Data from Global Cancer Statistics show that breast cancer (BC) is the most common type of cancer among women, leading the number of deaths caused by cancer. The developments in diagnosis and treatment techniques for ...Data from Global Cancer Statistics show that breast cancer (BC) is the most common type of cancer among women, leading the number of deaths caused by cancer. The developments in diagnosis and treatment techniques for the BC, including chemotherapy and/or radiotherapy, increased the survival rates for this type of cancer. One late complication induced by BC treatment is the cardiotoxicity. This term comprises different cardiotoxic side effects, which include blood pressure alterations, myocardial ischemia, congestive heart failure and other damages. This study aimed to evaluate the cardiac alterations induced by radiotherapy and chemotherapy, simulating a treatment for BC in Wistar rats. It is, therefore, important to understand the mechanisms involved in the cardiotoxicity, in order to prevent women from this late effect, when they undergo BC treatments. The major interests in this work are in Low atomic weight elements as Sodium, because it is strongly related to cardiomyocyte contraction;Magnesium, because it is important in the cardiac metabolism;and Iron, because BC treatment induced cardiotoxicity can be associated to the oxidative stress. Changes that occur in unhealthy tissues in case to cardiovascular damages can be better understood when elemental compounds and structures of healthy tissues are known. Low Energy X-ray Fluorescence (LEXRF) technique was used to obtain elemental maps of low Z-elements providing a semi-quantitative analysis of the tissues evaluated under different conditions. Through the technique LEXRF we obtained elemental and absorption maps. The results showed more damages when associating chemotherapy and radiotherapy in comparison to myocardium healthy. Those images taken together with light microscopy, X-ray absorption and phase contrast images, satisfactorily characterize the cardiac tissue for the first time in the literature, from the structural and morphological points of view. LEXRF was carried out at TwinMic beamline in the ELETTRA Synchrotron Fa-cility, at the beamline TwinMic, in Trieste, Italy.展开更多
针对传统电缆舞动检测器在面对电磁干扰和持续供电时灵敏度低、信噪比差、安装复杂和需额外供电等问题,提出一种新型双端Mach-Zehnder(M-Z)电缆扰动监测系统.该系统采用双端光纤M-Z光路结构,可实现长距离、大尺度、多维度的在线监测和...针对传统电缆舞动检测器在面对电磁干扰和持续供电时灵敏度低、信噪比差、安装复杂和需额外供电等问题,提出一种新型双端Mach-Zehnder(M-Z)电缆扰动监测系统.该系统采用双端光纤M-Z光路结构,可实现长距离、大尺度、多维度的在线监测和结构安全预警,从而实时定位舞动位置.该系统的检波器力学单元采用硅胶弹性体和黄铜质量块推挽式结构,经ANSYS软件进行参数化建模和有限元分析后,得出其固有频率为106.77 Hz,与实验所测数据的相对误差仅为1.65%.实验结果表明,该检测器在0~140 Hz内的相对灵敏度为41.25~66.78 dB (rad/Pa),对舞动信号具有较高灵敏度的检测能力.展开更多
文摘Data from Global Cancer Statistics show that breast cancer (BC) is the most common type of cancer among women, leading the number of deaths caused by cancer. The developments in diagnosis and treatment techniques for the BC, including chemotherapy and/or radiotherapy, increased the survival rates for this type of cancer. One late complication induced by BC treatment is the cardiotoxicity. This term comprises different cardiotoxic side effects, which include blood pressure alterations, myocardial ischemia, congestive heart failure and other damages. This study aimed to evaluate the cardiac alterations induced by radiotherapy and chemotherapy, simulating a treatment for BC in Wistar rats. It is, therefore, important to understand the mechanisms involved in the cardiotoxicity, in order to prevent women from this late effect, when they undergo BC treatments. The major interests in this work are in Low atomic weight elements as Sodium, because it is strongly related to cardiomyocyte contraction;Magnesium, because it is important in the cardiac metabolism;and Iron, because BC treatment induced cardiotoxicity can be associated to the oxidative stress. Changes that occur in unhealthy tissues in case to cardiovascular damages can be better understood when elemental compounds and structures of healthy tissues are known. Low Energy X-ray Fluorescence (LEXRF) technique was used to obtain elemental maps of low Z-elements providing a semi-quantitative analysis of the tissues evaluated under different conditions. Through the technique LEXRF we obtained elemental and absorption maps. The results showed more damages when associating chemotherapy and radiotherapy in comparison to myocardium healthy. Those images taken together with light microscopy, X-ray absorption and phase contrast images, satisfactorily characterize the cardiac tissue for the first time in the literature, from the structural and morphological points of view. LEXRF was carried out at TwinMic beamline in the ELETTRA Synchrotron Fa-cility, at the beamline TwinMic, in Trieste, Italy.
文摘针对传统电缆舞动检测器在面对电磁干扰和持续供电时灵敏度低、信噪比差、安装复杂和需额外供电等问题,提出一种新型双端Mach-Zehnder(M-Z)电缆扰动监测系统.该系统采用双端光纤M-Z光路结构,可实现长距离、大尺度、多维度的在线监测和结构安全预警,从而实时定位舞动位置.该系统的检波器力学单元采用硅胶弹性体和黄铜质量块推挽式结构,经ANSYS软件进行参数化建模和有限元分析后,得出其固有频率为106.77 Hz,与实验所测数据的相对误差仅为1.65%.实验结果表明,该检测器在0~140 Hz内的相对灵敏度为41.25~66.78 dB (rad/Pa),对舞动信号具有较高灵敏度的检测能力.
