Regulation of Quan Du Zhong capsule on VEGF/bFGF and expression of Bcl‑2/Bax and Caspase‑3 protein in the repairing process of canine femoral head necrosis

Objective:To explore the repair and treatment effect of Quan Du Zhong capsule on necrosis of femoral head in dogs.Methods:Totally 12 beagles were randomly divided into normal group,model group,Quan Du Zhong capsule group and Xianlinggubao capsule group,with three in each group.In addition to the normal group,the other groups established the femoral head necrosis model by liquid nitrogen alternative freezing.The normal group and the model group did not have any intervention during the modeling period,and the Quan Du Zhong group began to receive the Quan Du Zhong by gavage on the day of modeling;Xianlinggubao capsule group was given Xianlinggubao capsule by gavage once a day for 12 consecutive weeks on the day of modeling.The levels of VEGF and bFGF in the blood vessels of each group at the 12th week were compared,and the ratios of BMD,BS/BV,BV/TV,Tb.Th,Tb.N were measured by Micro CT,and the expressions of Bcl-2,Bax,Caspase-3 proteins were detected by immune reaction.Results:1.Compared with the normal group,the level of serum VEGF and bFGF in the model group decreased after 12 weeks of modeling(P<0.05);Compared with the model group,the levels of serum VEGF and bFGF water in the Xianlinggubao capsule group and the Quan Du Zhong capsule group increased on average at the 12th week of modeling,with statistical difference(P<0.05).The level of the Quan Du Zhong capsule group was the highest,followed by the Xianlinggubao capsule group.2.Compared with the normal group,BMD,BS/BV,BV/TV,Tb.Th and Tb.N in the model group were lower,and Tb.SP were higher,the results were statistically significant(P<0.05).Compared with the model group,the BMD,BV/TV,Tb.Th and Tb.N of Xianlinggubao capsule group and the total eucommia capsule group increased,while the BS/BV and Tb.SP decreased(P<0.05).3.The Quan Du Zhong capsule group and Xianlinggubao capsule group could significantly increase the expression of bcl-2 protein in the femoral head of dogs,which was significantly different from the model group(P<0.05).The expression of bax protein in the femoral head of dogs in the Quan Du Zhong capsule group and the Xianlinggubao capsule group was significantly reduced compared with the model group(P<0.05).The expression of caspase-3 protein in the femoral head of dogs was significantly reduced in the Quan Du Zhong capsule group and Xianlinggubao capsule group,which was significantly different from the model group(P<0.05).Conclusion:Quan Du Zhong capsule can increase the expression of VEGF and bFGF in serum,increase the expression of bcl-2,inhibit the expression of bax,and reduce the expression of caspase-3,which plays a synergistic role in the treatment of avascular necrosis of the femoral head,and has potential targets.

A Study on Fang Zhong’s Translation of Tao Yuan-Ming’s Poems from the Perspective of Supermemes of Translation

In the background of different language among different countries, a good translation becomes important when wecommunicate with foreigners and at the same time, some theories are concerned by the translators and learners oftranslation. This paper is to describe Fang Zhong’s translation version of Tao Yuan-Ming’s poems, themasterpieces favored by the public, using supermemes as follows: Source-target, the equivalence, untranslatability,Free-vs-literal, all-writing-is-translating, which are the inheritance and deepening of memes of translation, whichnaturally promotes cultural communication and mutual understanding among countries.

Can PC-9 Zhong chong replace K-1 Yong quan for the acupunctural resuscitation of a bilateral double-amputee? Stating the “random criterion problem” in its statistical analysis

AIM: To present an inclusion criterion for patients who have suffered bilateral amputation in order to be treated with the supplementary resuscitation treatment which is hereby proposed by the author.METHODS: This work is based on a Retrospective Cohort model so that a certainly lethal risk to the control group is avoided.RESULTS: This paper presents a hypothesis on acupunctural PC-9 Zhong chong point, further supported by previous statistical work recorded for the K-1 Yong quan resuscitation point.CONCLUSION: Thanks to the application of the resuscitation maneuver herein proposed on the previously mentioned point, patients with bilateral amputation would have another alternative treatment available in case basic and advanced CPR should fail.

基于Mallat-Zhong离散小波变换小波的超声图像各向异性扩散抑噪方法

针对传统各向异性扩散方法在超声图像散斑噪声抑制中存在的噪声抑制不充分与边缘特征保持不足的问题,提出一种基于Mallat-Zhong离散小波变换(MZ-DWT)小波的散斑噪声抑制方法。该方法将MZ-DWT小波分析与期望值最大化(EM)算法作为图像中均匀区域与边缘区域的鉴别因子,使扩散系数能够更准确地控制扩散强度与扩散速度,从而达到充分抑制噪声和保护边缘的目的。实验结果表明,所提方法在有效抑制散斑噪声的同时,更好地保持了图像细节信息,其性能优于传统各向异性扩散方法。

