Histo-Phenotypic Aspects of Breast Cancer in Women under 40 Years Old, in Yaoundé

Introduction: Breast cancer is the most common cancer in women worldwide, with an increasing incidence. Although it is rare and no much studied in young women, it represents 7% of cases worldwide and often appears more aggressive with a poor prognosis compared to its counterpart in older women. The main objective of our study was to describe the histological and phenotypic aspects of breast cancer in women of age under 40. Methodology: We conducted a descriptive and analytical cross-sectional study, with retrospective collection of data over a period of 05 years. All women diagnosed with breast cancer were included and divided into 2 study groups: under 40 years old and over 40 years old. Data were analyzed using SPSS version 23.0 software, compared using the Chi square or Fisher exact test. A p value Results: We retained 196 files, either 89 for those under 40 and 107 for those over 40. Young patients with breast cancer had a higher stage, grade and tumor size. Lymph node involvement was more observed in women under 40 years (69.6% vs 53.2%). Older women were more likely to be hormone receptor positive (54.2% vs 38.2%);p = 0.018. HER-2 overexpression was higher in women younger than 40 years (39.32% vs 25.23%);p = 0.080 with a high Ki67 proliferation index (30.3% versus 2.8%);p 0.001. Triple-negative and Her-2 tumors were much more frequent in young women (48.3% vs. 36.4%;p = 0.063) and (17.97% vs. 10.3%;p = 0.125). Conclusion: Breast cancer in young women remains more aggressive and is dominated by triple negative and Her-2 phenotypes.

Provision of Fertility Preservation for Young Women with Early-Stage Breast Cancer

Breast cancer is the most common cancer in women worldwide, constituting 25% of all cancer diagnoses. Even though it is only affecting 4% - 6% of women under the age of 40, it remains the most common malignancy among younger patients. Advancement in the treatment and earlier detection gives excellent 5 years of survival. However, the standard treatment that comprises surgical-chemo radiation therapy or hormonal treatment often results in an increased incidence of treatment-induced infertility. Therefore, adding fertility preservation to primary cancer treatment may offer the best opportunity for future fertility. However, despite advancements in Assisted Reproductive Technology (ART), the uptake of fertility services in this group remains low. In this review, we highlighted the effect of all breast cancer treatments on women’s fertility, the effectiveness and safety of ART in breast cancer patients as well as the safety of pregnancy in breast cancer survivors. Our aim is to improve awareness of fertility preservation for breast cancer to ensure all women diagnosed with breast cancer have multidisciplinary approaches with early referral to fertility specialists to discuss regarding potential risks and benefits of fertility preservation to improve the uptake of fertility preservation among this group of patients.

Oncologic efficacy of gonadotropin-releasing hormone agonist in hormone receptor-positive very young breast cancer patients treated with neoadjuvant chemotherapy

BACKGROUND Breast cancer in young women has been shown to have an aggressive behavior and poor prognosis.AIM To evaluate the outcomes of young hormone receptor(HR)-positive patients with breast cancer treated with neoadjuvant chemotherapy(NAC),and the oncologic efficacy of gonadotropin-releasing hormone(GnRH)agonists.METHODS This retrospective study involved a prospectively enrolled cohort.We included patients diagnosed with invasive breast cancer who were treated with NAC followed by curative surgery at the Samsung Medical Center and Samsung Changwon Hospital between January 2006 and December 2017.Among patients with HR-positive and human epidermal grow factor 2(HER2)-negative breast cancer,we analyzed the characteristics and oncology outcomes between the patients equal to or younger than 35 years and the patients older than 35 years.RESULTS Among 431 patients with NAC and HR-positive/HER2-negative breast cancer,78 were 35 years old or younger,and 353 patients were older than 35 years.The median follow-up was 71.0 months.There was no statistically significant difference in disease free survival(DFS,P=0.565)and overall survival(P=0.820)between the patients equal to or younger than 35 years and the patients older than 35 years.The two groups differed in that the GnRH agonist was used more frequently in the group of patients equal to or younger than 35 years than in the other group(52.4%vs 11.2%,P<0.001).Interestingly,for the DFS according to the GnRH agonist in the group of patients equal to or younger than 35 years,patients treated with the GnRH agonist had better DFS(P=0.037).CONCLUSION Administration of GnRH agonists might improve the DFS rate of HR-positive/HER2-negative breast cancer in the equal to or younger than 35 years group of patients with NAC.

