Metal-organic frameworks(MOFs)are promising new materials that have been intensively studied and possibly applied to various environmental remediation.However,little is known about the fate and risk of MOFs to living ...Metal-organic frameworks(MOFs)are promising new materials that have been intensively studied and possibly applied to various environmental remediation.However,little is known about the fate and risk of MOFs to living organisms in thewater environment.Here,the toxic effects of ZIF-8 nanoparticles(NPs)on benthic organisms were confirmed by sub-chronic toxicity experiments(7 and 14 days)using Corbicula fluminea as the model organism.With exposure doses ranging from 0 to 50 mg/L,ZIF-8 NPs induced oxidative stress behaviors similar to the hormesis effect in the tissues of C.fluminea.The oxidative stress induced by ZIF-8 NPs and the released Zn^(2+)was the crucial cause of the toxic effects.Besides,we also found that the ZIF-8 NPs and dissolved Zn^(2+)may result in different mechanisms of toxicity and accumulation depending on the dosages.The Zn^(2+)release rate of ZIF-8NPswas high at low dosages,leading to a higher proportion of Zn^(2+)taken up by C.fluminea than the particulate ZIF-8.Conversely,at high dosages,C.fluminea mainly ingested the ZIF-8 NPs and resulted in increased mortality.The results have important implications for understanding the fate and biological effects of ZIF-8 in natural aquatic environments.展开更多
文摘Metal-organic frameworks(MOFs)are promising new materials that have been intensively studied and possibly applied to various environmental remediation.However,little is known about the fate and risk of MOFs to living organisms in thewater environment.Here,the toxic effects of ZIF-8 nanoparticles(NPs)on benthic organisms were confirmed by sub-chronic toxicity experiments(7 and 14 days)using Corbicula fluminea as the model organism.With exposure doses ranging from 0 to 50 mg/L,ZIF-8 NPs induced oxidative stress behaviors similar to the hormesis effect in the tissues of C.fluminea.The oxidative stress induced by ZIF-8 NPs and the released Zn^(2+)was the crucial cause of the toxic effects.Besides,we also found that the ZIF-8 NPs and dissolved Zn^(2+)may result in different mechanisms of toxicity and accumulation depending on the dosages.The Zn^(2+)release rate of ZIF-8NPswas high at low dosages,leading to a higher proportion of Zn^(2+)taken up by C.fluminea than the particulate ZIF-8.Conversely,at high dosages,C.fluminea mainly ingested the ZIF-8 NPs and resulted in increased mortality.The results have important implications for understanding the fate and biological effects of ZIF-8 in natural aquatic environments.
