Objective The Susong complex zone(SCZ)is a relatively lowgrade metamorphic unit mostly with an epidoteamphibolite facies,located in the southernmost part of the Dabie orogen.However,its rock compositions,ages,
Due to the NP-hardness of the two-sided assembly line balancing (TALB) problem, multiple constraints existing in real applications are less studied, especially when one task is involved with several constraints. In ...Due to the NP-hardness of the two-sided assembly line balancing (TALB) problem, multiple constraints existing in real applications are less studied, especially when one task is involved with several constraints. In this paper, an effective hybrid algorithm is proposed to address the TALB problem with multiple constraints (TALB-MC). Considering the discrete attribute of TALB-MC and the continuous attribute of the standard teaching-learning-based optimization (TLBO) algorithm, the random-keys method is hired in task permutation representation, for the purpose of bridging the gap between them. Subsequently, a special mechanism for handling multiple constraints is developed. In the mechanism, the directions constraint of each task is ensured by the direction check and adjustment. The zoning constraints and the synchronism constraints are satisfied by teasing out the hidden correlations among constraints. The positional constraint is allowed to be violated to some extent in decoding and punished in cost fimction. Finally, with the TLBO seeking for the global optimum, the variable neighborhood search (VNS) is further hybridized to extend the local search space. The experimental results show that the proposed hybrid algorithm outperforms the late acceptance hill-climbing algorithm (LAHC) for TALB-MC in most cases, especially for large-size problems with multiple constraints, and demonstrates well balance between the exploration and the exploitation. This research proposes an effective and efficient algorithm for solving TALB-MC problem by hybridizing the TLBO and VNS.展开更多
Objective The northern Guangxi region is in the southwestern part of the Southern China continent,which is located at the junction of the southwest section of the Early Paleozoic Yangtze block and Cathaysian block.A s...Objective The northern Guangxi region is in the southwestern part of the Southern China continent,which is located at the junction of the southwest section of the Early Paleozoic Yangtze block and Cathaysian block.A series of NNE-trending ductile shear zones are developed in this region,and these ductile shear zones are mostly previously suggested boundary faults of the Early Paleozoic Yangtze block and Cathaysian block,such as the Shoucheng–Piaoli ductile shear zone in Northern Guangxi (Meng Yuanku et al., 2016; Zhang Xuefeng et al., 2015).展开更多
Constraint-induced movement therapy after cerebral ischemia stimulates axonal growth by decreasing expression levels of Nogo-A,RhoA,and Rho-associated kinase(ROCK)in the ischemic boundary zone.However,it remains uncle...Constraint-induced movement therapy after cerebral ischemia stimulates axonal growth by decreasing expression levels of Nogo-A,RhoA,and Rho-associated kinase(ROCK)in the ischemic boundary zone.However,it remains unclear if there are any associations between the Nogo-A/RhoA/ROCK pathway and angiogenesis in adult rat brains in pathological processes such as ischemic stroke.In addition,it has not yet been reported whether constraint-induced movement therapy can promote angiogenesis in stroke in adult rats by overcoming Nogo-A/RhoA/ROCK signaling.Here,a stroke model was established by middle cerebral artery occlusion and reperfusion.Seven days after stroke,the following treatments were initiated and continued for 3 weeks:forced limb use in constraint-induced movement therapy rats(constraint-induced movement therapy group),intraperitoneal infusion of fasudil(a ROCK inhibitor)in fasudil rats(fasudil group),or lateral ventricular injection of NEP1-40(a specific antagonist of the Nogo-66 receptor)in NEP1-40 rats(NEP1-40 group).Immunohistochemistry and western blot assay results showed that,at 2 weeks after middle cerebral artery occlusion,expression levels of RhoA and ROCK were lower in the ischemic boundary zone in rats treated with NEP1-40 compared with rats treated with ischemia/reperfusion or constraint-induced movement therapy alone.However,at 4 weeks after middle cerebral artery occlusion,expression levels of RhoA and ROCK in the ischemic boundary zone were markedly decreased in the NEP1-40 and constraint-induced movement therapy groups,but there was no difference between these two groups.Compared with the ischemia/reperfusion group,modified neurological severity scores and foot fault scores were lower and time taken to locate the platform was shorter in the constraint-induced movement therapy and fasudil groups at 4 weeks after middle cerebral artery occlusion,especially in the constraint-induced movement therapy