Objective： To observe the clinical efficacy and safety of Yiweining （异位宁, YWN） and gestrinone （GT） in treating post-operational patients of stage Ⅲ endometriosis （EM-Ⅲ）. Methods： Fifty-two patients of EM-...Objective： To observe the clinical efficacy and safety of Yiweining （异位宁, YWN） and gestrinone （GT） in treating post-operational patients of stage Ⅲ endometriosis （EM-Ⅲ）. Methods： Fifty-two patients of EM-Ⅲ after operation were randomly assigned into three groups, the YWN group （20 patients） was treated through oral intake of YWN 200 ml, twice a day; the GT group （19 patients） treated with gestrinone 2.5 mg, twice every week, with the medication starting from the 7th post-operational day and lasting for 6 months. The control group （13 patients） was untreated. Six months was one therapeutic course, and follow-up study was carried out in the 6-30 months after the end of the medication. Results： The recurrence rate in the YWN group and the GT group were 5.0% and 5.3% respectively, showing insignificant difference between the two groups, but they were lower than that in the control group （30.7%, P〈0.05）. Besides, the adverse reaction rate in the YWN group was lower than that in the GT group （ 10.0% vs 31.6%, P〈 0.05）. Conclusion： Application of YWN to prevent the post-operational recurrence of endometriosis is effective and safe, and its efficacy is similar to that of GT.展开更多
基金Supported by the Fund of Natural Sciene of Heilongjiang Province (2004-D55)
文摘Objective： To observe the clinical efficacy and safety of Yiweining （异位宁, YWN） and gestrinone （GT） in treating post-operational patients of stage Ⅲ endometriosis （EM-Ⅲ）. Methods： Fifty-two patients of EM-Ⅲ after operation were randomly assigned into three groups, the YWN group （20 patients） was treated through oral intake of YWN 200 ml, twice a day; the GT group （19 patients） treated with gestrinone 2.5 mg, twice every week, with the medication starting from the 7th post-operational day and lasting for 6 months. The control group （13 patients） was untreated. Six months was one therapeutic course, and follow-up study was carried out in the 6-30 months after the end of the medication. Results： The recurrence rate in the YWN group and the GT group were 5.0% and 5.3% respectively, showing insignificant difference between the two groups, but they were lower than that in the control group （30.7%, P〈0.05）. Besides, the adverse reaction rate in the YWN group was lower than that in the GT group （ 10.0% vs 31.6%, P〈 0.05）. Conclusion： Application of YWN to prevent the post-operational recurrence of endometriosis is effective and safe, and its efficacy is similar to that of GT.