Changing patterns and survival improvements of young breast cancer in China and SEER database, 1999-2017

Objective: Breast cancer in young females was usually considered more aggressive and requires aggressive therapy. We investigated whether early detection and improved treatments changed the patterns of characteristics,management and outcomes of young breast cancer patients over time.Methods: Females under 40 years of age diagnosed with breast cancer during the periods 1999-2017 and1999-2015 were identified in the Fudan University Shanghai Cancer Center(FUSCC) and the population-based Surveillance, Epidemiology, and End Results(SEER) registry, respectively. Clinicopathologic characteristics and treatment information were collected. Patients diagnosed before 2013 were followed up.Results: The proportions of young breast cancer patients were 15.0% and 5.3% in the FUSCC and SEER cohorts, respectively. In the FUSCC cohort, there was a significant increase in the proportion of ductal carcinoma in situ(DCIS)(from 8.8% to 16.9%;P<0.0001) and it remained stable in SEER cohort. The proportion of T1-stage tumors increased dramatically in the FUSCC cohort(from 35.3% to 41.9%;P=0.008), whereas it decreased in SEER cohort(from 42.4% to 33.0%;P<0.0001). The percentage of estrogen receptor(ER)-positive cancers was consistently increased in both the invasive ductal carcinoma(IDC) and DCIS patients in the two cohorts. Breastconserving surgery and immediate implant reconstruction after mastectomy both exhibited increased use over time in the FUSCC cohort. Both the FUSCC and SEER cohorts showed a significantly better prognosis in the recent time period.Conclusions: With the increased early-stage and ER-positive diseases in young patients as well as better systemic treatment strategies, improved survival has been observed in recent years. There has been a substantial deescalation in surgical therapies in young breast cancer patients.

Prognostic effect analysis of molecular subtype on young breast cancer patients

Objective： To make a prognostic effect analysis of molecular subtype on young breast cancer patients.Methods： Totally 187 cases of young breast cancer patients less than 40 years old treated in Obstetrics and Gynecology Hospital of Fudan University between June 2005 and June 2011 were included in our study. We described their clinical-pathological characteristics, disease-free survival（DFS） rate, and overall survival（OS） rate after a median follow-up period of 61 months. The factors associated with prognosis were also evaluated by univariate and multivariate analyses.Results： All patients were premenopausal, with an average age of 35.36±3.88 years old. The mean tumor size was 2.43±1.53 cm. Eighty-one cases had lymph node metastasis（43.3%）, 126 cases had lymphovascular invasion（67.4%）, and 125 cases had histological grade III（66.8%） disease. Twenty-seven cases（14.4%） were Luminal A subtype, 99 cases（52.9%） were Luminal B subtype, 29 cases（15.5%） were human epidermal growth factor receptor 2（HER-2） overexpression subtype, while 32 cases（17.1%） were triple negative breast cancer（TNBC） subtype according to 2013 St Gallen expert consensus. One hundred and thirty-five cases underwent mastectomy whereas 52 cases had breast-conserving surgery. One hundred and seventy-eight cases underwent adjuvant or neoadjuvant chemotherapy. Recurrence or metastasis occurred in 29 cases, 13 of which died. The 5-year DFS and OS rates were 84% and 92%. Multivariate analysis showed that nodal status（P=0.041） and molecular subtype（P=0.037） were both independent prognostic factors of DFS, while nodal status（P=0.037） and TNBC subtype（P=0.048） were both independent prognostic factors of OS. Conclusions： Molecular subtype is an independent prognostic factor of young breast cancer patients. TNBC has a high risk of relapse and death.

