Objective: To evaluate the effect of Zhizhu Kuanzhong Capsules (枳术宽中胶囊, ZKC) for functional dyspepsia (FD) through meta-analysis. Methods: Online databases, including PubMed, EM base, China National Knowledge In...Objective: To evaluate the effect of Zhizhu Kuanzhong Capsules (枳术宽中胶囊, ZKC) for functional dyspepsia (FD) through meta-analysis. Methods: Online databases, including PubMed, EM base, China National Knowledge Infrastructure, Wanfang Data, VIP database and Cochrane Library, were searched for randomized controlled trials (RCTs) of ZKC for FD from the inception to April, 2016. Trials were selected according to inclusion criteria and were evaluated with quality assessment standards in the Cochrane Handbook for Systematic Reviews of Interventions and Jadad scale. RevMan 5.3 and GRADEprofiler 3.6 were used for statistical analysis and evidence quality assessment. Results: Twenty-three trials with 2,496 patients were included and most of them were of poor methodological quality. ZKC alone or ZKC combined with routine Western medicine (WM) showed a better clinical effect rate compared with the control group of WM [odds ratio (OR)=3.32, 95% confidence interval (2.66, 4.15), P<0.00001]. No serious adverse reactions were reported. Conclusions: ZKC alone or ZKC combined with routine WM could significantly improve the clinical effective rate in the treatment of FD. The quality of the evidence is low, so it is necessary to design multicenter, strictly randomized and double-blind controlled trials with large samples to validate the conclusions.展开更多
目的探讨针灸配合枳术汤对急性脑梗死(acute cerebral infarct,ACI)患者神经功能及溶血磷脂酸(lysophosphatidic acid,LPA)的影响。方法选择2019年4月至2022年4月86例急性脑梗死患者,随机分为两组各43例,对照组予以常规西医治疗,试验组...目的探讨针灸配合枳术汤对急性脑梗死(acute cerebral infarct,ACI)患者神经功能及溶血磷脂酸(lysophosphatidic acid,LPA)的影响。方法选择2019年4月至2022年4月86例急性脑梗死患者,随机分为两组各43例,对照组予以常规西医治疗,试验组在对照组基础上加针灸配合枳术汤治疗。治疗前后采用美国国立卫生院神经功能缺损评分(national institute of health stroke scale,NIHSS)、Fugl-Meyer评分(FMA)、巴塞尔指数(Barthel)对患者进行评估,并检测LPA水平。结果两组的NIHSS评分都有降低的趋势,且试验组更低,差异有统计学意义(P<0.05)。另两项评分均有明显提高,且试验组更高,差异有统计学意义(P<0.05)。两组LPA水平均明显降低,但差异无统计学意义(P>0.05)。试验组愈显率比对照组高一些,差异有统计学意义(P<0.05),但两组之间的总有效率比较差异无统计学意义(P>0.05)。结论针灸配合枳术汤可有效促进ACI患者的神经功能恢复,提高临床疗效,但对血浆LPA无明显影响。展开更多
文摘Objective: To evaluate the effect of Zhizhu Kuanzhong Capsules (枳术宽中胶囊, ZKC) for functional dyspepsia (FD) through meta-analysis. Methods: Online databases, including PubMed, EM base, China National Knowledge Infrastructure, Wanfang Data, VIP database and Cochrane Library, were searched for randomized controlled trials (RCTs) of ZKC for FD from the inception to April, 2016. Trials were selected according to inclusion criteria and were evaluated with quality assessment standards in the Cochrane Handbook for Systematic Reviews of Interventions and Jadad scale. RevMan 5.3 and GRADEprofiler 3.6 were used for statistical analysis and evidence quality assessment. Results: Twenty-three trials with 2,496 patients were included and most of them were of poor methodological quality. ZKC alone or ZKC combined with routine Western medicine (WM) showed a better clinical effect rate compared with the control group of WM [odds ratio (OR)=3.32, 95% confidence interval (2.66, 4.15), P<0.00001]. No serious adverse reactions were reported. Conclusions: ZKC alone or ZKC combined with routine WM could significantly improve the clinical effective rate in the treatment of FD. The quality of the evidence is low, so it is necessary to design multicenter, strictly randomized and double-blind controlled trials with large samples to validate the conclusions.
文摘目的探讨针灸配合枳术汤对急性脑梗死(acute cerebral infarct,ACI)患者神经功能及溶血磷脂酸(lysophosphatidic acid,LPA)的影响。方法选择2019年4月至2022年4月86例急性脑梗死患者,随机分为两组各43例,对照组予以常规西医治疗,试验组在对照组基础上加针灸配合枳术汤治疗。治疗前后采用美国国立卫生院神经功能缺损评分(national institute of health stroke scale,NIHSS)、Fugl-Meyer评分(FMA)、巴塞尔指数(Barthel)对患者进行评估,并检测LPA水平。结果两组的NIHSS评分都有降低的趋势,且试验组更低,差异有统计学意义(P<0.05)。另两项评分均有明显提高,且试验组更高,差异有统计学意义(P<0.05)。两组LPA水平均明显降低,但差异无统计学意义(P>0.05)。试验组愈显率比对照组高一些,差异有统计学意义(P<0.05),但两组之间的总有效率比较差异无统计学意义(P>0.05)。结论针灸配合枳术汤可有效促进ACI患者的神经功能恢复,提高临床疗效,但对血浆LPA无明显影响。
