Using allantoin (ATN ) as a marker for reactive oxygen species (ROS), oxidative stress during antituberculous (anti-TB) therapy was compared in 10 young and 9 elderly patients.Before treatment, ATN plasma concentratio...Using allantoin (ATN ) as a marker for reactive oxygen species (ROS), oxidative stress during antituberculous (anti-TB) therapy was compared in 10 young and 9 elderly patients.Before treatment, ATN plasma concentrations in patients were similar to that of volunteers. Administration of a combination of isoniazid (INH ), rifampicin (RIF) and pyrazinamid e (PZA) increased plasma ATN in both groups of patients. ATN concentrations (M± SE) at six hours were higher (P <0.05 ) in elderly than in young patients on day one,8.22 ± 1.50 vs 1.89 ± 0.98 μg/mL); day 30, (5.85 ± 0.82 vs 0.87 ± 0.57 μg/mL; and day 90, (4.84 ± 1.24 vs 0.52 ± 0.50μg/mL). Because total amount of ATN excreted was similar in both groups on the three occasions, more ATN was formed in elderly than young patients. In conclusion, there was more oxidative stress in elderly than young patients. It is thereby suggested that Anti-TB drugs induce formation of ROS and elderly patients are at a greater risk of toxicity probably because of poor antioxidant mechanisms展开更多
This study explores the strategies Chinese families employ to navigate substantial caregiving challenges in the context of demographic changes characterized by low birth rates and an aging populace, alongside a dearth...This study explores the strategies Chinese families employ to navigate substantial caregiving challenges in the context of demographic changes characterized by low birth rates and an aging populace, alongside a dearth of public and commercial caring resources. It delves into familial intergenerational cooperation, utilizing various resources such as connections, norms, and emotions to develop resilience that withstands external pressures. The research acknowledges the positive role of family resilience in safeguarding vulnerable members and maintaining social stability. However, it also highlights the fact that family resilience has its limits and does not have unlimited sustainability. Sustainable family resilience can be bolstered by redefining the distribution of duties and resources among the government, the community, and families for the care of the young and the elderly. This involves creating a multifaceted welfare system anchored by government backing that places families at its center and by improving the commercial provision of care services. This facilitates the positive self-generation and reproduction of caring resources within the familial framework.展开更多
文摘Using allantoin (ATN ) as a marker for reactive oxygen species (ROS), oxidative stress during antituberculous (anti-TB) therapy was compared in 10 young and 9 elderly patients.Before treatment, ATN plasma concentrations in patients were similar to that of volunteers. Administration of a combination of isoniazid (INH ), rifampicin (RIF) and pyrazinamid e (PZA) increased plasma ATN in both groups of patients. ATN concentrations (M± SE) at six hours were higher (P <0.05 ) in elderly than in young patients on day one,8.22 ± 1.50 vs 1.89 ± 0.98 μg/mL); day 30, (5.85 ± 0.82 vs 0.87 ± 0.57 μg/mL; and day 90, (4.84 ± 1.24 vs 0.52 ± 0.50μg/mL). Because total amount of ATN excreted was similar in both groups on the three occasions, more ATN was formed in elderly than young patients. In conclusion, there was more oxidative stress in elderly than young patients. It is thereby suggested that Anti-TB drugs induce formation of ROS and elderly patients are at a greater risk of toxicity probably because of poor antioxidant mechanisms
文摘This study explores the strategies Chinese families employ to navigate substantial caregiving challenges in the context of demographic changes characterized by low birth rates and an aging populace, alongside a dearth of public and commercial caring resources. It delves into familial intergenerational cooperation, utilizing various resources such as connections, norms, and emotions to develop resilience that withstands external pressures. The research acknowledges the positive role of family resilience in safeguarding vulnerable members and maintaining social stability. However, it also highlights the fact that family resilience has its limits and does not have unlimited sustainability. Sustainable family resilience can be bolstered by redefining the distribution of duties and resources among the government, the community, and families for the care of the young and the elderly. This involves creating a multifaceted welfare system anchored by government backing that places families at its center and by improving the commercial provision of care services. This facilitates the positive self-generation and reproduction of caring resources within the familial framework.