Knowledge and Awareness of Breast Cancer among Young Women in the United Arab Emirates

Background: Breast cancer is the most common cancer among females in the United Arab Emirates (UAE). It carries poor prognosis when detected late. Patients usually present at late stages due to lack of awareness of various aspects of breast cancer. Aim: The objective of this study is to gain insight into the level of knowledge of breast cancer among young adult females in UAE. Methods: A cross-sectional study was conducted among females aged 25 to 45. A total of 492 females were selected using a convenience sampling method. Data were collected through an interview-based questionnaire. Frequency distributions and percentages were used to describe the knowledge tested within the questionnaire. Results: The mean age of the participants was 33.5 years. Almost 27% of our participants received a high school degree. The average total knowledge of our population was 51%. The majority (89%) knew that breast cancer is common and 45% knew that it affects ages above forty. The knowledge of signs and symptoms was 53%, and more than half (57%) knew that the most common presenting sign is a breast lump. The knowledge of risk factors was 43%. Almost 94% knew that cancer can be detected early, and 93% knew that early diagnosis improves outcome. The total knowledge of screening methods was 67%. Conclusion: The study revealed that respondents’ knowledge of breast cancer is less than expected. The increased burden of the disease should be accompanied by powerful means of spreading awareness by implementing campaigns that would improve knowledge deficits.

Clinico-pathological characteristics and prognosis of young women with breast

Background:Breast cancer is more common among young women in China than in developed countries.This study analyzes the clinicopathological features and prognosis of young women with breast cancer in southwest China.Materials and Methods:We reviewed the records of 406 breast cancer patients≤35 years old from 2008 to 2017 in southwest China,investigating their biological characteristics and prognosis.Results:In southwest China,8.77%of breast cancer patients were young women.Although the number of breast cancer cases increased over time,the proportion of young women declined.Patients in stages III and IV accounted for 32%of cases.Young women with breast cancer often experienced local and regional recurrence and had a poor prognosis(5-year disease-free survival rate of 54.9%and 5-year overall survival rate of 71.3%).T and N stages were significantly related to disease-free survival and overall survival.Hormone receptor status was associated with overall survival.Conclusions:In southwest China,young women with breast cancer tend to present with late-stage clinical features,and the prognosis remains poor.

Patients with Early-Stage and Estrogen Receptor-Negative Breast Cancers: Young Age Does Link to Poor Outcomes

Purpose: This study aimed to evaluate whether young adult breast cancer patients have poor outcomes independent of established prognostic factors and analyze differences in prognosis between younger and older patients stratified by tumor subtype. Methods: Of 10,950 breast cancer patients treated at West China Hospital between 1998 and 2017, 741 younger patients (Results: We identified 11 parameters (all P P P P = 0.024] and HR for DFS = 1.301 [95% CI, 1.077 - 1.572;P = 0.006]). When stratified by tumor subtype, younger patients with T1, N0, tumor stage I, G3, estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and Ki67 ≥ 14% had a poor BCSS;in addition, patients with T1, N1, tumor stages I and II, G3, ER-negative, PR-negative, and triple-negative had a poorer DFS than older patients. Conclusion: Young age was an independent prognostic factor for BCSS and DFS in breast cancer patients. The increased risk of relapse was most pronounced in early-stage breast cancer, especially in patients with ER-negative disease.

Breast Cancers in Young Woman under 40 Years in Sub-Saharan Africa: Experience of the Gynecology Department of the University and Hospital Center of Treichville (Abidjan—Cote d’Ivoire)

Objective: To describe the epidemiological, clinical and therapeutic characteristics of women under 40 years followed for breast cancer. Method: This is a retrospective and cohort study with descriptive purpose conducted over 10 years on the management of breast cancer in 105 patients under 40 years in the Gynecology Service of the University and Hospital Center of Treichville. Results: The incidence of breast cancer in women under 40 years was 8.4%, and the majority of patients were over 35 years old (64.8%) and had a low socioeconomic level (61.7%). Some patients had classic risk factors for breast cancer: menarche before 12 years (48.6%), nulliparity (20%), family history of breast cancer (1.9%). The discovery of a breast abnormality was made by patients in 97.1% of the cases. Cancers were either isolated (92.4%) or associated with pregnancy (5.7%) or bilateral (1.9%). The majority of cancers were infiltrating ductal carcinomas (86.7%), of SBR II grade (69%). Patients generally benefited from a mastectomy with axillary dissection, framed by chemotherapy. The global survival at 10 years was 5%. Conclusion: This study allowed us to confirm that breast cancers in younger women were a reality in our country and posed us enormous difficulties in their management.

