The objective of this study was to evaluate the difference in the pharmacokinetics of zolpidem tatrate in subjects from five Chinese ethnicities(Han,Mongolian,Uigur,Korean and Hui).Healthy subjects(10 Hans,10 Mongolia...The objective of this study was to evaluate the difference in the pharmacokinetics of zolpidem tatrate in subjects from five Chinese ethnicities(Han,Mongolian,Uigur,Korean and Hui).Healthy subjects(10 Hans,10 Mongolians,10 Uigurs,10 Koreans and 9 Huis)were recruited and each received a 10 mg tablet-dose of zolpidem tatrate.A total of 12 plasma samples were collected over a 12 h period after administration.The concentrations of zolpidem in plasma were determined by an HPLC-FLU method,after which the pharmacokinetic parameters were determined using DAS 2.0 software and analyzed by SPSS 16.0 software.After normalization by weight,no differences were noted in the pharmacokinetic parameters of zolpidem tatrate among the five ethnic groups(P>0.05).However,there were statistically significant differences between males and females for the pharmacokinetic parameters(P<0.05).The metabolism of zolpidem tatrate in males was faster than in females.Results indicate that ethnicity has no significant impact on the pharmacokinetics of zolpidem tatrate after a single oral dose in healthy Chinese subjects.However,an effect of gender on the pharmacokinetics of zolpidem tatrate can be noted.展开更多
基金This research work was supported financially by the Entire Armed Forces“11th 5-year plan”Medicine Health Science and Technology Attach Topic(06G023).
文摘The objective of this study was to evaluate the difference in the pharmacokinetics of zolpidem tatrate in subjects from five Chinese ethnicities(Han,Mongolian,Uigur,Korean and Hui).Healthy subjects(10 Hans,10 Mongolians,10 Uigurs,10 Koreans and 9 Huis)were recruited and each received a 10 mg tablet-dose of zolpidem tatrate.A total of 12 plasma samples were collected over a 12 h period after administration.The concentrations of zolpidem in plasma were determined by an HPLC-FLU method,after which the pharmacokinetic parameters were determined using DAS 2.0 software and analyzed by SPSS 16.0 software.After normalization by weight,no differences were noted in the pharmacokinetic parameters of zolpidem tatrate among the five ethnic groups(P>0.05).However,there were statistically significant differences between males and females for the pharmacokinetic parameters(P<0.05).The metabolism of zolpidem tatrate in males was faster than in females.Results indicate that ethnicity has no significant impact on the pharmacokinetics of zolpidem tatrate after a single oral dose in healthy Chinese subjects.However,an effect of gender on the pharmacokinetics of zolpidem tatrate can be noted.
