Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained four new spirostanol glycosides,named ypsilandrosides U-X(1-4),and one new cholestanol glycoside,named ypsilandroside Y(5).Their struc...Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained four new spirostanol glycosides,named ypsilandrosides U-X(1-4),and one new cholestanol glycoside,named ypsilandroside Y(5).Their structures have been established by extensive spectroscopic data and chemical methods.Among them,compound 4 is a rare spirostanol glycoside which possesses a novel 5(6→7)abeo-steroidal aglycone,while compound 1 is a first spiro-stanol bisdesmoside attached to C-3 and C-12,respectively,isolated from the genus Ypsilandra.The induced platelet aggregation activity of the isolates was tested.展开更多
Two new monosaccharide steroidal saponins,named ypsilandroside S(1)and ypsilandroside T(2),have been isolated from the whole plants of Ypsilandra thibetica.Their structures were elucidated as heloniogenin 3-O-b-D-apio...Two new monosaccharide steroidal saponins,named ypsilandroside S(1)and ypsilandroside T(2),have been isolated from the whole plants of Ypsilandra thibetica.Their structures were elucidated as heloniogenin 3-O-b-D-apiofuranoside(1)and pregna 5,16-dien-3b,12a-diol-20-one-3-O-b-D-apiofuranoside(2)by spectroscopic techniques(1D and 2D NMR,MS).Compounds 1 and 2 were tested for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells.展开更多
The whole plants of Ypsilandra thibetica have been analyzed as part of a systematic study on saponin constituents of medicinal plants.This has resulted in the isolation of two new bisdesmosidic furostanol saponins,nam...The whole plants of Ypsilandra thibetica have been analyzed as part of a systematic study on saponin constituents of medicinal plants.This has resulted in the isolation of two new bisdesmosidic furostanol saponins,named ypsilandroside P(1)and ypsilandroside Q(2),and one new pregnane glycoside,named ypsilandroside R(3),together with nine known steroidal glycosides.Their structures were elucidated on the basis of extensive spectroscopic analysis,including that of 2D NMR data,and the results of acidic hydrolysis.Ypsilandroside P(1)was cytotoxicity against two human tumor cell lines.展开更多
基金supported by the National Natural Science Foundation of China (U1802287 and 32000280)the Ten Thousand Talents Plan of Yunnan Province for Industrial Technology Leading Talentsthe State Key Laboratory of Phytochemistry and Plant Resources in West China (P2019-ZZ02).
文摘Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained four new spirostanol glycosides,named ypsilandrosides U-X(1-4),and one new cholestanol glycoside,named ypsilandroside Y(5).Their structures have been established by extensive spectroscopic data and chemical methods.Among them,compound 4 is a rare spirostanol glycoside which possesses a novel 5(6→7)abeo-steroidal aglycone,while compound 1 is a first spiro-stanol bisdesmoside attached to C-3 and C-12,respectively,isolated from the genus Ypsilandra.The induced platelet aggregation activity of the isolates was tested.
基金the National Natural Science Funding of China(No.31170333)the Natural Science Foundation of Yunnan Province(No.2009CC019).
文摘Two new monosaccharide steroidal saponins,named ypsilandroside S(1)and ypsilandroside T(2),have been isolated from the whole plants of Ypsilandra thibetica.Their structures were elucidated as heloniogenin 3-O-b-D-apiofuranoside(1)and pregna 5,16-dien-3b,12a-diol-20-one-3-O-b-D-apiofuranoside(2)by spectroscopic techniques(1D and 2D NMR,MS).Compounds 1 and 2 were tested for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells.
基金supported by National Natural Science Funding of China(No.31170333)the Natural Sci-ence Foundation of Yunnan Province(No.2009CC019)+1 种基金the West Light Foundation of the Chinese Academy of Sciences(No.2908025712W1)a fund(No.540806321211)of State Key Laboratory of Phytochemistry and Plant Resources in West China,Germplasm Bank of Wild Species and CAS Innovation Program of Kunming Institute of Botany.
文摘The whole plants of Ypsilandra thibetica have been analyzed as part of a systematic study on saponin constituents of medicinal plants.This has resulted in the isolation of two new bisdesmosidic furostanol saponins,named ypsilandroside P(1)and ypsilandroside Q(2),and one new pregnane glycoside,named ypsilandroside R(3),together with nine known steroidal glycosides.Their structures were elucidated on the basis of extensive spectroscopic analysis,including that of 2D NMR data,and the results of acidic hydrolysis.Ypsilandroside P(1)was cytotoxicity against two human tumor cell lines.