Breast Cancer in Young Women about 87 Cases in the General Surgery Department CHU Gabriel Touré

Our objectives were to determine the frequency of breast cancer in young women, to determine the risk factors for breast cancer in young women, to detail the diagnostic process of the disease, to determine the different therapeutic strategies. This was a retrospective and descriptive study going from January 2005 to December 2021, a period of 17 years. The study involved 87 women with an average age of 33.2 years. Patients consulted 66 times or 75.9% for breast mass. The size of the tumor was greater than or equal to 5 cm in 62 patients;it was localized in the supero external quadrant 41 times or 47.1%. Molecular classification revealed the following results: Luminal A 21.4%;receptive (HER2) positive 28.6%, and triple negative 42.9%. Stage II was the most represented with 47.4%. Histology found infiltrating carcinoma of non-specific type in 76 patients. The treatment was mastectomy axillary dissection in 66 patients, quadrantectomy + axillary dissection in 6 cases (6.9%) associated with radiotherapy in 6 patients, chemotherapy was performed in 79 of our patients and hormone therapy in 10 patients. Conclusion: Breast cancer is frequent in our country. Patients generally consult us at a late stage. The possibility of determining certain receptors and carrying out certain non-surgical treatments on site would improve the prognosis.

Prognostic nomograms for young breast cancer:A retrospective study based on the SEER and METABRIC databases

Background:Young breast cancer(YBC)is a subset of breast cancer that is often more aggressive,but less is known about its prognosis.In this study,we aimed to generate nomograms to predict the overall survival(OS)and breast cancer‐specific survival(BCSS)of YBC patients.Methods:Data of women diagnosed with YBC between 2010 and 2020 were obtained from the Surveillance,Epidemiology,and End Results(SEER)database.The patients were randomly allocated into a training cohort(n=15,227)and internal validation cohort(n=6,526)at a 7:3 ratio.With the Cox regression models,significant prognostic factors were identified and used to construct 3‐,5‐,and 10‐year nomograms of OS and BCSS.Data from the Molecular Taxonomy of Breast Cancer International Consortium(METABRIC)database were used as an external validation cohort(n=90).Results:We constructed nomograms incorporating 10 prognostic factors for OS and BCSS.These nomograms demonstrated strong predictive accuracy for OS and BCSS in the training cohort,with C‐indexes of 0.806 and 0.813,respectively.The calibration curves verified that the nomograms have good prediction accuracy.Decision curve analysis demonstrated their practical clinical value for predicting YBC patient survival rates.Additionally,we provided dynamic nomograms to improve the operability of the results.The risk stratification ability assessment also showed that the OS and BCSS rates of the low‐risk group were significantly better than those of the high‐risk group.Conclusions:Here,we generated and validated more comprehensive and accurate OS and BCSS nomograms than models previously developed for YBC.These nomograms can help clinicians evaluate patient prognosis and make clinical decisions.

