无溶剂超声波辅助Zn(OTf)_2催化Michael加成反应研究

在室温,超声波辅助、无溶剂条件下,Zn(OTf)2为催化剂有效地催化胺与α,β-不饱和化合物的Michael加成反应,可快速、高收率的得到相应的Michael加成产物。该方法除了具有实验简单、较好的底物适应性和选择性外,还具有反应速度快、实验后处理简便及对环境友好的优点,这些将有助于化学反应的绿色化进程。所有的Michael加成产物结构均经质谱、红外光谱和核磁共振氢谱分析进行确证。

Rh(Ⅱ) and Zn(Ⅱ) co-catalyzed multi-component reaction for the synthesis of vicinal diols

Oxonium ylide intermediates generated from α-diazocarbonyl compounds and water were trapped by Zn（Ⅱ）-activated α- dicarbonyl compounds. The reaction gave α,β-dihydroxyl acid derivatives in moderate yield.