, we demonstrated that electroacupuncture at Baihui （DU20） and Yintang （EX-HN3） regulates the expression of 21 genes. Real-time PCR showed that the genes Vgf, lgf2, Trnp32, Loc500373, Hifla, Folrl, Nrnb, and Rtn were upregulated or downregulated in depression and that their expression tended to nor- malize after electroacupuncture therapy. These results indicate that electroacupuncture at Baihui and Yintang modulates depression by regulating the expression of particular genes.
文摘Insomnia prevalence may reach up to 30%of the population considering at least one of the following criteria:difficulty in falling asleep,difficulty in remaining asleep,waking up too early,not repairing sleep or bad sleep quality,followed by daily consequences of lack of sleep such as lack of attention or stress.Several studies have reported the use of acupuncture as a therapeutic alternative for insomnia treatment showing important results such as anxiety decrease,improvement of sleep quality,decrease of daily consequences of insomnia,among others.The aim of this project was to use acupuncture as treatment for insomnia using the points Shenmen(神门HT7),Taiyuan(太渊LU9),Neiguan(内关PC6)and Yintang(印堂EX-HN3).After the signing of the TCLE,the patient answered a questionnaire during sessions 1,5 and10.The patient received insomnia treatment through puncture of the following points:HT7,LU9,PC6 and EX-HN3.The patient reported a significant improve in the sleep quality after the first sessions and absence of the symptoms after the tenth session.Therefore we conclude that the stimulation of these acupoints is useful in the insomnia treatment.