中青年乳腺癌患者及其配偶二元应对水平、自我表露与复发恐惧的相关性

目的:探究中青年乳腺癌患者及其配偶二元应对水平、自我表露与复发恐惧的相关性。方法:选取2022年1—10月蚌埠医学院第一附属医院收治的152例中青年乳腺癌患者及其配偶为研究对象。评价所有患者及其配偶应对方式、自我表露、复发恐惧情况,比较所有患者及其配偶不同时间点应对方式、自我表露、复发恐惧评分。分析不同时间点患者及其配偶应对方式、自我表露、复发恐惧评分三者的相关性。结果:T_(1)~T_(2),患者二元应对总分、授权二元应对评分、共同二元应对评分,患者及其配偶支持二元应对评分均升高,T_(3)~T_(4),患者二元应对总分、授权二元应对评分、共同二元应对评分,患者及其配偶支持二元应对评分均降低,差异有统计学意义(P<0.05)。乳腺癌患者自我表露总分于T_(3)达到最高,为(45.56±10.86)分,配偶自我表露总分于T_(3)达到最高,为(44.37±10.71)分,均随时间变化呈先上升再下降趋势,差异有统计学意义(P<0.05)。T3时,患者及其配偶复发恐惧总分、生理健康评分、社会家庭评分最高。T_(1)~T_(4),患者及其配偶复发恐惧总分、生理健康评分、社会家庭评分先上升后下降,差异有统计学意义(P<0.05)。T_(1),患者自我表露与患者及其配偶二元应对总分呈显著正相关关系;配偶自我表露评分与其二元应对评分呈显著正相关关系,与复发恐惧评分呈显著负相关关系(P<0.05)。T_(2),患者自我表露与自身二元应对、配偶自我表露呈显著正相关关系,与自身复发恐惧呈显著负相关关系;配偶自我表露与患者复发恐惧呈显著负相关关系,与自身二元应对呈显著正相关关系;患者二元应对与复发恐惧呈负相关,与配偶二元应对呈显著正相关关系;配偶二元应对与其复发恐惧呈显著负相关关系(P<0.05)。T_(3),患者自我表露与其复发恐惧呈负相关,与配偶二元应对、配偶自我表露均呈显著正相关关系;配偶自我表露与夫妻双方二元应对呈正相关,与配偶复发恐惧呈显著负相关关系;患者二元应对与配偶二元应对呈正相关,与配偶复发恐惧呈显著负相关关系;配偶二元应对与其复发恐惧呈显著负相关关系(P<0.05)。T_(4),患者自我表露与夫妻双方二元应对呈正相关,与自身复发恐惧呈负相关,与配偶自我表露呈显著正相关;配偶自我表露与夫妻双方二元应对均呈正相关,与配偶复发恐惧呈显著负相关;患者二元应对与自身复发恐惧呈负相关,与配偶二元应对呈显著正相关;配偶二元应对与夫妻双方复发恐惧均呈负相关(P<0.05)。结论:乳腺癌患者与其配偶的二元应对水平与自我表露、复发恐惧关系密切。建议针对不同治疗期的患者,临床上应提供有针对性的二元应对干预方案,适当提高患者夫妻自我表露水平,减轻患者的心理负担,并且降低患者对疾病复发的恐惧感,进而提高患者的生活质量。

中青年乳腺癌术后患者积极度及影响因素分析

目的了解中青年乳腺癌术后患者积极度现状并分析影响因素,为采取干预措施提高患者积极度提供参考。方法便利抽取208例乳腺癌术后患者为研究对象,采用一般资料调查表、患者积极度量表、社会影响量表(测评病耻感)、社会支持评定量表及乳腺癌幸存者自我效能感量表进行调查。结果中青年乳腺癌术后患者积极度得分为(58.10±9.45)分。多元线性回归分析显示,文化程度、是否保留乳房、病耻感、社会支持及自我效能感是中青年乳腺癌术后患者积极度的影响因素(均P<0.05)。结论中青年乳腺癌术后患者积极度处于中等水平,受多因素影响;可通过降低病耻感、增强社会支持及提高自我效能感,提高乳腺癌患者的自我管理积极度。

中青年乳腺癌幸存者性生活现状及其影响因素研究

目的:调查中青年乳腺癌幸存者的性生活及性健康教育需求现状,探索其影响因素,为今后制订有针对性的干预策略提供参考依据。方法:采取方便抽样法,选取2022年10月—2023年4月在江苏省某三级甲等肿瘤专科医院乳腺外科就诊的229例乳腺癌幸存者为研究对象。采用一般资料调查表、乳腺癌幸存者性生活满意度问卷和性生活的健康教育需求问卷对其进行调查。结果:乳腺癌幸存者性生活满意度问卷得分为(47.73±11.15)分,多元逐步回归分析结果显示年龄、手术方式、是否接受内分泌治疗以及术前决策时是否考虑过对性生活的影响是影响中青年乳腺癌幸存者性生活满意度的主要因素,可解释性生活满意度32.2%的变异。有74.2%的病人想追求性生活相关指导而没有正确的途径,99.6%的乳腺癌幸存者更倾向于向女性医护人员咨询性生活相关问题。结论:中青年乳腺癌幸存者性生活满意度较低,建议开展术前手术决策辅助支持、术后性生活指导等干预以促进健康的性生活。此外,需对接受内分泌等综合治疗的病人加强针对性干预。

