OBJECTIVE: To explore the effects of Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy on treating H.pylori-related gastritis. METHODS: Eighty-two patients with H. pylori-related gastritis treated...OBJECTIVE: To explore the effects of Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy on treating H.pylori-related gastritis. METHODS: Eighty-two patients with H. pylori-related gastritis treated in our hospital from January 2016 to December 2017 were selected according to the random number table method and divided into experimental group and control group, with 41 patients in each group. The control group was treated with standard triple therapy, while the experimental group was additionally treated with modified Chaihu Guizhi Ganjiang Decoction. The venous blood of one elbow was taken before and after treatment. The concentrations of serum CagA and Hp-NAP were detected by enzyme-linked immunosorbent assay(ELISA). The symptoms were evaluated according to the change of symptom scores before and after the intervention. The H.pylori eradication rate was calculated. RESULTS: There was no significant difference in CagA and Hp-NAP concentrations between the 2 groups before intervention(P > 0.05). After intervention, CagA and Hp-NAP concentrations in experimental group were(19.21±6.27) ng/L and(24.37±6.10) ng/L respectively which were lower than(25.81±7.14) ng/L and(32.09±5.73) ng/L of control group. The differences were statistically significant(P < 0.05). The total effective rate of major symptoms in experimental group was 39 cases(95.12%), which was significantly higher than that of the control group(31 cases, 75.61%). There was statistically significant difference between the 2 groups(P < 0.05). The eradication rate of H.pylori was 38 cases(92.68%) in the experimental group, which was significantly higher than 31 cases(75.61%) of the control group. The difference between the 2 groups was statistically significant(P < 0.05). CONCLUSION: Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy can effectively reduce CagA, Hp-NAP of serum level in patients with H.pylori-related gastritis, improve efficacy of symptoms and eradication rate of H.pylori, and is worthy of clinical promotion.展开更多
目的:对真武汤合桂枝茯苓丸加减联合常规药物治疗慢性心力衰竭的有效性进行系统评价。方法:系统检索中国知网、万方医学、维普、中国生物医学文献数据库、Pub Med、Cochrane Library、Web of Science、Embase数据库,收集真武汤合桂枝茯...目的:对真武汤合桂枝茯苓丸加减联合常规药物治疗慢性心力衰竭的有效性进行系统评价。方法:系统检索中国知网、万方医学、维普、中国生物医学文献数据库、Pub Med、Cochrane Library、Web of Science、Embase数据库,收集真武汤合桂枝茯苓丸加减治疗慢性心力衰竭的随机对照试验,搜索至2022年11月6日在库文章。由独立的2名研究者进行文献资料的筛选、资料的提取、评价纳入研究的偏倚风险后,采用Rev Man 5.3软件进行Meta分析。结果:7项纳入的随机对照试验,总样本量684例,其中试验组344例,对照组340例。Meta分析显示结果,治疗后试验组患者的临床综合疗效明显高于对照组,差异有统计学意义[比值比(OR)=4.77,95%置信区间(CI)(2.97,7.67),P<0.00001],降低血清B型脑钠肽水平[均数差(MD)=-70.90,95%CI(-122.89,-18.92),P=0.008]和血清N末端脑钠肽水平[MD=-0.66,95%CI(-1.27,-0.05),P=0.03],升高左心室射血分数[MD=4.64,95%CI(3.19,6.09),P<0.00001],降低左心室舒张末期内径[MD=-3.49,95%CI(-4.10,-2.88),P<0.00001],减少肿瘤坏死因子-α[MD=-4.05,95%CI(-6.18,-1.91),P=0.0002]和超敏C反应蛋白[MD=-2.23,95%CI(-2.99,-1.47),P<0.00001]。结论:当前证据显示,真武汤合桂枝茯苓丸联合常规药物治疗慢性心力衰竭具有较好的疗效,可以提高心功能,改善预后,效果优于单纯应用西药治疗。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。展开更多
文摘OBJECTIVE: To explore the effects of Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy on treating H.pylori-related gastritis. METHODS: Eighty-two patients with H. pylori-related gastritis treated in our hospital from January 2016 to December 2017 were selected according to the random number table method and divided into experimental group and control group, with 41 patients in each group. The control group was treated with standard triple therapy, while the experimental group was additionally treated with modified Chaihu Guizhi Ganjiang Decoction. The venous blood of one elbow was taken before and after treatment. The concentrations of serum CagA and Hp-NAP were detected by enzyme-linked immunosorbent assay(ELISA). The symptoms were evaluated according to the change of symptom scores before and after the intervention. The H.pylori eradication rate was calculated. RESULTS: There was no significant difference in CagA and Hp-NAP concentrations between the 2 groups before intervention(P > 0.05). After intervention, CagA and Hp-NAP concentrations in experimental group were(19.21±6.27) ng/L and(24.37±6.10) ng/L respectively which were lower than(25.81±7.14) ng/L and(32.09±5.73) ng/L of control group. The differences were statistically significant(P < 0.05). The total effective rate of major symptoms in experimental group was 39 cases(95.12%), which was significantly higher than that of the control group(31 cases, 75.61%). There was statistically significant difference between the 2 groups(P < 0.05). The eradication rate of H.pylori was 38 cases(92.68%) in the experimental group, which was significantly higher than 31 cases(75.61%) of the control group. The difference between the 2 groups was statistically significant(P < 0.05). CONCLUSION: Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy can effectively reduce CagA, Hp-NAP of serum level in patients with H.pylori-related gastritis, improve efficacy of symptoms and eradication rate of H.pylori, and is worthy of clinical promotion.
文摘目的:对真武汤合桂枝茯苓丸加减联合常规药物治疗慢性心力衰竭的有效性进行系统评价。方法:系统检索中国知网、万方医学、维普、中国生物医学文献数据库、Pub Med、Cochrane Library、Web of Science、Embase数据库,收集真武汤合桂枝茯苓丸加减治疗慢性心力衰竭的随机对照试验,搜索至2022年11月6日在库文章。由独立的2名研究者进行文献资料的筛选、资料的提取、评价纳入研究的偏倚风险后,采用Rev Man 5.3软件进行Meta分析。结果:7项纳入的随机对照试验,总样本量684例,其中试验组344例,对照组340例。Meta分析显示结果,治疗后试验组患者的临床综合疗效明显高于对照组,差异有统计学意义[比值比(OR)=4.77,95%置信区间(CI)(2.97,7.67),P<0.00001],降低血清B型脑钠肽水平[均数差(MD)=-70.90,95%CI(-122.89,-18.92),P=0.008]和血清N末端脑钠肽水平[MD=-0.66,95%CI(-1.27,-0.05),P=0.03],升高左心室射血分数[MD=4.64,95%CI(3.19,6.09),P<0.00001],降低左心室舒张末期内径[MD=-3.49,95%CI(-4.10,-2.88),P<0.00001],减少肿瘤坏死因子-α[MD=-4.05,95%CI(-6.18,-1.91),P=0.0002]和超敏C反应蛋白[MD=-2.23,95%CI(-2.99,-1.47),P<0.00001]。结论:当前证据显示,真武汤合桂枝茯苓丸联合常规药物治疗慢性心力衰竭具有较好的疗效,可以提高心功能,改善预后,效果优于单纯应用西药治疗。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。