BEIJING HUA ZHONG MEDICAL EQUIPMENT COMPANY

Beijing Hua Zhong Medical Equipment Company,managed by the New Technology Institute of China Academy of Tra-ditional Chinese Medicine before,now has become the base independently monopolizing such traditional Chinese medicalappliances as acupuncture needles and moxibustion apparatus.And our company has set up medical book department,TCMcomputer department,TCM medicine department and so on.All the equipments at our company have been appraised by fa-mous experts of TCM and granted qualified certificates or gold medals.All these kinds are very much favored by

“Eastern”Xi Yang Qian(Rubia tirctorum L.)and“Western”Zhong Guo Qian(Rubia cordifolia L.):Across the Regions

Qian Cao(Radix et Rhizoma Rubiae)is a perennial grass with red and yellow pigments in its roots.It has been used since ancient times for fabric dyeing and painting,and it’s the oldest red dye in both Europe and China.Xi Yang Qian(Rubia tirctorum L.)spread from the East to the West,while Zhong Guo Qian(Rubia cordifolia L.)spread from the West to the East.Both were integral in the development of Chinese and Western color cultures.Nowadays,although it is no longer commonly used in dyes and paints,Qian Cao is still used in clinical medicine as a medicinal herb.

SHIJIAZHUANG ZHONGYA CANDLE CO,.LTD.

Shijiazhuang zhongya candle co,.ltd.We produce candles since 1990s and begain to export candles on 2000 year.or candles most are exported to Africa,middle east,America,and some European Countries,and Russia there are and advanced production line and enquipment and very professinals and technical workers in my factory,.all materials come from china excenllent manufacturer.our so our candles are white,strong.with smooth surface.Our sellers are very professional and friendly.all the inquiry will be replied in the 24hours.Same as our quick shipment.Once we get your deposit we will ship in the 25-30days.

Filming the Margin of Society——Chengdu through the lens of independent filmmaker Chen Zhong

Regarded as the first independent filmmaker in Sichuan, Chen Zhong madeh is debut movie "Love Poems" in his hometown, soon after receiving his MFA on film from Temple University in the United States. The love story, set in Chengdu, perfectly captures the lifestyle of urban poor in the margins of Chinese society.

Effect of Bu-Zhong-Yi-Qi-Tang on deficiency of N-glycan/nitric oxide and islet damage induced by streptozotocin in diabetic rats

AIM: To investigate the effect of Bu-Zhong-Yi-Qi-Tang (Decoction for Reinforcing Middle Jiao and Replenishing Qi) on deficiency of N-glycan/nitric oxide (NO) and islet damage induced by injecting two medium doses of streptozotocin (STZ). METHODS: Diabetes was induced by intraperitoneal injection of STZ at 55 mg/kg on day 1 and day 8. Islet damage was evaluated using a scoring system. Nitrite, nitrate, α-mannosidase and amylase activities were measured by colorimetry. N-glycan patterns of amylase were determined with lectin [ConA, pisum sativum agglutinin (PSA), peanut agglutinin (PNA), and lens culinaris agglutinin (LCA)] affinity precipitation method. RESULTS: Severe islet necrosis and mild islet atrophy were observed in diabetic rats. The number and size ofislets, the activities of α-mannosidase, amylase and nitrite were decreased, while the binding of PNA and LCA to amylase was increased. All of which were improved after treatment with Bu-Zhong-Yi-Qi-Tang. Islet damage was significantly correlated with nitrite, nitrate, α-mannosidase, amylase and the binding of LCA, PNA, and PSA to amylase.CONCLUSION: STZ-induced islet damage is related to N-glycan deficiency in proteins by blocking α-mannosidase activity and no deficiency, accumulation of unfolded proteins, and endoplasmic reticulum stress and activation of cellular signals, all of which are improved after treatment with Bu-Zhong-YiQi-Tang.

Content Features of Medical Journal Zhong Xi Yi Xue Bao(《中西医学报》The International Medical Journal)during the Republican Period and Its Impact on Medicine

As a medical jourmal during the republican period,Zhong Xi Yi Xue Bao(《中西医学报》The International Medical Journal)was characterized by rich and popular content,wide range of know ledge,and better popularization.It had played an important role in spreading modem Western medicine and popularizing medical knowledge in China,promoted the development of modern Chinese medicine and its integration with Western medicine,thus provided essential research value and far-reaching influence for medical science.

Effect of Inter Stock ‘Zhong ai 1hao'on the Structure of Spindle-shaped 'Huangguan' Pear Trees

In order to investigate the effect of dwarfing inter stock on the structure of pear trees,investigations were made to the tree and group structure of the 4-year-old spindle-shaped‘Huangguan'pear grafted with vigorous stock( Pyrus betulaefolia stock) and that grafted with the dwarfing inter stock‘Zhong ai 1 hao'( P. betulaefolia rootstock). The results showed that the 4-year-old‘Huangguan'pear trees grafted with the dwarfing inter stock‘ Zhong ai 1 hao'were 2. 87 m high on average,with 70. 70% of short braches,converted into 21 016. 0 branches per 667 m^2,840. 64 m^2 of leaf area per 667 m^2 with the leaf area coefficient of 1. 75.On the other hand,for the‘Huangguan'trees grafted with vigorous stocks,the average tree height was 3. 17 m,and the short branch proportion was 63. 20%,converted into 15 806. 4 branches per 667 m^2,719. 28 m^2 of leaf area per 667 m^2 with the leaf area coefficient of 1. 55. Therefore,the use of dwarfing inter stock‘Zhong ai 1 hao'had significant dwarfing effect on‘Huangguan'pear trees,which also showed significant yield increasing effect.