乳腺X线摄影及超声检查对不同病理类型及分子分型青年乳腺癌的诊断价值

目的 探讨乳腺X线摄影及超声检查对不同病理类型及分子分型青年女性乳腺癌的诊断价值。方法 选取我院经病理证实的青年女性乳腺癌患者87例,分析基本特征、病理类型、分子分型、影像学表现特点,对比乳腺X线摄影及超声检查的灵敏度及其联合灵敏度。结果 浸润性导管癌(invasive ductal carcinoma,IDC)为最常见病理类型(46.0%),最常见分子分型为Luminal B型(48.3%)。乳腺X线摄影中IDC常表现为不规则形,边缘模糊的肿块;IDC并导管原位癌(ductal carcinoma in situ,DCIS)以无定形、成簇或集群样分布的钙化为主;DICS以钙化或其他征象(结构扭曲或局灶性不对称)为主,钙化呈段样或弥漫性分布;其他类型癌主要表现为不规则或团块状,边缘清晰的肿块。Luminal B型以单纯钙化为主(35.7%);Luminal A型及三阴性型以肿块为主(分别为34.5%、42.9%);HER-2过表达型常表现为钙化(55.6%)。超声检查各病理类型及分子分型乳腺超声纵横比、病灶内部或(及)周围血流情况差异无统计学意义(P>0.05)。乳腺X线摄影的灵敏度为59.8%,超声检查的灵敏度为72.4%,二者结合的灵敏度为82.8%。结论 青年女性乳腺癌的个别影像学特征可用来预测肿瘤的某些病理类型。超声检查灵敏度高于乳腺X线摄影,超声检查联合乳腺X线摄影检查,可以提高灵敏度。

年轻乳腺癌患者生育忧虑的潜在剖面分析

目的探讨年轻乳腺癌患者生育忧虑的潜在类别特征,并分析不同类别患者的特征差异。方法采用一般资料调查表、癌症后生育忧虑量表、痛苦表露指数量表修订版、感知伴侣回应性量表对哈尔滨市两所三级甲等医院300例年轻乳腺癌患者进行问卷调查,采用潜在剖面分析和无序多分类Logistic回归模型探索生育忧虑潜在类别特征及其影响因素。结果获得4个潜在类别组:低生育忧虑-自身担忧型(12.67%)、中生育忧虑-均衡型(35.67%)、中生育忧虑-自身担忧型(21.33%)、高生育忧虑-均衡型(30.33%)。年龄、家庭人均月收入、是否为独生子女、家庭生育意愿、癌症家族史、自我表露、感知伴侣回应性是患者生育忧虑潜在类别的影响因素。结论年轻乳腺癌患者生育忧虑存在明显的异质性,临床护理中应根据不同分类特征及影响因素,构建个性化干预措施,以降低患者的生育忧虑水平。

中青年乳腺癌患者术后心理反应的变化轨迹及影响因素研究

目的探讨中青年乳腺癌患者术后心理反应的异质性,并分析自我怜悯及感知伴侣回应对轨迹类别的预测作用。方法基于前瞻性研究设计,于2021年2月至2022年8月选取符合标准的247例中青年乳腺癌患者,采用一般资料调查表、乳腺癌患者心理反应量表、感知伴侣回应量表及自悯量表于术后化疗前、首次化疗后、化疗中期及化疗结束4个时间点进行随访调查,使用潜变量增长混合模型识别轨迹类型。结果中青年乳腺癌患者术后心理反应存在3种不同变化轨迹,命名为中等迟发下降组(61.13%)、低心理反应组(23.89%)和高危持续缓解组(14.98%);多分类logistic回归分析显示,心理反应轨迹类型的影响因素包括手术方式、自我怜悯及感知伴侣回应(均P<0.05)。结论中青年乳腺癌患者术后心理反应存在不同变化轨迹,手术方式、自我怜悯及感知伴侣回应能够预测患者的心理反应轨迹,应加强对中青年乳腺癌患者的心理反应干预,根据轨迹类型制定有效干预方案。

