(Z)-3-dodecen-1-yl(E)-2-butenoate was synthesized starting from acetylene. The key feature of this approach is use of ethylene diamine in the reaction of acetylene and sodium amide for synthesizing 1-decyne. This reac...(Z)-3-dodecen-1-yl(E)-2-butenoate was synthesized starting from acetylene. The key feature of this approach is use of ethylene diamine in the reaction of acetylene and sodium amide for synthesizing 1-decyne. This reaction allowed a convenient preparation of terminal alkyne with a long chain from cheap and common chemicals. The title sex pheromone synthesized showed highly attractant activity in the field to cylas formicarius fabricius.展开更多
将α-蒎烯选择性氧化制备马鞭草烯酮,对羰基进行肟化和分离,再发生亲核取代反应,合成得到40个新型( Z )-/( E )-马鞭草烯酮肟醚(4a ~4t ,包括20对 Z / E 异构体),采用 1 H NMR、 13 C NMR 、FT-IR、UV-vis和ESI-MS对目标化合物进行了结...将α-蒎烯选择性氧化制备马鞭草烯酮,对羰基进行肟化和分离,再发生亲核取代反应,合成得到40个新型( Z )-/( E )-马鞭草烯酮肟醚(4a ~4t ,包括20对 Z / E 异构体),采用 1 H NMR、 13 C NMR 、FT-IR、UV-vis和ESI-MS对目标化合物进行了结构表征,并测试其抑菌活性。研究结果表明:在质量浓度50 mg/L下,目标化合物对8种植物病原菌均显示出不同程度的抑菌活性,其中化合物( E )- 4r (R=2,6-Cl)对苹果轮纹病菌的抑制率为77.8%,化合物( E )- 4s (R=2,6-F)对水稻纹枯病菌的抑制率为72.7%,化合物( E )- 4n (R= p -CN)对玉米小斑病菌的抑制率为70.8%,( Z )-/( E )-异构体对一些植物病原菌的抑制活性显示一定差异。建立了( E )-马鞭草烯酮肟醚化合物对水稻纹枯病菌抑制活性的CoMFA模型( r 2 =0.992, q 2 =0.507),进行3D-QSAR研究,结果表明建立的模型可用于设计具有潜在高活性的先导化合物。展开更多
Two practical methods for highly stereoselective synthesis of (Z)-2-acylamido-4-phenylcrotonates 2a similar to b have been developed. The key step in the first route was how to control the acid-catalyzed isomerization...Two practical methods for highly stereoselective synthesis of (Z)-2-acylamido-4-phenylcrotonates 2a similar to b have been developed. The key step in the first route was how to control the acid-catalyzed isomerization of condensation mixtures of alpha-keto ester 5 with carbomite. In the second route the key step was reduction of oxime 8, derived from alpha-keto ester 5, with iron powder in the presence of acetic anhydride.展开更多
Alkynylstannanes 1 react with Cp2Zr(H)Cl (Cp=?-C5H5) giving (Z)--stannylvinyl- zirconium complexes 2, which are trapped with NBS or iodine in THF at 0C to stereoselectively afford (Z)-a-bromovinylstannanes and (E)- a-...Alkynylstannanes 1 react with Cp2Zr(H)Cl (Cp=?-C5H5) giving (Z)--stannylvinyl- zirconium complexes 2, which are trapped with NBS or iodine in THF at 0C to stereoselectively afford (Z)-a-bromovinylstannanes and (E)- a-iodovinylstannanes 3, respectively.展开更多
It is demonstrated that (3Z)-nonenal (NON) and (3Z)-hexenal (HEX) are oxidized in a cascade by lipoxygenase (LOX) and hydroperoxide peroxygenase (HP peroxygenase) into (2E)-4-hydroxy-2- nonenal (HNE) and (2E)-4-hydrox...It is demonstrated that (3Z)-nonenal (NON) and (3Z)-hexenal (HEX) are oxidized in a cascade by lipoxygenase (LOX) and hydroperoxide peroxygenase (HP peroxygenase) into (2E)-4-hydroxy-2- nonenal (HNE) and (2E)-4-hydroxy-2-hexenal (HHE), respectively. In turn, HNE inactivates LOX terminating the cascade. The hydroxy-alkenals produced serve to inhibit plant pathogens, which initiated the cascade. In addition to LOX, other unknown oxygenases may be involved in the cascade.展开更多
A series of new Schiff bases derived from 2-aminopyridenes and various aromatic aldehydes have been synthesized and thoroughly investigated by 1H and 13C NMR spectroscopy. The imines were found to exist as only a sing...A series of new Schiff bases derived from 2-aminopyridenes and various aromatic aldehydes have been synthesized and thoroughly investigated by 1H and 13C NMR spectroscopy. The imines were found to exist as only a single E-isomer at ambient temperature. Interestingly, 1H- and 13C-NMR chemical shifts of the (CH=N) amino group are affected by the type of substituent group (X) on the aryl ring. Furthermore UV and IR Spectra of some of the title compounds are also reported.展开更多
文摘(Z)-3-dodecen-1-yl(E)-2-butenoate was synthesized starting from acetylene. The key feature of this approach is use of ethylene diamine in the reaction of acetylene and sodium amide for synthesizing 1-decyne. This reaction allowed a convenient preparation of terminal alkyne with a long chain from cheap and common chemicals. The title sex pheromone synthesized showed highly attractant activity in the field to cylas formicarius fabricius.