group.Immunofluorescent staining demonstrated that fasudil promoted an immune response of nerve-regeneration-related markers(BrdU in combination with CD31(platelet endothelial cell adhesion molecule),Nestin,doublecortin,NeuN,and glial fibrillary acidic protein)in the subventricular zone and ischemic boundary zone ipsilateral to the infarct.After 3 weeks of constraint-induced movement therapy,the number of regenerated nerve cells was noticeably increased,and was accompanied by an increased immune response of tight junctions(claudin-5),a pericyte marker(a-smooth muscle actin),and vascular endothelial growth factor receptor 2.Taken together,the results demonstrate that,compared with fasudil,constraint-induced movement therapy led to stronger angiogenesis and nerve regeneration ability and better nerve functional recovery at 4 weeks after cerebral ischemia/reperfusion.In addition,constraint-induced movement therapy has the same degree of inhibition of RhoA and ROCK as NEP1-40.Therefore,constraint-induced movement therapy promotes angiogenesis and neurogenesis after cerebral ischemia/reperfusion injury,at least in part by overcoming the Nogo-A/RhoA/ROCK signaling pathway.All protocols were approved by the Institutional Animal Care and Use Committee of China Medical University,China on December 9,2015(approval No.2015 PS326 K).展开更多
长江经济带是我国重要的水资源聚集区、水生态功能区,但是水环境污染和水资源消耗已成为其可持续发展的障碍。为推动长江经济带绿色高质量发展,本文旨在探究以水资源要素为中心考量长江经济带的资源分配如何影响绿色发展效率,同时厘清...长江经济带是我国重要的水资源聚集区、水生态功能区,但是水环境污染和水资源消耗已成为其可持续发展的障碍。为推动长江经济带绿色高质量发展,本文旨在探究以水资源要素为中心考量长江经济带的资源分配如何影响绿色发展效率,同时厘清长江经济带产业结构调整在其水资源要素影响绿色发展效率过程中发挥的重要作用。论文基于2003—2020年面板数据,运用超效率SBM(slack based measure)模型测算绿色发展效率,分析水资源总量、用水效率和水资源质量三重约束对长江经济带绿色发展效率的影响,并检验了产业结构调整的3个维度,即产业结构合理化、产业结构高级化以及产业结构软化的中介效应及其与水资源约束的交互效应。结果表明:1)水资源约束中用水效率对长江经济带绿色发展效率影响最大,表现为正向促进作用,促进力度表现出上游>中游>下游的特征;2)从中介效应来看,长江经济带全流域主要是产业结构软化在用水效率影响绿色经济发展时发挥了中介作用,分流域来看主要是产业结构高级化发挥了主要作用,产业结构高级化在上游地区水资源总量影响绿色发展效率时表现出了中介作用,在下游地区用水效率、水资源质量影响绿色发展效率过程中也表现出了中介效应;3)从交互效应来看,长江经济带全流域用水效率与产业结构高级化、产业结构软化之间均存在交互作用,此外还存在水量约束与产业结构合理化的交互效应,分区域来看,下游是交互效应作用范围最广的地区,用水效率与产业结构合理化、软化之间以及水量约束与产业结构合理化、高级化、软化之间均存在交互作用。展开更多
基金financially supported by the National Basic Research Program of China(grant No.2015CB856104)the National Natural Science Foundation of China(grant No.41773020)
文摘Objective The Susong complex zone(SCZ)is a relatively lowgrade metamorphic unit mostly with an epidoteamphibolite facies,located in the southernmost part of the Dabie orogen.However,its rock compositions,ages,
基金Supported by National Natural Science Foundation of China(Grant Nos.51275366,50875190,51305311)Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20134219110002)
文摘Due to the NP-hardness of the two-sided assembly line balancing (TALB) problem, multiple constraints existing in real applications are less studied, especially when one task is involved with several constraints. In this paper, an effective hybrid algorithm is proposed to address the TALB problem with multiple constraints (TALB-MC). Considering the discrete attribute of TALB-MC and the continuous attribute of the standard teaching-learning-based optimization (TLBO) algorithm, the random-keys method is hired in task permutation representation, for the purpose of bridging the gap between them. Subsequently, a special mechanism for handling multiple constraints is developed. In the mechanism, the directions constraint of each task is ensured by the direction check and adjustment. The zoning constraints and the synchronism constraints are satisfied by teasing out the hidden correlations among constraints. The positional constraint is allowed to be violated to some extent in decoding and punished in cost fimction. Finally, with the TLBO seeking for the global optimum, the variable neighborhood search (VNS) is further hybridized to extend the local search space. The experimental results show that the proposed hybrid algorithm outperforms the late acceptance hill-climbing algorithm (LAHC) for TALB-MC in most cases, especially for large-size problems with multiple constraints, and demonstrates well balance between the exploration and the exploitation. This research proposes an effective and efficient algorithm for solving TALB-MC problem by hybridizing the TLBO and VNS.
基金funded by the National Natural Science Foundation of China(grants No.41572191 and 41702211)the Natural Science Foundation of Guangxi(grant No.2017GXNSFBA198166)
文摘Objective The northern Guangxi region is in the southwestern part of the Southern China continent,which is located at the junction of the southwest section of the Early Paleozoic Yangtze block and Cathaysian block.A series of NNE-trending ductile shear zones are developed in this region,and these ductile shear zones are mostly previously suggested boundary faults of the Early Paleozoic Yangtze block and Cathaysian block,such as the Shoucheng–Piaoli ductile shear zone in Northern Guangxi (Meng Yuanku et al., 2016; Zhang Xuefeng et al., 2015).
