Objective： To investigate the effect of Modified Zhuye Shigao Decoction （加味竹叶石膏汤, MZSD） and its components on preventing radiation esophagitis of rats. Me,otis： One hundred Wistar rats were randomly divided...Objective： To investigate the effect of Modified Zhuye Shigao Decoction （加味竹叶石膏汤, MZSD） and its components on preventing radiation esophagitis of rats. Me,otis： One hundred Wistar rats were randomly divided into 5 groups, including the control group, radiation model group, MZSD group, Zhuye Shigao Decoction （竹叶石膏汤, ZSD） group, and added ingredients group, 20 rats in each group. The model of radiation esophagitis of rat was established by once local radiation of 40 Gy （330 Mu/min） with a high energy linear accelerator. The administration of Chinese medicine was continued for 14 days from 7 days before radiation application in the three treatment groups. On the 7th and 14th day, the serum was isolated and the levels of inflammatory cytokines tumor necrosis factor （TNF-α）, interleukin 1 β （IL-1 β） and IL-8 were tested. The pathological slices of esophagus were obtained, and the pathological changes were observed. During the whole process, weight and food intake were recorded each day. Resale： On the 7th day after radiation, the esophagus of rats in the MZSD group was almost intact, and the pathological injury score was significantly lower than that of the radiation model group, ZSD group and added ingredients group （P〈0.01）. Compared with the control group, the body weight and food intake of rats in the radiation model group were significantly decreased, and the levels of TNF-α, IL-1 β and IL-8 were significantly increased （P〈0.05 or P〈0.01）, while the MZSD group showed a significant increase in body weight and food intake, and a significant decrease in the levels of TNF- α, IL-1 β and IL-8 compared with the radiation model group, ZSD group and added ingredients group （P〈0.05 or P〈0.01）. Conclusion： MZSD prevents the development of radiation esophagitis probably by inhibiting the generation and release of the inflammatory cytokines TNF- α, IL-1βand iL-8.展开更多
目的观察竹叶石膏汤治疗肺癌胃阴亏虚型化疗呕吐的临床疗效。方法将60例肺癌胃阴亏虚化疗呕吐患者按照数字抽签法随机分为2组。对照组30例采取甲氧氯普胺进行止吐治疗,治疗组30例在对照组治疗基础上采用竹叶石膏汤治疗。观察至化疗后第...目的观察竹叶石膏汤治疗肺癌胃阴亏虚型化疗呕吐的临床疗效。方法将60例肺癌胃阴亏虚化疗呕吐患者按照数字抽签法随机分为2组。对照组30例采取甲氧氯普胺进行止吐治疗,治疗组30例在对照组治疗基础上采用竹叶石膏汤治疗。观察至化疗后第7天临床疗效、恶心呕吐情况及不良反应率,并观察2组治疗前后均对患者进行生活质量(quality of life,QOL)评分。结果治疗组临床疗效优于对照组,差异具有统计学意义(P<0.05);治疗组恶心呕吐分度轻于对照组(P<0.05);治疗组不良反应率低于对照组(P<0.05)。2组治疗后生活质量均有一定的改善(P<0.05),治疗组治疗后QOL评分明显高于对照组(P<0.05)。结论竹叶石膏汤治疗胃阴亏虚型化疗呕吐疗效显著,能有效改善患者的呕吐症状。展开更多
基金Supported by the National Natural Science Foundation of China(No.81173195)Capital Medical Development Fund,China(No.SF-2009-Ⅲ-45)
文摘Objective： To investigate the effect of Modified Zhuye Shigao Decoction （加味竹叶石膏汤, MZSD） and its components on preventing radiation esophagitis of rats. Me,otis： One hundred Wistar rats were randomly divided into 5 groups, including the control group, radiation model group, MZSD group, Zhuye Shigao Decoction （竹叶石膏汤, ZSD） group, and added ingredients group, 20 rats in each group. The model of radiation esophagitis of rat was established by once local radiation of 40 Gy （330 Mu/min） with a high energy linear accelerator. The administration of Chinese medicine was continued for 14 days from 7 days before radiation application in the three treatment groups. On the 7th and 14th day, the serum was isolated and the levels of inflammatory cytokines tumor necrosis factor （TNF-α）, interleukin 1 β （IL-1 β） and IL-8 were tested. The pathological slices of esophagus were obtained, and the pathological changes were observed. During the whole process, weight and food intake were recorded each day. Resale： On the 7th day after radiation, the esophagus of rats in the MZSD group was almost intact, and the pathological injury score was significantly lower than that of the radiation model group, ZSD group and added ingredients group （P〈0.01）. Compared with the control group, the body weight and food intake of rats in the radiation model group were significantly decreased, and the levels of TNF-α, IL-1 β and IL-8 were significantly increased （P〈0.05 or P〈0.01）, while the MZSD group showed a significant increase in body weight and food intake, and a significant decrease in the levels of TNF- α, IL-1 β and IL-8 compared with the radiation model group, ZSD group and added ingredients group （P〈0.05 or P〈0.01）. Conclusion： MZSD prevents the development of radiation esophagitis probably by inhibiting the generation and release of the inflammatory cytokines TNF- α, IL-1βand iL-8.
文摘目的观察竹叶石膏汤治疗肺癌胃阴亏虚型化疗呕吐的临床疗效。方法将60例肺癌胃阴亏虚化疗呕吐患者按照数字抽签法随机分为2组。对照组30例采取甲氧氯普胺进行止吐治疗,治疗组30例在对照组治疗基础上采用竹叶石膏汤治疗。观察至化疗后第7天临床疗效、恶心呕吐情况及不良反应率,并观察2组治疗前后均对患者进行生活质量(quality of life,QOL)评分。结果治疗组临床疗效优于对照组,差异具有统计学意义(P<0.05);治疗组恶心呕吐分度轻于对照组(P<0.05);治疗组不良反应率低于对照组(P<0.05)。2组治疗后生活质量均有一定的改善(P<0.05),治疗组治疗后QOL评分明显高于对照组(P<0.05)。结论竹叶石膏汤治疗胃阴亏虚型化疗呕吐疗效显著,能有效改善患者的呕吐症状。