青年女性乳腺癌患者生育忧虑水平及影响因素的研究

目的:了解青年女性乳腺癌患者生育忧虑水平,并分析其影响因素。方法:选取本院2022年1月-2023年6月收治的青年女性乳腺癌患者为研究对象。采用一般资料调查表、癌症后生育忧虑量表、社会支持评定量表进行调查。采用单因素及多重线性回归模型分析影响青年女性乳腺癌患者生育忧虑水平的相关因素。结果:青年女性乳腺癌患者生育忧虑量表得分为(63.9±11.5)分,社会支持得分为(40.7±5.3)分,社会支持与生育忧虑呈负相关(r=-0.479,P<0.001)。多重线性回归分析显示,年龄(β=-0.105)、家庭经济收入(β=-0.196)、子女数量(β=-0.230)、疾病病程(β=0.118)、手术方式(β=0.184)、社会支持水平(β=-0.219)是青年女性乳腺癌患者生育忧虑的影响因素。结论:低龄、低收入、无子女、病程较长、术后乳房缺失的青年女性乳腺癌患者生育忧虑水平较高。增加社会支持,对患者生育忧虑具有保护作用。建议主动为患者提供生育咨询,制定个体化的治疗计划和生育保留方案,并鼓励患者主动寻求和利用社会支持缓解疾病压力,以降低生育忧虑。

年轻女性乳腺癌不同分子亚型的超声声像图特征分析

目的:探讨40岁以下年轻女性乳腺癌患者不同分子亚型的超声声像图特征。方法:回顾并分析2019年1月—2023年5月于南京中医药大学附属医院行乳腺超声检查并行乳腺癌切除术,且经手术后病理学检查证实为乳腺癌的年轻女性患者60例。按免疫组织化学检查结果分为Luminal A型、Luminal B型、三阴性型及人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)过表达型,分析不同亚型在肿块最大径、方位、纵横比、形态、边界、边缘毛刺征、内部回声、钙化灶、后方回声、血流分级、弹性评分方面的超声特点。结果:在60例乳腺癌患者中,Luminal A型较为常见(40.0%),HER2过表达型最少见(15.0%)。在不同分子亚型中,肿物的边缘毛刺征、钙化灶、后方回声差异有统计学意义(P<0.05),其中Luminal A型与Luminal B型多以边缘毛刺征(79.2%、55.3%)为主要表现,三阴性型多以后方回声增强或不变(91.7%)为主要表现,HER2过表达型多以钙化灶(88.9%)为主要表现。而在肿块最大径、方位、纵横比值、形态、边界、内部回声、血流分级、弹性评分中差异无统计学意义(P>0.05)。结论:年轻女性乳腺癌患者的超声声像图特征与其分子亚型存在一定相关性,可为术前预测乳腺癌分子亚型提供有价值的参考。

PERMA积极心理干预对青年乳腺癌病人康复心理的影响

目的:探究PERMA积极心理干预对青年乳腺癌病人康复心理的影响。方法:选择医院2021年3月—2023年2月收治的110例青年乳腺癌病人为研究对象,按随机数字表法分为对照组、观察组,每组55例。对照组采取常规护理,观察组在对照组基础上增加PERMA积极心理干预,采用中文版癌症病人恐惧疾病进展简化量表、乳腺癌病人心理弹性量表分别评估病人的癌症复发恐惧及心理弹性水平。结果:观察组病人癌症复发恐惧评分低于对照组(P<0.05);观察组病人心理弹性评分高于对照组(P<0.05)。结论:PERMA积极心理干预应用于青年乳腺癌病人中能缓解病人癌症复发恐惧,有助于提升病人心理弹性水平。