基金supported by the National Natural Science Foundation of China(General Program),No.81771271(to JF)
文摘Constraint-induced movement therapy after cerebral ischemia stimulates axonal growth by decreasing expression levels of Nogo-A,RhoA,and Rho-associated kinase(ROCK)in the ischemic boundary zone.However,it remains unclear if there are any associations between the Nogo-A/RhoA/ROCK pathway and angiogenesis in adult rat brains in pathological processes such as ischemic stroke.In addition,it has not yet been reported whether constraint-induced movement therapy can promote angiogenesis in stroke in adult rats by overcoming Nogo-A/RhoA/ROCK signaling.Here,a stroke model was established by middle cerebral artery occlusion and reperfusion.Seven days after stroke,the following treatments were initiated and continued for 3 weeks:forced limb use in constraint-induced movement therapy rats(constraint-induced movement therapy group),intraperitoneal infusion of fasudil(a ROCK inhibitor)in fasudil rats(fasudil group),or lateral ventricular injection of NEP1-40(a specific antagonist of the Nogo-66 receptor)in NEP1-40 rats(NEP1-40 group).Immunohistochemistry and western blot assay results showed that,at 2 weeks after middle cerebral artery occlusion,expression levels of RhoA and ROCK were lower in the ischemic boundary zone in rats treated with NEP1-40 compared with rats treated with ischemia/reperfusion or constraint-induced movement therapy alone.However,at 4 weeks after middle cerebral artery occlusion,expression levels of RhoA and ROCK in the ischemic boundary zone were markedly decreased in the NEP1-40 and constraint-induced movement therapy groups,but there was no difference between these two groups.Compared with the ischemia/reperfusion group,modified neurological severity scores and foot fault scores were lower and time taken to locate the platform was shorter in the constraint-induced movement therapy and fasudil groups at 4 weeks after middle cerebral artery occlusion,especially in the constraint-induced movement therapy group.Immunofluorescent staining demonstrated that fasudil promoted an immune response of nerve-regeneration-related markers(BrdU in combination with CD31(platelet endothelial cell adhesion molecule),Nestin,doublecortin,NeuN,and glial fibrillary acidic protein)in the subventricular zone and ischemic boundary zone ipsilateral to the infarct.After 3 weeks of constraint-induced movement therapy,the number of regenerated nerve cells was noticeably increased,and was accompanied by an increased immune response of tight junctions(claudin-5),a pericyte marker(a-smooth muscle actin),and vascular endothelial growth factor receptor 2.Taken together,the results demonstrate that,compared with fasudil,constraint-induced movement therapy led to stronger angiogenesis and nerve regeneration ability and better nerve functional recovery at 4 weeks after cerebral ischemia/reperfusion.In addition,constraint-induced movement therapy has the same degree of inhibition of RhoA and ROCK as NEP1-40.Therefore,constraint-induced movement therapy promotes angiogenesis and neurogenesis after cerebral ischemia/reperfusion injury,at least in part by overcoming the Nogo-A/RhoA/ROCK signaling pathway.All protocols were approved by the Institutional Animal Care and Use Committee of China Medical University,China on December 9,2015(approval No.2015 PS326 K).
文摘长江经济带是我国重要的水资源聚集区、水生态功能区,但是水环境污染和水资源消耗已成为其可持续发展的障碍。为推动长江经济带绿色高质量发展,本文旨在探究以水资源要素为中心考量长江经济带的资源分配如何影响绿色发展效率,同时厘清长江经济带产业结构调整在其水资源要素影响绿色发展效率过程中发挥的重要作用。论文基于2003—2020年面板数据,运用超效率SBM(slack based measure)模型测算绿色发展效率,分析水资源总量、用水效率和水资源质量三重约束对长江经济带绿色发展效率的影响,并检验了产业结构调整的3个维度,即产业结构合理化、产业结构高级化以及产业结构软化的中介效应及其与水资源约束的交互效应。结果表明:1)水资源约束中用水效率对长江经济带绿色发展效率影响最大,表现为正向促进作用,促进力度表现出上游>中游>下游的特征;2)从中介效应来看,长江经济带全流域主要是产业结构软化在用水效率影响绿色经济发展时发挥了中介作用,分流域来看主要是产业结构高级化发挥了主要作用,产业结构高级化在上游地区水资源总量影响绿色发展效率时表现出了中介作用,在下游地区用水效率、水资源质量影响绿色发展效率过程中也表现出了中介效应;3)从交互效应来看,长江经济带全流域用水效率与产业结构高级化、产业结构软化之间均存在交互作用,此外还存在水量约束与产业结构合理化的交互效应,分区域来看,下游是交互效应作用范围最广的地区,用水效率与产业结构合理化、软化之间以及水量约束与产业结构合理化、高级化、软化之间均存在交互作用。