文摘将α-蒎烯选择性氧化制备马鞭草烯酮,对羰基进行肟化和分离,再发生亲核取代反应,合成得到40个新型( Z )-/( E )-马鞭草烯酮肟醚(4a ~4t ,包括20对 Z / E 异构体),采用 1 H NMR、 13 C NMR 、FT-IR、UV-vis和ESI-MS对目标化合物进行了结构表征,并测试其抑菌活性。研究结果表明:在质量浓度50 mg/L下,目标化合物对8种植物病原菌均显示出不同程度的抑菌活性,其中化合物( E )- 4r (R=2,6-Cl)对苹果轮纹病菌的抑制率为77.8%,化合物( E )- 4s (R=2,6-F)对水稻纹枯病菌的抑制率为72.7%,化合物( E )- 4n (R= p -CN)对玉米小斑病菌的抑制率为70.8%,( Z )-/( E )-异构体对一些植物病原菌的抑制活性显示一定差异。建立了( E )-马鞭草烯酮肟醚化合物对水稻纹枯病菌抑制活性的CoMFA模型( r 2 =0.992, q 2 =0.507),进行3D-QSAR研究,结果表明建立的模型可用于设计具有潜在高活性的先导化合物。
文摘Two practical methods for highly stereoselective synthesis of (Z)-2-acylamido-4-phenylcrotonates 2a similar to b have been developed. The key step in the first route was how to control the acid-catalyzed isomerization of condensation mixtures of alpha-keto ester 5 with carbomite. In the second route the key step was reduction of oxime 8, derived from alpha-keto ester 5, with iron powder in the presence of acetic anhydride.
文摘Alkynylstannanes 1 react with Cp2Zr(H)Cl (Cp=?-C5H5) giving (Z)--stannylvinyl- zirconium complexes 2, which are trapped with NBS or iodine in THF at 0C to stereoselectively afford (Z)-a-bromovinylstannanes and (E)- a-iodovinylstannanes 3, respectively.
文摘It is demonstrated that (3Z)-nonenal (NON) and (3Z)-hexenal (HEX) are oxidized in a cascade by lipoxygenase (LOX) and hydroperoxide peroxygenase (HP peroxygenase) into (2E)-4-hydroxy-2- nonenal (HNE) and (2E)-4-hydroxy-2-hexenal (HHE), respectively. In turn, HNE inactivates LOX terminating the cascade. The hydroxy-alkenals produced serve to inhibit plant pathogens, which initiated the cascade. In addition to LOX, other unknown oxygenases may be involved in the cascade.
文摘A series of new Schiff bases derived from 2-aminopyridenes and various aromatic aldehydes have been synthesized and thoroughly investigated by 1H and 13C NMR spectroscopy. The imines were found to exist as only a single E-isomer at ambient temperature. Interestingly, 1H- and 13C-NMR chemical shifts of the (CH=N) amino group are affected by the type of substituent group (X) on the aryl ring. Furthermore UV and IR Spectra of some of the title compounds are also reported.