A Phoenix Reborn An Interview with Zhong Shan, Chairman of the Board and General Manager of the Zhejiang Zhongda Group Holding Co Ltd

After series of reforms including the introduction of the shareholding system, re-organization of capital, expansion of business fields and scale through cooperation or merge with other enterprises,Zhongda Group has now become a comprehensive enterprise group integrating import and export, foreign and domestic trade, ?and industry and serviceS.In the past five years stan-

结合国标对翡翠的种进行分级

翡翠的种一词起源于商业活动中,因在翡翠质量评价中占据着极其重要的位置而被广泛地推广和使用。于2009年国家颁布了翡翠分级的国标,明确给出了翡翠的定义和透明度、质地、净度、颜色、工艺的分级标准。这极大地促进了翡翠行业的规范性发展,也让其迈向国际市场更近了一步。截至目前,该国标中尚未涵盖种的介绍和分级并且专家学者们对种的概念认识不一,不仅造成了业内人士和学者们的理解困惑也给翡翠质量评估带来了阻力。因此,为进一步补充和完善翡翠分级的内容,笔者总结了前人的经验并以翡翠分级国标中相关内容为基础,从材料学的角度提出了“六面体结构”,详尽讲述了翡翠的成分、相组成、结构及密度、硬度、韧性、强度、抛光性对种的影响,提出了种的评价多因素论。在商业中,种的称谓多为形象描述,类别较多且十分混杂并不适用于翡翠的分级标准。本文列举了种分级的各类影响因素并分析了多因素间的相关性且进一步对它进行简化和归一,最终提出采用表面粗糙度这一指标作为种的分级标准,依此对种划分了四个等级,即好、较好、较差、差。

“这种人”负面评价意义的规约化

短语“这种人”高频用于负面评价,且类型丰富,经常与贬义“指人NP”、贬义属性谓语或修饰语共现。从立场表达三角理论来看,“人称+这种人”是立场表达者对特定主体或客体的负面评价。“语境吸收”“礼貌原则”和“概括机制”是“这种人”负面评价倾向形成的主要机制。

发展型人力资源管理实践对员工主动变革行为的影响机制:中庸思维的调节作用

作为新兴的人力资源管理实践,发展型人力资源管理实践能够对员工的工作动机、行为产生积极影响。然而,在中国本土文化情境下,鲜有文献涉及发展型人力资源管理实践如何影响员工主动变革行为。基于资源保存理论和“能力—动机—机会(AMO)”框架,探讨发展型人力资源管理实践对员工主动变革行为的影响机制和边界条件。通过对三阶段349份有效样本的分析发现,发展型人力资源管理实践对员工主动变革行为具有显著正向影响;员工工作重塑在发展型人力资源管理实践与员工主动变革行为间发挥部分中介作用;中庸思维会进一步强化发展型人力资源管理实践与主动变革行为间关系,且该调节效应会被工作重塑中介。

基于史源学考察的金中都城门问题补证

金贞元元年(1153)海陵王迁都燕京,称金中都。《金史·地理志》记载中都有城门十三,而《大金国志》《金虏图经》《析津志》等文献却称金中都城门十二。针对这两种不同说法,自清代以来学者多有解释讨论,目前学界倾向于认为金中都城门初有十二,后于东北增辟光泰门,成十三之数,又正北“通玄门”曾改名“清夷门”。但这一论断的得出缺乏对相关文献史料源流的充分辨析,且对增辟光泰门及改通玄门名的时间亦论证不清。实际上,其实若从史源学的角度出发,重新梳理相关文献记载,厘清源流,既可补证上述论断,还可进一步推定金章宗为游幸万宁宫的便利而增辟光泰门,“通玄门”改名“清夷门”则是金宣宗迁都汴梁后因避忌蒙古而追改的结果,进而丰富我们对金中都城门制度的认识。

清代雍正时期黄中海道针经考释

黄中海道针经,是雍正五年至七年由文登县知县黄中,根据邑中长老口述而加工编撰的一段从天津至山东自北而南沿海航行的指南。雍正《山东通志》将是段海程收录,这是目前所见最接近原始记录的文献。是部海道针经,详细记叙了沿山东半岛一带海域的地文、水文与气象现象,并总结其规律,具有很强的科学性与实操性,它代表了在传统社会条件下海洋科学技术所能达到的最高峰。同时,它展现出一幅沿线生民捕鱼、商贸、信仰与国家海上管理的清晰生动图景。对黄中海道针经的考释,也让我们重新思考国家层面上的河运海运之争,清代因袭明重农防海的基本国策,由此构建出的一套话语体系,不但遮蔽了繁忙发达的海上往来,而且极大地延迟了海运替代河运的时间。